Clinical trials
Musculoskeletal Pain clinical trials
Below are recruiting musculoskeletal pain clinical trials, each written for real people, not researchers. We’re tracking 100 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06671860Recruiting
Exercises and hands-on therapy for neck pain
This study tests whether combining eye exercises with hands-on therapy helps people with non-specific neck pain (pain not caused by a known injury or disease). It may help improve how your neck moves and reduce discomfort.
IstanbulAges 18–65 - NCT06600685Enrolling by invitation
Music therapy for long-term pain
This study tests whether a special type of music therapy (called FMT) can help reduce long-term pain in muscles and bones. If you have had pain for at least 3 months and can speak Swedish or English, this may be an option for you.
Eskilstuna, EskilstunaAges 18 years+ - NCT06398847Recruiting
Virtual reality self-hypnosis for HIV-related pain
This study tests if using a virtual reality (VR) headset for self-hypnosis can help people with HIV manage chronic pain. You would practice at home with a smartphone app, and researchers will track your pain levels over time.
New York, New YorkAges 18 years+ - NCT07321483Recruiting
Reflex therapy for jaw pain
This trial tests if a special reflex therapy can help people with jaw muscle pain that isn't caused by joint damage. It might be a new way to reduce discomfort and improve function.
OlomoucAges 18 years+ - NCT06395428RecruitingPhase 4
Haloperidol for severe back pain in the ER
This study tests whether the medication haloperidol, given in the emergency room, can help relieve severe back pain that started on its own (not from an injury). It compares haloperidol to a common pain reliever called ketorolac.
Kalamazoo, MichiganAges 18–65 - NCT07179016Recruiting
Acupressure for chronic pain in rural areas
This trial tests if a self-managed acupressure program can help people living in rural areas manage long-term muscle or joint pain, like neck, back, or knee pain. You would learn to press small seeds on your ear to ease pain.
Columbia, South CarolinaAges 18–85 - NCT06549660Recruiting
Light therapy for chronic low back pain relief
This study tests if a special light treatment (photobiomodulation) can temporarily ease chronic low back pain that comes and goes. It's for people who have had this pain for at least 3 months and speak Portuguese.
São PauloAges 18–65 - NCT03696134Recruiting
Study of musculoskeletal health, frailty, pain, and disability
This study looks at musculoskeletal health and wellbeing in adults, especially people who are frail or at risk of developing frailty-related problems like pain or limited ability to move. It may help researchers understand what puts people at risk and what could improve comfort and function.
NottinghamAges 18 years+ - NCT06685107Recruiting
Virtual reality for pain relief in older ER patients
This trial tests if using virtual reality along with standard pain medication helps reduce pain better than medication alone for older adults with muscle or joint pain in the emergency room.
Brooklyn, New YorkAges 65–120 - NCT06832852Recruiting
Comparing cost-effective care for muscle and joint pain
This study compares different models of care to find the most cost-effective way to treat common muscle and joint problems (like back, neck, knee, or shoulder pain). It looks at which approach works best for patients with persistent pain to guide future treatment decisions.
Québec, QuebecAges 18–65 - NCT05989230Recruiting
Emotional awareness therapy for pain after orthopedic injury
This trial tests a therapy that helps people understand and express their emotions to manage long-term pain after a serious bone injury. It may help if you have had pain most days for at least three months following surgery for an orthopedic injury.
Baltimore, MarylandAges 18 years+ - NCT07732062Recruiting
Emotion-focused therapy for chronic pain patients using medical cannabis
This study tests a new type of talking therapy (vEAET-H) to see if it helps people with chronic pain who are already using medical cannabis. The goal is to find out if adding this therapy can improve pain and well-being.
Tel AvivAges 18 years+ - NCT06685094Recruiting
Pain, movement, and quality of life study for Albanian speakers
This study is translating health questionnaires into Albanian to better understand pain, movement, mood, and quality of life. It aims to help people with muscle, joint, or back pain.
Murcia, MurciaAges 18–80 - NCT07393503Enrolling by invitationPhase 4
Pain relief for new muscle and joint injuries
This trial compares two common treatments for new muscle or joint pain: an over-the-counter pain reliever (Tylenol and ibuprofen) versus an oral steroid (a stronger anti-inflammatory medication). The goal is to see which option works better for short-term pain and recovery.
Buffalo, New YorkAges 18 years+ - NCT06509087Recruiting
Combining CT and MRI for joint pain procedure
This study tests a procedure called transarterial microembolization for chronic shoulder or knee pain that hasn't improved with other treatments. It uses both CT and MRI to guide the procedure and see if it can help reduce pain.
TaipeiAges 20–80 - NCT07532070Recruiting
Exercise and Therapy for Chronic Pain and Sleep Problems
This study tests whether exercise, talk therapy for sleep problems, or both together can help people with long-term back, hip, or knee pain who also struggle with sleep. You'll attend video appointments and try one of these approaches for several weeks.
San Antonio, NevadaAges 18 years+ - NCT07554664Recruiting
Desk Work, Stress, and Muscle Pain With or Without Migraine
This study looks at how office work, job stress, and muscle tension relate to migraines and neck/shoulder pain in desk workers. Researchers want to understand if certain body changes (called central sensitization) connect these issues, which could lead to better ways to help office workers feel better.
Gaziantep, MerkezAges 18–65 - NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80 - NCT07692126Recruiting
Neck pain and hand strength: core vs shoulder exercises
This study compares two types of exercises to see which better improves hand grip strength and neck pain. If you have had chronic myofascial neck pain (trigger points) in the upper shoulder muscle for over 6 months, this trial may help find which exercise works best for you.
Giza, Giza GovernorateAges 25–45 - NCT07245303Recruiting
How Light Affects Pain in Chronic Pain
This study looks at how different kinds of light might change pain levels in people with chronic widespread pain, like fibromyalgia. By using brain scans (MRI), researchers hope to find new ways to manage pain without medication.
Chapel Hill, North CarolinaAges 18 years+ - NCT07347054Recruiting
Trigger point injection for shoulder arthritis pain
This study tests whether injecting a medication into painful knots in the shoulder muscle can reduce pain from shoulder arthritis. It may be a good option if you have had shoulder pain for at least 3 months and other treatments haven't worked well enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT05905146Recruiting
Personalized opioid plan to shorten treatment time
This trial tests whether a personalized medication plan can help patients with short-term, non-cancer muscle or joint pain need strong opioid medicine for a shorter time. It’s aimed at improving how long treatment lasts while still managing pain.
LilleAges 18 years+ - NCT07746284Enrolling by invitation
Understanding knee osteoarthritis through computer modeling
This study looks at how knee osteoarthritis pain works and aims to build a computer model to better understand it. By joining, you may help doctors improve future treatments for chronic knee pain.
Herndon, VirginiaAges 18–99 - NCT07704853Recruiting
Neck joint study for healthy adults 18–35
This study tests a quick neck move (like a chiropractic adjustment) to see how it affects the small joints in your neck. It may help researchers understand how such moves work on healthy tissue.
Fort Myers, FloridaAges 18–35
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Common questions
- Are there clinical trials for musculoskeletal pain?
- Yes. Clin2 currently lists 100 recruiting musculoskeletal pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a musculoskeletal pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a musculoskeletal pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.