Clinical trials
Peripheral Arterial Occlusive Disease clinical trials
Below are recruiting peripheral arterial occlusive disease clinical trials, each written for real people, not researchers. We’re tracking 57 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05078814Recruiting
Survey of a heart and leg condition’s gene differences
This study collects information to understand how often certain genetic variants (ALDH gene family) show up in people with blocked leg arteries or an acute heart condition. The results may help researchers better understand the biology behind these illnesses.
TainanAges 20 years+ - NCT05391815Recruiting
Observational study of endovascular treatment for blocked leg arteries
This is a real-world observational study that follows people who get minimally invasive procedures to treat blocked arteries in the lower abdomen and pelvis. It aims to understand how well these treatments work in the middle and long term.
ShanghaiAges 18–80 - NCT05894863Recruiting
Smart stent for severe leg artery blockages
This trial studies a new “smart” stent placed in the thigh-to-knee artery to treat significant blockages. It may help improve blood flow to the foot, and you would be followed closely to see how well the stent works over time.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05701293Recruiting
RenZan stent check for leg artery narrowing
This trial follows how well the RenZan stent works and how safe it is for people with blocked or badly narrowed thigh-to-knee leg arteries. It may help by improving blood flow and adding careful monitoring to see how outcomes compare over time.
SienaAges 18 years+ - NCT06082466Recruiting
Comparing two types of leg bypass surgery
This study compares two types of bypass surgery for blocked leg arteries. One uses a standard vein from your own body, and the other uses a vein supported by a special metal frame. The goal is to see which works better and lasts longer.
SalzburgAges 18 years+ - NCT07811024Recruiting
Strolimus-coated balloon for blocked coronary arteries
This study tests a balloon coated with a drug that may help keep arteries open after they've been cleared, especially for people with a narrowing inside a previously placed stent or in a small heart artery. It's a first-time-in-humans study to check if the treatment is safe and works.
TashkentAges 21 years+ - NCT06022653Recruiting
Aorta and peripheral artery disease registry
This study collects information from people who have had treatment for aorta or peripheral artery disease at Asan Medical Center since 2011. It helps researchers understand how patients are doing over time.
SeoulAges 19 years+ - NCT06539689Recruiting
Sperstent for remaining blockages after balloon treatment in leg arteries
This trial tests a special stent called Sperstent for people who still have blockages or tears in their leg arteries after balloon treatment. It is designed to help improve blood flow and reduce symptoms like leg pain or sores.
Beijing, Beijing MunicipalityAges 18–85 - NCT07672249Recruiting
Study on iliac stenting to prevent major leg events
This study looks at people with narrowed or blocked arteries in the pelvis (iliac arteries) who receive a stent to improve blood flow. It aims to understand which factors might predict future serious problems in the legs, like worsening pain or amputation.
Milan, MiAges 18 years+ - NCT07614386Recruiting
Radial artery access outcomes in heart and vessel procedures
This registry collects data from patients undergoing heart or blood vessel procedures using a small artery in the wrist (radial or ulnar artery) for access. Researchers track outcomes to better understand the safety and effectiveness of this approach.
Mersin, MezitliAges 18 years+ - NCT07427108Recruiting
Road map vs. ultrasound for retrograde leg angioplasty
This trial compares two imaging methods (road map vs. ultrasound) to guide a needle puncture from the ankle area during angioplasty for blocked leg arteries. It aims to see which method is safer and more effective for patients with severe leg wounds or ulcers that need this retrograde approach.
SohagAges 18 years+ - NCT07397390Enrolling by invitation
Study of a new scoring balloon for leg artery blockages with heavy calcium buildup
This study tests a new balloon device that scores the artery walls to treat leg artery blockages with heavy calcium deposits. It aims to see if the device helps prepare the vessel safely and effectively before placing a stent.
Dalian, LiaoningAges 18–85 - NCT07385573Recruiting
Testing a drug-coated balloon for leg artery blockages
This trial tests a special balloon that releases medication to help keep leg arteries open. It's for people with narrowed or blocked arteries in the leg, either above or below the knee.
