Clinical trials
Peripheral Arterial Disease clinical trials
Below are recruiting peripheral arterial disease clinical trials, each written for real people, not researchers. We’re tracking 223 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04511247Recruiting
Drug-coated balloon for artery disease below the knee
This trial tests a drug-coated balloon to open narrowed or blocked arteries in the lower leg (below the knee) and help them stay open. It’s meant for people with significant symptoms, to reduce re-narrowing after treatment.
SingaporeAges 21 years+ - NCT04584632Recruiting
Stent-like device for blocked leg arteries in the thigh or knee
This trial studies a new stent-like vascular scaffold to improve blood flow in people with symptomatic blockage in the thigh/knee artery. It may help reduce symptoms from narrowed or blocked arteries, but you must meet several artery and health requirements.
Sydney, New South WalesAges Any age - NCT04743180Recruiting
Registry of a drug balloon for leg artery blockages
This study follows people with blocked blood vessels in the thigh and behind the knee to see how well a drug-coated balloon (“Luminor”) works over 5 years. It’s designed to collect real-world results and track safety and outcomes long term.
Bordeaux, New AquitaineAges 18 years+ - NCT04774159RecruitingPhase 3
Low-dose colchicine to lower risk in leg artery disease
This trial tests whether low-dose colchicine can reduce “residual” risk—future heart and blood-vessel problems—in people with peripheral artery disease (PAD). It targets PAD symptoms and complications like poor blood flow in the legs, even after certain procedures.
New Haven, ConnecticutAges 18 years+ - NCT04903912Recruiting
Study of people with blocked blood vessels or aneurysms
This registry study follows people with peripheral artery disease (blocked leg arteries), certain carotid artery narrowing, or an abdominal aortic aneurysm. It may help doctors better understand these conditions and improve care over time.
NaplesAges 18–90 - NCT04912323Recruiting
Drug dissolving stent for blocked below-knee arteries
This trial studies a drug-eluting dissolving scaffold placed in blocked arteries below the knee to improve blood flow. It may help people whose leg circulation problems are severe enough to limit walking or threaten the limb, but only if their blockages fit specific imaging and procedure requirements.
GrazAges 18–90 - NCT05078814Recruiting
Survey of a heart and leg condition’s gene differences
This study collects information to understand how often certain genetic variants (ALDH gene family) show up in people with blocked leg arteries or an acute heart condition. The results may help researchers better understand the biology behind these illnesses.
TainanAges 20 years+ - NCT05134311Recruiting
3D ultrasound check for blood-flow problems in wound care
This study tests whether a 3D ultrasound scan can better assess blood-flow problems that may affect healing in the wound clinic. If you’re already scheduled for an ultrasound evaluation at the wound center, the trial may use an additional 3D ultrasound approach to help doctors understand your circulation.
Lake Success, New YorkAges 18 years+ - NCT05371145RecruitingPhase 1/Phase 2
Carnosine study for people with blocked leg arteries
This Phase 1/2 study tests whether L-carnosine can improve symptoms or circulation in people with peripheral arterial disease (blocked arteries in the legs). You may be able to join if you’re in the right age range and have specific test results showing moderate artery blockage.
Louisville, KentuckyAges 50–80 - NCT05391815Recruiting
Observational study of endovascular treatment for blocked leg arteries
This is a real-world observational study that follows people who get minimally invasive procedures to treat blocked arteries in the lower abdomen and pelvis. It aims to understand how well these treatments work in the middle and long term.
ShanghaiAges 18–80 - NCT05465070Recruiting
Heat therapy trial for leg blood-flow problems
This trial studies whether applying heat to your legs can improve symptoms and function in people with peripheral artery disease (reduced blood flow to the legs). You may be tested with a simple blood-flow check and an MRI scan, depending on eligibility.
Indianapolis, IndianaAges 50 years+ - NCT05628948Recruiting
Donate blood for a heart and metabolism research biobank
This study builds a “biobank,” which is a collection of blood and related samples, to support future research on heart and metabolic (sugar/body-fat) conditions. It may help researchers better understand these diseases and improve future prevention and treatments.
