Clinical trials
Peripheral Arterial Disease clinical trials
Below are recruiting peripheral arterial disease clinical trials, each written for real people, not researchers. We’re tracking 215 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06828172Enrolling by invitation
Arm crank exercise study for people with or without PAD
This study compares how arm crank exercise affects the body in people with and without peripheral artery disease (PAD). It aims to understand how the body responds to this type of exercise, which may help guide future rehabilitation.
São Paulo, São PauloAges 50 years+ - NCT02280733Recruiting
Chronic wound registry for real-world care documentation
This study is a real-world registry that collects information about chronic wounds and ulcers as they’re treated in everyday settings. It may help improve how care is tracked and supported, even if you don’t get a new medicine from the study.
The Woodlands, TexasAges Any age - NCT04792320Recruiting
Probiotics and fiber for kidney disease with leg artery blockage
This study tests whether an oral absorbent plus probiotics can improve gut health and circulation in people who have chronic kidney disease and symptomatic peripheral artery disease (PAD). It will also track changes in blood markers and how well blood vessels function.
TaipeiAges 20 years+ - NCT06777901RecruitingPhase 4
Laser plus balloon vs. balloon alone for leg artery blockages
This study compares using a laser device (Auryon) plus balloon angioplasty versus balloon angioplasty alone to open blocked arteries in the lower leg. The goal is to improve blood flow and reduce pain or heal sores in people with advanced peripheral artery disease.
Phoenix, ArizonaAges Any age - NCT04433572RecruitingPhase 3
Temsirolimus treatment to improve below-knee artery procedures
This trial studies whether delivering a medicine called temsirolimus directly into the artery during a below-knee revascularization procedure can improve blood flow and outcomes. It may help people with severe leg artery disease who have symptoms like pain while walking or threatened limb tissue loss.
Houma, LouisianaAges 18 years+ - NCT06657976RecruitingPhase 2
Beetroot juice and exercise for PAD
This study tests whether beetroot juice, which contains natural nitrates that help blood vessels relax, combined with exercise, can improve walking ability in people with peripheral artery disease (PAD). You might be able to join if you have PAD, can walk without a walker, and are willing to avoid beet products for a while.
Chicago, IllinoisAges 50 years+ - NCT06114732Recruiting
Walking improvement study for leg pain from PAD
This study tests if a combination of a behavioral program and electrical stimulation (TENS) can help people with peripheral artery disease walk farther with less pain. It aims to boost physical activity and quality of life.
Glasgow, LanarkshireAges 18 years+ - NCT06544135Recruiting
Thermal camera study for blood flow in PAD with tissue loss
This study uses a special camera that detects heat to see blood flow in your leg before and after a procedure to open blocked arteries.
Beachwood, OhioAges 18–99 - NCT05868161Recruiting
Registry for patients treated with a thrombectomy device
This registry collects past treatment information from people who had a clot procedure using the Pounce Thrombectomy System. It helps researchers understand how this device is used in real-world care and what outcomes may look like.
Peoria, IllinoisAges 18 years+ - NCT06409949Recruiting
MitoQ for leg pain from blocked arteries
This study tests whether MitoQ, a supplement that protects cells, can improve leg pain and walking ability in people with peripheral artery disease. It aims to see if it helps the tiny blood vessels and muscle fibers in the leg.
Omaha, NebraskaAges 21 years+ - NCT06124586Recruiting
Early angioplasty for diabetic foot ulcers
This trial tests if an early procedure to open blocked leg arteries (angioplasty) helps heal foot ulcers in people with type 2 diabetes. It aims to improve blood flow and prevent amputation.
DüsseldorfAges 18 years+ - NCT06112171Recruiting
Comparing treatments for leg artery blockages with severe calcium
This trial tests a special preparation method (breaking up calcium) plus a Supera stent versus standard preparation plus stenting for people with severe calcium buildup and long blockages in the thigh or behind-the-knee artery. It aims to see which approach works better for opening the artery and keeping it open.
