Clinical trials
Peripheral Arterial Disease clinical trials
Below are recruiting peripheral arterial disease clinical trials, each written for real people, not researchers. We’re tracking 223 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04889105Recruiting
Exercise coaching for leg artery disease using a phone app
This study tests whether a phone-based program can help improve walking in Veterans with peripheral artery disease (PAD) by guiding regular exercise. It aims to reduce leg symptoms by making walking practice safer and easier to stick with.
Decatur, GeorgiaAges 40 years+ - NCT05313165Recruiting
Stent procedure for poor blood flow in the leg ulcers and gangrene
This trial tests a new minimally invasive procedure (placing a small stent) to improve blood flow to a severely threatened foot or lower leg. It may help people whose ulcers or gangrene are not treatable with standard bypass or other surgeries.
La Jolla, CaliforniaAges 18–95 - NCT05437562Recruiting
Trial compares recovery after lower-leg amputation in Veterans
This trial looks at outcomes after a below-knee (lower-leg) amputation in Veterans. It focuses on people who have blood flow likely to heal and who plan to join rehabilitation to walk again with a prosthesis.
Decatur, GeorgiaAges Any age - NCT05612945Recruiting
High-intensity versus easier walking exercise for PAD symptoms
This study tests whether harder interval exercise works better than easier, moderate exercise to improve walking symptoms in people with peripheral artery disease (PAD). It may help you compare which exercise level improves your ability to walk comfortably.
Lausanne, Canton of VaudAges 18 years+ - NCT05620095Recruiting
Drug-coated balloon angioplasty for lower leg artery blockages
This trial tests whether a drug-coated balloon can better reopen blocked arteries in the lower leg (below the knee). It may help keep blood flow open and reduce the chance the blockage comes back, after a procedure to cross and open the narrowed area.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05624125Recruiting
Beetroot juice study for circulation problems in leg arteries
This trial tests whether drinking beetroot juice can improve how well people with peripheral artery disease (PAD) can function and walk. It’s looking at circulation-related measurements in the legs and how you do on walking tests.
Chicago, IllinoisAges 50 years+ - NCT05749250Recruiting
Ultrasound treatment for severe leg artery disease ulcers
This trial studies a specific ultrasound-based treatment aimed at improving healing of severe circulation-related ulcers in the legs. It may help if you have poor blood flow and a wound that hasn’t improved despite usual care.
Charlottesville, VirginiaAges 18 years+ - NCT05868161Recruiting
Registry for patients treated with a thrombectomy device
This registry collects past treatment information from people who had a clot procedure using the Pounce Thrombectomy System. It helps researchers understand how this device is used in real-world care and what outcomes may look like.
Peoria, IllinoisAges 18 years+ - NCT05884840Recruiting
Cardiovascular risk screening for people without heart disease
This trial tests a new way to check cardiovascular (heart and blood vessel) risk during a routine primary care visit. If your risk score is high enough, it may help your care team better target prevention early.
BarcelonaAges 50–74 - NCT06003855Recruiting
Oxygen-guided walking therapy for leg pain
This study tests if monitoring oxygen levels during supervised walking therapy helps people with leg pain from narrowed arteries. It may improve how far you can walk without pain.
Omaha, NebraskaAges Any age - NCT06009276Recruiting
Gut bacteria, muscle blood flow, and fitness study
This study looks at how the bacteria in your gut affect blood flow to your muscles and your overall fitness. You will provide samples and do some exercise tests to help researchers understand this link.
Charlottesville, VirginiaAges 18 years+ - NCT06112171Recruiting
Comparing treatments for leg artery blockages with severe calcium
This trial tests a special preparation method (breaking up calcium) plus a Supera stent versus standard preparation plus stenting for people with severe calcium buildup and long blockages in the thigh or behind-the-knee artery. It aims to see which approach works better for opening the artery and keeping it open.
