Clinical trials
Neoadjuvant clinical trials
Below are recruiting neoadjuvant clinical trials, each written for real people, not researchers. We’re tracking 882 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06542588RecruitingPhase 2
Short radiation plus chemo and immunotherapy for rectal cancer
This trial tests a combination of short-course radiation, chemotherapy, and two types of immunotherapy (HLX07 and Serplulimab) before surgery for advanced rectal cancer. It aims to see if this approach helps shrink tumors and improve outcomes.
Wuhan, HubeiAges 18–75 - NCT07549399RecruitingPhase 3
Radiation, Chemotherapy, and Immunotherapy for Rectal Cancer
This trial tests a combination of radiation, chemotherapy, and immunotherapy drugs before surgery for people with locally advanced rectal cancer. The goal is to shrink the tumor and improve outcomes for patients with higher-risk disease.
Guangzhou, GuangdongAges 18–75 - NCT07546695Recruiting
Axillary lymph node surgery choices for HER2+ and triple-negative breast cancer
This study examines the best surgical approach for removing underarm lymph nodes in patients with HER2-positive or triple-negative breast cancer who have received chemotherapy before surgery and still have cancer in their lymph nodes. The goal is to understand whether removing more lymph nodes improves outcomes for these patients.
BaselAges Any age - NCT07550972Enrolling by invitationPhase 2
Combination drug treatment before surgery for advanced head and neck cancer
This study tests two drugs (pertuzumab and lenvatinib) given together before surgery for advanced head and neck squamous cell carcinoma. The goal is to shrink the tumor and improve outcomes for patients who haven't received prior cancer treatment.
Hangzhou, ZhejiangAges 18–75 - NCT05601505RecruitingPhase 2
DNA blood test–guided treatment before rectal cancer surgery
This trial uses a special DNA blood test (circulating tumor DNA) to help guide chemotherapy and radiation before surgery for locally advanced rectal cancer. It aims to improve outcomes by tailoring treatment based on the DNA signals from the tumor.
Beijing, Beijing MunicipalityAges 18–75 - NCT06747728Recruiting
Bevacizumab before surgery for new high-grade brain tumors
This trial tests whether giving bevacizumab (a drug that blocks blood vessel growth) before surgery helps treat newly diagnosed high-grade gliomas. It may be an option for adults who have not had prior anti-angiogenic therapy.
Zhengzhou, HenanAges 18 years+ - NCT06430658RecruitingPhase 2
Combination treatment before surgery for unresectable esophageal cancer
This trial tests a combination of treatments given before surgery to shrink tumors in patients with esophageal cancer that is considered too advanced for immediate surgery. The goal is to make surgery possible and improve outcomes.
BeijingAges 18–75 - NCT07537361RecruitingPhase 2
Leucine-Restricted Diet With Chemotherapy for Gastric Cancer
This trial tests whether a special diet low in leucine (an amino acid) combined with chemotherapy and immunotherapy drugs can help treat locally advanced gastric cancer before surgery. The goal is to see if this combination is safe and more effective than standard treatment alone.
Jinan, ShandongAges 18–70 - NCT07541521Recruiting
Robot-Assisted Lung Surgery After Immunotherapy for Lung Cancer
This trial tests whether combining immunotherapy with chemotherapy before robot-assisted lung surgery improves outcomes for patients with stage II–III non-small cell lung cancer. The goal is to shrink the tumor before surgery and then remove it completely using minimally invasive robotic techniques.
Fuzhou, FujianAges Any age - NCT07534033RecruitingPhase 2
Probiotic LR607 for newly diagnosed lung cancer
This study tests whether a probiotic supplement (LR607) can help patients with newly diagnosed non-small cell lung cancer—a common type of lung cancer. Probiotics are beneficial bacteria that may help your immune system fight cancer alongside standard treatments.
GuangzhouAges 18–80 - NCT07542496Recruiting
Real-world study of breast cancer treatment with pertuzumab biosimilar
This study observes how a biosimilar version of pertuzumab (a targeted breast cancer drug) works in real-world patients. Researchers will track outcomes in patients receiving this drug either before surgery or as a first treatment for advanced breast cancer.
AlgiersAges 19 years+ - NCT05939830Recruiting
Skipping axillary lymph node surgery after treatment response
This study looks at whether some breast cancer patients can safely skip a surgery that removes lymph nodes in the armpit after their initial (pre-surgery) treatment shows the armpit is likely clear. It may reduce surgical side effects if the armpit truly responds well.