Leipzig, SaxonyAges 18 years+ - NCT06003855Recruiting
Oxygen-guided walking therapy for leg pain
This study tests if monitoring oxygen levels during supervised walking therapy helps people with leg pain from narrowed arteries. It may improve how far you can walk without pain.
Omaha, NebraskaAges Any age - NCT06009276Recruiting
Gut bacteria, muscle blood flow, and fitness study
This study looks at how the bacteria in your gut affect blood flow to your muscles and your overall fitness. You will provide samples and do some exercise tests to help researchers understand this link.
Charlottesville, VirginiaAges 18 years+ - NCT05620095Recruiting
Drug-coated balloon angioplasty for lower leg artery blockages
This trial tests whether a drug-coated balloon can better reopen blocked arteries in the lower leg (below the knee). It may help keep blood flow open and reduce the chance the blockage comes back, after a procedure to cross and open the narrowed area.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05624125Recruiting
Beetroot juice study for circulation problems in leg arteries
This trial tests whether drinking beetroot juice can improve how well people with peripheral artery disease (PAD) can function and walk. It’s looking at circulation-related measurements in the legs and how you do on walking tests.
Chicago, IllinoisAges 50 years+ - NCT05437562Recruiting
Trial compares recovery after lower-leg amputation in Veterans
This trial looks at outcomes after a below-knee (lower-leg) amputation in Veterans. It focuses on people who have blood flow likely to heal and who plan to join rehabilitation to walk again with a prosthesis.
Decatur, GeorgiaAges Any age - NCT05313165Recruiting
Stent procedure for poor blood flow in the leg ulcers and gangrene
This trial tests a new minimally invasive procedure (placing a small stent) to improve blood flow to a severely threatened foot or lower leg. It may help people whose ulcers or gangrene are not treatable with standard bypass or other surgeries.
La Jolla, CaliforniaAges 18–95 - NCT04794530RecruitingPhase 3
Cocoa extract trial for walking problems in blocked leg arteries
This Phase 3 study tests whether cocoa extract (cocoa flavanols) can improve walking ability and circulation in people with peripheral artery disease (PAD). It may help people who have PAD-related walking limits and can safely avoid competing cocoa sources and caffeine.
Chicago, IllinoisAges 55 years+ - NCT04252950Recruiting
Exercise program after blood-flow procedures for leg artery disease
This study tests whether a community-based exercise program helps people recover and improve walking after a procedure to restore blood flow in the leg arteries. It may help if your main problem is leg circulation problems and you’re able to take part in exercise safely.
Minneapolis, MinnesotaAges 40–90 - NCT03995238Recruiting
Gait training for veterans with leg amputations
This study tests a walking rehabilitation plan to improve how you walk after a lower-leg amputation. It may help if your walking steps are uneven and you have diabetes and/or circulation problems in your legs.
Aurora, ColoradoAges 40–89 - NCT07830719RecruitingPhase 2
Study of a new drug for heart disease and inflammation
This study tests a new medicine called YMI024 for people with stable coronary artery disease (blockages in heart arteries) and higher than normal levels of inflammation. The drug aims to reduce inflammation and may lower the risk of future heart problems.
Fairhope, AlabamaAges 18–80 - NCT07232069RecruitingPhase 3
Early heart disease trial for women and men with mild plaque buildup
This trial tests whether two medicines, a statin and colchicine, can slow or stop early heart artery plaque from growing in people who have mild plaque but no heart disease symptoms yet. It uses special CT scans to measure plaque over 2 years.
Birmingham, AlabamaAges 30–60 - NCT06878482RecruitingPhase 4
Botulinum toxin injection for severe leg artery disease
This trial tests whether a single injection of botulinum toxin (a muscle-relaxing substance) into the leg can improve blood flow and help heal wounds in people with severe blocked leg arteries who cannot have standard procedures like angioplasty.
Yongin-si, Gyeonggi-doAges 20 years+
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Common questions
- Are there clinical trials for peripheral arterial disease?
- Yes. Clin2 currently lists 215 recruiting peripheral arterial disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a peripheral arterial disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a peripheral arterial disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.