Clinical trials
Phase 1 clinical trials
Below are recruiting phase 1 clinical trials, each written for real people, not researchers. We’re tracking 285 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07423000RecruitingPhase 1
Testing PVT401 in healthy volunteers
This study tests a new investigational drug called PVT401 in healthy people. It is a first-in-human study to see how the drug is handled by the body and to check for any side effects.
Melbourne, VictoriaAges 18–65 - NCT07425821RecruitingPhase 1
Marburg Virus Vaccine Safety Trial
This trial tests a new vaccine to protect against Marburg virus, a rare but serious infection. The vaccine uses a weakened virus to teach your body to fight the Marburg virus, and researchers are checking if it is safe and how well it works.
Washington D.C., District of ColumbiaAges 18–50 - NCT07462377RecruitingPhase 1
Testing EPI-326 for EGFR-mutant lung and head & neck cancers
This trial tests a new drug, EPI-326, in people with advanced lung or head & neck cancers that have certain EGFR changes. The goal is to see if it is safe and may help shrink the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT07464925RecruitingPhase 1
Testing GLIX1 for adults with returning high-grade glioma
This trial tests a new drug called GLIX1 to find a safe dose for people whose high-grade glioma (a fast-growing brain tumor) has come back or is getting worse after earlier treatments. It may be an option if you've had no more than two prior treatments.
Tampa, FloridaAges 18 years+ - NCT07458347RecruitingPhase 1
A new oral drug for KRAS-mutated advanced cancer
This trial tests a new oral drug, KST-6051, for people with advanced solid tumors (like lung, pancreatic, colon, or other cancers) that have a specific KRAS gene mutation. The goal is to find the best dose and see if it's safe.
Los Angeles, CaliforniaAges 18 years+ - NCT07491900RecruitingPhase 1
Study of HB2198 for lupus with moderate to severe symptoms
This trial tests a new drug called HB2198 to see if it can help people with moderate to severe lupus. It may be an option for those whose current treatments haven't worked well enough.
BrisbaneAges 18–65 - NCT07498218RecruitingPhase 1
Studying VELGRAFT for diabetic foot ulcers
This trial tests a new treatment called VELGRAFT, which is made from living cells, for diabetic foot ulcers that haven't healed with standard care. The goal is to see if it can help the wound close and heal more effectively.
Phoenix, ArizonaAges 18 years+ - NCT07501039RecruitingPhase 1
Testing a new drug in healthy adults
This trial tests a new study drug called BLKR201 in healthy adults. It is a Phase 1 study to see how the drug works in the body and to check for side effects. Participants will stay at the research unit and follow a specific routine.
Lincoln, NebraskaAges 18–55 - NCT07519655RecruitingPhase 1
New Cancer Drug Treatment for Advanced Lung, Esophageal, or Skin Cancer
This study tests a new drug called PF-08046033 in people with advanced lung cancer (NSCLC), esophageal cancer (ESCC), or melanoma (skin cancer) that has spread or can't be surgically removed. The drug targets a specific protein to help slow or stop cancer growth.
Denver, ColoradoAges 18 years+ - NCT07525947RecruitingPhase 1
Safety Study of JADE101 in Healthy Japanese and Chinese Adults
This is an early-stage safety study of an experimental medicine called JADE101. Researchers want to give a single dose to healthy volunteers of Japanese or Chinese heritage to see how the body handles it and watch for any side effects.
Glendale, CaliforniaAges 18–55 - NCT07544589RecruitingPhase 1
Testing DISP-10 for Advanced Gastrointestinal Cancers
This early-stage trial tests a new experimental therapy called DISP-10 in patients with advanced cancers of the stomach, esophagus, or colon that have spread. The goal is to see if this treatment can help shrink tumors and how safe it is.
Duarte, CaliforniaAges 18 years+ - NCT07544628RecruitingPhase 1
Safety Study of Navlimetostat Tablet in Healthy Women
This is an early-stage safety study testing a new tablet form of navlimetostat in healthy adult women. The goal is to understand how the body processes this drug and make sure it is safe and well-tolerated.
Decatur, GeorgiaAges 18–55 - NCT07568678RecruitingPhase 1
Testing HMS1005 in adults with type 2 diabetes
This study tests a new medicine called HMS1005 in people with type 2 diabetes. Researchers want to see how safe it is and how the body responds to different doses. You may qualify if you have type 2 diabetes that is either untreated or controlled with common diabetes medications.
