Clinical trials · Pennsylvania
Pediatrics clinical trials in Pennsylvania
We’re tracking 135 recruiting pediatrics studies with a site in Pennsylvania — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT02708134Recruiting
Study of CPR quality in children and young adults
This trial looks at how well CPR (chest compressions) is done during an emergency resuscitation in children and young adults. The goal is to understand what helps improve care during life-saving resuscitation.
Philadelphia, PennsylvaniaAges birth–18 years - NCT05550298Recruiting
Study of virus infections after pediatric transplants
This study looks at how respiratory viruses behave and how the body responds in children who are about to receive, or have recently received, a transplant. It may help doctors better diagnose and treat viral infections in transplant patients by studying blood samples and test results.
Pittsburgh, PennsylvaniaAges Up to 18 years - NCT06192576Recruiting
Long-term safety study of olipudase alfa in children under 2 with ASMD
This study looks at the long-term safety and effects of olipudase alfa in children under 2 years old with acid sphingomyelinase deficiency (ASMD), a rare genetic condition. It aims to see how the treatment works over time and if it is safe for young children.
Philadelphia, PennsylvaniaAges Up to 2 years - NCT06173518RecruitingPhase 1
CAR T-cell therapy for children with B-cell leukemia or lymphoma
This trial tests a CAR T-cell therapy that targets CD19 on cancer cells. It is for children whose B-cell acute lymphoblastic leukemia or aggressive B-cell non-Hodgkin lymphoma has come back or not responded to other treatments.
Philadelphia, PennsylvaniaAges birth–18 years - NCT06177067RecruitingPhase 1
Study of 3 drugs for young AML patients with genetic changes
This trial tests a combination of three drugs (revumenib, azacitidine, and venetoclax) for children and young adults with a hard-to-treat type of leukemia that has a specific genetic change. The goal is to see if this new mix can help when standard treatments have not worked.
Philadelphia, PennsylvaniaAges 1–30 - NCT06111040Recruiting
Parenting study for food-driven young children
This study tests a program to help parents handle feeding their 4- or 5-year-old child who is very motivated by food. It aims to support healthy eating habits.
Philadelphia, PennsylvaniaAges 4–5 - NCT06094010RecruitingPhase 3
Flu treatment and transmission study for children and families
This study tests how well a single-dose flu treatment (baloxavir marboxil) works for children with the flu and whether it stops the flu from spreading to family members. If your child has early flu symptoms and lives with others, participation could help protect your household.
Smithfield, PennsylvaniaAges 3 weeks–11 years - NCT04511806Recruiting
Study of inherited cancer risk in children and families
This study looks at how inherited “cancer predisposition” conditions run in families, even if a child has not had cancer yet. It may help doctors better understand who is at higher risk and guide future monitoring or care.
Philadelphia, PennsylvaniaAges Any age - NCT03401398RecruitingPhase 3
Hydrocortisone for children with septic shock in the ICU
This Phase 3 trial tests whether giving stress-dose hydrocortisone can improve outcomes for children with septic shock in the pediatric intensive care unit (PICU). It is designed for children who are already receiving strong medicines to support blood pressure because of a serious infection.
Hershey, PennsylvaniaAges 1 month–17 years - NCT05024929Recruiting
Test targeted drugs to help radioactive iodine reach thyroid cancer
This study looks at whether certain cancer “targeted therapy” medicines can make radioactive iodine (RAI) therapy work better for thyroid cancer that has spread to the lungs. It also involves taking special whole-body scans to measure how much radioactive iodine gets taken up by the cancer.
Philadelphia, PennsylvaniaAges birth+ - NCT05783323RecruitingPhase 2
Larotrectinib plus radiation for thyroid cancer with NTRK fusion
This Phase 2 trial tests larotrectinib (a targeted medicine) to help radioactive iodine (RAI) work better in people with differentiated thyroid cancer that has an NTRK gene fusion. It may improve how much thyroid cancer the RAI can reach and shrink.
Philadelphia, PennsylvaniaAges 2–99 - NCT06049680RecruitingPhase 4
Safety study of SMOFlipid for patients needing IV nutrition
This trial tests if SMOFlipid, a special lipid emulsion given through an IV, is safe for children and adults who need most of their nutrition from IV for at least 8 weeks. It looks for side effects like essential fatty acid deficiency or liver problems.
Pittsburgh, PennsylvaniaAges 1 month–17 years - NCT05947071RecruitingPhase 2
Higher-dose flu vaccine versus standard dose in child transplant patients
This trial compares a higher-dose flu vaccine to the standard dose in children who recently received a kidney, heart, and/or liver transplant. It aims to see which dose better protects children against influenza while checking for safety.
