Clinical trials
Opioid Use Disorder, Severe clinical trials
Below are recruiting opioid use disorder, severe clinical trials, each written for real people, not researchers. We’re tracking 149 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06104280Recruiting
How opioid addiction meds affect sleep and eyes
This study tests how three common medications for opioid use disorder (methadone, buprenorphine, and naltrexone) affect eye function, sleep, and daily body rhythms. It may help find ways to improve treatment for opioid addiction.
Birmingham, AlabamaAges 18–80 - NCT06067737RecruitingPhase 2
Psilocybin and buprenorphine for opioid use disorder
This study tests whether adding psilocybin (a psychedelic medicine) to buprenorphine (a medication for opioid use disorder) can help people stop using opioids and stay in recovery. It is for people who have already been on buprenorphine but are still using other opioids.
Baltimore, MarylandAges 21–70 - NCT05957159RecruitingEarly Phase 1
Testing an alcohol brain imaging study based on opioid receptor balance
This early-phase study looks at how the brain’s opioid receptor balance may be different in people with alcohol use disorder (AUD), using brain scans and blood testing. It may help researchers understand why some people respond differently to alcohol and related treatments.
New Haven, ConnecticutAges 21–70 - NCT05834478RecruitingPhase 3
Noninvasive vagus nerve stimulation for opioid use disorder
This trial tests whether noninvasive vagus nerve stimulation can help people with opioid use disorder during supervised withdrawal and treatment afterward. It may be considered if you can safely move to medication or behavioral care after withdrawal.
Atlanta, GeorgiaAges 18–75 - NCT05829655RecruitingEarly Phase 1
Measuring drug cravings in people with opioid use disorder
This study tests whether the medication suvorexant can reduce drug cravings in people with opioid use disorder. You will take either suvorexant or a placebo and have your cravings measured in a safe setting.
Baltimore, MarylandAges 18–65 - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75 - NCT05683184RecruitingPhase 1
Brain imaging study for opioid use disorder
This study uses brain scans to understand opioid use disorder better. If you have opioid addiction, you might be eligible to help researchers learn more about how the brain is affected.
New Haven, ConnecticutAges 18 years+ - NCT05589753RecruitingPhase 1/Phase 2
Testing treatment for sleep breathing problems in people on opioids
This trial studies a treatment approach for sleep-disordered breathing (breathing problems during sleep) in Veterans who take prescription opioids. It may help doctors learn safer ways to manage sleep breathing issues that can be made worse by opioid use.
Detroit, MichiganAges 18–89 - NCT05529927RecruitingPhase 2
Dexamphetamine given long-acting to reduce cocaine use
This Phase 2 study tests whether a long-acting form of dexamphetamine can reduce cocaine use in people with moderate to severe cocaine use disorder. It also checks safety, including heart and mental health side effects, while you attend study visits regularly.
The HagueAges 18 years+ - NCT05511909RecruitingPhase 2
Buspirone study for opioid withdrawal symptoms
This Phase 2 study tests whether buspirone can help reduce symptoms during opioid detox (withdrawal). You may be able to take part if you have opioid withdrawal and are planning medically supervised detox.
Baltimore, MarylandAges 18–75 - NCT05450718RecruitingPhase 4
Low-dose buprenorphine start for opioid use disorder
This trial tests whether starting buprenorphine using a low-dose plan is a safe and workable way to treat opioid use disorder. You may be able to join if you are 18+, have opioid use disorder, and can follow the study medication and visits.
The Bronx, New YorkAges 18 years+ - NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT05138614Recruiting
Help for people with opioid use disorder and mental health needs
This trial studies a program meant to improve treatment access and support recovery for people with opioid use disorder who also have mental health symptoms. It may help if you are new to the program or recently relapsed, or if mental health symptoms have worsened—even without a relapse.
Holyoke, MassachusettsAges 18 years+ - NCT05011266RecruitingPhase 2/Phase 3
Buprenorphine plus naltrexone shot to prevent opioid relapse
This trial tests whether a combination of buprenorphine (through your care plan) and a monthly extended-release naltrexone (XR-NTX) shot can help prevent opioid relapse. It may help people who are ready to move toward a naltrexone-based relapse-prevention treatment after detox.
Rockville, MarylandAges 18–65 - NCT04458545RecruitingPhase 1/Phase 2
Opioid vaccine study for adults with heroin or fentanyl use
This trial tests a vaccine made from parts designed to help the body respond to opioids (heroin or fentanyl). It is mainly for adults with moderate-to-severe opioid use disorder who are using opioids that match the study dosing needs and who are willing to do frequent visits over about a year.
Eatontown, New JerseyAges 18–59 - NCT04375033RecruitingPhase 4
Comparing Buprenorphine pill vs injection for opioid use disorder
This study compares two forms of a medication called buprenorphine (one is a pill you take under the tongue, the other is an injection) to see which works better for treating opioid use disorder. If you are eligible, you will receive one of these forms for a year and regular check-ups.
Tuscaloosa, AlabamaAges 18 years+ - NCT04354077Recruiting
Deep brain stimulation for opioid addiction
This study tests whether deep brain stimulation (DBS), a surgical treatment that uses electrical pulses to target specific brain areas, can help reduce cravings and relapse in people with opioid use disorder who haven't found relief from other treatments.
Pittsburgh, PennsylvaniaAges 22–65 - NCT04197921Recruiting
Brain-focused ultrasound for opioid addiction-related substance use
This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.
Tampa, FloridaAges 18–60 - NCT03396276Enrolling by invitationPhase 4
Emergency system to help people stop opioid misuse
This Phase 4 study tests an “emergency opioid engagement system” that aims to help people who are opioid-dependent start stopping opioid use. If you’re willing to stop and can safely participate, the program may offer structured support when you’re in the emergency setting.
Houston, TexasAges 18 years+ - NCT01730781Recruiting
PET scan study to image cannabinoid receptors in the brain
This study uses a special brain scan (PET) to measure cannabinoid receptors—areas in the brain that interact with cannabis-like chemicals. It may help researchers better understand how these receptors relate to conditions such as schizophrenia, PTSD, opioid use disorder, or early psychosis risk.
New Haven, ConnecticutAges 18–55 - NCT07829263Recruiting
Brain stimulation with talk therapy for cocaine use disorder
This study tests whether a non-invasive brain stimulation method (high-definition transcranial direct current stimulation, or HD-tDCS) combined with cognitive behavioral therapy (a type of talk therapy) can help people reduce cocaine use. It explores if this combination is safe and practical.
Richmond, VirginiaAges 18–65 - NCT07825818RecruitingEarly Phase 1
Brain scan study for heavy drinkers
This study uses a special brain scan to look at how alcohol use affects energy production in brain cells. It may help researchers find new ways to treat alcohol use disorder.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07612631RecruitingEarly Phase 1
Brain imaging study of alcohol and stress response
This research uses brain imaging to understand how two brain systems—one involved in stress and one involved in reward—interact in people with alcohol use disorder. The goal is to find new ways to help people reduce heavy drinking.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07490600Recruiting
Testing brain stimulation and rewards for quitting cocaine
This trial combines deep transcranial magnetic stimulation (TMS) with a reward program (contingency management) to help people stop using cocaine. It may help if you are struggling with moderate to severe cocaine use and want a non-drug treatment.
Houston, TexasAges 18–65
Hear when a new Opioid Use Disorder, Severe trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for opioid use disorder, severe?
- Yes. Clin2 currently lists 149 recruiting opioid use disorder, severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a opioid use disorder, severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a opioid use disorder, severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.