Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 281 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05924373RecruitingPhase 2
Stem cell treatment for chronic gum disease defects
This Phase 2 trial studies whether injections of human dental pulp stem cells can improve chronic periodontitis (long-term gum disease) by helping repair damaged bone around teeth. If you have a specific type of bone defect and moderate gum pocket depth, you may be eligible and could benefit from a novel regenerative approach.
Beijing, BeijngAges 18–65 - NCT05970965Recruiting
Teeth and gum study in children with Down syndrome
This study looks at how gums and inflammation work in children with Down syndrome by collecting and analyzing biological samples. It may help researchers understand gum health differences and improve future care.
Ivry-sur-SeineAges 3–12 - NCT06006429Recruiting
Using a scanner to check teeth and gums
This study tests if a special intraoral scanner can help dentists find gum problems and tooth issues. If you have receding gums, you may be able to join.
ReimsAges 18 years+ - NCT06068270Recruiting
MOPs cleaning aid for gum disease patients getting braces
This trial tests whether a special type of oral hygiene device (called MOPs) helps protect teeth and gums during orthodontic treatment (braces or aligners) in people with severe gum disease (stage IV periodontitis). It may help prevent further damage and improve the success of moving teeth.
Madrid, MadridAges 18–80 - NCT06073704Recruiting
Light therapy for gum disease in people with obesity
This study tests whether adding a special light-activated cleaning (antimicrobial photodynamic therapy) to standard gum disease treatment can help people with obesity who have gum disease. It aims to see if this extra step improves gum health more than standard treatment alone.
Bauru, São PauloAges 18–70 - NCT06091228Recruiting
Tongue scraping for bad breath with gum disease treatment
This trial checks if adding tongue scraping to regular gum disease treatment can help reduce bad breath more than gum treatment alone.
LeuvenAges 18 years+ - NCT06105112Recruiting
Comparing hyaluronic acid to enamel matrix for gum regrowth
This trial tests whether a gel made from hyaluronic acid helps rebuild bone and gum tissue around teeth as well as a standard treatment (enamel matrix derivative). It's for people with advanced gum disease who have completed initial cleaning and still have deep pockets that need repair.
TurinAges 18 years+ - NCT06110143Recruiting
Gum health and pregnancy complications study
This study looks at how gum disease (periodontitis) during pregnancy might affect pregnancy outcomes. It may help you if you have gum disease and want to learn more about its impact on your pregnancy.
Holbæk, HolbaekAges 16–48 - NCT06186908Recruiting
Saliva test for gum disease diagnosis
This trial studies certain proteins in your saliva to see if they can help identify different types of gum disease. It may help improve how we diagnose and treat periodontal problems.
Izmir, ÇiğliAges 20–60 - NCT06210789Recruiting
Gum reconstruction after enlargement removal
This trial tests a procedure to repair gum tissue that may recede after removing overgrown gum areas. It may help you if you have healthy gums and a small area of enlargement.
BudapestAges 18 years+ - NCT06290414Recruiting
Infrared imaging to check gum health
This trial uses a special camera that measures heat in your gums to see if it can tell if your gums are healthy, have gingivitis, or have periodontitis. It may help dentists spot gum disease earlier.
CairoAges 18–60 - NCT06505759RecruitingPhase 1
Bromelain gel vs. chlorhexidine for gum disease treatment
This trial tests if a gel made from bromelain (a pineapple enzyme) works as well as a standard antibiotic gel to treat gum pockets caused by periodontitis. It may offer a gentler option for patients with moderate gum disease.
Bengaluru, KarnatakaAges 30–50 - NCT06507280Recruiting
Gum treatment study for children with gingivitis
This study tests whether a gum treatment (periodontal therapy) can reduce inflammation in children with gingivitis. It measures certain proteins in the fluid around the gums to see if the treatment helps.
AydinAges 11–14 - NCT06520137Recruiting
Wisdom tooth removal and gum disease study
This study looks at how removing an impacted upper wisdom tooth affects gum health. It may help people who need this tooth removed and do not have advanced gum disease.
Siena, Italy/SIAges 19–64 - NCT06574802Recruiting
Laser and air polishing for gum disease treatment
This study tests if a special laser and air polishing can help treat gum disease. It may offer a gentler, more effective way to clean below the gum line compared to standard scaling.
Beijing, Beijing MunicipalityAges 35–65 - NCT06676826Recruiting
Comparing two gum-graft materials for bone defects
This study tests two types of gum-graft materials to see which works better for rebuilding bone next to deep pockets caused by gum disease. Both materials are used during a minor surgical procedure to help your gums and bone heal stronger.
BernAges 18 years+ - NCT06684769Recruiting
Chitosan brush and enamel proteins for gum treatment
This trial tests a new way to clean deep gum pockets at the base of molars using a chitosan brush and enamel proteins. It's for people who still have gum problems after standard treatment.
RigaAges 18 years+ - NCT06692582Recruiting
Saltwater rinse for treating gum disease
This study tests whether rinsing your mouth with a special saltwater solution (electrolyzed water) can help treat gum disease. It's for people who have advanced gum disease and want to try a simple, gentle addition to regular care.
LjubljanaAges 18–80 - NCT07688278Recruiting
Diabetes screening for people with advanced gum disease
This trial tests whether checking blood sugar (HbA1c) at the dentist can find undiagnosed diabetes. It is for adults with advanced periodontitis (severe gum disease) who have not already been told they have diabetes.
SkåneAges 18 years+ - NCT06726876RecruitingPhase 3
Manuka honey rinse for gum disease in dialysis patients
This study tests whether a manuka honey mouth rinse can help treat gum disease in people who are on dialysis for kidney failure. If you have both kidney failure and gum disease, this study may offer a natural way to improve your oral health.
BanhāAges 18 years+ - NCT06753305Recruiting
Ozone therapy for gum reshaping after inflammation
This study tests if ozone therapy helps heal gums after reshaping surgery for overgrown gum tissue caused by inflammation. It may reduce recovery time or improve results.
KütahyaAges 18 years+ - NCT06755372Recruiting
TLR-4 in gum disease patients with kidney failure
This study looks at a specific immune marker (TLR-4) in people with gum disease, comparing those who also have end-stage kidney disease (on dialysis) to those who are otherwise healthy. The goal is to understand how gum disease might be different when kidney failure is also present.
Al Fayyum, Faiyum GovernorateAges 30–60 - NCT06784817Recruiting
Gum health in smokers and heated tobacco users
This study compares gum health in three groups: daily cigarette smokers, exclusive users of heated tobacco products (like IQOS), and never-smokers. It aims to see if heated tobacco has different effects on gums compared to traditional smoking.
Budapest, Pest CountyAges 18 years+ - NCT06978712Recruiting
Gum inflammation and body stress link study
This study checks if gum inflammation (periodontitis) affects your body's stress system (allostatic load). It aims to find a link between severe gum disease and overall health stress.
Rohtak, HaryanaAges 30–50
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 281 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.