Clinical trials
Parkinson's Disease and Parkinsonism clinical trials
Below are recruiting parkinson's disease and parkinsonism clinical trials, each written for real people, not researchers. We’re tracking 723 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06841718Enrolling by invitation
Brain study of freezing in Parkinson's disease
This study uses brain imaging to understand why some people with Parkinson's suddenly feel like their feet are glued to the floor (freezing of gait). It may help find better treatments for this symptom.
LeuvenAges 18 years+ - NCT06705517Recruiting
Mediterranean diet study for Parkinson's disease
This trial tests whether a Mediterranean diet can help people with Parkinson's disease. You would either follow your usual diet or switch to a Mediterranean diet for six months and provide blood and stool samples.
Varese, VareseAges 40–85 - NCT06602544Recruiting
Robotic suit to prevent freezing in Parkinson's
This study tests a robotic suit designed to help prevent freezing of gait (a sudden feeling of being stuck) in people with Parkinson's disease. You'll attend 8 visits to see if the suit can improve your walking and reduce falls.
Allston, MassachusettsAges 18–90 - NCT06785298RecruitingPhase 2/Phase 3
Fexofenadine as add-on treatment for Parkinson's disease
This trial tests whether adding fexofenadine, a common allergy medicine, to your current Parkinson's treatment can help improve symptoms. It's for people aged 50 or older who are already on dopamine replacement therapy.
TantaAges 50–70 - NCT06680830RecruitingPhase 2
Testing NEU-411 for early Parkinson's with LRRK2 gene change
This trial tests an experimental drug called NEU-411 for people with early Parkinson's disease who have a specific genetic change (LRRK2). It aims to see if the drug can slow the disease progression.
Sun City, ArizonaAges 40–80 - NCT06679374RecruitingPhase 2
Can varenicline help reduce falls in Parkinson disease?
This phase 2 trial tests a medicine called varenicline (brand name Chantix) to see if it can reduce falls in people with Parkinson disease who also have a specific brain change (loss of a chemical called acetylcholine in the back of the brain) and mild cognitive problems. The study will help determine if this medicine is safe and effective for this group.
Ann Arbor, MichiganAges 45 years+ - NCT06582121Recruiting
Sleep disorders in early and advanced Parkinson's disease
This study looks at sleep problems in people with Parkinson's disease, people with REM sleep behavior disorder (a condition that causes acting out dreams), and healthy volunteers. The goal is to understand how sleep is affected in early and full Parkinson's disease.
Clermont-FerrandAges 18 years+ - NCT06508801Recruiting
Blood flow restriction to improve balance in Parkinson's
This study tests whether gently restricting blood flow to your legs during exercise can help improve balance for people with Parkinson's disease. You will do simple leg exercises while wearing a special cuff, which may strengthen muscles and improve steadiness.
San Antonio, TexasAges 40–85 - NCT06344026Enrolling by invitationPhase 1
A cell therapy trial for Parkinson's disease
This trial tests a new treatment made from your own cells to replace damaged brain cells, aiming to improve movement and reduce symptoms. It's for people who have had Parkinson's for at least 4 years and respond well to levodopa.
Tucson, ArizonaAges 40–75 - NCT05998772Recruiting
How sugar affects Parkinsons symptoms
This study looks at how sugar levels might change the way Parkinsons disease feels. If you have mild to moderate Parkinsons, you may be able to join and help researchers learn more about the role of food in your symptoms.
KielAges 50–80 - NCT06341829Enrolling by invitation
Vision and emotions in Parkinson's disease
This study explores how Parkinson's disease affects visual and emotional abilities. It aims to understand these challenges better to improve future care.
Messina, MessinaAges 18–90 - NCT05516732Recruiting
Testing serotonin activity in the brain in people with Parkinson’s
This study uses special scans to measure how serotonin is released in parts of the brain involved in movement in Parkinson’s disease. It may help researchers understand disease changes and the role of serotonin systems in movement problems.
Exeter, DevonAges 25–85 - NCT05516719Recruiting
Study tracking I2BS in Parkinson’s over time
This study follows people with Parkinson’s to see how “I2BS” changes over time using special brain scans and other tests. It may help researchers better understand Parkinson’s and improve how it’s measured in future trials.
