Clinical trials
Pain and Anxiety clinical trials
Below are recruiting pain and anxiety clinical trials, each written for real people, not researchers. We’re tracking 143 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06924268Enrolling by invitation
Art therapy for mood and symptoms in palliative care
This trial tests whether a single art therapy session can improve mood and reduce symptom burden for patients in a palliative care unit. It aims to see if creative expression can help you feel better emotionally and physically.
Halifax, Nova ScotiaAges 18 years+ - NCT06758973Enrolling by invitation
Turkish pain anxiety scale study
This study is testing a short Turkish questionnaire about how pain affects your emotions. If you have chronic pain (lasting at least 3 months) that happens 4 or more days a week and is at least a 3 out of 10 in intensity, you may be able to help.
Kırşehir, MerkezAges 18–65 - NCT06729294Recruiting
Does music help during knee replacement surgery?
This study tests if listening to music during knee replacement surgery under spinal anesthesia can lower anxiety, pain, and stress hormone levels. It may help make the experience calmer for patients.
Kocasinan, KayseriAges 18 years+ - NCT02463266Recruiting
PACE/PACENET program outcomes study for people 65+
This study looks at how well the PACE/PACENET care program works for older adults over time. If you join, you’ll provide consent for a check-in about your outcomes about 3 months after the acute (most intense) phase of care ends, with follow-up around 6 months.
Philadelphia, PennsylvaniaAges 65 years+ - NCT06297200Recruiting
Ultrasound treatment for complex back pain patients
This study tests a new, non-invasive ultrasound treatment for people with long-term back pain who also have opioid use disorder and anxiety. It aims to see if this gentle brain stimulation can reduce pain and improve quality of life.
Roanoke, VirginiaAges 18–65 - NCT05883540RecruitingPhase 2
LSD therapy in palliative care for comfort and well-being
This Phase 2 study tests how LSD may affect comfort and quality of life for people with advanced or end-stage life-limiting illness. It also checks whether the medicine is safe and can be given in a controlled way in palliative care settings.
BaselAges 22 years+ - NCT04214561Enrolling by invitation
Studies how sleep measures relate to teeth grinding
This study looks at sleep testing results to understand what relates to sleep bruxism, which is teeth grinding or clenching during sleep. It may help researchers better understand the causes and patterns behind this condition.
WroclawAges 18–70 - NCT07650591Recruiting
Tapping and vibration to ease needle pain in children
This study tests whether rhythmic tapping and gentle vibration near the skin can help children ages 6–12 feel less pain and fear during blood draws. Researchers want to see if these simple techniques can make the procedure more comfortable.
Antalya, KepezAges 6–12 - NCT07113080RecruitingPhase 4
Do Lemongrass and Lavender Help Kids With Dental Shots?
This study tests whether smelling lemongrass and lavender scents can help reduce fear and pain when a child gets a numbing shot at the dentist. It is for children ages 7 to 11 who are healthy and have never been to the dentist before.
Cairo, Cairo GovernorateAges 7–11 - NCT07009028Recruiting
Storigami to reduce pain and fear from IV insertion in kids
This study tests a fun storytelling-and-paper-folding method called 'storigami' to see if it helps children feel less pain, fear, and worry when they get an IV. It's for children who need an IV for the first time during this hospital visit.
Izmir, BornovaAges 6–9 - NCT07835191Recruiting
Cooling and sweet solution to ease dental shot pain in children
This study tests whether cooling the injection site and using a sweet-tasting solution before the dental numbing shot can reduce pain for children aged 7 to 11. If your child needs a dental procedure requiring a local anesthetic injection, this might help make the experience more comfortable.
Cairo, El SheroukAges 7–11 - NCT07319806Enrolling by invitation
Two ways to help kids feel better during breathing tube removal
This study tests two different methods to lower pain, fear, and emotional upset when a breathing sample is taken from hospitalized children aged 6 to 12. The goal is to find which approach works best to make the experience easier for your child.