Leipzig, SaxonyAges 18 years+ - NCT06114732Recruiting
Walking improvement study for leg pain from PAD
This study tests if a combination of a behavioral program and electrical stimulation (TENS) can help people with peripheral artery disease walk farther with less pain. It aims to boost physical activity and quality of life.
Glasgow, LanarkshireAges 18 years+ - NCT06124586Recruiting
Early angioplasty for diabetic foot ulcers
This trial tests if an early procedure to open blocked leg arteries (angioplasty) helps heal foot ulcers in people with type 2 diabetes. It aims to improve blood flow and prevent amputation.
DüsseldorfAges 18 years+ - NCT06237621Recruiting
Using a special camera to check leg circulation
This study tests a special camera (SnapshotNIR) that takes pictures of blood flow in your legs while you move them into different positions. It may help doctors better understand your circulation and diagnose peripheral artery disease (PAD) without needles or dye.
San Antonio, TexasAges 35–99 - NCT06263322Recruiting
Recovery tracking after leg artery surgery
This study tests a mobile app to track your recovery after surgery for severe leg artery disease. The goal is to see if using the app helps improve your recovery and quality of life.
Gainesville, FloridaAges 60–100 - NCT06409949Recruiting
MitoQ for leg pain from blocked arteries
This study tests whether MitoQ, a supplement that protects cells, can improve leg pain and walking ability in people with peripheral artery disease. It aims to see if it helps the tiny blood vessels and muscle fibers in the leg.
Omaha, NebraskaAges 21 years+ - NCT06544135Recruiting
Thermal camera study for blood flow in PAD with tissue loss
This study uses a special camera that detects heat to see blood flow in your leg before and after a procedure to open blocked arteries.
Beachwood, OhioAges 18–99 - NCT06566976Recruiting
Exercise before and after stent for PAD
This study tests a program of exercise before and after a stent procedure for people with peripheral artery disease who have leg pain while walking. The goal is to see if this helps improve walking ability and recovery.
Palo Alto, CaliforniaAges 18 years+ - NCT06713850Recruiting
Balloon treatment for leg artery blockages with calcium
This trial uses a special balloon (Shockwave IVL) to break up calcium in leg artery blockages, improving blood flow and reducing pain. It's for people with moderate to severe calcium buildup in the femoropopliteal artery.
Wuhan, HubeiAges 18 years+ - NCT06777901RecruitingPhase 4
Laser plus balloon vs. balloon alone for leg artery blockages
This study compares using a laser device (Auryon) plus balloon angioplasty versus balloon angioplasty alone to open blocked arteries in the lower leg. The goal is to improve blood flow and reduce pain or heal sores in people with advanced peripheral artery disease.
Phoenix, ArizonaAges Any age - NCT06952998RecruitingPhase 4
Platelet-rich plasma for diabetic foot ulcers with artery disease
This trial tests if a special treatment made from your own blood (platelet-rich plasma) can help heal foot ulcers in people with diabetes and poor circulation in their legs. The goal is to see if it improves wound healing compared to standard care.
Bilbao, BizkaiaAges 18 years+ - NCT07016698Recruiting
Real-world registry study of the Rotarex device for clearing leg blockages
This study collects information on people who are treated with a device called Rotarex that uses a spinning tool to remove plaque from blocked leg arteries. It aims to understand how well the device works in real-world use to help patients with reduced blood flow to their legs.
Lakeland, FloridaAges 22 years+ - NCT07076082RecruitingPhase 4
Vascular trial registry for leg artery procedures
This study is a registry that collects information on people who have or will have a leg artery procedure to open blocked blood vessels. It helps doctors learn more about how well these procedures work and how to improve care.
Detroit, MichiganAges 45 years+
Hear when a new Peripheral Arterial Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for peripheral arterial disease?
- Yes. Clin2 currently lists 223 recruiting peripheral arterial disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a peripheral arterial disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a peripheral arterial disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.