Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06517056Recruiting
3D Knee Assessment for Active Duty Knee Pain
This trial tests a 3D camera device that measures how your knee moves. It may help find the best way to treat your front-of-knee pain and keep you mission-ready.
Honolulu, HawaiiAges 18–50 - NCT06518421Recruiting
Emotions and Memory in Chronic Facial Nerve Pain
This study looks at how emotions and memory are affected in people with chronic trigeminal neuralgia (a type of facial nerve pain). Participants will have an MRI scan and fill out questionnaires to help researchers understand the link between chronic pain and cognitive changes.
Toronto, OntarioAges 35–60 - NCT06528288Recruiting
Numbing injection for pain relief after back fusion surgery
This study tests whether a special numbing injection (called an erector spinae plane block) given near the spine during surgery can reduce pain after lumbar fusion. If you qualify, you might have less pain and need fewer painkillers after your operation.
Worcester, MassachusettsAges 18 years+ - NCT06528574Recruiting
Pain after root canal cleaning methods
This trial compares two methods of cleaning a tooth's root canal to see which causes less pain after the procedure. It is for people with a specific type of tooth nerve pain (acute pulpitis) in a lower back molar.
Cleveland, OhioAges 18–50 - NCT06529874Recruiting
Pain, balance, and strength in children with sickle cell
This study looks at how children (ages 9-14) with sickle cell anemia or who are healthy handle pressure, balance, and strength. It aims to understand pain and movement better to help improve care.
GizaAges 9–14 - NCT06530602Recruiting
3D Shoulder Mobilization for Frozen Shoulder
This study tests a new hands-on physical therapy technique (3-D shoulder mobilization) to see if it helps people with frozen shoulder move better and feel less pain.
Rawalpindi, Punjab ProvinceAges 40–65 - NCT06531317Recruiting
EEG and brain stimulation for nerve pain after spinal cord injury
This study tests whether a personalized brain stimulation treatment (using a non-invasive technique called tDCS) can help reduce nerve pain in people with spinal cord injury. The researchers will also use EEG (a cap that records brain activity) to see how your brain responds.
Badalona, BarcelonaAges 18–99 - NCT06533345Recruiting
Pain-free research for chronic pain
This trial studies a collaborative approach to help people with chronic pain, which is pain that lasts beyond a recent injury. It may be a good fit if you're not currently seeking medication for your pain.
Auburn, AlabamaAges 21–80 - NCT06533917Recruiting
Spinal cord stimulation for chronic abdominal pain
This trial tests whether spinal cord stimulation (a device that sends mild electrical pulses to nerves in your spine) can reduce chronic abdominal pain that hasn't improved with standard care. It might be an option if you've tried medications or nerve blocks without success.
LeedsAges 18–130 - NCT06536504Recruiting
Music before brain surgery for stress and pain
This study looks at whether listening to live or recorded music before brain or spine surgery can help reduce stress, improve mood, and lessen pain. You may be able to join if you are scheduled for neurosurgery and can hear and speak English.
Houston, TexasAges 18 years+ - NCT06538233RecruitingPhase 2
Pain after buffered vs. non-buffered numbing medicine
This trial compares two versions of a numbing medicine (articaine) to see which causes less pain during dental work on upper front teeth.
Cleveland, OhioAges 18–60 - NCT06541184Recruiting
Ziconotide via spine pump for chronic non-cancer pain
This study looks at a medicine called ziconotide, given through a pump in your spine (intrathecal delivery) to treat chronic pain that is not from cancer. It aims to learn how safe and effective this treatment is in real-world patients.
AubagneAges 18 years+ - NCT06542666Recruiting
Cognitive functional therapy for chronic shoulder pain
This trial tests a new approach called cognitive functional therapy for people with long-term shoulder pain. It combines mental strategies with gentle movements to help you manage pain and improve function.
João Pessoa, ParaíbaAges 18–60 - NCT06544291RecruitingPhase 2
THC and CBD for pain and opioid use disorder
This study tests whether a combination of THC and CBD can help people who have both opioid use disorder and chronic low back pain. You would need to be on a stable dose of methadone and have used cannabis at least once in your life.
New Haven, ConnecticutAges 18–65 - NCT06548646Recruiting
Nerve blocks for pain relief after mastectomy
This study compares two types of nerve blocks (thoracic interfascial plane block vs. erector spinae plane block) to see which provides better pain relief after a mastectomy. It may help you have less pain and need fewer painkillers after surgery.
Cairo, AbbasiyaAges 21 years+ - NCT06549660Recruiting
Light therapy for chronic low back pain relief
This study tests if a special light treatment (photobiomodulation) can temporarily ease chronic low back pain that comes and goes. It's for people who have had this pain for at least 3 months and speak Portuguese.
São PauloAges 18–65 - NCT06549985Recruiting
Group care for endometriosis pain
This trial tests a weekly group program combining education, movement, and support to help manage chronic pelvic pain caused by endometriosis. It aims to improve quality of life without surgery.
St Louis, MissouriAges 18–48 - NCT06556758Recruiting
Stripping massage for rhomboid trigger points in women
This study tests whether a specific massage technique (stripping massage) can relieve upper back pain caused by trigger points in the rhomboid muscles. It focuses on women aged 18 to 40 who have not had neck or shoulder surgery.
Rawalpindi, Punjab ProvinceAges 18–40 - NCT06557993Recruiting
Nerve block injection for myofascial pain syndrome
This study tests a type of nerve block injection (called serratus posterior superior intercostal plane block) guided by ultrasound to see if it helps relieve pain from myofascial pain syndrome. It may be a treatment option for people with MPS who haven't had recent procedures.
IstanbulAges 18–65 - NCT06559215RecruitingPhase 2
Pain management with Exparel after knee surgery in teens
This trial is testing a long-acting numbing medicine called Exparel to see how well it controls pain after a specific knee surgery (MPFL reconstruction) in teens and young adults. It may help reduce the need for strong painkillers after the operation.
Frisco, TexasAges 13–21 - NCT06559735Recruiting
Brain oxygen measurement in chronic pain with spinal cord stimulation
This trial tests a new device to measure oxygen levels in the brain of people with chronic pain who are receiving spinal cord stimulation. It aims to see if brain oxygen changes can help manage pain better.
Walnut Creek, CaliforniaAges 18 years+ - NCT06565416Recruiting
Pain & opioid treatment in Native communities
This study is testing better ways to treat pain and opioid use in Native American communities. It may help if you have chronic pain or struggle with opioids.
Arcata, CaliforniaAges 18 years+ - NCT06565520Recruiting
Brain stimulation for kneecap pain
This study tests whether a gentle brain stimulation technique can help improve how your knee moves when you have kneecap pain. It's for people whose kneecap pain has lasted at least 3 months and whose knee tends to cave inward.
Las Vegas, NevadaAges 18–45 - NCT06567093Recruiting
Massage for pain during heel blood draw in newborns
This study tests whether a gentle leg and heel massage can help reduce pain in newborns during a standard heel blood test. It's for healthy babies born at full term (38–41 weeks) who are less than a month old.
Bartın, ProvinceAges 1 day–4 weeks
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.