Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06002022Recruiting
How hormone therapy affects your quality of life
This study looks at how hormone therapy affects your quality of life. You'll answer questionnaires about your symptoms and well-being over time.
ValenciaAges 18–75 - NCT06009263Recruiting
Exercises for chronic low back pain
This study compares two types of exercises to see which one better strengthens a key lower back muscle. It may help if you have ongoing back pain.
Giza, DokkiAges 25–55 - NCT06012097RecruitingPhase 4
Aromatherapy gel for De Quervain's wrist pain
This trial tests if a gel made with essential oils can help reduce pain from De Quervain's disease, a painful wrist condition. If it works, it could be a natural option to relieve discomfort.
StrasbourgAges 18–75 - NCT06015165Recruiting
Pain control plan for complex anorectal surgery
This study tests a pain management plan led by anesthesiologists for people having complex anorectal surgery. The goal is to see if this approach can better control pain and improve recovery.
Beijing, Beijing MunicipalityAges 18–85 - NCT06023706RecruitingPhase 3
Capsaicin patch for tailbone pain
This trial tests a capsaicin 8% patch — a pain-relieving skin patch — to see if it can reduce tailbone pain that has lasted more than 3 months. You may be eligible if you have tried other treatments without success and have nerve-related pain symptoms.
BrestAges 18 years+ - NCT06030570Recruiting
Spine rehab program: how well does it work?
This trial tests a spine rehabilitation program that combines different types of care (like physical therapy and counseling) for adults with spine problems that haven't gotten better on their own. It aims to see if this program helps improve function and quality of life.
LeuvenAges 18 years+ - NCT06032559RecruitingPhase 3
Mindfulness and methadone for chronic pain
This study tests if adding a mindfulness program (MORE) to regular methadone treatment helps people with long-term pain. It may improve pain and support recovery.
New Brunswick, New JerseyAges 18 years+ - NCT06038409Recruiting
Ketamine therapy for chronic conditions
This trial tests if ketamine can help people with long-term health issues. It aims to find new treatments for chronic conditions that haven't responded well to other therapies.
Helena, MontanaAges 18 years+ - NCT06045936RecruitingPhase 4
Nerve block for phantom limb pain
This study tests whether a nerve block in the remaining part of your leg can help reduce phantom limb pain or pain in the residual limb. It is for people who have had an amputation more than a year ago and still have pain despite trying other treatments.
Mankato, MinnesotaAges 18 years+ - NCT06053255Recruiting
Testing a new device for low back pain from sacroiliitis
This trial tests a device called the Neurolyser XR to treat chronic low back pain caused by inflammation of the sacroiliac joint. It may help if you've had pain for over a year and other treatments haven't worked.
Charlottesville, VirginiaAges 18 years+ - NCT06059586Recruiting
Pre-hab program for women getting pelvic radiation for cancer
This trial tests a pre-rehabilitation (pre-hab) program to help women stay stronger before and during pelvic radiation for certain cancers. The goal is to see if it improves quality of life and reduces treatment side effects.
Avon, IndianaAges 18 years+ - NCT06067958RecruitingPhase 3
Nose spray medicine for pain during eye exams in preemies
This study tests a nose spray medicine (dexmedetomidine) to help reduce pain and discomfort in premature babies who need eye exams for retinopathy of prematurity (a condition that can affect vision). The goal is to see if the spray works better than the usual care for calming babies during the exam.
Be’er Ya‘aqov, CenterAges 4 weeks+ - NCT06070766Recruiting
At-home ketamine study for chronic conditions
This trial tests a ketamine protocol you can use at home. It may help if you have a long-term health condition.
Bigfork, MontanaAges 18 years+ - NCT06071637RecruitingPhase 3
Preventing mouth sores with laser therapy in stem cell transplant
This trial tests if a low-power laser can prevent painful mouth sores and throat pain in people getting a stem cell transplant from a donor. The laser is applied to the mouth before sores start, aiming to reduce pain and speed healing.
Rio de Janeiro, Rio de JaneiroAges 18–100 - NCT06074744Recruiting
Nerve blocks for knee replacement pain relief
This study compares two types of nerve blocks (subsartorial and femoral) to see which provides better pain control after knee replacement surgery. Both are injections that numb the nerves around your knee to help with recovery.
LucerneAges 18 years+ - NCT06075004Recruiting
Hip pain relief study comparing two injection methods
This trial tests two ways to give pain medicine around the hip joint during surgery to see which provides better pain relief. It may help patients experience less pain after hip replacement.
Santiago, Santiago MetropolitanAges 18–80 - NCT06077227Recruiting
Virtual reality for phantom limb pain
This study tests whether virtual reality therapy can help reduce phantom limb pain or uncomfortable sensations after amputation. If you have a major limb amputation and feel pain or other sensations in the missing limb, this might be an option to try.
Charlotte, North CarolinaAges 18 years+ - NCT06080997Recruiting
Patient expectations before spine surgery
This study looks at what patients expect before having spinal surgery. It may help improve how doctors support you before and after the operation.
Køge, Region SjællandAges 18–100 - NCT06081998Recruiting
How lack of sleep affects itch and pain
This study looks at how not sleeping affects your sensitivity to itch and pain. Researchers want to understand the connection between sleep and these sensations, which could help treat conditions like chronic itching or pain.
AalborgAges 18–60 - NCT06081946Recruiting
Does broken sleep affect itch and pain sensitivity?
This study looks at how a poor night's sleep (short, broken sleep) affects your sensitivity to itching and pain. The goal is to understand if sleep problems might make skin conditions worse.
AalborgAges 18–60 - NCT06087510RecruitingPhase 4
Different doses of esketamine and dexmedetomidine for pain after scoliosis surgery
This trial tests two different doses of esketamine and dexmedetomidine to see which provides better pain relief after scoliosis correction surgery. It aims to improve your recovery and long-term outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06088420Recruiting
Pain relief after cesarean section with nerve blocks
This study compares different nerve blocks for pain control after a planned cesarean delivery. The goal is to find which block provides the best pain relief with fewer side effects.
Asyut, ManfaloutAges 18–40 - NCT06091241Recruiting
Nerve blocks for pain relief after DIEP breast reconstruction
This trial compares two types of nerve blocks (ESPBs and TAPs) to see which provides better pain control after DIEP flap surgery for breast cancer. Women with breast cancer who are otherwise healthy or have mild to moderate medical conditions may be able to join.
Kansas City, KansasAges 18–70 - NCT06095050Recruiting
Embolization for chronic shoulder pain
This trial tests a procedure called embolization to treat long-lasting shoulder pain that hasn't improved with other treatments like physical therapy or injections. The goal is to see if blocking certain blood vessels can reduce pain and improve function.
Boston, MassachusettsAges 21–80
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.