Philadelphia, PennsylvaniaAges 3–17 - NCT05948943RecruitingPhase 2/Phase 3
Alpelisib for lymphatic malformations with a PIK3CA change
This trial tests alpelisib (a targeted medicine) for people who have lymphatic malformations (LyM) that cause symptoms and have a PIK3CA mutation. It may help shrink or control these lesions when other procedures are delayed until after the first 24 weeks.
Philadelphia, PennsylvaniaAges birth–100 years - NCT05923073RecruitingPhase 3
Guselkumab for children with active Crohn’s disease
This Phase 3 trial tests guselkumab to treat children with moderately to severely active Crohn’s disease and ongoing inflammation in the bowel. If you qualify, the study will check whether the medicine can improve symptoms and healing, especially in children who did not respond to other treatments.
Philadelphia, PennsylvaniaAges 2–17 - NCT05918640RecruitingPhase 1/Phase 2
Lurbinectedin for cancers with specific EWS-related gene fusions
This early-phase study tests lurbinectedin, a chemotherapy medicine, in children and young adults whose solid tumors have a specific “FET fusion” gene change. It may help shrink tumors that have come back or did not respond to prior treatment, depending on the exact fusion type.
Philadelphia, PennsylvaniaAges 10 years+ - NCT05905926Enrolling by invitationPhase 3
Tenapanor safety study for teens with constipation-predominant IBS
This trial checks the safety of tenapanor in children and teens (ages 6 to under 18) with IBS-C. It is only for people who finished a previous related study and agreed to continue follow-up.
Scottdale, PennsylvaniaAges 6–18 - NCT05861999RecruitingPhase 4
Risdiplam for young children with SMA after gene therapy plateau
This trial studies whether risdiplam is safe and helpful for children under 2 with spinal muscular atrophy (SMA) whose function has leveled off or declined after gene therapy. It may be an option if you saw benefits from gene therapy but then noticed a stop or setback in key abilities.
Philadelphia, PennsylvaniaAges 3 months–2 years - NCT05861986RecruitingPhase 4
Risdiplam for very young children after gene therapy for SMA
This trial studies whether risdiplam, given early after gene therapy, is safe and helps children with spinal muscular atrophy (SMA) keep improving or stay stable. It focuses on children under 2 years old who already received gene therapy and need to meet timing and health requirements.
Philadelphia, PennsylvaniaAges 3 months–2 years - NCT05865301Recruiting
Outcomes after approved immunotherapy for young blood cancer patients
This study looks at the real-world results of treating certain B-cell blood cancers in children and young adults with commercially available immunotherapy. It may help doctors better understand how these treatments work for patients after relapse or when they need additional therapy.
Pittsburgh, PennsylvaniaAges Up to 26 years - NCT05835310RecruitingPhase 3
IV anifrolumab for active lupus in children
This study tests whether an intravenous medicine called anifrolumab can safely improve active systemic lupus (SLE) in children. If you qualify, you may receive the study treatment and be closely monitored for safety and lupus symptoms.
Philadelphia, PennsylvaniaAges 5–17 - NCT05839379Recruiting
Targeted therapy study for children and young adults with brain tumors
This trial studies a targeted medicine approach for high-grade glioma (a fast-growing brain tumor) and some diffuse midline tumors, including DIPG. It may help by matching treatment to tumor biology using tumor testing done before or around starting standard therapy.
Philadelphia, PennsylvaniaAges 1–39 - NCT05711667RecruitingPhase 3
Letermovir to prevent CMV after stem cell transplant in kids
This trial tests whether the medicine letermovir can prevent a common virus (CMV) from coming back after an allogeneic stem cell transplant in children. It may help lower the risk of CMV infection during the vulnerable period right after transplant.
Hershey, PennsylvaniaAges 2–18 - NCT05734066RecruitingPhase 1/Phase 2
Lurbinectedin drug study for young people with Ewing sarcoma
This trial tests lurbinectedin, a cancer medicine, by itself (no other drugs) in children and young adults whose Ewing sarcoma has come back or did not respond to prior treatment. It aims to see how safe the drug is and whether it can help control the cancer.
Philadelphia, PennsylvaniaAges 2–30
Pediatrics trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting pediatrics studies listed above.
- Children's Hospital of Philadelphia · 15 studies
- UPMC Children's Hospital of Pittsburgh · 4 studies
- Frontier Clinical Research · 2 studies
- Frontier Clinical Research, LLC
- Penn State Children's Hospital
- Penn State Milton S. Hershey Children's Hospital
- Pulse InfoFrame US Inc.- Site Number: 001001
- Research Site
What taking part in a pediatrics study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Pediatrics trials in other states
Common questions
- Are there pediatrics clinical trials in Pennsylvania?
- Yes. We're currently tracking 135 recruiting pediatrics studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pediatrics study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pediatrics trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pediatrics studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.