Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06570577Recruiting
Nerve block for pain after cervical spine surgery
This trial tests whether a nerve block can reduce the need for opioid pain medication after back-of-neck spine surgery. It may help patients have better pain control with fewer side effects.
Stony Brook, New YorkAges 18–75 - NCT06573996Recruiting
Testing a mouth TENS device for braces pain
This trial tests if a small device placed inside the mouth can ease pain from braces. You'll receive either real or fake treatment with the TENS device to see if it helps with soreness after adjustments.
San Francisco, CaliforniaAges 12 years+ - NCT06579040Recruiting
Hyperbaric oxygen for endometriosis pain
This trial tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help reduce endometriosis-related pelvic pain. It is for people with ongoing moderate to severe pain who are waiting for surgery.
Toronto, OntarioAges 18 years+ - NCT06582134Recruiting
Mindfulness for jaw pain in university students
This trial tests whether brief mindfulness exercises can help reduce jaw pain in university students. If you have had jaw pain for at least 3 months, you may be able to join.
Kuala Lumpur, Kuala LumpurAges 18–30 - NCT06584721Recruiting
Foot exercises and taping for low back pain with flat feet
This study tests whether simple foot exercises combined with special tape on the foot can reduce low back pain in people whose feet roll inward too much (a condition called hyper-pronation). It may help if you have had back pain for months and also have flat feet.
Wāh, Punjab ProvinceAges 25–45 - NCT06585033Recruiting
Spinal cord stimulation for pain after back surgery
This trial tests how much of the pain relief from spinal cord stimulation is due to the placebo effect. It is for people with ongoing leg pain after back surgery who have already tried other treatments without success.
ArnhemAges 18–70 - NCT06587399Recruiting
Manual Therapy vs. Shock Waves for Shoulder Pain
This study compares two non-surgical treatments—manual therapy (hands-on techniques) and radial shock wave therapy (sound wave pulses)—to see which works better for long-lasting shoulder pain. It may be a good fit if your pain is from a common cause called impingement syndrome.
Alcalá de Henares, MadridAges 18–80 - NCT06590116Recruiting
Spinal manipulation for chronic low back pain
This study looks at how people feel about spinal manipulation therapy for long-term low back pain. It's for adults who have had pain in their lower back for more than three months and want to share their views on this type of treatment.
Gainesville, FloridaAges 18–70 - NCT06594796Recruiting
Lifestyle program for back pain and weight
This trial tests a combined exercise and lifestyle program for people with long-lasting low back pain who are overweight or have obesity. The program is delivered by physical therapists and aims to improve physical function and reduce pain.
AmsterdamAges 18 years+ - NCT06595329RecruitingPhase 1
Pain relief after kidney cancer surgery: epidural vs spinal opioids
This trial compares two ways to manage pain after open kidney cancer surgery: an epidural (a thin tube placed near your spine) versus a single spinal injection of opioids. Both aim to control pain, but the study wants to see which method works better, with fewer side effects.
SplitAges 18 years+ - NCT06598618Recruiting
Comparing two therapies for kneecap pain
This study compares two types of hands-on treatments—Instrument-Assisted Soft Tissue Mobilization (IASTM) and Muscle Energy Technique—to see which works better for kneecap pain. It aims to find a therapy that can help reduce your pain and improve movement.
Rawalpindi, Punjab ProvinceAges 18–35 - NCT07689396Recruiting
What affects treatment expectations for muscle pain?
This study tests how your expectations about treatment affect your recovery from myofascial pain (a type of muscle pain with tender spots). You will be in physical therapy and answer questions about your pain and outlook.
KonyaAges 18 years+ - NCT06349772RecruitingEarly Phase 1
Pain relief after robotic sleeve gastrectomy: Zynrelef vs Exparel
This trial compares two long-acting pain medicines, Zynrelef and Exparel, to see which works better for pain control after robotic sleeve gastrectomy. The goal is to improve recovery and reduce the need for stronger painkillers.
Lubbock, TexasAges 18–65 - NCT07689461Recruiting
Virtual reality for pain after hip replacement
This trial tests if using virtual reality can help reduce pain after hip replacement surgery. It may be a good option if you are having a hip replacement and have moderate to severe pain.
MalatyaAges 18–99 - NCT06361472Recruiting
Personalized physical therapy for chronic neck pain
This study tests a standard physical therapy program for neck pain, with added focus on factors like your personal situation and beliefs, to see if it helps more than therapy alone. It is for Spanish-speaking adults who have had moderate neck pain for over a month without serious underlying causes.
Ciudad Autónoma de Buenos Aires, Buenos AiresAges 18 years+ - NCT07605546Recruiting
Radiation Therapy for Cancer Pain Relief
This trial tests whether a focused radiation treatment called SRS (stereotactic radiosurgery) can help relieve severe cancer pain that hasn't improved with strong pain medications. You would receive a one-time radiation procedure aimed at pain-causing areas in your brain.
Los Angeles, CaliforniaAges 18 years+ - NCT06601634Recruiting
Neck pain improvement after cervical spine surgery
This study looks at what factors help predict better neck pain after a specific type of neck surgery called ACDF. If you have a degenerative neck condition and are scheduled for this surgery, the results could help doctors understand what leads to the best pain relief.
Krakow, Lesser Poland VoivodeshipAges 18–65 - NCT06602271RecruitingPhase 3
Study of PF614 for Pain After Tummy Tuck Surgery
This study tests a new painkiller called PF614 for pain after tummy tuck surgery. It compares the study drug to a placebo (a pill with no medicine) to see how well it works and how safe it is.
Atlanta, GeorgiaAges 18–75 - NCT06603792RecruitingEarly Phase 1
Neurofeedback for diabetic nerve pain
This trial tests whether a brain-training technique called neurofeedback can help reduce nerve pain caused by diabetes. It is for people with type 1 or type 2 diabetes who have had moderate-to-severe nerve pain for at least 3 months.
OdenseAges 18–82 - NCT06616324Recruiting
Virtual reality to reduce pain during kidney stone treatment
This study tests whether using a virtual reality (VR) headset during a kidney stone treatment called ESWL can help reduce pain and anxiety. If you're scheduled for ESWL at a hospital in Region Zealand, you may be able to use VR to distract yourself during the procedure.
RoskildeAges 18 years+ - NCT06623669RecruitingPhase 2
Mobile program to reduce pain and improve health in older adults
This trial tests a mobile program to help reduce pain and improve health in older adults with knee or hip arthritis who are not very active. The program involves exercise and may help with weight management.
Winston-Salem, North CarolinaAges 65 years+ - NCT06626958Recruiting
Stress ball for pain and comfort during labor
This trial tests if squeezing a stress ball during active labor can reduce pain and increase comfort for women having a vaginal birth. It may offer a simple, drug-free way to manage labor pain.
Muş, MerkezAges 18–40 - NCT06635902RecruitingPhase 2
Citrulline for sickle cell pain crisis
This trial tests if an intravenous medication called L-citrulline can help treat pain crises in children and young adults with sickle cell disease. Participants receive either the study drug or a placebo while in the hospital for a severe pain episode.
Washington D.C., District of ColumbiaAges 4–21 - NCT06637709Recruiting
Pain after osteoarthritis treatment: a 24-month study
This study looks at why some people still have pain after knee surgery or other treatments for osteoarthritis. It tests a marker in the blood to see if it relates to ongoing pain. You would be followed for 24 months.
Roma, RomaAges 18–99
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.