Clinical trials
Musculoskeletal Diseases or Conditions clinical trials
Below are recruiting musculoskeletal diseases or conditions clinical trials, each written for real people, not researchers. We’re tracking 4,026 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05531786RecruitingPhase 1/Phase 2
Pacritinib for hard-to-treat chronic graft-versus-host disease
This early-phase study tests pacritinib, a targeted medicine, for chronic graft-versus-host disease (cGVHD) that hasn’t improved after prior treatments. If you qualify, the goal is to reduce cGVHD symptoms and improve how well you function after a stem cell transplant.
Miami, FloridaAges 18–120 - NCT05511363RecruitingPhase 3
Study of a new medicine for psychosis in Alzheimer's disease
This trial tests a new drug called KarXT to see if it can safely reduce hallucinations and delusions in people with Alzheimer's disease. If you or a loved one has Alzheimer's and experiences these symptoms, this study might offer a new treatment option.
Homewood, AlabamaAges 55–90 - NCT05505500Recruiting
Parent and patient interviews for childhood kidney swelling
This study uses interviews to understand how swelling from nephrotic syndrome affects daily life for children and their caregivers. It may help researchers design better care by capturing the patient and parent perspective.
Ann Arbor, MichiganAges 2 years+ - NCT01962415RecruitingPhase 2
Reduced-intensity stem cell transplant for non-cancer disorders
This trial tests whether a gentler (reduced-intensity) conditioning treatment before a stem cell transplant works for non-cancer diseases. It uses specific donor stem cell matches and checks heart, lung, liver, and kidney function to help lower transplant stress while still aiming for benefit.
Pittsburgh, PennsylvaniaAges 2 months–55 years - NCT00692939RecruitingPhase 1/Phase 2
Stem cell transplant for people with Crohn’s who need new options
This trial studies whether an “autologous” stem cell transplant (using your own cells) can improve Crohn’s disease that has not responded to standard treatments. It may help people who have ongoing, hard-to-control Crohn’s even after medicines and/or who have complications that make surgery risky.
Pittsburgh, PennsylvaniaAges 10–60 - NCT05500807RecruitingPhase 1
Emicizumab study for severe von Willebrand disease or overlap disorder
This Phase 1 trial studies how well and safely emicizumab works for people with severe von Willebrand disease (VWD) or VWD plus hemophilia A. Emicizumab is a preventive medicine given regularly to reduce bleeding risk.
Orange, CaliforniaAges birth–90 years - NCT05463796Recruiting
Prevention and early detection for people at high cancer risk
This study looks at surveillance (watching closely), prevention, and early “interception” steps to lower the chance that cancer will develop or be found later. It is for people with genetic risk, past cancer treatment exposures, strong family history, or certain early pre-cancer or high-risk conditions.
Boston, MassachusettsAges Any age - NCT05384132Recruiting
Dental gel trial with deep cleaning for gum disease
This study tests whether a new dental gel used along with deep gum cleaning (scaling and root planing) can improve periodontitis. If you qualify, you would receive standard gum treatment plus the study gel, then be followed over time.
Birmingham, AlabamaAges 18–85 - NCT05457998Enrolling by invitation
Study of Alzheimer’s brain markers using memory testing
This trial looks for signs of Alzheimer’s disease in the brain by using memory and thinking tests, and related study procedures. It may help researchers find better ways to identify Alzheimer’s-related changes earlier.
Providence, Rhode IslandAges 50–80 - NCT05443425RecruitingPhase 1
Leflunomide plus steroids for acute graft-versus-host disease
This early-phase trial tests whether adding leflunomide to standard steroid treatment can better control acute graft-versus-host disease (aGvHD) after a stem cell transplant. It may help reduce the immune reaction that damages the body while keeping treatment safe and manageable.
Duarte, CaliforniaAges 18 years+ - NCT05443906Recruiting
Home exercise program for people with neurodegenerative conditions
This trial studies whether a home exercise program is safe and helpful for people with certain neurodegenerative conditions, including X-linked adrenoleukodystrophy and DARS2-related disease, as well as some other similar diagnoses. You would be asked to do exercises at home and be assessed on your walking and strength/safety.
Baltimore, MarylandAges 5–75 - NCT05452356Recruiting
Testing a phone-based care plan for people with heart conditions
This trial tests a phone app that helps deliver organized “care plans” for people with cardiovascular (heart/vessel) conditions. You might join to see if this phone-based support improves how care is delivered and helps you manage your condition.
