Clinical trials
Pain Syndrome clinical trials
Below are recruiting pain syndrome clinical trials, each written for real people, not researchers. We’re tracking 288 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06306157Enrolling by invitationPhase 4
Low dose naltrexone for complex regional pain syndrome
This trial tests whether a low dose of naltrexone, a medication that may help calm overactive immune and pain signals, can reduce pain and improve daily life in people with complex regional pain syndrome (CRPS), a chronic condition that often causes severe pain and swelling.
New York, New YorkAges 18–85 - NCT07767747Enrolling by invitation
Neck and shoulder pain relief: comparing two hands-on therapies
This study compares two gentle, hands-on treatments (Emmett and Bowen techniques) to see which works better for long-lasting neck and shoulder pain caused by muscle knots (trigger points). It may help you find a non-invasive way to ease pain and improve movement.
Sialkot, Punjab ProvinceAges 18–45 - NCT07750392Recruiting
Dry needling and gentle laser therapy for recent neck pain
This trial tests two therapies—dry needling (thin needles into muscle knots) and low-level laser/microcurrent (gentle energy) treatment—alone or combined, to relieve acute neck pain from muscle knots (myofascial pain). It aims to reduce pain and improve function for people with recent onset symptoms.
Denpasar, BaliAges 20–45 - NCT07573527Recruiting
Online therapy for upper back muscle pain from trigger points
This study tests whether remote physical therapy (done online) can help relieve neck and upper back pain caused by tight knots in your rhomboid muscles. You would receive guided exercises and treatment through video calls instead of visiting a clinic in person.
Karachi, SindhAges 18–35 - NCT07646899Recruiting
Unstable Loads and Shoulder Movement in Overhead Athletes
This study investigates how using unstable equipment (like a wobbly barbell) affects shoulder blade movement and muscle use during overhead pressing in athletes with shoulder impingement pain. The goal is to understand whether unstable loads might help improve shoulder mechanics and reduce pain in overhead athletes.
TaipeiAges 18–40 - NCT07734051Enrolling by invitation
Mobilization for kneecap pain
This trial tests if adding a groin-area mobilization to foot mobilization helps with kneecap (patellofemoral) pain. It may be for you if you have one-sided kneecap pain for at least 3 months, especially when climbing stairs, squatting, or sitting for long periods.
Fāqūs, SharkeyaAges 18–40 - NCT03184545RecruitingPhase 3
Electrical stimulation vs physical therapy for knee pain
This trial compares an electrical stimulation treatment to standard physical therapy for people with long-lasting pain in the front of the knee. It aims to see which approach better improves symptoms and function for patellofemoral pain syndrome.
New York, New YorkAges 18–40 - NCT04689646Recruiting
Mind-body therapy for chronic back pain
This study tests whether a mind-body therapy approach can reduce disability and how bothersome chronic back pain feels. It may help people whose pain has lasted for months and affects daily life.
Boston, MassachusettsAges 18–67 - NCT05972837Recruiting
Home electrical stimulation for long-lasting neck muscle pain
This trial studies whether a home-based electrical stimulation device placed on the neck can reduce pain for people with long-lasting neck muscle pain. It may help if your pain has lasted at least 2 months and is moderate to severe.
New Taipei CityAges 20–60 - NCT06204874Recruiting
Nerve stimulation for bladder pain in women
This trial tests a new nerve stimulation approach for women with bladder pain syndrome. It aims to find a gentler way to reduce pain and urgency without surgery.
Bethesda, MarylandAges 18 years+ - NCT06393101RecruitingPhase 1
High-CBD cannabis extract for complex regional pain syndrome treatment
This study tests a high-CBD cannabis extract (BRC-002) to see if it can help reduce pain and improve health in people with Complex Regional Pain Syndrome (CRPS). Participants will not use opioids or other cannabis during the study.
La Jolla, CaliforniaAges 21–75 - NCT06409442Recruiting
Support and vibration for shoulder impingement
This study tests two non-invasive treatments—corrective external support (like special tape) and regional vibration—for people with subacromial impingement syndrome, a common cause of shoulder pain. It aims to see if these treatments can reduce pain and improve shoulder function.
