Clinical trials
Peripheral Arterial Disease clinical trials
Below are recruiting peripheral arterial disease clinical trials, each written for real people, not researchers. We’re tracking 223 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07130526Recruiting
Distrupt Stiffness: studying a new treatment for hardened leg arteries
This trial tests a new approach to treat severe, hardened blockages in the leg arteries. It may help people with painful leg symptoms or wounds that won't heal.
Essen, North Rhine-WestphaliaAges 18–85 - NCT07161583Recruiting
Advanta VXT and Flixene Graft Registry
This registry follows people who have already received an Advanta VXT or Flixene graft to repair or replace a peripheral artery. It collects information from medical records to see how the grafts perform over time.
Boston, MassachusettsAges 18 years+ - NCT02842424RecruitingPhase 4
Ramipril for walking pain from blocked leg arteries
This study tests whether ramipril (a blood-pressure medicine) can improve leg muscle problems linked to poor blood flow in people with chronic claudication—pain that limits walking. It’s mainly looking at changes related to oxidative stress and muscle scarring (fibrosis).
Omaha, NebraskaAges 18–90 - NCT02280733Recruiting
Chronic wound registry for real-world care documentation
This study is a real-world registry that collects information about chronic wounds and ulcers as they’re treated in everyday settings. It may help improve how care is tracked and supported, even if you don’t get a new medicine from the study.
The Woodlands, TexasAges Any age - NCT07619885RecruitingPhase 1
Testing a New Blood Thinner Called CG-0255 in Healthy People
This study tests how a new blood-thinning medication (CG-0255) works in the body and compares it with Plavix, a common blood thinner. Researchers will measure how much of the drug enters your bloodstream and what effects it has on your blood clotting ability.
Miami, FloridaAges 18–55 - NCT06828172Enrolling by invitation
Arm crank exercise study for people with or without PAD
This study compares how arm crank exercise affects the body in people with and without peripheral artery disease (PAD). It aims to understand how the body responds to this type of exercise, which may help guide future rehabilitation.
São Paulo, São PauloAges 50 years+ - NCT07232069RecruitingPhase 3
Early heart disease trial for women and men with mild plaque buildup
This trial tests whether two medicines, a statin and colchicine, can slow or stop early heart artery plaque from growing in people who have mild plaque but no heart disease symptoms yet. It uses special CT scans to measure plaque over 2 years.
Birmingham, AlabamaAges 30–60 - NCT06204237RecruitingEarly Phase 1
PET imaging safety study for leg artery disease patients and healthy volunteers
This study tests whether a new radioactive tracer called APAC is safe and can be seen in PET/CT scans. It is for people with blocked leg arteries (PAOD/CLI) and for healthy volunteers. The goal is to see where the tracer goes in the body and how the body tolerates it.
GroningenAges 40–85 - NCT06878482RecruitingPhase 4
Botulinum toxin injection for severe leg artery disease
This trial tests whether a single injection of botulinum toxin (a muscle-relaxing substance) into the leg can improve blood flow and help heal wounds in people with severe blocked leg arteries who cannot have standard procedures like angioplasty.
Yongin-si, Gyeonggi-doAges 20 years+ - NCT06186037RecruitingPhase 4
Lower-dose combo vs. higher-dose alone for heart artery disease
This trial compares a lower-dose cholesterol pill (rosuvastatin plus ezetimibe) to a higher-dose version of just rosuvastatin for people with mild to moderate heart artery blockages who have not had a stent or bypass. It aims to see which approach works better and is safer.
Suwon, Gyeonggi-doAges 19 years+ - NCT01759225Enrolling by invitation
Registry study of people with heart and blood vessel disease
This is a registry (a study that collects health information) for people with certain heart and blood vessel conditions. It may help researchers better understand who has these diseases, how they are managed, and outcomes over time.
Tel AvivAges Any age - NCT06900270Recruiting
Comparing blood markers in coronary artery disease
This study looks at blood proteins and other molecules in people with different types of coronary artery disease. The goal is to see how these markers differ between those with blocked arteries, those with narrowed arteries, and those with no artery disease. This may help doctors better understand the disease and improve treatment.
