Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06084520Recruiting
Pain questionnaire study for opioid and non-opioid patients
This study tests two questionnaires for people with long-term pain. Researchers want to see if the tools work well for both those taking opioids and those who are not. Your answers can help improve pain care.
Uppsala, UpplandAges 18–75 - NCT06085313Recruiting
Web-based program for cancer pain in Asian women
This trial tests a web-based program to help women of Chinese, Korean, or Japanese heritage manage breast cancer pain and depressive symptoms. If you've had breast cancer, have had pain in the past week, and feel some depression, this program could help you cope better.
Austin, TexasAges 18 years+ - NCT06088602Recruiting
Cold therapy for pain after knee replacement
This trial tests a cold treatment called cryoneurolysis to reduce pain after knee replacement surgery. It may help you move better and use less pain medication.
HvidovreAges 18 years+ - NCT06092749Recruiting
A new treatment for chronic leg and back pain
This trial tests a procedure for people with long-standing leg and back pain that hasn't improved with standard treatments like physical therapy or pain medicine.
CairoAges 21 years+ - NCT06094660Recruiting
Nerve blocking for knee arthritis pain
This study tests two treatments for knee arthritis pain when knee replacement isn't an option: a nerve block using heat (radiofrequency ablation) or a chemical injection (phenol), compared to standard care. It aims to find a better way to reduce pain and improve daily function.
Hoorn, North HollandAges 35–90 - NCT06096597RecruitingPhase 2/Phase 3
Amniotic Membrane Therapy for Bladder Pain
This trial tests a treatment made from amniotic membrane (a natural tissue) to help reduce pain and discomfort in people with Interstitial Cystitis (also called Painful Bladder Syndrome). It is for women who have tried at least one other treatment without success.
Clevleand, OhioAges 18 years+ - NCT06097091Recruiting
Pain education for fibromyalgia patients
This trial tests if learning about how your brain and nerves process pain can help reduce fibromyalgia symptoms. You will attend sessions that teach you about the science of pain and how to manage it better.
TaipeiAges 18–64 - NCT06100822RecruitingPhase 1
Testing metformin for chronic Achilles tendon pain
This study tests whether a common diabetes medication, metformin, can help people with chronic Achilles tendon pain. If you have this condition and meet certain health requirements, you may be able to join.
Pittsburgh, PennsylvaniaAges 18–50 - NCT06105788Recruiting
Exercise and pain relief for knee arthritis
This study looks at how moving your arms and legs might help reduce pain for people with knee osteoarthritis. If you join, you will do some light exercise so researchers can see if it helps your knee feel better.
El Paso, TexasAges 45–90 - NCT06106984Recruiting
Home rehab for phantom limb pain in Veterans
This study tests a home-based rehab program for Veterans with phantom limb pain after a below-knee amputation. It uses telehealth to help you manage pain without needing to travel to a clinic.
Minneapolis, MinnesotaAges 18–89 - NCT07607262Recruiting
Comparing two injection methods for pain relief after gallbladder surgery
This trial tests two ways of giving pain medicine during gallbladder removal surgery. One method uses standard local anesthetic injection, the other uses a special injection technique that may provide better pain relief.
Sancaktepe, IstanbulAges 18–75 - NCT06128772Recruiting
Acupuncture study for chronic pain
This study tests if battlefield acupuncture, a specific type of ear acupuncture using tiny needles or tacks, can help veterans with chronic pain. It may be a good option if you have a history of substance use disorder and are interested in a non-drug approach to pain relief over 16 weeks.
Bedford, MassachusettsAges 18 years+ - NCT06129890Recruiting
Brain stimulation for nerve pain and depression
This trial tests whether a noninvasive brain stimulation technique (rTMS) can help people with long-term nerve pain who also have depression. It aims to see if this treatment can reduce pain and improve mood.
Saint-EtienneAges 18–85 - NCT06131658Recruiting
Functional training for iliotibial band syndrome in runners
This trial tests whether functional motor control exercises can reduce pain and improve flexibility and leg function in runners with IT band syndrome. It may help you run without pain on the outside of your knee.
Faisalābad, Punjab ProvinceAges 19–40 - NCT06139510Recruiting
Understanding Pain in Sickle Cell Disease
This study looks at what causes pain in people with sickle cell disease. They hope to learn more about pain patterns to better help patients manage it.
Durham, North CarolinaAges 15–40 - NCT06145516Recruiting
Sleep program to ease pain after joint replacement
This study tests whether a sleep program can help with pain after knee or hip replacement. If you have insomnia and arthritis pain, you may be able to join before your surgery.
Uppsala, UpplandAges 18–100 - NCT06146894Recruiting
Comparing filling methods for tooth pain after root canal
This study compares different ways to fill a tooth's root canals after cleaning them. It looks at which method causes the least pain after a single visit root canal treatment.
Kafr ash Shaykh, Kafr El-ShaikhAges 18–60 - NCT06153199Recruiting
Managing low back pain in nursery and landscape workers
This study tests a self-management program to help people who work in nurseries or landscaping manage their low back pain. It aims to give you practical tools to reduce pain and stay active at work.
Gainesville, FloridaAges 18 years+ - NCT06153303Recruiting
Online therapy for endometriosis and chronic pain
This trial tests if an internet-based program based on acceptance and commitment therapy (ACT) can help people with endometriosis and chronic pain. It aims to improve daily functioning and quality of life.
Lund, Skåne CountyAges 18–65 - NCT06153589Recruiting
Music therapy for leg ulcer pain relief
This trial tests whether listening to music during wound cleaning can reduce pain for people with leg ulcers caused by vein or artery problems. It aims to make the procedure more comfortable.
Fort-de-FranceAges 18 years+ - NCT06155916Recruiting
Sleep and nerve pain: a pregabalin study
This study tests whether a nerve pain medication (pregabalin) helps people with long-term nerve pain sleep better. It involves brain scans to see how the medication affects the brain.
Helsinki, HUSAges 18–75 - NCT06158620RecruitingPhase 1/Phase 2
Nasal spray for pain after ureter stent placement
This trial tests whether a nasal spray form of the painkiller ketorolac can safely reduce pain from a ureteral stent after stone surgery. If you are having a ureteroscopy with stent placement, this might help you manage discomfort without stronger medications.
Dallas, TexasAges 18 years+ - NCT06160323Recruiting
Pain block for inoperable pancreatic cancer
This trial tests whether an early nerve block during endoscopy can better control pain from pancreatic cancer compared to waiting and using standard treatments.
Hong Kong, Hong KongAges 18 years+ - NCT06161805RecruitingPhase 3
Esketamine for chronic pain from endometriosis
This trial tests if esketamine, a nasal spray, can reduce chronic pelvic pain in women with endometriosis that hasn't improved with standard painkillers. You may qualify if you have severe pain and are scheduled for endometriosis surgery.
DelftAges 18–50
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.