Izmir, BalçovaAges 18 years+ - NCT07693634Recruiting
Online rehab for knee pain in active adults
This study tests a home-based tele-rehabilitation program for people with front knee pain (patellofemoral pain syndrome) who are recreational athletes. It aims to see if online guided exercises can reduce pain and improve function.
Faisalābad, PunjanAges 18–35 - NCT06511362Recruiting
Balance or strength training for front knee pain
Researchers want to see which type of exercise program better helps people with front knee pain. You will do either balance challenge training or strengthening exercises to see which reduces your pain more.
Lahore, Punjab ProvinceAges 15–30 - NCT06598618Recruiting
Comparing two therapies for kneecap pain
This study compares two types of hands-on treatments—Instrument-Assisted Soft Tissue Mobilization (IASTM) and Muscle Energy Technique—to see which works better for kneecap pain. It aims to find a therapy that can help reduce your pain and improve movement.
Rawalpindi, Punjab ProvinceAges 18–35 - NCT07689396Recruiting
What affects treatment expectations for muscle pain?
This study tests how your expectations about treatment affect your recovery from myofascial pain (a type of muscle pain with tender spots). You will be in physical therapy and answer questions about your pain and outlook.
KonyaAges 18 years+ - NCT06674707Recruiting
Agility training with foot exercises for kneecap pain
This trial tests whether adding foot exercises to agility training can better relieve long-lasting knee pain (patellofemoral pain syndrome) in adults ages 20 to 40. Eligible participants will have had pain behind the kneecap for over 6 months.
Lahore, Punjab ProvinceAges 20–40 - NCT06729151Recruiting
Botox vs. standard care for bladder pain and sexual health
This study compares the effect of Botox injections into the bladder versus standard care (without injections) on sexual function in women with bladder pain syndrome. It aims to see if Botox can improve both pain and sexual health.
Bethesda, MarylandAges 18–99 - NCT06758050Recruiting
Core exercises for front knee pain
This study tests whether doing core exercises can help reduce knee pain in people with patellofemoral pain syndrome—pain at the front of the knee that comes on gradually. It is meant for young adults with a healthy weight who have had this type of knee pain for more than 3 months.
GizaAges 18–35 - NCT06875804Recruiting
Compressive release for knee cap tracking in knee pain
This trial tests a hands-on therapy called compressive myofascial release for the muscle on the outside of your thigh. It aims to see if it helps with kneecap tracking problems that cause pain during daily activities.
Lahore, Punjab ProvinceAges 20–40 - NCT07004881Recruiting
Comparison of two hand-on knee treatments for kneecap pain
This trial compares two gentle physical therapy techniques (Mulligan and Maitland mobilization) to see which works better for kneecap pain. If you have had knee pain for at least 2 months and it hurts with stairs, sitting, or squatting, this study may help find the best treatment for you.
IslamabadAges 18–40 - NCT07318987Recruiting
Nerve release surgery for knee pain relief
This study tests if surgically releasing a nerve in the knee (the saphenous nerve) can reduce pain in people with patellofemoral pain syndrome (pain around the kneecap). If you've had anterior knee pain for at least six weeks and the nerve test is positive, this trial may offer relief.
CairoAges 18–35 - NCT07511751Recruiting
Comparing treatments for myofascial pain syndrome
This trial compares three different treatments to find which works best for long-term back pain caused by myofascial pain syndrome, a condition where tight muscle knots cause pain. It is for people who have not found relief with standard treatments.
Adapazarı, SakaryaAges 18–65 - NCT07600827Recruiting
Restricted Blood Flow Exercise for Knee Pain
This study tests a special exercise method that combines knee strengthening with partial blood flow restriction (using a cuff, similar to taking a blood pressure reading) to treat patellofemoral pain syndrome—a common knee pain condition. The goal is to see if this approach relieves your pain and improves function.
NanjingAges 18–40
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Common questions
- Are there clinical trials for pain syndrome?
- Yes. Clin2 currently lists 288 recruiting pain syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.