Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07077122Recruiting
Comparing five gum disease treatments
This trial tests five different non-surgical gum treatments to see how they affect overall health. It may be a good fit for people with advanced gum disease who do not smoke heavily or take certain medications.
AthensAges Any age - NCT07081230Recruiting
Albumin vs hyaluronic acid with growth factors for gum disease
This trial tests whether adding albumin or hyaluronic acid (both natural substances) to a special gum treatment helps heal gum pockets better. It is for people with moderate to advanced gum disease.
Al Mansurah, MansouraAges 25–45 - NCT06980675Recruiting
Ozonized olive oil for gum disease treatment
This trial tests if a special ozonized olive oil gel can help treat deep gum pockets caused by periodontitis (advanced gum disease). If you have gum pockets that are 4 mm or deeper, this could be an option to reduce infection and improve healing.
Bari, BAAges 18 years+ - NCT05906810Recruiting
Treating gum inflammation around implants to improve blood vessel function
This study looks at whether non-surgical gum treatment around dental implants can improve early problems in blood vessel function. It includes people with implant gum disease, and also compares them with healthy people who do not have gum disease.
CataniaAges Any age - NCT07069881Recruiting
Comparing two dental cleaning methods for chronic root infection
This trial compares two ultrasonic cleaning methods (regular vs. passive) for treating a chronic tooth infection called chronic apical periodontitis. It aims to see which approach is more effective at clearing the infection and saving the tooth.
Guangzhou, GuangdongAges 18–59 - NCT07069140Recruiting
Lactoferrin mouthwash for gum health during pregnancy
This study tests if a daily lactoferrin mouthwash can improve gum health in pregnant women with gum disease, without needing antibiotics or other treatments. Researchers want to see if this natural protein helps keep gums healthier during the second trimester.
Pavia, LombardyAges 18–45 - NCT07054177Recruiting
Saliva test for gum disease in pregnancy
This study looks at how pregnancy and gum disease might change the chemicals in your saliva. By comparing pregnant women and non-pregnant women, researchers hope to find a simple way to screen for gum problems during pregnancy.
Istanbul, FatihAges 18–40 - NCT07054008Recruiting
Gum Flap Surgery and Healing
This study looks at how gum surgery (flap surgery) affects healing. It aims to improve recovery for people with gum disease who need surgery.
San Antonio, TexasAges 18–18 - NCT07029360Recruiting
Coenzyme Q10 and Probiotics for Gum Health in Pregnancy
This trial tests whether adding coenzyme Q10 and probiotics to standard gum treatment can improve gum health and reduce inflammation in pregnant women. If you are in your second or third trimester and have gum concerns, this treatment may help both you and your baby.
Pavia, LombardyAges 18 years+ - NCT06991998Enrolling by invitation
Comparing tooth graft vs. bone graft for gum disease bone defects
This trial tests whether a graft made from your own extracted tooth works as well as a traditional bone graft, both combined with a special enamel protein, to repair bone loss from gum disease.
Budapest, BudapestAges 18 years+ - NCT06978712Recruiting
Gum inflammation and body stress link study
This study checks if gum inflammation (periodontitis) affects your body's stress system (allostatic load). It aims to find a link between severe gum disease and overall health stress.
Rohtak, HaryanaAges 30–50 - NCT06980714Enrolling by invitation
Electric vs. manual toothbrush for advanced gum disease
This study compares electric and manual toothbrushes to see which one works better for people with advanced gum disease (stage 3 or 4 periodontitis). It might help you find a more effective way to care for your teeth and gums at home.
L’AquilaAges 18 years+ - NCT06755372Recruiting
TLR-4 in gum disease patients with kidney failure
This study looks at a specific immune marker (TLR-4) in people with gum disease, comparing those who also have end-stage kidney disease (on dialysis) to those who are otherwise healthy. The goal is to understand how gum disease might be different when kidney failure is also present.
Al Fayyum, Faiyum GovernorateAges 30–60 - NCT06768424Recruiting
Treating deep gum pockets with laser or scalpel and platelet gel
This study compares two ways to fix deep gum pockets around teeth: a laser (MIST) or a traditional scalpel (GBT). Both methods use a gel made from your own blood (PRF) to help healing. The goal is to see which works better.
Budapest, BudapestAges 18–65 - NCT06753305Recruiting
Ozone therapy for gum reshaping after inflammation
This study tests if ozone therapy helps heal gums after reshaping surgery for overgrown gum tissue caused by inflammation. It may reduce recovery time or improve results.
KütahyaAges 18 years+ - NCT06726876RecruitingPhase 3
Manuka honey rinse for gum disease in dialysis patients
This study tests whether a manuka honey mouth rinse can help treat gum disease in people who are on dialysis for kidney failure. If you have both kidney failure and gum disease, this study may offer a natural way to improve your oral health.
BanhāAges 18 years+ - NCT06699654Enrolling by invitation
Spirulina gel for gum disease treatment
This trial tests if a gel made from spirulina can help treat mild-to-moderate gum disease (periodontitis). You may be a good fit if your gum disease is at a specific stage and you are otherwise healthy.
El-Sheikh Zayed City, Cairo GovernorateAges Any age - NCT06684769Recruiting
Chitosan brush and enamel proteins for gum treatment
This trial tests a new way to clean deep gum pockets at the base of molars using a chitosan brush and enamel proteins. It's for people who still have gum problems after standard treatment.
RigaAges 18 years+ - NCT06692582Recruiting
Saltwater rinse for treating gum disease
This study tests whether rinsing your mouth with a special saltwater solution (electrolyzed water) can help treat gum disease. It's for people who have advanced gum disease and want to try a simple, gentle addition to regular care.
LjubljanaAges 18–80 - NCT06676826Recruiting
Comparing two gum-graft materials for bone defects
This study tests two types of gum-graft materials to see which works better for rebuilding bone next to deep pockets caused by gum disease. Both materials are used during a minor surgical procedure to help your gums and bone heal stronger.
BernAges 18 years+ - NCT05907161Recruiting
Low laser and hyaluronic acid for gum disease
This trial studies whether adding low-level laser treatment and hyaluronic acid can improve gum health when combined with regular non-surgical gum therapy. It may help reduce problems from more advanced gum disease without surgery.
LjubljanaAges 25–70 - NCT06373848Enrolling by invitation
Vitamin E and Coenzyme Q10 for early gum disease
This study tests whether adding vitamin E and coenzyme Q10 to standard gum treatment can help heal early-stage chronic gum disease. It is for otherwise healthy adults aged 28-35 with mild gum pockets on their lower molars.
TehranAges 28–40 - NCT06308497Enrolling by invitation
Periodontal treatment with CoQ10 and probiotics for pregnant women
This study tests whether a combination of coenzyme Q10 and probiotics can improve gum health in pregnant women. It aims to find a safe, gentle treatment for gum problems during pregnancy.
Pavia, LombardyAges 18–40 - NCT06311253Enrolling by invitation
Gum treatment with lactoferrin toothpaste in pregnancy
This study tests whether special toothpaste and mouthwash with lactoferrin (a natural protein) can help treat gum problems in pregnant women. It may offer a safe way to care for your gums during pregnancy.
Pavia, LombardyAges 18–40
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 271 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.