AalstAges 18–99 - NCT07352800RecruitingPhase 2
Study of APAC for peripheral artery disease and severe leg ischemia
This trial tests a new drug called APAC to see if it safely prevents blood clots and improves blood flow in people with narrowed leg arteries. It may help those with severe symptoms like pain at rest or non-healing wounds, or those with claudication (leg pain when walking).
HelsinkiAges Up to 85 years - NCT07316933Recruiting
Exercise with light blood flow restriction before knee replacement
This trial tests if a specific type of exercise, done with a cuff that lightly restricts blood flow to your leg, can help you get stronger and recover better while you wait for knee replacement surgery. The blood flow restriction is carefully controlled and adjusted during exercise, which may make the workout more effective.
Valencia, ValenciaAges 50–85 - NCT06878482RecruitingPhase 4
Botulinum toxin injection for severe leg artery disease
This trial tests whether a single injection of botulinum toxin (a muscle-relaxing substance) into the leg can improve blood flow and help heal wounds in people with severe blocked leg arteries who cannot have standard procedures like angioplasty.
Yongin-si, Gyeonggi-doAges 20 years+ - NCT07283289Recruiting
Obstructive sleep apnea in patients with PAD
This study looks at how common obstructive sleep apnea is in people with peripheral artery disease (PAD). Participants will have a sleep test as part of their regular care.
Toulon, VarAges 18 years+ - NCT07173062Recruiting
Algae supplement for heart health and gut bacteria
This study tests whether a supplement made from algae can help improve markers of heart health and affect the bacteria in your gut. It is for people age 50 and older who already have a condition like heart disease, kidney disease, or diabetes.
PortoAges 50 years+ - NCT07122167Recruiting
Study of a drug-coated stent for blocked leg arteries
This study is testing a new drug-coated stent for blocked arteries in the thigh or behind the knee. It may help people with moderate to severe leg pain or wounds by improving blood flow without needing surgery.
Chrzanów, ChrzanowAges 18–80 - NCT07052435Recruiting
Measuring pressure and flow during leg artery treatment
This study looks at how well blood flows through leg arteries after using a balloon to open blockages. It uses special measurements to check if the treatment fully restores blood flow, which may help guide future treatments.
PátraiAges Any age - NCT07023965Enrolling by invitation
Long-term follow-up study for gene therapy in critical limb ischemia
This study follows up with people who previously took part in a clinical trial testing an experimental gene therapy for critical limb ischemia (severe leg pain or sores due to blocked arteries). It aims to see how well the treatment works over time. If you were in that earlier trial and received at least one dose, joining this follow-up could help researchers learn more about the therapy's lasting effects.
Beijing, Beijing MunicipalityAges 20–85 - NCT06979284Recruiting
Ultrasound-guided angioplasty for severe leg pain or wounds
This study tests whether using a special ultrasound probe inside the artery during a leg procedure helps doctors open blockages more safely and effectively. It aims to improve blood flow and save the leg for people with severe peripheral artery disease who have pain, wounds, or gangrene.
Montreal, QuebecAges 18 years+ - NCT04511234Recruiting
Sirolimus-coated balloon vs standard balloon for leg artery narrowing
This trial compares two balloon treatments used during a procedure to open blocked or narrowed arteries in the thigh and behind the knee. It tests whether the sirolimus-coated balloon works better at keeping the artery open than a standard balloon.
SingaporeAges 21 years+ - NCT04511247Recruiting
Drug-coated balloon for artery disease below the knee
This trial tests a drug-coated balloon to open narrowed or blocked arteries in the lower leg (below the knee) and help them stay open. It’s meant for people with significant symptoms, to reduce re-narrowing after treatment.
SingaporeAges 21 years+
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Common questions
- Are there clinical trials for peripheral arterial occlusive disease?
- Yes. Clin2 currently lists 57 recruiting peripheral arterial occlusive disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a peripheral arterial occlusive disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a peripheral arterial occlusive disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.