Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07718061Recruiting
Bacteria in dental plaque with orthodontic retainers
This trial studies the types of bacteria found in dental plaque from people who have orthodontic retainers after braces. It aims to understand how retainers affect oral bacteria.
MurciaAges 18–40 - NCT07711431Recruiting
Connection between gum disease and ongoing neck pain
This study looks at whether there is a link between gum (periodontal) disease and long-term neck pain without a clear cause. If you are between 30 and 55, have most of your own teeth, and don't take regular pain medicine, you may be able to help doctors understand this connection.
Niğde, Niğde ProvinceAges 30–55 - NCT07703345Recruiting
Saliva markers in people with diabetes and gum disease
This study checks whether certain substances in saliva can help detect gum disease in people with type 2 diabetes. It compares the levels of these substances in people with diabetes and gum disease, people with gum disease only, people with diabetes only, and healthy volunteers.
Konya, KonyaAges 18–80 - NCT07688278Recruiting
Diabetes screening for people with advanced gum disease
This trial tests whether checking blood sugar (HbA1c) at the dentist can find undiagnosed diabetes. It is for adults with advanced periodontitis (severe gum disease) who have not already been told they have diabetes.
SkåneAges 18 years+ - NCT06186908Recruiting
Saliva test for gum disease diagnosis
This trial studies certain proteins in your saliva to see if they can help identify different types of gum disease. It may help improve how we diagnose and treat periodontal problems.
Izmir, ÇiğliAges 20–60 - NCT07671963Recruiting
Bone Graft Options for Gum Disease Surgery
This trial tests two bone-replacement materials (a synthetic bone substitute and a natural bone graft) placed during gum surgery to see which one better helps rebuild bone and gum support around teeth with deep pockets.
Cagliari, ItalyAges 18–80 - NCT07666126Recruiting
Uric acid and gum bone health study
This study looks at whether high uric acid levels affect the bone around your teeth. If you are between 18 and 65, have at least 20 natural teeth, and are either healthy or have high uric acid and gum disease, this trial may be for you.
RizeAges 18–65 - NCT07613606Recruiting
Platelet-Rich Fibrin Injection for Gum Disease Treatment
This study tests a new injectable treatment using your own blood cells to help repair damaged gum tissue and bone around teeth affected by periodontal disease (gum disease). The goal is to see if this minimally invasive approach can regenerate healthy gum and bone without major surgery.
CairoAges 18 years+ - NCT07587606Enrolling by invitation
Studying Healing Tissue in Deep Gum Pockets
This study examines how gum tissue heals in deep pockets that remain after standard gum disease treatment. Researchers will collect small samples of healing tissue to better understand gum disease and improve future treatments.
Roma, RomaAges 18–75 - NCT07585721Recruiting
Pain Relief After Root Canal Treatment: Two Different Medications
This study compares two types of medications placed inside a tooth after root canal treatment to see which one reduces pain better. You'll be asked about your pain levels after treatment, and researchers will measure a pain-related substance in your saliva.
CairoAges 18–45 - NCT07575997Recruiting
Testing Different Interdental Brushes for Gum Disease
This study compares different types of small brushes designed to clean between your teeth in adults with periodontal disease (a serious gum condition). The goal is to see which brush works best at improving gum health.
BrusselsAges 18–80 - NCT05356806Recruiting
Tracking gum inflammation around implants after gum disease treatment
This study looks at how often gum inflammation (peri-implant mucositis) happens around dental implants in people who previously had gum disease and are now in maintenance care. The results may help clinicians spot risk earlier and improve oral care around implants.
MadridAges 18 years+ - NCT07535177Recruiting
Gas6 and MerTK Protein Markers in Gum Disease
This study measures two proteins (Gas6 and MerTK) in the blood and gum tissue of people with and without gum disease to better understand how these proteins relate to periodontal health. Results may help doctors identify new ways to diagnose or treat gum disease in the future.
Bolu, BoluAges 18 years+ - NCT07532694Recruiting
Laser Treatment for Gum Disease in Kidney Transplant Patients
This study tests whether a special diode laser can safely and effectively treat gum disease (periodontitis) in people who have received a kidney transplant. Gum disease is common in transplant recipients and can affect overall health, so this treatment may help protect both oral and transplant health.
Hanoi, HadongAges Any age - NCT07531875Recruiting
Probiotics to Help Treat Advanced Gum Disease
This trial tests whether taking probiotics (beneficial bacteria) alongside standard gum disease treatment can help reduce deep pockets in your gums and improve healing. You'd be asked to take probiotics as an add-on to the care you're already receiving.
Kuala Lumpur, Kuala LumpurAges 18 years+ - NCT07522684Recruiting
Gel treatment for deep gum bone loss around teeth
This trial tests a special gel made with growth-promoting compounds and animal-derived material to help repair deep bone loss in the gums around teeth. It may help restore bone that periodontitis (advanced gum disease) has damaged.
Ribeirão Preto, São PauloAges 18 years+ - NCT06505759RecruitingPhase 1
Bromelain gel vs. chlorhexidine for gum disease treatment
This trial tests if a gel made from bromelain (a pineapple enzyme) works as well as a standard antibiotic gel to treat gum pockets caused by periodontitis. It may offer a gentler option for patients with moderate gum disease.
Bengaluru, KarnatakaAges 30–50 - NCT07487272Recruiting
Cell mapping in gum disease tissues
This study looks at the cells in gum tissue from people with different types of periodontitis (aggressive or chronic) and healthy gums. By understanding which cells are active and how they interact, researchers hope to find better ways to diagnose or treat gum disease.
Hangzhou, ZhejiangAges 20–40 - NCT06789458Recruiting
Pro-resolution mediators in severe gum disease before and after treatment
This study looks at natural substances in your blood that help reduce gum inflammation. Researchers want to see how these substances change after standard gum disease treatment, which may lead to better ways to manage severe periodontitis.
Manial, Cairo GovernorateAges 18–80 - NCT07463859Recruiting
Treating gum disease and bad breath in diabetes patients
This trial tests whether combining standard gum treatment with a light-activated therapy can reduce bad breath in people with type 2 diabetes and advanced gum disease.
Bauru, São PauloAges 18–70 - NCT07466966Recruiting
Non-surgical treatment for implant infection
This study tests a less invasive way to treat peri-implantitis (infection around a dental implant) without removing the implant crown or using antibiotics. It may help people with infected implants who have not smoked or used antibiotics recently.
BrnoAges 18 years+ - NCT07459049RecruitingPhase 4
Ibuprofen for gum inflammation after deep cleaning
This trial tests whether ibuprofen can help calm gum inflammation after a deep cleaning for periodontitis. It is for adults with moderate-to-severe gum disease who are otherwise healthy.
BaghdadAges 18 years+ - NCT07443917Recruiting
Study of Treponema Parvum in gum disease patients
This study looks for a specific bacteria called Treponema Parvum in the gums of people with periodontitis (severe gum disease). It aims to understand if this bacteria is linked to gum disease and could help improve future treatments.
BaghdadAges 30 years+ - NCT06574802Recruiting
Laser and air polishing for gum disease treatment
This study tests if a special laser and air polishing can help treat gum disease. It may offer a gentler, more effective way to clean below the gum line compared to standard scaling.
Beijing, Beijing MunicipalityAges 35–65
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 271 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.