NanjingAges 18–70 - NCT06054906RecruitingPhase 2
Immunotherapy plus chemo before surgery for stomach cancer
This trial tests a combination of an immunotherapy drug (sintilimab) and a low-dose weekly chemotherapy regimen before surgery for locally advanced stomach cancer that can be removed. The goal is to see if this approach helps shrink the tumor and improve outcomes.
ShanghaiAges 18 years+ - NCT07528209RecruitingPhase 3
Chemotherapy with or without immunotherapy for advanced rectal cancer
This study tests whether adding an immunotherapy drug (pucotenlimab) to standard chemotherapy (CAPOX) before surgery helps treat locally advanced rectal cancer better. The goal is to shrink tumors and improve survival while preserving bowel function when possible.
Guangzhou, GuangdongAges 18–75 - NCT07528716RecruitingPhase 3
AI-guided treatment for HER2-positive breast cancer
This trial tests whether an artificial intelligence model can help doctors choose the best targeted therapy before surgery for HER2-positive breast cancer (a type of breast cancer with a protein called HER2). The goal is to improve how well the treatment works and reduce side effects.
ShanghaiAges 18–75 - NCT07528066Recruiting
Surgery After Chemotherapy and Immunotherapy for Advanced Lung Cancer
This study follows patients with advanced non-small cell lung cancer (NSCLC) who receive combination chemotherapy and immunotherapy before surgery. Researchers will track how well surgery works after this pre-surgical treatment and compare different surgical approaches.
Fuzhou, FujianAges Any age - NCT07527026RecruitingPhase 2
Camrelizumab and chemotherapy with radiation for advanced rectal cancer
This trial tests a combination of an immunotherapy drug (camrelizumab) with chemotherapy and radiation to shrink advanced rectal cancer before surgery. The goal is to help more patients have successful surgery with complete tumor removal.
Beijing, Beijing MunicipalityAges 18–75 - NCT07525869Recruiting
Pegfilgrastim to prevent low white blood cells in triple-negative breast cancer
This study tests whether a medicine called pegfilgrastim can help prevent dangerously low white blood cell counts in women with triple-negative breast cancer receiving a specific chemotherapy combination. Low white blood cells increase infection risk, so this medicine may help patients stay safer during treatment.
Seoul, Seodaemun-guAges 19–70 - NCT06755866Recruiting
Predicting chemo-radiation response with improved MRI for esophageal cancer
This trial uses a special MRI technique to see if it can predict how well esophageal cancer responds to chemo-radiotherapy before surgery. It may help doctors choose the best treatment plan for you.
Kunming, YunnanAges 18–80 - NCT06756217Recruiting
PET scan to check early response to immunotherapy before lung cancer surgery
This trial tests a special PET scan (68Ga-grazytracer) to see if it can predict early whether immunotherapy is working in people with lung cancer that can be surgically removed. If successful, this scan could help doctors tailor treatment sooner.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07522879RecruitingPhase 2
Testing a new drug combo for recurrent sinus cancer
This trial tests whether combining the targeted drug becotatug vedotin with chemo can shrink recurrent adenoid cystic sinus tumors that can't be fully removed by surgery. It's for people whose tumors have a specific protein called EGFR.
ShanghaiAges 18 years+ - NCT07518979RecruitingPhase 2
EGFR-targeted drug plus immunotherapy for advanced penile cancer
This trial tests a new combination treatment for advanced penile cancer that hasn't been treated before. It combines a targeted drug (becotatug vedotin) designed to attack cancer cells with an immunotherapy drug (pucotenlimab) that helps your immune system fight cancer.
Chengdu, SichuanAges 18 years+ - NCT06755684RecruitingPhase 2
Pre-surgery targeted drug combo for EGFR-mutant lung cancer
This trial tests a new targeted pill (befotertinib) given before surgery, either with another targeted drug (bevacizumab) or with standard chemotherapy. The goal is to shrink the tumor and improve outcomes for people with a specific type of lung cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07498933Recruiting
FAP-targeted imaging for lung cancer
This trial uses a special imaging test (PET/NIR) to find lung cancer cells. It may help doctors see tumors more clearly before and after treatment.
Beijing, Beijing MunicipalityAges 18–70
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Common questions
- Are there clinical trials for neoadjuvant?
- Yes. Clin2 currently lists 882 recruiting neoadjuvant studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a neoadjuvant trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a neoadjuvant trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.