Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03434392Recruiting
Testing pain-sensing to predict treatment response in chronic pancreatitis
This study uses a special pain-testing method to better predict how people with chronic pancreatitis-related pain (or similar conditions) will respond to treatment. It may help doctors choose therapies that work better for each person’s type of pain.
Baltimore, MarylandAges 18 years+ - NCT03596424Recruiting
Testing ketamine and dexmedetomidine during lung surgery
This trial studies whether the anesthesia medicines ketamine and dexmedetomidine can improve care during elective lung (video-assisted) surgery. It may help with comfort during and after the operation, depending on how these medicines affect pain and recovery.
Montreal, QuebecAges 18–80 - NCT03625011RecruitingPhase 4
Gabapentin before tonsil surgery to reduce pain
This trial tests whether giving gabapentin before pediatric tonsil (and possibly adenoid) removal can reduce postoperative pain. It may help children feel more comfortable after surgery while still being safe to use in the right patients.
Atlanta, GeorgiaAges 3–18 - NCT03646955Recruiting
Partial breast radiation versus no radiation after lumpectomy
This trial compares giving radiation only to part of the breast versus not giving radiation at all after breast-conserving surgery. It’s meant for women with early, hormone-driven breast cancer to see if skipping radiation can be safe and reduce treatment burden.
SantiagoAges 60 years+ - NCT03696199RecruitingPhase 4
Test better pain control after ankle fracture surgery
This trial studies a pain-control approach (a kind of nerve block) to see if it can reduce pain after surgery for certain ankle fractures. It may help you feel more comfortable while your ankle heals after an operation.
Burlington, MassachusettsAges 18–89 - NCT03696134Recruiting
Study of musculoskeletal health, frailty, pain, and disability
This study looks at musculoskeletal health and wellbeing in adults, especially people who are frail or at risk of developing frailty-related problems like pain or limited ability to move. It may help researchers understand what puts people at risk and what could improve comfort and function.
NottinghamAges 18 years+ - NCT03711773Recruiting
Low-impact exercise classes for joint pain
This study tests a gentle, low-impact exercise program to improve pain and function for adults with knee, ankle, and/or hip pain. You’ll also attend dietitian and behavioral health classes as part of standard care while you participate.
Columbia, MissouriAges 18 years+ - NCT03715517Recruiting
Spinal anesthesia to improve recovery after liver surgery
This trial studies whether using spinal/epidural anesthesia during liver tumor removal surgery can help people recover better and with less pain. It compares this approach to standard general anesthesia care to see if recovery is smoother.
Winnipeg, ManitobaAges 18 years+ - NCT03725527Recruiting
Nerve block test to improve breathing after belly surgery
This trial studies whether a numbing injection near the abdominal muscle (rectus sheath block) helps your breathing and diaphragm function after elective upper belly surgery. If you qualify, you may receive or not receive this pain/nerve block as part of the study.
Asyut, Assiut GovernorateAges 18–50 - NCT03759028RecruitingPhase 4
Study of pain relief after elbow fracture surgery
This trial looks at how well different pain medicines work after surgery for a specific type of broken elbow bone. It may help find a safer, more comfortable pain-control plan while the fracture heals.
Los Angeles, CaliforniaAges 4–12 - NCT03756961Recruiting
Opioid-free care plan for people having weight-loss surgery
This trial studies whether an opioid-free or opioid-sparing care pathway can improve comfort and outcomes for adults undergoing laparoscopic weight-loss surgery. It may help people avoid side effects from opioid pain medicines while still managing pain safely.
Lindesberg, Region ÖrebroAges 18 years+ - NCT03794362Recruiting
Testing how pain medicines change pupils in children
This study looks at how different pain treatments affect a child’s pupils (the dark center of the eye). It may help doctors better understand which pain medicines are working and how to measure pain treatment effects more accurately.
Washington D.C., District of ColumbiaAges 7–21 - NCT03796572RecruitingPhase 4
Nerve-block pain relief after a specific elbow bone fracture
This trial studies whether a pain-relief “nerve block” with medicine helps control pain after surgery for a particular type of elbow (humerus) fracture. It may help you feel more comfortable during recovery, compared with standard pain control.
Los Angeles, CaliforniaAges 4–12 - NCT03819738Recruiting
Brain scan during deep brain stimulation
This study checks how brain imaging works in people who already have a deep brain stimulation (DBS) device. If you have a DBS system, the study may help researchers better understand what the stimulation is doing in the brain.
Leuven, Vlaams-BrabantAges 18 years+ - NCT03834818Recruiting
Using a phone app to track pain after orthopedic surgery
This study collects information about pain and recovery after planned (elective) orthopedic surgery. It uses a smartphone to help understand outcomes and pain levels so care may improve.
Durham, North CarolinaAges 18–90 - NCT03838107Recruiting
Tracking changes in pediatric CRPS using study markers
This study looks at how signs in the body change over time in children with CRPS (complex regional pain syndrome). It mainly involves being assessed alongside the usual CRPS care, and often includes MRI checks to better understand the pain course.
Cincinnati, OhioAges 10–17 - NCT03858231RecruitingPhase 4
Opioid vs non-opioid pain relief after knee arthroscopy
This study compares opioid pain medicine with non-opioid pain medicine after arthroscopic (keyhole) knee surgery. It aims to see which approach controls pain well while keeping side effects and risks lower.
Fargo, North DakotaAges 18–80 - NCT03867539RecruitingPhase 4
Numbing shot and education to reduce opioids after carpal tunnel surgery
This study tests whether giving a long-lasting numbing injection (Exparel) plus education about pain management can help people avoid taking opioid pain pills after carpal tunnel release surgery. It may help reduce opioid use while still supporting comfort during recovery.
Dayton, OhioAges 18 years+ - NCT03876054Recruiting
Tracking outcomes after Abbott neurostimulator implantation
This study follows people long-term after they get an Abbott device implanted to help with chronic pain. It aims to learn how well the therapy works in real-world care over time.
Phoenix, ArizonaAges 18 years+ - NCT03913819Recruiting
Standard treatment for bladder problems caused by substance abuse
This trial tests how well a set “standard” treatment plan works for people with bladder emptying problems caused by substance abuse. You might consider it if you have this specific type of bladder issue and can follow the treatment plan.
ShatinAges Any age - NCT03949400Recruiting
Exercise therapy and a soft knee brace for knee arthritis
This study tests whether an exercise program plus education, along with a soft brace, helps improve symptoms and function in adults with knee osteoarthritis. It may help people who have knee pain by combining movement training with daily support.
Aalborg, NothernAges 18 years+ - NCT03976180Recruiting
High-flow oxygen for painful sickle cell episodes
This trial tests whether giving high-flow oxygen can help treat a painful sickle cell “vaso-occlusive crisis” (VOC) and lower the risk of a serious lung complication. You may be eligible if you’re an adult with sickle cell disease experiencing an opioid-requiring pain flare and have higher risk for lung trouble.
CréteilAges 18 years+ - NCT06808048Recruiting
Medical cannabis and behavior in chronic pain patients
This study looks at how medical cannabis affects thinking and behavior in people with chronic pain. It compares medical cannabis users to pain patients who don't use cannabis over a four-month period.
Minneapolis, MinnesotaAges 30–75 - NCT07564882Recruiting
Music and Mobile Apps to Help Babies With Heart Surgery Pain
This study tests whether music and a mobile app can help reduce pain and stress in babies aged 2–12 months who have had heart surgery. Researchers will measure pain levels and vital signs like heart rate and breathing.
AnkaraAges 2 months–1 year
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.