Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05868330RecruitingPhase 4
Compare two nerve-block methods for shoulder replacement
This trial compares two different ways of giving numbing medicine around the shoulder nerve before reverse shoulder replacement surgery. It may help find which method works better for pain control and comfort after surgery.
Iowa City, IowaAges 18–90 - NCT05876117Recruiting
Pre-medication to help claustrophobic patients complete MRI
This trial tests whether a pre-medicine approach can help people with claustrophobia successfully complete an MRI scan. It may help you avoid having to stop early due to anxiety or panic in the scanner.
Surrey, British ColumbiaAges 20–99 - NCT05883540RecruitingPhase 2
LSD therapy in palliative care for comfort and well-being
This Phase 2 study tests how LSD may affect comfort and quality of life for people with advanced or end-stage life-limiting illness. It also checks whether the medicine is safe and can be given in a controlled way in palliative care settings.
BaselAges 22 years+ - NCT05883241RecruitingPhase 1
Sound-based treatment for fracture pain
This early-stage study tests a device that uses sound to reduce pain from a bone fracture and improve daily quality of life. If you have mild-to-moderate fracture pain and can follow the device routine, you may be able to try this treatment while avoiding other pain medicines and fracture-area therapies.
Trumbull, ConnecticutAges 18–80 - NCT05883436Recruiting
Testing a specific neck fusion implant for nerve pain
This trial studies a specific implant used to fuse certain neck discs (C3 to C7) in people with nerve-related arm symptoms. It may help by supporting healing of the painful, damaged disc(s) and improving arm pain or numbness.
Orange, CaliforniaAges 18 years+ - NCT05883358Recruiting
Treating kratom withdrawal with clonidine or buprenorphine
This trial studies medicines (clonidine and/or buprenorphine) to help manage kratom dependence and kratom withdrawal symptoms. You may be asked to regularly track withdrawal symptoms in diaries to help the study team monitor safety and response.
Surrey, British ColumbiaAges 20–99 - NCT05885061Recruiting
Spinal cord stimulation study for adults with chronic pain
This study looks at how spinal cord stimulation affects chronic pain in adults who already have the device implanted. It may help researchers understand who benefits most and how stable pain and treatments need to be to measure results.
AarhusAges 18–99 - NCT05888038Recruiting
Virtual reality to reduce pain after scoliosis surgery
This trial looks at whether virtual reality can lower pain for children and teens after scoliosis repair surgery, which may also reduce how much opioid pain medicine they need. If you join, you would use a virtual reality experience during the post-operative period.
Staten Island, New YorkAges 7–21 - NCT05896826Recruiting
Magnetocardiography to better spot heart attack patients
This study tests whether magnetocardiography—a scan that measures heart signals using magnets—can more accurately identify myocardial infarction (heart attack). It may help doctors detect heart attacks faster and more accurately using safer, non-invasive testing.
Jinan, ShandongAges 18–79 - NCT05898035Recruiting
Testing symptoms after root-end dental surgery
This study looks at what symptoms you feel after endodontic microsurgery (a type of root-end tooth procedure). It will help doctors understand what to expect after surgery in properly selected patients.
IrbidAges 18–65 - NCT05898529Recruiting
Testing COVID status in children having surgery
This study looks at how COVID-19 infection is handled in children (ages 2–17) who are scheduled for surgery. The goal is to compare testing/safety approaches and see how they may protect pediatric surgical patients.
Surrey, British ColumbiaAges 2–17 - NCT05905419Recruiting
Brain scan study of opioid effects in women with pain
This study uses brain imaging (MRI) to understand how opioid medications may affect the brain in women. People with chronic pain who take opioids (or do not) and healthy women without chronic pain may be invited to participate.
Durham, North CarolinaAges 18 years+ - NCT05926921Recruiting
Music during IV placement for newborn babies
This trial tests whether playing music while a newborn gets an IV line helps during the procedure. It may be aimed at making the experience less stressful, while staff also monitor the baby’s vital signs.
Haarlem, North HollandAges Any age - NCT05969561Recruiting
Ultrasound-guided nerve block for hip-fracture pain in the ER
This trial tests whether an emergency doctor can safely and effectively place a pain-relieving nerve block in the thigh using ultrasound for people with hip fractures. It may help reduce pain while you are in the emergency department.
Douliu, Yunlin CountyAges 20 years+ - NCT05973201Recruiting
Virtual reality to ease anxiety and pain during lung scope
This study tests whether virtual reality (VR) can reduce anxiety and pain and shorten the time during a non-emergency breathing tube/airway procedure in the ICU. If you’re eligible, you may use VR during your first bronchoscopy during this hospital stay.
Aix-en-ProvenceAges 18 years+ - NCT05978362Recruiting
Capsular repair value in Latarjet shoulder surgery
This trial compares two surgical methods for treating shoulder instability. It tests whether repairing the capsule (the tissue around the shoulder joint) provides extra benefit over the standard Latarjet procedure alone.
ParisAges 18 years+ - NCT05979493RecruitingPhase 4
Nerve block for pain after fibroid surgery
This study tests whether a nerve block (QL block) can help with pain after surgery to remove uterine fibroids while keeping the uterus. It may be a good option if you are having a laparoscopic myomectomy and want to manage pain without strong opioids.
Beachwood, OhioAges 18–45 - NCT05981573Recruiting
Measuring methadone doses for chronic pain
This trial is for people with chronic pain who take daily methadone. It aims to measure how much methadone is in your body to help doctors find the right dose.
Lemon Grove, CaliforniaAges 18–70 - NCT05981989Recruiting
Spinal cord stimulation to improve arm and hand function after stroke
This trial tests if a device placed near the spinal cord can help improve movement, feeling, and pain after a stroke. It is for people who have had one stroke and have weakness on one side of the body.
Hualien CityAges 20–70 - NCT05985772Recruiting
Surgery vs no surgery for a type of knee tear
This trial compares surgery with non-surgical treatment for a specific tear in the knee's meniscus, the posterior-medial root tear. It aims to find out which approach works better and helps you decide with your doctor.
Chicago, IllinoisAges 18 years+ - NCT05986370Recruiting
Study on back pain and spinal manipulation
This trial tests whether spinal manipulation therapy (a type of hands-on treatment) can help people with long-term low back pain. It also compares their results to healthy volunteers of the same age and sex.
Trois-Rivières, QuebecAges 18–60 - NCT05988710RecruitingPhase 4
Low-dose buprenorphine for pain in opioid-naive adults
This study tests a low-dose form of buprenorphine (a medicine for pain) placed inside the cheek. It is designed for people who have never taken opioids before, to see how well it works for pain and how likely it is to be misused.
Nashville, TennesseeAges 18–65 - NCT05991453Recruiting
Recovery after IV vs. inhaled anesthesia for non-cardiac surgery
This trial compares recovery after two types of general anesthesia: one given through an IV (propofol) and one inhaled as a gas. It aims to see which approach leads to a smoother recovery for people having non-cardiac surgery.
Little Rock, ArkansasAges 18 years+ - NCT05996367Recruiting
Single radiation dose for painful myeloma bone lesions
This trial is testing whether a single dose of radiation can effectively relieve bone pain caused by multiple myeloma. It is designed for people who have a painful bone lesion and are stable on or off treatment.
São Paulo, São PauloAges 18–85
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.