London, OntarioAges 18 years+ - NCT05353322Recruiting
Exercise breaks to improve heart and sugar health
This study tests whether taking regular breaks from sitting for long periods can improve heart-related and blood-sugar-related health. It’s for adults who mostly sit, but who don’t already have certain long-term conditions or limits.
New York, New YorkAges 18 years+ - NCT05330923Recruiting
HIV and fatty liver check-in study with ultrasound follow-up
This study follows people with HIV who also have fatty liver disease and checks their health over time. It may help by improving monitoring and care planning, especially using ultrasound scans and regular follow-up.
Beijing, Beijing MunicipalityAges Any age - NCT05347407Recruiting
Gut nerve cell biomarkers study for Parkinson’s risk
This trial studies nerve cell “biomarkers” from the gut to learn whether they can help detect Parkinson’s disease (or related conditions) earlier. You may be asked to undergo a colonoscopy to collect gut tissue for testing.
New York, New YorkAges 45–75 - NCT05326451Recruiting
At-home brain stimulation for Huntington’s behavior and thinking symptoms
This trial tests an at-home, noninvasive brain stimulation treatment to help with behavioral and cognitive (thinking) symptoms in people with Huntington’s disease. You and a caregiver work together during sessions and questionnaires to see if symptoms improve and stay stable.
Houston, TexasAges 18–80 - NCT05356104RecruitingPhase 2
GLP-1 treatment to slow small blood-vessel brain damage
This Phase 2 study tests whether a GLP-1–like medicine can slow worsening “small vessel” disease changes in the brain and related walking and thinking problems. It aims to see if the treatment can prevent progression in people who already show early brain changes on MRI.
Wenzhou, ZhejiangAges 55–80 - NCT05321017Recruiting
Training wrist muscle signals after spinal cord injury
This trial studies a special training approach to improve weak wrist muscle function in people with an incomplete spinal cord injury. It focuses on improving brain-to-muscle electrical signals to help wrist extension, while keeping your current medicines stable.
Charleston, South CarolinaAges 18 years+ - NCT05089227RecruitingPhase 2
Long-term apixaban to prevent clots in autoimmune hemolytic anemia
This Phase 2 trial tests whether taking long-term apixaban (a blood thinner) can prevent venous blood clots in people with autoimmune hemolytic anemia (AIHA). It may help reduce the risk of dangerous clotting events if you meet safety and risk criteria.
DijonAges 18 years+ - NCT05268887Recruiting
Light, sound, and touch therapy for Parkinson’s symptoms
This trial tests whether high-frequency light, sound, and gentle touch can improve movement and thinking problems in people with Parkinson’s disease. You may help the researchers learn if this kind of stimulation is safe and beneficial alongside your usual Parkinson’s medications.
Cambridge, MassachusettsAges 45–90 - NCT05288842Recruiting
Study spinal fluid and brain changes in dementia types
This study looks at spinal fluid and MRI results in people with Alzheimer’s disease, frontotemporal dementia, or normal thinking (controls). It aims to understand differences in brain-related cells and measure what might help explain or track these conditions.
LilleAges 40–85 - NCT05289167RecruitingPhase 1/Phase 2
Medicines to prevent graft-versus-host disease after a transplant
This trial tests a combination of medicines (post-transplant cyclophosphamide, bortezomib, and abatacept) to lower your chance of developing graft-versus-host disease (when transplanted immune cells attack your body) after a transplant. If you qualify, you’ll receive the study medicines as part of your post-transplant care and be followed closely to check safety and prevention of GvHD.
New Hyde Park, New YorkAges 14–100 - NCT05295615Recruiting
Pulsed magnetic treatment for mild to moderate Alzheimer’s
This trial tests whether a pulsed electromagnetic field (a non-drug device that uses magnetic pulses) can help people with mild to moderate Alzheimer’s. Participants typically stay on stable Alzheimer’s medicines and follow daily home treatments during the study.
Hackensack, New JerseyAges 50–100 - NCT05236374Recruiting
Daily beef in a heart-healthy diet to study zinc cells
This study tests whether eating daily beef as part of a heart-healthy diet changes how your body’s cells handle zinc, a mineral important for many functions. It’s designed for older adults and includes strict diet and medication rules to keep results accurate.
Davis, CaliforniaAges 55–70
Hear when a new Musculoskeletal Diseases or Conditions trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for musculoskeletal diseases or conditions?
- Yes. Clin2 currently lists 4,026 recruiting musculoskeletal diseases or conditions studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a musculoskeletal diseases or conditions trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a musculoskeletal diseases or conditions trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.