Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04028687Recruiting
Study of a hip stem used in select adult hip replacements
This trial follows people who have had a hip replacement using a specific “Taperloc Complete” stem. It is meant to monitor outcomes after surgery and see how well the stem performs over time for certain non-infectious hip problems.
Henderson, NevadaAges 18 years+ - NCT04109365Recruiting
Study of epidural placement technique during labor
This trial studies an approach to placing an epidural (pain medicine placed near the spine) during early labor. It aims to improve how safely and accurately epidurals are positioned, which may help with comfort during childbirth.
Palo Alto, CaliforniaAges 18 years+ - NCT04130269Recruiting
Study of stress, anxiety, and pain after heart attack
This study looks at how anxiety, stress, and pain may affect people after a heart attack. It may help researchers understand who could benefit from supportive strategies after myocardial infarction (heart attack).
Graz, StyriaAges 19–90 - NCT04177511Recruiting
Vagus nerve ear stimulation for endometriosis pelvic pain
This trial tests whether stimulating a nerve through the ear (non-surgical, through the skin) can reduce chronic pelvic pain from endometriosis. It may help if standard care hasn’t fully controlled symptoms like painful periods or pain during sex.
Suresnes, Île-de-France RegionAges 15 years+ - NCT04209504Recruiting
Nerve block study for one-sided breathing muscle weakness after shoulder surgery
This trial tests whether a longer-lasting nerve block during shoulder surgery can better manage pain and affect one-sided diaphragm (breathing muscle) weakness. It may help people having planned (first-time) shoulder surgery who are able to follow study pain-checks.
Durham, North CarolinaAges 18–80 - NCT04211259RecruitingEarly Phase 1
Loratadine to reduce bone pain during stem cell collection
This early trial studies whether loratadine (an allergy medicine) can reduce bone pain caused by G-CSF, which is used to help your body collect stem cells. If you have multiple myeloma and are preparing for stem cell mobilization, this may make treatment-related bone pain more tolerable.
New Brunswick, New JerseyAges 18 years+ - NCT04217733RecruitingPhase 3
Ethosuximide plus pentoxifylline for IBS belly pain
This Phase 3 study tests whether two medicines (ethosuximide and pentoxifylline) can reduce belly pain from irritable bowel syndrome (IBS). It may help people whose IBS pain has been moderate to severe recently and who can keep their current IBS treatment steady.
TantaAges 18 years+ - NCT04218422Recruiting
Battlefield-style ear acupuncture for hidradenitis pain
This trial tests a type of ear acupuncture (“battlefield acupuncture”) to reduce pain from hidradenitis suppurativa, a long-term skin condition. You may be eligible if your hidradenitis pain is frequent and your treatments are stable.
Dearborn, MichiganAges 18 years+ - NCT04219956Recruiting
Low-sugar diet aims to reduce belly-surgery pain
This study tests whether a special diet low in polyamines (a food-related substance) can reduce pain after major abdominal surgery. It compares pain control while you use a patient-controlled morphine pump or take opioid tablets by mouth after surgery.
BrestAges 18 years+ - NCT04288427Recruiting
Testing a prostate marker to predict response to finasteride
This study looks at a prostate test marker to understand who is more likely to benefit from 5-ARI medicines such as finasteride or dutasteride. If you have enlarged prostate symptoms and are getting a biopsy, the results may help doctors better choose or interpret 5-ARI treatment.
Boston, MassachusettsAges 50 years+ - NCT04305743RecruitingPhase 4
Compare pain after 5 vs 20 bladder botox injections
This study looks at how much discomfort you have after receiving bladder Botox injections, comparing a smaller (5) dose vs a larger (20) dose. It’s only for certain overactive bladder conditions and specifically when the procedure is done without sedation or special anesthesia.