Cleveland, OhioAges 18 years+ - NCT05701293Recruiting
RenZan stent check for leg artery narrowing
This trial follows how well the RenZan stent works and how safe it is for people with blocked or badly narrowed thigh-to-knee leg arteries. It may help by improving blood flow and adding careful monitoring to see how outcomes compare over time.
SienaAges 18 years+ - NCT05712395Recruiting
Pain-free exercise program for people with leg artery disease
This trial tests a new kind of exercise that is meant to be non-ischemic (not reduce blood flow) and pain-free, to see if it helps people with peripheral artery disease (PAD) who get leg pain when walking. You may be eligible if you have PAD confirmed by specific treadmill and blood-pressure measurements and meet the exercise and health safety requirements.
Oklahoma City, OklahomaAges 40 years+ - NCT05780359Recruiting
Testing a drug-coated stent for leg artery blockages
This study tests whether a special “drug-eluting” stent placed in a leg artery works safely and improves blood flow for people with peripheral artery disease. It may help reduce re-narrowing and improve walking, depending on your blockage details and overall health.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05811364Recruiting
Stent versus bare-metal treatment for blocked leg arteries
This study compares a new balloon-expandable stent to standard bare-metal stenting to treat complex blockages in the iliac arteries (main blood vessels to the legs). It may help people with symptoms like leg pain with walking, pain at rest, or minor tissue injury by improving blood flow and reducing repeat procedures.
Little Rock, ArkansasAges 18 years+ - NCT05854641RecruitingPhase 4
Stem cell treatment for poor blood flow in the leg ulcers
This trial tests whether a stem cell product (Stempeucel®) can improve healing and safety for people with critical limb ischemia caused by peripheral artery disease. It is for patients who cannot have (or have already tried) procedures to reopen blocked leg arteries and who have a leg ulcer and low blood-flow measurements.
Kuala LumpurAges 18–65 - NCT05880641Recruiting
Shockwave balloon treatment for very hard, blocked iliac arteries
This trial tests a device called Shockwave M5+/L6 intravascular lithotripsy to help deliver stent grafts when the iliac (pelvic) arteries are extremely calcified and hard to access. It may help people who are being evaluated for endovascular (through-the-blood-vessel) treatment but whose anatomy makes standard access difficult.
Ancona, AnconaAges 18 years+ - NCT05894863Recruiting
Smart stent for severe leg artery blockages
This trial studies a new “smart” stent placed in the thigh-to-knee artery to treat significant blockages. It may help improve blood flow to the foot, and you would be followed closely to see how well the stent works over time.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05916950Recruiting
Study of a new treatment for blocked leg arteries
This trial studies a device-based treatment approach for people with blocked (narrowed or fully blocked) arteries in the thigh or behind the knee that reduce blood flow to the leg. It may help improve blood flow and walking ability, but you must meet specific artery and imaging requirements.
St. Helena, CaliforniaAges 18 years+ - NCT05933720Recruiting
Study drug peptides for blocked leg artery disease
This study tests how well a drug called Slavinorm® (regulatory polypeptides) works and is safe for adults with blocked arteries in the legs due to atherosclerosis. You might be considered if you have confirmed leg artery blockage and can safely do a treadmill walking test.
RyazanAges 18–80 - NCT06022653Recruiting
Aorta and peripheral artery disease registry
This study collects information from people who have had treatment for aorta or peripheral artery disease at Asan Medical Center since 2011. It helps researchers understand how patients are doing over time.
SeoulAges 19 years+ - NCT06032065RecruitingPhase 3
Exercise for peripheral artery disease
This trial tests whether a home-based exercise program is as effective as supervised exercise for improving walking ability in people with peripheral artery disease (PAD). You will be randomly assigned to one of two exercise groups, and you may be asked to drink beetroot juice as part of the study.
Chicago, IllinoisAges 50 years+ - NCT06033924Recruiting
Home Walking Program for Vets with Leg Artery Disease
This study tests a home-based walking program delivered through telehealth for Veterans with peripheral artery disease (PAD). It aims to help you walk farther with less pain.
Birmingham, AlabamaAges 21 years+
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Common questions
- Are there clinical trials for peripheral arterial disease?
- Yes. Clin2 currently lists 223 recruiting peripheral arterial disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a peripheral arterial disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a peripheral arterial disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.