Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06182293Recruiting
Mouth bacteria in early systemic sclerosis
This study looks at the bacteria in the mouth (periodontal microbiota) of people with early systemic sclerosis compared to those without the condition. It may help understand if there is a link between oral health and systemic sclerosis.
StrasbourgAges 18 years+ - NCT06149585Recruiting
Bacteria changes in gum disease patients getting all dental implants
This study looks at how bacteria in your mouth change when all your teeth are removed and replaced with dental implants. If you have severe gum disease and need all your teeth extracted, joining this trial could help researchers understand your healing process.
Cleveland, OhioAges 21 years+ - NCT06091228Recruiting
Tongue scraping for bad breath with gum disease treatment
This trial checks if adding tongue scraping to regular gum disease treatment can help reduce bad breath more than gum treatment alone.
LeuvenAges 18 years+ - NCT06073704Recruiting
Light therapy for gum disease in people with obesity
This study tests whether adding a special light-activated cleaning (antimicrobial photodynamic therapy) to standard gum disease treatment can help people with obesity who have gum disease. It aims to see if this extra step improves gum health more than standard treatment alone.
Bauru, São PauloAges 18–70 - NCT06006429Recruiting
Using a scanner to check teeth and gums
This study tests if a special intraoral scanner can help dentists find gum problems and tooth issues. If you have receding gums, you may be able to join.
ReimsAges 18 years+ - NCT04669717RecruitingPhase 4
Testing antibiotic dosing alongside periodontal treatment
This study tests how antibiotics should be added to standard gum (periodontal) treatment, including dosing and blood-level timing. It may help people whose gum disease is severe, by improving how antibiotics are used with routine dental care.
Geneva, Canton of GenevaAges 18–80 - NCT01568697Recruiting
Studying gum disease in people with immune and genetic differences
This study looks at how mouth bacteria and the immune system may work together to cause gum disease (periodontitis), especially in people with certain genetic immune problems. It may help researchers understand what drives severe gum disease and how to better monitor or treat it in the future.
Bethesda, MarylandAges 7–100 - NCT03934957Recruiting
Study of health in people living in Hamburg
This study follows adults living in Hamburg to better understand health and health-related factors over time. You may help researchers learn what influences health in this age group.
HamburgAges 45–74 - NCT07868315Recruiting
Single-visit root canal pain and success comparison
This study compares pain after a single-visit root canal treatment using different sealers (materials used to fill the root canal) in asymptomatic (pain-free) teeth. It aims to find which sealer causes less discomfort and has a better success rate.
Istanbul, EsenlerAges 18–65 - NCT05221450Recruiting
Study of what affects root canal treatment outcomes
This study looks at which factors can change how well root canal (endodontic) treatment works. It may help improve future care by understanding what leads to better healing.
LjubljanaAges 18 years+ - NCT07836231Recruiting
Comparing two procedures for deep gum pockets
This study compares two surgical methods to treat deep gum disease pockets around teeth. Both methods aim to help the bone and gum heal better after treatment.
Giza, Giza GovernorateAges 18 years+ - NCT06043453Recruiting
Revitalizing injured, growing permanent teeth
This trial tests a new approach to help injured, still-growing permanent teeth heal and continue to develop naturally. It may be an option if your child has a traumatized tooth with an infection and the root is not yet fully formed.
GhentAges 6–18 - NCT07808424Recruiting
Comparing two ways to place MTA in root-end surgery for back teeth
This study compares two ways of placing a special filling material (MTA) at the root tip during a surgical procedure called apicoectomy (removing the tip of the root). One method is done from the top of the tooth (orthograde), and the other is done from the bottom (retrograde). The goal is to see which method works better for saving a tooth with a persistent infection after a root canal.
Rohtak, HaryanaAges 18–55 - NCT07767682Recruiting
Deeper gum sulcus after mouth surgery
This trial tests whether adding a special absorbent dressing helps the mouth heal after surgery to deepen the gum area. It may help people who have shallow gum sulcus and need more space for dentures.
Izmir, ÇiğliAges 18–70 - NCT07764029Recruiting
Platelet-rich fibrin with bone graft for molar gum disease
This study tests whether using platelet-rich fibrin (a concentrate from your own blood) with a bone graft helps heal gum disease around a lower back tooth. It may improve the support for the tooth and reduce the need for more invasive treatment.
Ho Chi Minh City, Ho Chi Minh City (HCMC)Ages 18 years+ - NCT07762482Recruiting
Surgical correction for gummy smile
This study tests a surgical procedure to correct a gummy smile caused by a specific gum condition. It aims to see if the gum tissue stays stable after surgery.
Ribeirão Preto, São PauloAges 18 years+ - NCT07755800Enrolling by invitation
Arginine toothpaste for gum health in periodontitis patients
This study tests whether an arginine-containing toothpaste improves gum health in people with treated periodontitis during their maintenance care. It may reduce gum inflammation and promote better bacterial balance below the gumline.
Iowa City, IowaAges 18–95 - NCT07734987Recruiting
Root tip surgery accuracy with a 3D-printed guide
This trial tests whether using a custom 3D-printed guide helps make root-end surgery more accurate and improves healing. It may be right for you if you have an infected or damaged root tip that needs surgery.
Ho Chi Minh CityAges 16 years+ - NCT07725913Recruiting
Gel for gum treatment after deep cleaning
This trial tests if a special gel placed in the gums after deep cleaning helps treat periodontitis (advanced gum disease). You may qualify if you have gum pockets of 5mm or deeper that bleed when probed.
Bologna, BOAges 18 years+ - NCT07722390Recruiting
Injection treatment for deep gum pockets
This study tests whether injecting a special substance made from your own blood can help treat deep gum pockets without surgery. It may be an option for people with advanced gum disease who have already had initial cleaning.
CairoAges Any age - NCT07718932Recruiting
Healing gel for wisdom tooth extraction recovery
This trial tests a regenerative gel placed in the socket after wisdom tooth removal to improve healing. It may reduce pain, swelling, and speed up recovery.
ThessalonikiAges 18–35 - NCT07688421Enrolling by invitation
Short 3D-printed implants for back jaw teeth: 3-year study
This trial tests shorter implants made with 3D-printing for replacing missing teeth in the back of the mouth. Researchers will check how well they work over 3 years using X-rays.
Guarulhos, São PauloAges 18 years+ - NCT07666100Recruiting
Study of medication side effects in a periodontology clinic
This study looks at side effects from medications prescribed in a gum disease clinic. It aims to understand what types of side effects patients experience, which can help doctors choose safer medicines.
SivasAges 16 years+ - NCT07671326Recruiting
Bioceramic vs calcium hydroxide for infected molars
This study compares two types of medication placed inside a root canal to fight infection. It may be an option if you have an infected lower molar and are in generally good health.
Istanbul, IstanbulAges 18–65
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 271 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.