Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,136 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07361809Recruiting
Desvenlafaxine for shingles pain relief
This trial tests if desvenlafaxine (an antidepressant also used for nerve pain) can safely reduce pain from shingles. It may be an option if your shingles pain is moderate to severe and started within the last 3 months.
BeijingAges 18 years+ - NCT07361796Recruiting
Venlafaxine to prevent nerve pain after shingles
This trial tests whether the drug venlafaxine, usually used for depression, can help prevent long-term nerve pain (postherpetic neuralgia) after a shingles infection. If you are currently experiencing shingles pain, joining this study might reduce your chances of developing chronic pain later.
BeijingAges 18 years+ - NCT07361822Recruiting
Opioid use after surgery: standard vs smart pump
This trial compares two ways to give pain medicine through an IV pump after surgery. It tests if a smart pump that adjusts the dose based on feedback works better than a standard pump that delivers a steady, fixed dose. This might help patients use less opioid pain medicine.
BeijingAges 18–65 - NCT07365800Enrolling by invitationPhase 4
Combination pain control after complex spine surgery
This study tests a combination of three medications (methadone, dexmedetomidine, and ketamine) to control pain after major spine surgery. If you are having complex spine surgery, this trial may offer better pain relief without needing as much opioid medication.
Columbia, MissouriAges 18–79 - NCT07363395RecruitingPhase 1
A study of ASCT-83 in healthy adults
This trial tests a new medication called ASCT-83 in healthy adults to see how safe it is and how the body processes it. It may help researchers understand the right dose for future studies.
Saint Paul, MinnesotaAges 18–64 - NCT06845631Recruiting
Study of Freedom PNS for chronic pain
This study looks at how well the Freedom PNS system works for people who already have it implanted. It helps doctors learn more about treating chronic pain with this device.
Cleveland, OhioAges 18 years+ - NCT06765486Recruiting
Exercise and pain relief: arm vs leg training
This trial compares how resistance training of the arms versus legs affects your body's natural ability to reduce pain. It may help understand which type of exercise is best for managing pain.
MadridAges 18–64 - NCT05254574RecruitingPhase 1
Acoustic therapy for ongoing joint pain from osteoarthritis
This Phase 1 study tests a sustained acoustic medicine device to help reduce pain from osteoarthritis (wear-and-tear arthritis) in joints like knees or hips. Because it’s early-stage research, you may be asked to follow strict rules about pain medicines and device use while the team monitors safety and comfort.
Tampa, FloridaAges 35–85 - NCT07354581Recruiting
Pain blocks after lower back surgery
This trial compares two types of pain-block injections (erector spinae plane block versus quadro-iliac plane block) given during lower back surgery to see which controls pain better. It may help you have less pain and need fewer pain medicines after your operation.
BursaAges 18–65 - NCT07354750Recruiting
Parasternal block for pain in pediatric heart surgery
This trial tests whether a nerve block given before a heart surgery incision reduces the need for pain medicine during the operation in children aged 6 months to 7 years having their first heart surgery through the breastbone.
AnkaraAges 6 months–7 years - NCT07353931RecruitingPhase 3
Study of eloralintide for knee osteoarthritis pain in people with overweight or obesity
This trial tests an investigational drug called eloralintide to see if it can reduce knee pain in people with osteoarthritis who also have overweight or obesity. You may be able to join if you have knee osteoarthritis, a BMI of 27 or higher, and have tried to lose weight with diet before.
Mobile, AlabamaAges 18 years+ - NCT07361198Recruiting
Knee artery embolization for arthritis pain
This trial tests a minimally invasive procedure to block small blood vessels in the knee, which may reduce pain from osteoarthritis. It's for people with ongoing knee pain even after standard treatments like medication or physical therapy.
Ústí nad LabemAges 40–80 - NCT07353632Recruiting
What affects re-participation in Danish colorectal screening
This study looks at why some people come back for a second round of the Danish bowel cancer screening program after their first colonoscopy. It aims to learn what factors influence their decision to participate again.
AabenraaAges 50–75 - NCT07360392Recruiting
Nerve block comparison for knee replacement pain
This study compares two numbing techniques (nerve blocks) for pain relief after knee replacement surgery. The goal is to find which one works better and helps you recover with less pain.
AmasyaAges 18–80 - NCT07353996RecruitingPhase 4
Finding the right dose of a new IV painkiller after bone surgery
This trial tests a single dose of a new pain medicine called tegileridine fumarate given through a vein right after orthopedic surgery (like spine, hip, or knee surgery). The goal is to find the best dose that works well for pain without causing side effects.
Hanzhong, ZhejiangAges 18–75 - NCT07354542Recruiting
Relaxation therapy for pain and sleep after joint replacement
This trial tests if different relaxation methods, such as breathing exercises or virtual reality, can help reduce pain and improve sleep after hip or knee replacement surgery. It is designed for people who have had a joint replacement and are able to use a mobile phone or tablet.
Bartın, CenterAges 18 years+ - NCT05883241RecruitingPhase 1
Sound-based treatment for fracture pain
This early-stage study tests a device that uses sound to reduce pain from a bone fracture and improve daily quality of life. If you have mild-to-moderate fracture pain and can follow the device routine, you may be able to try this treatment while avoiding other pain medicines and fracture-area therapies.
Trumbull, ConnecticutAges 18–80 - NCT06453005Recruiting
Comparison of two tooth cap methods for baby molars
This trial compares two ways to fix cavities in baby molars: the SMART Hall technique (a newer, less invasive method) and the traditional stainless steel crown. The goal is to see which works better for children aged 3 to 9.
Tirupati, AndhrapradeshAges 3–9 - NCT07351981Enrolling by invitation
Cooled radiofrequency for knee osteoarthritis pain
This study tests a new approach called cooled radiofrequency (TcPRF) to calm knee pain from osteoarthritis. It may be an option if standard treatments haven't worked and you haven't had certain other treatments recently.
AthensAges 45 years+ - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT07349173Recruiting
Testing a new way to assess hand and arm awareness
This study explores how people perceive the space around their affected arm or hand after a condition called 'exclusion' (partial loss of awareness or use). It uses virtual reality to test this, which might lead to better therapies.
NancyAges 18 years+ - NCT07352683Recruiting
Nerve block for kids having belly surgery
This trial tests a nerve block to reduce pain in children aged 1–15 who are having open abdominal surgery. It aims to see if this approach improves recovery.
UppsalaAges 1–15 - NCT07350148Recruiting
Text messages to support opioid medication adherence
This study tests whether daily supportive text messages help people stay on track with their methadone or buprenorphine treatment for opioid use disorder. It is designed for adults who recently started or resumed this medication and have a cellphone.
Albuquerque, New MexicoAges 18 years+ - NCT07352514Recruiting
Natural supplements and exercise for chemo nerve pain
This study tests if a combination of two natural supplements (PEA and Scutellaria) plus a specific exercise program can help reduce nerve pain caused by chemotherapy. It is for people who have had chemotherapy in the last 6 months and still have moderate to severe nerve pain.
Palermo, ItaliaAges 18 years+
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,136 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.