Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 270 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06123000Recruiting
Comparing two surgeries for gum disease
This study compares two types of gum surgery for people with advanced gum disease. It's designed to see which method works better for treating deep gum pockets and saving bone.
Florence, FIAges 18 years+ - NCT07070453Recruiting
Light-activated therapy for gum disease treatment
This study tests whether adding a light-activated therapy (photodynamic therapy) to standard deep-cleaning can improve gum disease treatment. It is for adults with periodontitis who have not had recent gum treatment or taken certain medications.
Almada, Monte Da CaparicaAges 18 years+ - NCT06726902Enrolling by invitation
Comparing air polishing powders for gum disease treatment
This trial tests whether different air polishing powders improve nonsurgical gum disease treatment in people with moderate to severe periodontitis. It aims to find a better way to clean below the gum line without surgery.
AlexandriaAges 30–65 - NCT06486012Recruiting
Light therapy for gum disease in diabetic patients
This trial tests if regular use of antibacterial light therapy can help manage and prevent gum disease symptoms in people with diabetes. It may offer a simple, non-invasive way to improve oral health.
Tampere, PirkanmaaAges 18 years+ - NCT06656325Recruiting
Laser treatment for gum disease study
This study tests a special low-level laser (Erchonia FX-405) as an extra treatment for gum disease (periodontitis). It aims to see if adding this laser to standard care helps improve gum health and reduce infection.
Thousand Oaks, CaliforniaAges 22–75 - NCT06633640Enrolling by invitationEarly Phase 1
Algae bone graft for gum disease bone defects
This study tests a new bone graft material made from algae, used with a collagen membrane, to help repair bone damage caused by gum disease. It might be an option if you have a deep pocket in the bone around a tooth and are healthy enough for the procedure.
CairoAges 20–65 - NCT06012019Recruiting
Gum Disease and Inflammation Study
This study looks at gum disease (periodontitis and gingivitis) and inflammation using blood and dental samples. It may help researchers understand how inflammation affects gum health.
Ivry-sur-SeineAges 18 years+ - NCT06514664Enrolling by invitation
Do probiotic toothpastes help gums and teeth?
This trial tests whether using a probiotic toothpaste can improve gum health in people with gum disease (periodontitis). It may help reduce inflammation and slow bone loss.
KütahyaAges 18–99 - NCT04046237Recruiting
Treating gum disease to study heart artery inflammation after a heart attack
This study tests whether treating severe gum disease in people who recently had a heart attack can reduce inflammation in the artery plaque. It may help researchers understand if gum treatment could benefit heart health after a heart attack.
ParisAges 30–70 - NCT02833285Recruiting
Study immune cells in people with gum disease
This study looks at how the immune system (B cells) works in gum disease and may help doctors better understand the condition. You may be asked to take part if you need gum surgery and meet other health and treatment rules.
BrestAges 18–75 - NCT05439330Recruiting
Dental MRI to help diagnose jaw, gum, and tooth problems
This study tests whether a special dental MRI can give useful pictures to diagnose jaw joint problems, tooth-related tissue changes, and gum/inflammation issues, and to help plan some dental implant treatments. If you need imaging for these reasons, the trial may help doctors choose the best next treatment by using clearer, dedicated scans.
AarhusAges 18 years+ - NCT04831060Recruiting
Study of inflammation in gum and implant disease
This trial studies people with advanced gum disease (periodontitis) or gum inflammation around dental implants (peri-implantitis), and compares them with people who have healthy gums. The goal is to understand inflammation and how it relates to these dental conditions.
Ivry-sur-SeineAges 18 years+ - NCT04719026Recruiting
Teeth and heart attack link in people with or without heart attacks
This study compares dental health in people who were recently admitted for a heart attack with similar people who have not had a heart attack. It aims to see whether gum and dental health might be related to heart attack risk.
AberdeenAges 20–90 - NCT06105112Recruiting
Comparing hyaluronic acid to enamel matrix for gum regrowth
This trial tests whether a gel made from hyaluronic acid helps rebuild bone and gum tissue around teeth as well as a standard treatment (enamel matrix derivative). It's for people with advanced gum disease who have completed initial cleaning and still have deep pockets that need repair.
TurinAges 18 years+ - NCT07873697Recruiting
Gum disease and dry eye study
This study looks at whether people who have gum disease (periodontitis) are more likely to have dry eye disease. If you have both conditions, taking part could help doctors understand how they might be connected and improve care.
Sulaymaniyah, As Sulaymaniyah GovernorateAges 30–65 - NCT07864220Recruiting
Gum bacteria and pregnancy loss study
This study looks at whether bacteria in the mouth and related inflammation are linked to missed abortion, a type of early pregnancy loss. It may help find ways to prevent pregnancy loss in the future.
Konya, KonyaAges 18–40 - NCT07867951Recruiting
Pain after two root canal medicines
This study compares two medicines placed inside a tooth during root canal treatment to see which one reduces pain better afterward. It may help people with an infected tooth causing pain.
Swāt, KpkAges 16–50 - NCT07776756Recruiting
Gum tissue repair for molar furcation defects
This trial tests whether a special enamel protein combined with bone graft material can help repair gum and bone damage around the roots of back teeth (molars). It may improve the health of the area and reduce the need for more serious treatments.
Ho Chi Minh City, Binh PhuAges 18 years+ - NCT07770256Recruiting
Bone regeneration surgery for lower molar gum disease
This study looks at the shape of lower molar teeth with a certain type of gum disease and tests a surgical treatment to help regrow the bone around those teeth. If you have advanced gum disease and a lower molar with a specific type of bone loss, this treatment might help save the tooth.
Ho Chi Minh CityAges 18 years+ - NCT07775378Recruiting
Boron and inflammation in gum disease
This study looks at how boron levels, oxidative stress (cell damage), and inflammation (swelling) relate to periodontitis (severe gum disease). It may help understand what causes gum disease and could lead to better treatments.
Istanbul, MaltepeAges 18–65 - NCT07746206RecruitingEarly Phase 1
Insulin vs hyaluronic acid gel for advanced gum disease
This study compares two treatments applied directly to the gums to see which one better helps severe gum disease (periodontitis) heal. If you have advanced gum disease and haven't had treatment recently, you may be able to join.
CairoAges Any age - NCT07740447Recruiting
Non-surgical gum treatment and its effect on body chemistry
This study looks at whether a standard non-surgical gum disease treatment changes certain chemicals in your blood or saliva. It may help show how treating gum disease can improve your overall health.
Catania, ItalyAges 18–70 - NCT07725393Recruiting
Pomegranate gel for moderate to advanced gum disease
This study tests a gel made from pomegranate peel extract placed under the gums, along with standard deep-cleaning treatment, for people with moderate to advanced gum disease. It may help reduce gum inflammation and pocket depth naturally.
Cairo, Cairo GovernorateAges 30–60 - NCT07718061Recruiting
Bacteria in dental plaque with orthodontic retainers
This trial studies the types of bacteria found in dental plaque from people who have orthodontic retainers after braces. It aims to understand how retainers affect oral bacteria.
MurciaAges 18–40
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 270 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.