Washington D.C., District of ColumbiaAges 18 years+ - NCT04321408Recruiting
Study of ziconotide pain treatment in routine care
This study follows adults with severe, long-lasting pain that has not responded to other treatments, to see how the pain medicine ziconotide works in everyday clinical practice. You may be considered if you’re being evaluated for an implanted pain-delivery system that gives ziconotide into the spinal fluid.
AngersAges 18 years+ - NCT04326192Recruiting
Spinal cord stimulation to reduce stubborn back and leg pain
This trial tests whether spinal cord stimulation (a treatment where a device sends mild signals to the spinal cord) can improve persistent nerve-type back and leg pain. It is mainly for adults who are already planning to try spinal cord stimulation but have not tried it before.
Portland, OregonAges 21–70 - NCT04363541Recruiting
Thermotherapy for mild to moderate COVID-19 symptoms
This trial studies whether local heat treatment (thermotherapy) can improve outcomes for people with mild to moderate COVID-19. It’s designed for people early in their illness (within 5 days) who still have good oxygen levels.
Guadalajara, JaliscoAges 18 years+ - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Hinsdale, IllinoisAges 18–85 - NCT04381208Recruiting
Using health and movement data to diagnose sacroiliac pain
This study looks at medical records and physical/neurological exam findings to help diagnose sacroiliac joint dysfunction, a common source of chronic low back or buttock pain. It may help your care team better sort out what’s causing your pain and choose the right next steps.
Valencia, ValenciaAges 18 years+ - NCT04399707Recruiting
Nerve-pain device study for pain after C-section
This study tests whether a small skin electrical nerve stimulator (called TENS) can reduce pain after a planned or not-urgent C-section. You may be more likely to have less pain and use fewer pain medicines if the TENS helps you.
Honolulu, HawaiiAges 18 years+ - NCT04425395Recruiting
Sounds without words may change pain tolerance
This study looks at whether nonverbal vocal sounds (like certain tones or sounds) change how much pain you can tolerate. You might be asked to listen to or produce sounds while your pain response is measured.
Saint-EtienneAges 18–60 - NCT04427709RecruitingPhase 2
Testing a brain-activity measure using oxytocin and eye movements
This study tests whether a particular brain-activity signal—seen in small rhythmic eye movements—can be measured reliably. It also looks at how oxytocin (a hormone used in medical settings) affects that signal.
Winston-Salem, North CarolinaAges 18–75 - NCT04441034RecruitingPhase 4
Compare two medicines for long-term pain in real life
This trial compares two types of medicines—anti-convulsants and anti-depressants—for people with persistent pain lasting more than 3 months. It aims to find out which option works better in everyday care and for which patients.
Redwood City, CaliforniaAges 18 years+ - NCT04445545Recruiting
Laser treatment for tight neck trigger points
This trial tests whether high-intensity laser therapy applied to specific “trigger points” in the neck muscles can help people with painful tight spots. You may be eligible if you have those trigger points and meet safety rules about recent neck/shoulder problems and skin and nerve conditions.
Santiago, Las CondesAges 18 years+ - NCT04457895Recruiting
Yoga and physical therapy program for hormone therapy breast cancer pain
This trial studies whether a combined physical therapy, yoga, and patient education program can reduce pain in people with non-metastatic breast cancer who are taking hormone therapy. It may help with pain and day-to-day comfort while you continue hormone treatment.
Libourne, AquitaineAges 18–99 - NCT04576078RecruitingPhase 2
Nefopam for less pain after knee replacement surgery
This Phase 2 study tests whether oral nefopam can reduce pain after total knee replacement done with spinal anesthesia. It looks at whether this medicine works better than the usual post-surgery pain plan and how safely it can be used.
Lyon, LyonAges 18–75 - NCT04577690RecruitingPhase 4
PECS pain study for children getting a chest device implanted
This trial tests a pain-control method (PECS) during surgery for children who are having a small chest device implanted. It may help reduce discomfort during and after the operation.
Toronto, OntarioAges 3–18
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.