DüzceAges 6–12 - NCT07201480Recruiting
Thinking about death and emotions: a lab study
This study looks at how thinking about death affects feelings of anxiety and sadness. You'll do a short lab task and answer questions.
Cluj-NapocaAges 18–65 - NCT07718477Recruiting
Comparing child and parent pain during dental numbing
This study compares the pain a child feels during a numbing injection at the dentist to the pain the parent thinks the child is feeling. It helps doctors understand the difference between a child's actual pain and what parents perceive, which may improve how pain is managed during dental visits.
Clermont-FerrandAges 6–15 - NCT07778069Enrolling by invitation
Virtual reality for children having joint steroid injections
This study tests whether using virtual reality (VR) during a steroid joint injection helps children feel less pain and anxiety. If it works, it could make the procedure easier for patients from 5 to 17 years old.
Columbus, OhioAges 5–17 - NCT07638254Recruiting
Buffered vs. Standard Numbing for Dental Pain in Children
This study tests whether a specially prepared numbing medicine works better than standard numbing to reduce pain and anxiety during a dental procedure for children with a painful infected tooth. The goal is to find the gentlest way to numb the area before treatment.
San Luis Potosí City, San Luis PotosíAges 6–12 - NCT07591324Recruiting
3D-Printed vs. Traditional Space Holders for Kids' Teeth
This study compares two types of dental devices that hold space in a child's mouth after baby molars fall out early. The research tests whether a newer 3D-printed version works as well as or better than the traditional wire-based device.
Ismailia, Ismailia GovernorateAges 7–9 - NCT07545850Enrolling by invitation
Virtual Reality Glasses to Reduce Pain During IUD Insertion
This study tests whether wearing virtual reality glasses during an IUD insertion procedure can help reduce pain and anxiety. You would wear the glasses during the procedure to see if they help you feel calmer and experience less discomfort.
MalatyaAges 18–49 - NCT07538427Recruiting
Music Therapy for Health in Rural Elder Care
This study explores whether music can improve health and wellbeing in older adults living in rural care facilities. Researchers will work with residents to understand how music might help with mood, memory, and quality of life.
Flagstaff, ArizonaAges Any age - NCT07542730RecruitingPhase 4
Diphenhydramine to ease discomfort during early abortion procedure
This study tests whether adding diphenhydramine (a common allergy medicine) to sedation helps patients feel more comfortable during a procedural abortion in the first trimester. Researchers want to see if it improves pain control and overall experience.
Rochester, New YorkAges 18 years+ - NCT07524049Recruiting
Giving Children a Voice in Pediatric Anesthesia
This study listens to what children, their families, and doctors think about anesthesia care (the medication that puts you to sleep during surgery). Researchers want to understand how to make the experience better and less scary for kids having procedures.
Aarau, Canton of AargauAges 6 years+ - NCT07464860Recruiting
Breathwork for older adults after knee surgery
This study tests a breathing exercise program to help older adults recover after knee replacement surgery. Participants practice controlled breathing at home using a smartphone or computer.
Tucson, ArizonaAges 65 years+ - NCT07427862Recruiting
Virtual reality for kids having interventional radiology
This study tests if using virtual reality (VR) during interventional radiology procedures can help children feel more comfortable and less anxious. It is looking for children ages 8 and older who are in the normal range of development.
Los Angeles, CaliforniaAges 8 years+ - NCT07423039Recruiting
Ear acupressure for anxiety and pain during breast cancer surgery
This study tests if pressing on specific points on the ear (acupressure) can help reduce anxiety and pain during breast cancer surgery. It compares acupressure plus standard care to standard care alone, and may be a drug-free way to help you feel calmer before and after your procedure.
StuttgartAges 18–99
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Common questions
- Are there clinical trials for pain and anxiety?
- Yes. Clin2 currently lists 143 recruiting pain and anxiety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain and anxiety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain and anxiety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.