Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 281 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07770256Recruiting
Bone regeneration surgery for lower molar gum disease
This study looks at the shape of lower molar teeth with a certain type of gum disease and tests a surgical treatment to help regrow the bone around those teeth. If you have advanced gum disease and a lower molar with a specific type of bone loss, this treatment might help save the tooth.
Ho Chi Minh CityAges 18 years+ - NCT07069881Recruiting
Comparing two dental cleaning methods for chronic root infection
This trial compares two ultrasonic cleaning methods (regular vs. passive) for treating a chronic tooth infection called chronic apical periodontitis. It aims to see which approach is more effective at clearing the infection and saving the tooth.
Guangzhou, GuangdongAges 18–59 - NCT07613606Recruiting
Platelet-Rich Fibrin Injection for Gum Disease Treatment
This study tests a new injectable treatment using your own blood cells to help repair damaged gum tissue and bone around teeth affected by periodontal disease (gum disease). The goal is to see if this minimally invasive approach can regenerate healthy gum and bone without major surgery.
CairoAges 18 years+ - NCT07169305Recruiting
Study on filling placement depth and tooth health
This trial tests how the depth of a filling below the gumline affects the health of the tooth's nerve and surrounding gum tissue. It may help people with cavities that go below the gum to get better care.
Rohtak, HaryanaAges 18 years+ - NCT07562295Recruiting
How Smoking Affects Gum Health
This study compares gum and tooth health in young adults who smoke cigarettes, e-cigarettes, or hookah. Researchers want to understand how each type of smoking affects your mouth and gums differently.
Homs, Homs GovernorateAges 18–25 - NCT06640218Recruiting
Comparing two ultrasound tools for tooth pain after root canal
This trial tests two different ultrasound methods used during root canal treatment to see which one reduces pain better afterwards. It focuses on people with a specific kind of tooth pain and infection.
Cairo, New CairoAges 18–40 - NCT06768424Recruiting
Treating deep gum pockets with laser or scalpel and platelet gel
This study compares two ways to fix deep gum pockets around teeth: a laser (MIST) or a traditional scalpel (GBT). Both methods use a gel made from your own blood (PRF) to help healing. The goal is to see which works better.
Budapest, BudapestAges 18–65 - NCT06789458Recruiting
Pro-resolution mediators in severe gum disease before and after treatment
This study looks at natural substances in your blood that help reduce gum inflammation. Researchers want to see how these substances change after standard gum disease treatment, which may lead to better ways to manage severe periodontitis.
Manial, Cairo GovernorateAges 18–80 - NCT07304752Recruiting
Probe Material Effect on Implant Gums Measurement
This study compares how different materials used for probing around dental implants affect accuracy. It is for people with a single implant (with a screw-retained crown, no abutment) that has been in use for at least a year and is either healthy or has only mild gum inflammation.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT07114523Recruiting
Collagen membranes for healing after wisdom tooth surgery
This trial tests whether placing a collagen membrane after wisdom tooth removal helps the nearby second molar heal better. If you have impacted lower wisdom teeth on both sides, this study may compare healing with and without the membrane.
Ho Chi Minh CityAges 25 years+ - NCT07746206RecruitingEarly Phase 1
Insulin vs hyaluronic acid gel for advanced gum disease
This study compares two treatments applied directly to the gums to see which one better helps severe gum disease (periodontitis) heal. If you have advanced gum disease and haven't had treatment recently, you may be able to join.
CairoAges Any age - NCT07185191Recruiting
Device to treat gum shrinkage and black triangles between teeth
This trial tests a medical device (RDM36) to see if it safely and effectively treats gum shrinkage and black triangles between the front teeth, which can affect your smile.
Brescia, ItalyAges 18 years+ - NCT07156695Recruiting
Deep filling study for tooth decay and gum health
This trial tests a technique called deep marginal elevation for fixing deep cavities near the gumline. It aims to see if this method affects your gum health compared to a healthy tooth on the other side.
Tanta, El-GharbiaAges 18–60 - NCT07740447Recruiting
Non-surgical gum treatment and its effect on body chemistry
This study looks at whether a standard non-surgical gum disease treatment changes certain chemicals in your blood or saliva. It may help show how treating gum disease can improve your overall health.
Catania, ItalyAges 18–70 - NCT07718061Recruiting
Bacteria in dental plaque with orthodontic retainers
This trial studies the types of bacteria found in dental plaque from people who have orthodontic retainers after braces. It aims to understand how retainers affect oral bacteria.
MurciaAges 18–40 - NCT07725393Recruiting
Pomegranate gel for moderate to advanced gum disease
This study tests a gel made from pomegranate peel extract placed under the gums, along with standard deep-cleaning treatment, for people with moderate to advanced gum disease. It may help reduce gum inflammation and pocket depth naturally.
Cairo, Cairo GovernorateAges 30–60 - NCT07711431Recruiting
Connection between gum disease and ongoing neck pain
This study looks at whether there is a link between gum (periodontal) disease and long-term neck pain without a clear cause. If you are between 30 and 55, have most of your own teeth, and don't take regular pain medicine, you may be able to help doctors understand this connection.
Niğde, Niğde ProvinceAges 30–55 - NCT07703345Recruiting
Saliva markers in people with diabetes and gum disease
This study checks whether certain substances in saliva can help detect gum disease in people with type 2 diabetes. It compares the levels of these substances in people with diabetes and gum disease, people with gum disease only, people with diabetes only, and healthy volunteers.
Konya, KonyaAges 18–80 - NCT04669717RecruitingPhase 4
Testing antibiotic dosing alongside periodontal treatment
This study tests how antibiotics should be added to standard gum (periodontal) treatment, including dosing and blood-level timing. It may help people whose gum disease is severe, by improving how antibiotics are used with routine dental care.
Geneva, Canton of GenevaAges 18–80 - NCT05077618Recruiting
Teeth bacteria study in seniors with and without Alzheimer’s
This study looks at the bacteria in the mouth (periodontal microbiota) to see whether they differ between seniors with Alzheimer’s disease and seniors without it. You may be asked for a sample from your gums/teeth and background health information.
Nice, CHU de NICEAges 18–90 - NCT05188196Recruiting
Collagen sponge vs collagen membrane after tooth removal
This study compares two types of collagen dental materials placed after a back tooth (molar) is removed. The goal is to see which one better helps preserve the jawbone so you can later get a dental implant.
Hangzhou, ZhejiangAges 18–70 - NCT05356806Recruiting
Tracking gum inflammation around implants after gum disease treatment
This study looks at how often gum inflammation (peri-implant mucositis) happens around dental implants in people who previously had gum disease and are now in maintenance care. The results may help clinicians spot risk earlier and improve oral care around implants.
MadridAges 18 years+ - NCT05906810Recruiting
Treating gum inflammation around implants to improve blood vessel function
This study looks at whether non-surgical gum treatment around dental implants can improve early problems in blood vessel function. It includes people with implant gum disease, and also compares them with healthy people who do not have gum disease.
CataniaAges Any age - NCT05907161Recruiting
Low laser and hyaluronic acid for gum disease
This trial studies whether adding low-level laser treatment and hyaluronic acid can improve gum health when combined with regular non-surgical gum therapy. It may help reduce problems from more advanced gum disease without surgery.
LjubljanaAges 25–70
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 281 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.