Clinical trials
Phase 1 clinical trials
Below are recruiting phase 1 clinical trials, each written for real people, not researchers. We’re tracking 303 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05055063RecruitingPhase 1
Belantamab for high-risk smoldering myeloma safety and early benefit
This Phase 1 trial tests belantamab mafodotin, a cancer medicine, in people with high-risk smoldering multiple myeloma to see how safe it is and whether it may shrink or control the disease. Because it’s an early-stage study, you would be closely monitored and treated with one main study drug.
Houston, TexasAges 18 years+ - NCT04608110RecruitingPhase 1
Novel therapy for myelodysplastic syndrome
This study tests a new combination treatment for people with myelodysplastic syndrome (MDS), a blood disorder. The drug aims to slow the disease and improve blood counts, and might be an option for patients who haven't responded to other treatments.
Bunkyō CityAges 20 years+ - NCT04547777RecruitingPhase 1
Early Phase brain tumor treatment with implanted device and injections
This Phase 1 study tests a new brain-tumor treatment in people with recurrent (coming back) high-grade glioma (brain cancer). The study uses injected medicine along with an implanted tumor device and aims to find whether the treatment is safe and can shrink or control tumors.
Durham, North CarolinaAges 18 years+ - NCT04371900Recruiting
Study children of mothers using birth control access in Michigan
This study looks at children ages 0 to 17 whose mothers took part in a Michigan program to access birth control. Researchers will track child and family outcomes to understand how improving access to contraception can affect families.
Ann Arbor, MichiganAges birth–17 years - NCT04234048RecruitingPhase 1
ST-001 trial for stubborn T-cell lymphoma that came back
This Phase 1 trial tests ST-001, an experimental treatment, for T-cell lymphomas that have returned or did not respond to prior therapy. It aims to find a safe dose and see whether it can shrink or control the lymphoma.
Scottsdale, ArizonaAges 18 years+ - NCT04024761RecruitingPhase 1
NK cell therapy for leukemia relapse after transplant
This Phase 1 study tests whether an infusion of special immune cells (NK cells) from a donor can help control leukemia or related blood cancers that come back or do not fully go away after a stem cell transplant. It also uses short chemotherapy to “make space” for the NK cells to work, and IL-2 to help them function.
Boston, MassachusettsAges 12 years+ - NCT03802695RecruitingPhase 1
Orca-Q pill to help during stem cell transplant
This Phase 1 trial studies Orca-Q to see if it is safe and works when added around the time of an allogeneic (donor) stem cell transplant for certain blood cancers. If you qualify, the study may offer a new option for managing the transplant immune response.
Duarte, CaliforniaAges 12–78 - NCT03715933RecruitingPhase 1
Test drug INBRX-109 for advanced or metastatic solid tumors
This Phase 1 trial tests INBRX-109, a cancer-targeting drug, in people whose solid cancers are locally advanced or spread to other parts of the body. Because it’s Phase 1, the main goal is to see whether it’s safe and how well it can work for different tumor types that meet specific requirements.
Scottsdale, ArizonaAges 12–85 - NCT06107010Recruiting
Robotic exoskeleton for walking after stroke
This trial tests a robotic exoskeleton (Atalante) to help people who have had a stroke and have trouble walking. It looks at whether using the device early (1–4 months after stroke) can improve the ability to walk again.
CréteilAges 18 years+ - NCT04602806Enrolling by invitation
Precision medicine study for traumatic brain injury
This study is looking at people with traumatic brain injuries to improve how they are treated. If you join, you will get an MRI and other tests within the first two days after your injury, and the researchers will track your recovery over time.
San Francisco, CaliforniaAges 18–65 - NCT05244486Recruiting
RestoreX traction therapy after prostate surgery
This trial studies whether RestoreX penile traction can help preserve erectile function after a prostatectomy (surgery to remove the prostate), especially when nerves are spared. If you qualify, you may be asked to use the device and be followed over time to see how erections change.
Phoenix, ArizonaAges 18 years+ - NCT07488546Enrolling by invitationPhase 1/Phase 2
HCL001 cell therapy for advanced liver cirrhosis
This trial tests a new cell injection called HCL001 for people with decompensated cirrhosis (advanced liver scarring causing complications). The goal is to see if it's safe and helps improve liver function. It may be an option if you've tried standard treatments and meet specific health criteria.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06232434RecruitingPhase 2/Phase 3
New gel treatment for advanced stomach cancer that has spread
This trial tests a new gel called Prospidelong given once into the abdomen during surgery for stomach cancer that has spread to the lining of the belly. The goal is to see if it is safe and works well.
