Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 281 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06980675Recruiting
Ozonized olive oil for gum disease treatment
This trial tests if a special ozonized olive oil gel can help treat deep gum pockets caused by periodontitis (advanced gum disease). If you have gum pockets that are 4 mm or deeper, this could be an option to reduce infection and improve healing.
Bari, BAAges 18 years+ - NCT07029360Recruiting
Coenzyme Q10 and Probiotics for Gum Health in Pregnancy
This trial tests whether adding coenzyme Q10 and probiotics to standard gum treatment can improve gum health and reduce inflammation in pregnant women. If you are in your second or third trimester and have gum concerns, this treatment may help both you and your baby.
Pavia, LombardyAges 18 years+ - NCT07054008Recruiting
Gum Flap Surgery and Healing
This study looks at how gum surgery (flap surgery) affects healing. It aims to improve recovery for people with gum disease who need surgery.
San Antonio, TexasAges 18–18 - NCT07054177Recruiting
Saliva test for gum disease in pregnancy
This study looks at how pregnancy and gum disease might change the chemicals in your saliva. By comparing pregnant women and non-pregnant women, researchers hope to find a simple way to screen for gum problems during pregnancy.
Istanbul, FatihAges 18–40 - NCT07069140Recruiting
Lactoferrin mouthwash for gum health during pregnancy
This study tests if a daily lactoferrin mouthwash can improve gum health in pregnant women with gum disease, without needing antibiotics or other treatments. Researchers want to see if this natural protein helps keep gums healthier during the second trimester.
Pavia, LombardyAges 18–45 - NCT07069166Recruiting
Good bacteria mouth rinse for gum disease and diabetes
This study tests whether a mouth rinse containing helpful bacteria (called parabiotics) can improve gum health in people who have both gum disease and type 2 diabetes. It may offer a simple, non-drug way to manage inflammation.
Pavia, LombardyAges 18–70 - NCT07077122Recruiting
Comparing five gum disease treatments
This trial tests five different non-surgical gum treatments to see how they affect overall health. It may be a good fit for people with advanced gum disease who do not smoke heavily or take certain medications.
AthensAges Any age - NCT07081230Recruiting
Albumin vs hyaluronic acid with growth factors for gum disease
This trial tests whether adding albumin or hyaluronic acid (both natural substances) to a special gum treatment helps heal gum pockets better. It is for people with moderate to advanced gum disease.
Al Mansurah, MansouraAges 25–45 - NCT07256613Recruiting
Gum treatment and kidney health in type 2 diabetes
This study tests whether non-surgical gum treatment can help improve kidney function in people with type 2 diabetes and gum disease. If you have both conditions and your kidneys are still working well, this treatment may help prevent further kidney damage.
Karachi, SindhAges 30–65 - NCT07257887Recruiting
Testing OROXID oral solution for gum disease
This trial tests a mouth rinse (OROXID) to see if it helps treat advanced gum disease (periodontitis). You may qualify if you have at least three deep gum pockets and have not had dental cleanings or used antibiotics recently.
LjubljanaAges 18 years+ - NCT07258303Recruiting
Probiotic Spray for Gum Disease in Older Adults
This trial tests an oral spray that contains good bacteria (probiotics) to help prevent and treat gum disease in older adults. It may be a simple addition to your daily routine to support gum health.
Hanoi, HanoiAges 35 years+ - NCT07263113Recruiting
Gum disease and heart health study
This study looks at whether severe gum disease (periodontitis) is linked to stiffer arteries and higher heart risk. If you have advanced gum disease or healthy gums, you may be able to join to help researchers understand this connection.
NantesAges 40–69 - NCT07286916Recruiting
Guided biofilm therapy for gum disease
This study tests a new, guided gum cleaning method (biofilm therapy) to see how it affects certain markers of gum health and healing. It may help people with active gum disease that has not improved with standard care.
BaghdadAges 18 years+ - NCT07293481Recruiting
Finding markers for gum disease diagnosis
This study looks for new markers in the body that could help diagnose gum disease. It's for adults with mild gum problems who haven't had recent dental treatment or antibiotics.
Shanghai, Shanghai MunicipalityAges 18–40 - NCT07298057RecruitingEarly Phase 1
Dental implant study for people with diabetes
This study tests if adding an antibiotic (Arestin) to standard gum cleaning can improve gum health and blood sugar control in people with type 2 diabetes.
Cleveland, OhioAges 18 years+ - NCT07302581Recruiting
Study of dental implants with natural ligament for single tooth replacement
This trial tests a new type of dental implant that includes a ligament (like a natural tooth's shock absorber). It's for people who need to have a single front or side tooth pulled and have healthy gum and bone around the area. The goal is to see if this implant works well and stays healthy over time.
Kōriyama, FukushimaAges 18 years+ - NCT07311512Recruiting
Gum treatment and mouthwash study for gum disease
This trial tests if a professional gum cleaning combined with a special mouthwash can improve gum health and blood vessel function. It may help people with early gum disease who haven't had recent gum treatment.
Portsmouth, HampshireAges 30–75 - NCT07339605Recruiting
Gum bone regeneration with hyaluronic acid vs enamel matrix
This trial compares two treatments to help regrow bone and gum tissue around teeth with deep bone defects. It tests if hyaluronic acid works as well as enamel matrix derivative, both applied during a minimally invasive procedure.
Valencia, ValenciaAges 18 years+ - NCT06149585Recruiting
Bacteria changes in gum disease patients getting all dental implants
This study looks at how bacteria in your mouth change when all your teeth are removed and replaced with dental implants. If you have severe gum disease and need all your teeth extracted, joining this trial could help researchers understand your healing process.
Cleveland, OhioAges 21 years+ - NCT07368699Recruiting
Gum disease treatment with oxygen gel and light therapy
This trial tests a new gel that releases oxygen combined with a special light treatment to help heal advanced gum disease. It might help if standard treatments haven't been enough.
Alexandria, Bab SharqAges 30–70 - NCT01568697Recruiting
Studying gum disease in people with immune and genetic differences
This study looks at how mouth bacteria and the immune system may work together to cause gum disease (periodontitis), especially in people with certain genetic immune problems. It may help researchers understand what drives severe gum disease and how to better monitor or treat it in the future.
Bethesda, MarylandAges 7–100 - NCT07424846RecruitingPhase 2/Phase 3
Xylitol gum to prevent gum disease and early birth
This trial tests if chewing xylitol gum during pregnancy can reduce gum disease and preterm birth. You would chew gum after meals and attend dental visits and follow-ups.
LilongweAges Any age - NCT07443917Recruiting
Study of Treponema Parvum in gum disease patients
This study looks for a specific bacteria called Treponema Parvum in the gums of people with periodontitis (severe gum disease). It aims to understand if this bacteria is linked to gum disease and could help improve future treatments.
BaghdadAges 30 years+ - NCT07459049RecruitingPhase 4
Ibuprofen for gum inflammation after deep cleaning
This trial tests whether ibuprofen can help calm gum inflammation after a deep cleaning for periodontitis. It is for adults with moderate-to-severe gum disease who are otherwise healthy.
BaghdadAges 18 years+
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 281 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.