Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 281 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07070453Recruiting
Light-activated therapy for gum disease treatment
This study tests whether adding a light-activated therapy (photodynamic therapy) to standard deep-cleaning can improve gum disease treatment. It is for adults with periodontitis who have not had recent gum treatment or taken certain medications.
Almada, Monte Da CaparicaAges 18 years+ - NCT07274189Recruiting
Gum health and sodium bicarbonate toothpaste study
This trial tests whether a sodium bicarbonate (baking soda) toothpaste can improve gum health compared to a standard toothpaste. If you have some gum problems (but not too severe), it might help.
PlymouthAges 18 years+ - NCT07287540Recruiting
Anti-inflammatory diet for gum disease treatment
This trial tests whether an anti-inflammatory diet can improve the results of standard gum disease treatment. It is for people diagnosed with periodontitis who are otherwise healthy and do not smoke.
RizeAges 20–65 - NCT07304596Recruiting
Oral health impact questionnaire for periodontitis patients
This study evaluates a Hindi questionnaire that measures how periodontitis affects your daily life. It is designed for patients with periodontitis who can fill out forms on their own.
Rohtak, HaryanaAges 18 years+ - NCT07384221Recruiting
Gum health and disease severity in Pemphigus Vulgaris
This study looks at how Pemphigus Vulgaris (a rare blistering skin condition) affects gum health. Researchers will check your teeth and gums to see if the disease is linked to gum problems.
AnkaraAges 18 years+ - NCT02833285Recruiting
Study immune cells in people with gum disease
This study looks at how the immune system (B cells) works in gum disease and may help doctors better understand the condition. You may be asked to take part if you need gum surgery and meet other health and treatment rules.
BrestAges 18–75 - NCT07406867Recruiting
Can photos and bitewings detect gum disease?
This study tests whether photos, X-rays, and other non-invasive methods can identify gum disease as accurately as a clinical exam. It may help patients avoid needles or probing.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07452640Recruiting
Comparing two non-surgical gum treatments for advanced periodontitis
This study compares two methods for treating advanced gum disease (periodontitis) without surgery: one uses a special ultrasound device (Vector® system) and the other uses small hand tools (Mini-Five curettes). The goal is to see which cleans deeper pockets better and helps gums heal.
AnkaraAges 18–65 - NCT07491848Recruiting
Mouth health study for hepatitis B and D patients
This study looks at mouth health in people with hepatitis B and D, including those taking a medicine called bulevirtide and those not taking it. It may help understand how these infections affect the mouth and gums.
CraiovaAges 18 years+ - NCT07530978Recruiting
Oral Health, Gum Disease, and Quality of Life Study
This study looks at how gum health affects daily life and quality of living. Researchers want to understand the connection between oral hygiene habits, gum disease status, and how patients feel overall.
Bolu, BoluAges Any age - NCT07549347Recruiting
Smart Toothbrush vs. Professional Cleaning for Gum Disease
This study tests whether using an intelligent (electric) toothbrush with a smartphone app can manage early gum inflammation as effectively as professional dental cleaning. If you have mild gum disease, this trial may help you avoid or delay professional treatments.
Shanghai, Shanghai MunicipalityAges 18–64 - NCT07575347Recruiting
Gum Disease and Rare Kidney Disorders Study
This study explores whether people with certain rare kidney diseases or chronic kidney problems have more gum disease than others. Researchers will examine your teeth and gums to understand the connection and help improve care for people with kidney conditions.
BucharestAges 18 years+ - NCT07636733Recruiting
Vitamin D for Gum and Bone Health in Periodontal Disease
This study tests whether vitamin D supplements can reduce inflammation and improve healing in people with gum disease, ranging from mild gingivitis to advanced periodontitis. Researchers will compare how vitamin D affects different stages of gum disease.
RizeAges 18–70 - NCT07615361Enrolling by invitation
Tooth Graft and Laser Therapy for Dental Implants
This study tests whether material from extracted teeth, combined with low-level laser treatment, can help bone heal better before dental implants are placed. The goal is to improve implant success and reduce bone loss after tooth removal.
Istanbul, UskudarAges 18–65 - NCT07573761Enrolling by invitation
Tooth Grafts to Help Bone Grow for Dental Implants
This trial tests whether material made from extracted teeth can help bone regrow in the jaw after tooth removal, so you can get a dental implant. Researchers will compare this new approach to see if it works better for rebuilding bone in areas where teeth need to be replaced.
Istanbul, UskudarAges 18–65 - NCT07491627Enrolling by invitation
Nicotine's effect on gum disease treatment in smokers and non-smokers
This study looks at how smoking and nicotine affect the success of gum disease treatment. It compares results between smokers and non-smokers who have gum disease.
Liège, LiegeAges 18 years+ - NCT07426224Enrolling by invitation
Blood sugar screening for advanced gum disease patients
This trial checks if treating advanced gum disease at a specialist clinic can help find hidden high blood sugar and support you in managing your overall health.
StockholmAges 18 years+ - NCT07233512Enrolling by invitation
Periodontal treatment for Alzheimer's disease
This trial tests whether treating gum disease can improve outcomes for people with Alzheimer's disease. If you have mild to moderate Alzheimer's and gum disease, you may be able to join.
LiègeAges Any age - NCT06726902Enrolling by invitation
Comparing air polishing powders for gum disease treatment
This trial tests whether different air polishing powders improve nonsurgical gum disease treatment in people with moderate to severe periodontitis. It aims to find a better way to clean below the gum line without surgery.
AlexandriaAges 30–65 - NCT06633640Enrolling by invitationEarly Phase 1
Algae bone graft for gum disease bone defects
This study tests a new bone graft material made from algae, used with a collagen membrane, to help repair bone damage caused by gum disease. It might be an option if you have a deep pocket in the bone around a tooth and are healthy enough for the procedure.
CairoAges 20–65 - NCT06514664Enrolling by invitation
Do probiotic toothpastes help gums and teeth?
This trial tests whether using a probiotic toothpaste can improve gum health in people with gum disease (periodontitis). It may help reduce inflammation and slow bone loss.
KütahyaAges 18–99 - NCT07775378Recruiting
Boron and inflammation in gum disease
This study looks at how boron levels, oxidative stress (cell damage), and inflammation (swelling) relate to periodontitis (severe gum disease). It may help understand what causes gum disease and could lead to better treatments.
Istanbul, MaltepeAges 18–65 - NCT07776756Recruiting
Gum tissue repair for molar furcation defects
This trial tests whether a special enamel protein combined with bone graft material can help repair gum and bone damage around the roots of back teeth (molars). It may improve the health of the area and reduce the need for more serious treatments.
Ho Chi Minh City, Binh PhuAges 18 years+ - NCT06182293Recruiting
Mouth bacteria in early systemic sclerosis
This study looks at the bacteria in the mouth (periodontal microbiota) of people with early systemic sclerosis compared to those without the condition. It may help understand if there is a link between oral health and systemic sclerosis.
StrasbourgAges 18 years+
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 281 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.