São Paulo, São PauloAges 50–80 - NCT05908331Recruiting
Balloon treatment test for narrowed stents in heart arteries
This trial tests whether a special drug-coated balloon (“MagicTouch”) can treat re-narrowing inside a previously placed stent. It may help patients whose stent has become blocked again, by improving blood flow and reducing repeat narrowing.
Birmingham, AlabamaAges 18–110 - NCT06829134Recruiting
Kidney nerve block for high blood pressure during surgery
This trial tests if numbing the nerves around the kidney artery during laparoscopic surgery can better control high blood pressure. It is for people already needing surgery for certain kidney or adrenal conditions who also have hypertension.
ShanghaiAges 18–75 - NCT05902923Recruiting
Testing balloon and stent devices for blocked kidney or leg arteries
This trial studies how safe and well several balloon and stent devices work for treating narrowed or blocked arteries in the kidney area or the groin/upper leg. It may help patients who fit the specific artery location and device-use instructions for these treatments.
AvignonAges 18 years+ - NCT07009418Recruiting
CT scan vs. usual care after heart stent or balloon treatment
This trial tests whether a CT scan of the heart arteries is a safe and effective alternative to standard follow-up tests in people who have had a stent or drug-coated balloon placed in a high-risk coronary artery. It may help reduce the need for additional invasive procedures.
Bucheon-siAges 19 years+ - NCT07110389Enrolling by invitation
Heart health app program for coronary disease
This study tests a home-based cardiac rehabilitation program delivered through a smartphone app for people with coronary heart disease. If you join, you'll use the app to track your health and get support, which may help you recover and stay heart-healthy.
Taoyuan, Guishan Dist.Ages 20 years+ - NCT06477289Recruiting
Blood vessel function and thinking in sickle cell disease
This study looks at how blood vessel function in the fingers (using a simple test called arterial tonometry) relates to thinking and memory in people with sickle cell disease. It involves a non-invasive measurement and cognitive tasks.
Memphis, TennesseeAges 12–25 - NCT07062471Recruiting
Shockwave balloon treatment for hardened carotid arteries before stenting
This study tests a special balloon that uses sound waves to break up calcium buildup in the carotid artery (the main artery in your neck) before placing a stent. It's for people who are at high risk for traditional surgery and have heavy calcium deposits in their artery.
Little Rock, ArkansasAges 18 years+ - NCT06484647Recruiting
Stenting methods for blocked artery forks
This trial compares two techniques for placing stents in the tricky area where a coronary artery splits into two branches (a bifurcation). The goal is to see which method leads to better blood flow and fewer complications for people with blockages there.
Rivoli, TurinAges 18 years+ - NCT06653387Recruiting
Testing a new carotid stent with blood-flow reversal for high-risk patients
This trial tests a new carotid stent system used with a special blood-flow reversal device to treat blocked carotid arteries. It is for people with high-risk conditions who might not be good candidates for traditional open surgery, and aims to see if the stent is safe and effective in preventing strokes.
Sacramento, CaliforniaAges 18–79 - NCT06656988RecruitingPhase 3
Saving kidney function during leg artery treatment with carbon dioxide
This trial tests if using carbon dioxide gas instead of standard dye during a leg artery procedure can protect the kidneys. It is for people with blocked leg arteries who also have reduced kidney function.
InnsbruckAges 18 years+ - NCT06494501RecruitingPhase 3
Preventing heart attacks in middle-aged adults with early plaque
This study tests whether starting cholesterol-lowering treatment early can prevent heart attacks in people aged 30-50 who already have early signs of artery plaque but no history of heart disease.
New York, New YorkAges 30–50 - NCT04709900Recruiting
Tests for stable chest pain using heart scans and pressure measurements
This trial studies how well different heart tests (imaging the blood flow and measuring blood pressure in the heart) work for people with stable chest pain. It may help guide safer, more accurate evaluation when you are not having a heart attack.
CopenhagenAges Any age
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Common questions
- Are there clinical trials for peripheral arterial disease?
- Yes. Clin2 currently lists 223 recruiting peripheral arterial disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a peripheral arterial disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a peripheral arterial disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.