Minsk, Minsk CityAges 18–75 - NCT06077838Recruiting
RELAXaHEAD app test for migraine relief
This study tests a smartphone app called RELAXaHEAD that teaches relaxation techniques to help people with migraine. If you have 4–29 headache days per month and haven't tried relaxation therapy for headaches recently, this app might help reduce your symptoms.
New York, New YorkAges 16–80 - NCT07364513RecruitingPhase 1
Safety study of IMSB301 for type 1 interferon disorders
This study tests an experimental drug (IMSB301) for people with rare genetic conditions that cause too much type 1 interferon activity (a part of the immune system). The goal is to see if the drug is safe and can help reduce symptoms.
SydneyAges 12 years+ - NCT07322445Recruiting
Study of neck and shoulder pain with special MRI
This study uses special MRI scans to look at muscles and nerves in people with long-term neck or shoulder pain caused by trigger points (tender spots in muscles). The goal is to understand what happens in the body with this type of pain—so doctors can find better ways to treat it.
St Louis, MissouriAges 18–80 - NCT07263438RecruitingPhase 2
Trimipramine, atezolizumab, and bevacizumab for recurrent glioblastoma
This trial tests a combination of three drugs—trimipramine (an antidepressant), atezolizumab (an immunotherapy), and bevacizumab (a targeted therapy)—in people whose glioblastoma has come back after initial treatment. The goal is to see if this mix can help shrink the tumor or slow its growth.
Basel, BaselAges 18 years+ - NCT05155033RecruitingPhase 2
A trial of PD-1 plus aldesleukin for melanoma or kidney cancer
This Phase 2 study tests whether combining anti–PD-1 treatment with aldesleukin can shrink or control metastatic melanoma or metastatic kidney (renal cell) cancer. It is mainly for people who have either not had anti–PD-1 before, or whose cancer did not respond to prior anti–PD-1 treatment.
Bethesda, MarylandAges 18–120 - NCT07108868RecruitingPhase 1
Study of MB-CART2219.1 for blood cancers
This trial tests a new CAR T-cell therapy called MB-CART2219.1 in people with certain types of blood cancer (like lymphoma or leukemia) that have come back or not responded to other treatments. CAR T-cells are your own immune cells that are modified to better find and kill cancer cells.
Tübingen, Baden-WurttembergAges 12–75 - NCT05508464Recruiting
Test targeted radiation to control many metastases safely
This study tests whether a focused, high-precision type of radiation can control many cancer spread-out spots (“metastases”) at the same time, while keeping side effects acceptable. It may help people with many metastases live longer or have better disease control by aiming treatment at every treatable spot.
London, OntarioAges 18 years+ - NCT06839235RecruitingPhase 1/Phase 2
Testing ABO-101 for primary hyperoxaluria type 1
This trial tests a new treatment called ABO-101 for people with primary hyperoxaluria type 1, a rare disease that causes high oxalate levels in urine. The study aims to see if ABO-101 can lower oxalate and protect kidney function.
Rochester, MinnesotaAges 6–64 - NCT07412821Enrolling by invitationPhase 1
Study of ASA-001 for ADSS1 deficiency muscle disease
This trial tests a drug called ASA-001 (adenylosuccinic acid) for people with a rare genetic muscle disease caused by ADSS1 deficiency. The goal is to see if it is safe and helps muscle function.
Los Angeles, CaliforniaAges 18 years+ - NCT07277764RecruitingPhase 2
Radiation and immunotherapy for returning nasopharyngeal cancer
This trial tests a combination of high and low dose radiation plus an immunotherapy drug (PD-1 inhibitor) for people whose nasopharyngeal cancer has come back after previous treatment. The goal is to see if this approach can be more effective while reducing side effects.
Nanchang, JiangxiAges 18–75 - NCT06542939Enrolling by invitation
Telehealth for diabetes and hypertension in South Asians
This study tests a telehealth program to help South Asian adults manage both diabetes and high blood pressure. If you have these conditions and your blood pressure is not well controlled, this program could help you improve your health from home.
Atlanta, GeorgiaAges 21 years+
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Common questions
- Are there clinical trials for phase 1?
- Yes. Clin2 currently lists 303 recruiting phase 1 studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a phase 1 trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a phase 1 trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.