Obstructive Coronary Artery Disease clinical trials

Study Evaluating the Effects of Red Grape Juice Consumption on Metabolism in Men With Coronary Artery Disease

Comparing minimally invasive vs. traditional bypass for multi-vessel heart disease

This study compares two types of heart bypass surgery for people with blockages in multiple heart arteries: a newer, less invasive technique (minimally invasive CABG) versus the traditional open-chest approach. It aims to see which approach leads to better recovery and outcomes.

Stress test study of heart blood-flow issues in adults

This study tests a new kind of stress test to understand how small blood-vessel heart problems relate to heart relaxation problems in people with angina (chest pain) but no blocked arteries. It may help doctors learn better ways to diagnose and guide treatment for these conditions.

Microvascular dysfunction in angina patients

This study tests if chest pain with clear arteries is caused by tiny heart vessel problems. It may help find better treatments for patients whose arteries look normal on angiograms.

Comparing two imaging tests for chronic coronary syndrome

This trial sees if a carotid ultrasound is as good as a CT calcium score to detect heart disease in people with chest pain. It may help avoid more expensive or less available scans.

Blood tests to study heart pain with blocked-unblocked arteries

This study looks at blood “biomarkers” and platelet function to better understand INOCA (heart-related chest pain despite no major artery blockage). You may be eligible if you have INOCA and are already taking aspirin, and if you haven’t taken certain blood-thinner or platelet-altering medicines recently.

Testing a new heart bypass graft in people needing multi-vessel CABG

This study tests a new way to connect a bypass graft during heart bypass surgery for people with blocked heart arteries. The goal is to see if the new graft can be safely placed and works well enough to improve outcomes compared with the standard approach.

Testing heart artery function with and without nitroglycerin

This study compares two ways of testing the small blood vessels in the heart to understand chest pain when no major blockages are found. It may help doctors learn more about why you have chest pain and how to treat it.

Using MCG to assess heart blood flow in stable artery disease

This trial is testing a new magnetic heart scan (called MCG) to see if it can better detect when your heart isn't getting enough blood. It is for people with stable chest discomfort and a previous heart CT that showed moderate blockages in the arteries.

Blood sample study for better health screening

This study collects blood samples and health information over time to improve early detection of diseases. It may help researchers find ways to prevent serious conditions.

Testing a lab-made blood vessel for heart bypass surgery

This trial tests a lab-made blood vessel (called an ATEV) used as a bypass graft during heart surgery. The ATEV is designed for people who don't have enough healthy leg vein for standard bypass grafts, and it may help restore blood flow to the heart more safely.

Study of heart vessel dysfunction seen on heart imaging

This study looks at coronary microvascular dysfunction (small blood vessel problems in the heart) using heart imaging. It may help researchers understand causes of chest tightness with activity and shortness of breath when the main heart arteries are not blocked.

Testing blood vessel function in people of different health conditions

This early study measures how well your blood vessels work using tests that may include MRI. It compares healthy people with people who have conditions like COPD, pulmonary arterial hypertension, heart failure, or high blood pressure, to better understand “vascular function” in health and disease.

Study links health records and samples to understand health gaps

This study asks people affected by a specific illness (or their family member) to share saliva (and sometimes blood) and answer health and quality-of-life questions. The goal is to better understand and reduce health inequality by matching new information with medical records.

Staged heart bypass plus TAVR versus TAVR alone

This study compares doing a staged coronary bypass (revascularization) along with a valve procedure (TAVR) versus doing TAVR and medical treatment alone. It aims to see which approach better helps people with both aortic valve narrowing and coronary artery disease.

Tests a targeted plan for people with chest pain from heart artery disease

This study aims to match people with angina (chest pain from heart artery problems) to the most helpful treatment plan based on their test results. It’s done around the time doctors are planning an invasive heart scan to look at the coronary arteries.

CT heart scan for intermediate-risk chest pain

This study tests whether a special heart CT scan can help evaluate the cause of chest pain in people at intermediate risk for blocked heart arteries. It may help doctors decide what to do next after an emergency room visit.

CMR vs CT scan for coronary artery disease

This study compares two heart-imaging tests—cardiac MRI (CMR) and CT—to see which better helps evaluate coronary artery disease in people with chest pain. You may be asked to have one of these scans as part of your heart work-up.

Testing heart blood-flow problems without clogged arteries

This study looks at how well the heart’s blood vessels work in people who have symptoms of reduced blood flow but no major artery blockage. It uses special heart tests with medicines to check how the vessels respond and may help guide better diagnosis and treatment.

Check whether exercise heart tests help diagnose artery blockage

This study looks at whether an “exercise heart test” can better diagnose blockage in the heart’s coronary arteries. Participants may also have a heart scan or imaging test for comparison, within a short time window.

Eplerenone for heart injury without blocked heart arteries

This Phase 2 study tests whether eplerenone can improve outcomes after a heart attack (or similar heart injury) when coronary angiography shows no blocked heart arteries. It focuses on people with added cardiovascular risk factors and evaluates how well the treatment works for heart recovery and strain on the heart.

Testing heart vessel dysfunction after a heart attack

This trial looks at how to assess small blood-vessel (microvascular) problems in people who had a heart attack but whose main heart arteries are not blocked. It may help doctors better find what’s driving symptoms and choose the right tests and treatments.

Medications during heart surgery to help control breathing and circulation

This study looks at whether giving dexamethasone and olanzapine during certain heart surgeries can improve how blood flow and ventilation (breathing support) are managed. It’s meant to see if these medicines help the body handle heart-lung bypass more safely.

Heart failure patients having bypass surgery are studied

This study looks at tiny structures inside heart muscle cells (especially “power stations” in the cells) in people with certain types of heart failure who are getting coronary bypass surgery. It may help researchers better understand what changes happen in the heart and how this could guide future care.