Clinical trials
Postoperative Pain clinical trials
Below are recruiting postoperative pain clinical trials, each written for real people, not researchers. We’re tracking 538 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06483659RecruitingPhase 2
Oxytocin for pain after minimally invasive hysterectomy
This study tests if giving oxytocin (a natural hormone) through an IV can help reduce pain after a minimally invasive hysterectomy. If you are having this surgery, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT05278494Recruiting
Dextromethorphan to reduce pain after knee replacement
This trial studies whether dextromethorphan (a medicine sometimes used for cough) can reduce pain after total knee replacement surgery. If you’re having this operation and meet safety criteria, it may help improve how you feel during recovery.
Los Angeles, CaliforniaAges 18 years+ - NCT04860141RecruitingPhase 4
Gabapentin before wisdom tooth removal to reduce pain
This trial tests whether taking gabapentin before extracting a wisdom tooth helps with pain and comfort after the procedure. It may help people who need a third-molar removal, if they meet the safety and health requirements.
Loma Linda, CaliforniaAges 18–59 - NCT03737292RecruitingPhase 4
Numbing medicine for chest surgery pain after small lung operations
This trial tests whether a long-lasting numbing shot (liposomal bupivacaine) works better than a regular numbing shot (plain bupivacaine) for pain after minimally invasive chest surgery. It may help you have less post-surgery pain and potentially use less pain medication.
Hershey, PennsylvaniaAges 18 years+ - NCT07310953Recruiting
Using new pain scales to guide rescue pain medicine after surgery
This trial tests if a simple pain scale (the NVS and PFAS) can help doctors better decide when to give extra pain medicine after surgery. It may help control pain more quickly and effectively after a procedure called VATS.
VigoAges 18 years+ - NCT06752486RecruitingPhase 1
Gabapentin for pain after laser eye surgery
This study tests if a medicine called gabapentin can safely reduce pain after a type of laser eye surgery called surface ablation. It's looking for adults with stable vision who are generally healthy and have not had previous eye procedures.
GizaAges 18–65 - NCT07553611Recruiting
Regional anesthesia and shoulder surgery recovery outcomes
This study compares different numbing techniques used during shoulder arthroscopy (a minimally invasive shoulder surgery) to see which one helps patients recover better, use less pain medication, and experience fewer complications like temporary paralysis of the breathing muscle under the rib cage.
Antalya, MuratpaşaAges 18–65 - NCT06978335Enrolling by invitation
Acupoint stimulation for better wound pain relief after surgery
This study tests if gentle stimulation of acupoints (like acupressure or a small device) can ease pain from a surgical wound. It is for adults who are having a surgery with a long incision and will be using a pain pump afterward.
Taipei, Peitou DistAges 18 years+ - NCT07568093Recruiting
Music therapy to reduce agitation after abdominal surgery
This study tests whether listening to music after abdominal surgery can help reduce agitation and anxiety during recovery. Researchers will compare patients who receive music therapy with standard care to see if it improves comfort and outcomes.
Hanover, Lower SaxonyAges 18 years+ - NCT07771816Enrolling by invitation
Mouth rinse and cold therapy for lower molar pain
This study tests whether using different strengths of a disinfectant rinse inside the tooth, sometimes combined with cold therapy, can reduce pain after a type of root canal treatment for lower molars. It aims to find the most comfortable and effective approach for managing post-procedure pain.
Cairo, Cairo GovernorateAges 15–40 - NCT07720739Recruiting
Adding morphine to a spine block for belly surgery pain
This study tests whether adding a small dose of morphine to a numbing injection near the spine (called erector spinae plane block) provides better pain relief after midline belly surgery. It may help reduce the need for other pain medicines and improve recovery.
SohagAges 18–60 - NCT07709598RecruitingPhase 2/Phase 3
HL-1186 for pain after abdominal surgery
This study tests a new painkiller called HL-1186 for people having abdominal surgery. If you qualify and enroll, you will receive the drug after surgery to see if it safely helps reduce your pain better than a placebo (a pill with no medicine).
Chengdu, SichuanAges 18–75 - NCT07699601RecruitingPhase 2/Phase 3
Testing a pain tablet after orthopedic surgery
This trial tests an investigational tablet called HL-1186 for controlling pain after orthopedic surgery. It explores whether the drug can safely reduce moderate to severe pain when given after the procedure.