Exeter, DevonAges 25 years+ - NCT06084533Enrolling by invitation
Brain inflammation imaging in Parkinson's disease
This study uses a special PET scan to look for signs of brain inflammation in people with Parkinson's disease. It aims to understand how inflammation relates to Parkinson's and may help in developing new treatments.
St Louis, MissouriAges 50 years+ - NCT05962489Recruiting
Sleep-focused DBS therapy study for Parkinson’s disease
This study looks at a sleep-focused approach to brain stimulation (DBS) in people with Parkinson’s disease. You may be able to join if you’re planning or scheduled for specific DBS surgery at the University of Minnesota and have the needed brain imaging.
Minneapolis, MinnesotaAges 21 years+ - NCT05864157Recruiting
Targeted training to improve walking in Parkinson’s disease
This study tests a targeted motor training approach to improve walking (gait) in people with Parkinson’s disease. You may be considered if your walking is affected but you can already walk steadily for 10 minutes without help.
Chapel Hill, North CarolinaAges 50–80 - NCT04735458Recruiting
Brain network study for Parkinson’s or essential tremor
This study looks at how “inhibitory control” brain networks work in people with Parkinson’s disease or essential tremor. If you are eligible for surgery and can do the study tasks, your results may help researchers better understand movement disorders and guide future treatments.
Birmingham, AlabamaAges 18 years+ - NCT05748028Recruiting
Testing treatment for pain and nerve symptoms in Parkinson’s
This study looks at pain and “autonomic” (automatic body) symptoms in people with Parkinson’s disease or a related condition called multiple system atrophy. It aims to understand what helps and to learn more about these symptoms in different types of Parkinson-like illnesses.
Telese Terme, BeneventoAges 18 years+ - NCT05603715RecruitingPhase 2
Pyridostigmine to help constipation in Parkinson’s
This trial tests whether pyridostigmine can improve constipation symptoms in people with Parkinson’s disease. If you have Parkinson’s and functional constipation (with infrequent bowel movements), this study may offer a new medication option and closely track your bowel function.
Burlington, VermontAges 18 years+ - NCT05568498RecruitingPhase 2
Probiotic trial for depression in Parkinson’s disease
This Phase 2 study tests whether taking probiotics can improve depression and mood symptoms in people with Parkinson’s disease. It’s meant for those with mild to moderate depression and stable Parkinson’s and mood treatments.
Vancouver, British ColumbiaAges 40–80 - NCT05357612RecruitingPhase 4
PET scan study for brain serotonin in neurodegenerative diseases
This study uses a special PET brain scan tracer to better understand serotonin receptor activity in people with certain neurodegenerative conditions, especially when they develop hallucinations or delusions. The results may help researchers improve how these brain changes are measured and tracked over time.
Nashville, TennesseeAges 50–85 - NCT04997642Recruiting
Parkinson’s patient database for memory and movement tracking
This study builds a research database of people who receive care for Parkinson’s disease, including those with mild memory problems or dementia. It aims to collect consistent information that researchers can use to better understand Parkinson’s and related thinking changes.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04804202Recruiting
Virtual cycling program for people with Parkinson disease
This study tests whether a virtual, guided stationary bike exercise program is safe and helpful for people with Parkinson disease. It may help improve movement and fitness by letting you ride at home or in a controlled setting while using visual and audio guidance.
Newark, New JerseyAges 45–75 - NCT04566341Enrolling by invitation
Study gut problems in Parkinson’s and changes in gut nerves
This study looks at how digestive (gut) problems happen in people with Parkinson’s and whether there are related changes in the nerve tissue in the digestive tract. It may help researchers better understand the cause of these symptoms and find new ways to monitor or treat them.
Boston, MassachusettsAges 40–85
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Common questions
- Are there clinical trials for parkinson's disease and parkinsonism?
- Yes. Clin2 currently lists 723 recruiting parkinson's disease and parkinsonism studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a parkinson's disease and parkinsonism trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a parkinson's disease and parkinsonism trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.