Miami, FloridaAges 18–65 - NCT07599761RecruitingPhase 1
Study of How Itraconazole Affects ABBV-722 in Healthy Adults
This early-stage study tests how a common antifungal medicine (itraconazole) affects how the body processes an experimental drug called ABBV-722. Researchers enroll only healthy people to safely measure these interactions.
Grayslake, IllinoisAges 18–65 - NCT07612176RecruitingPhase 1
Testing NEOK001 drug for advanced solid tumors
This study tests a new cancer drug called NEOK001 that targets two proteins (B7-H3 and ROR1) found on certain tumor cells. The drug combines a cancer-fighting molecule with a toxic payload to kill cancer cells while sparing healthy tissue.
New York, New YorkAges 18 years+ - NCT07364877Enrolling by invitationPhase 1
Safety study of DW4421 and DW4421S in healthy adults
This trial tests two forms of a new drug, DW4421 and DW4421S, to see how safe they are and how the body processes them. It is for healthy volunteers aged 19 to 50.
Cheongju-siAges 19–50 - NCT07218003Enrolling by invitationPhase 1
Study of RNDO-564 alone or with pembrolizumab for bladder cancer
This trial tests an experimental drug, RNDO-564, either by itself or combined with another drug (pembrolizumab), for people with advanced bladder cancer or other solid tumors that have stopped responding to standard treatments. The goal is to see if it can shrink tumors or slow cancer growth.
San Francisco, CaliforniaAges 18 years+ - NCT06613282Enrolling by invitation
Brain stimulation safety study in healthy volunteers
This early-phase trial tests a combination of two non-invasive brain stimulation techniques (LI-TMS and AVS) in healthy people to see if they are safe and well-tolerated. It is a first step before studying these treatments for stroke recovery.
Novosibirsk, Novosibirsk OblastAges 35–65 - NCT06537050Enrolling by invitationPhase 1
Safety study of JX2105 in healthy volunteers
This study tests a new oral drug called JX2105 in healthy people to see how safe it is and how the body handles it. It is a first-in-human phase 1 trial, so participants will help find the right dose and check for any side effects.
Beijing, Beijing MunicipalityAges 18–75 - NCT06375993Enrolling by invitationPhase 1
Prula-cel for autoimmune diseases: a phase 1 study
This trial tests a new treatment called prulacabtagene leucel (prula-cel), which is a type of immune cell therapy (CAR T-cells) for people with certain autoimmune diseases. It aims to see if it can reset the immune system and reduce disease activity in conditions like lupus, scleroderma, vasculitis, or myositis.
Redwood City, CaliforniaAges 18–80 - NCT05367700RecruitingPhase 1
Test drug HS-10382 for chronic myeloid leukemia after prior treatment
This early-phase study tests HS-10382 in adults with chronic myeloid leukemia (CML) whose leukemia is resistant to or not tolerated of standard pills. It aims to see if the drug can control CML when earlier treatment hasn’t worked for you.
Wuhan, HubeiAges 18–74 - NCT06107010Recruiting
Robotic exoskeleton for walking after stroke
This trial tests a robotic exoskeleton (Atalante) to help people who have had a stroke and have trouble walking. It looks at whether using the device early (1–4 months after stroke) can improve the ability to walk again.
CréteilAges 18 years+ - NCT05244486Recruiting
RestoreX traction therapy after prostate surgery
This trial studies whether RestoreX penile traction can help preserve erectile function after a prostatectomy (surgery to remove the prostate), especially when nerves are spared. If you qualify, you may be asked to use the device and be followed over time to see how erections change.
Orem, UtahAges 18 years+ - NCT07488546Enrolling by invitationPhase 1/Phase 2
HCL001 cell therapy for advanced liver cirrhosis
This trial tests a new cell injection called HCL001 for people with decompensated cirrhosis (advanced liver scarring causing complications). The goal is to see if it's safe and helps improve liver function. It may be an option if you've tried standard treatments and meet specific health criteria.
Shanghai, Shanghai MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for phase 1?
- Yes. Clin2 currently lists 285 recruiting phase 1 studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a phase 1 trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a phase 1 trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.