Changsha, HunanAges 18–75 - NCT07658521Enrolling by invitation
Nerve blocks for pain after heart bypass surgery
This study tests whether adding two numbing injections (nerve blocks) to standard care provides better pain relief after heart bypass surgery. It is for adults having planned surgery and compares pain scores and recovery.
Cairo, Cairo GovernorateAges 18–75 - NCT06728371RecruitingPhase 3
IV methadone for pain after heart surgery
This trial tests if methadone given through a vein can control pain better after heart surgery done through a breastbone incision. It may be an option for adults having planned heart surgery who are expected to wake up and breathe on their own within 12 hours.
Hong KongAges 18 years+ - NCT07533786RecruitingPhase 2
New Pain Medicine After Abdominal Surgery
This study tests a new medication called HSK55718 to treat pain after abdominal surgery. If you're having moderate to severe pain within 4 hours of surgery, this trial may help you get relief and contribute to finding better pain treatments.
Changsha, HunanAges 18 years+ - NCT06548646Recruiting
Nerve blocks for pain relief after mastectomy
This study compares two types of nerve blocks (thoracic interfascial plane block vs. erector spinae plane block) to see which provides better pain relief after a mastectomy. It may help you have less pain and need fewer painkillers after surgery.
Cairo, AbbasiyaAges 21 years+ - NCT07370428Recruiting
Numbing injection for pain relief after lower back surgery
This study tests whether an ultrasound-guided numbing injection near the hip area can provide better pain relief after lower back surgery. If you qualify, you may receive this injection to help control pain after your operation.
BursaAges 18–65 - NCT07315308Recruiting
Nerve block before heart surgery and painkiller use
This study tests whether a numbing injection in the chest before heart surgery can reduce the amount of pain medicine needed during the operation. It may help you manage pain better and recover more comfortably.
Gaziantep, SahinbeyAges 18–65 - NCT07113483RecruitingPhase 3
Remimazolam vs. Midazolam for sedation in older adults having orthopedic surgery
This trial compares two sedatives, remimazolam and midazolam, to see which one leads to better recovery of thinking skills after orthopedic surgery. It is for people aged 65 and older who are having surgery on a bone or joint while awake but relaxed.
BucharestAges 65 years+ - NCT06384664Recruiting
Freezing Nerves to Reduce Pain After Chest Surgery
This study tests whether freezing a nerve (cryoablation) during chest surgery can reduce pain after the operation. It might help patients who are having their first chest surgery and have never used strong painkillers.
Ann Arbor, MichiganAges 18 years+ - NCT04260854Enrolling by invitationPhase 1
Bupivacaine for pain control during skin surgery
This Phase 1 study tests bupivacaine, a numbing medicine, to see how well it controls pain during cutaneous (skin) surgery. It’s primarily looking at safety and how the medicine works for people undergoing the procedure.
Chicago, IllinoisAges 19 years+ - NCT04134702Recruiting
Acupuncture for less pain after outpatient knee surgery
This study tests whether acupuncture can reduce pain after outpatient arthroscopic knee surgery done under general anesthesia. It may help by improving pain control while avoiding certain medicine side effects, but you must meet several specific safety and medication limits.
Greifswald, VorpommernAges 19–55 - NCT07394816Recruiting
Can ultrasound-guided pain blocks reduce lung complications after abdominal surgery?
This study tests whether using ultrasound-guided pain blocks (fascial plane blocks) during major abdominal surgery can reduce lung complications after surgery, especially in older adults. It may offer better pain control and faster recovery.
Yenimahalle, AnkaraAges 65 years+
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Common questions
- Are there clinical trials for postoperative pain?
- Yes. Clin2 currently lists 538 recruiting postoperative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a postoperative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a postoperative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Postoperative Pain, Acute
- Postoperative Pain Management
- Chronic Postoperative Pain
- Total Knee Arthroplasty (Postoperative Pain)
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
- Postoperative Pain After Endodontic Treatment
- Postoperative Pain Following Knee Arthroplasty
- Postoperative Pain Management in Oral Surgery
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.