Clinical trials
Pregnancy, High Risk clinical trials
Below are recruiting pregnancy, high risk clinical trials, each written for real people, not researchers. We’re tracking 361 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06812039RecruitingPhase 2
Perioperative treatment for high-risk liver cancer using HAIC, donafenib, and sintilimab
This trial tests a combination of treatments—chemotherapy delivered through the liver artery (HAIC), a targeted drug (donafenib), and an immunotherapy (sintilimab)—given before and after surgery for liver cancer that has a high chance of coming back. The goal is to see if this approach can lower the risk of recurrence.
Fuzhou, FujianAges 18–75 - NCT04469530RecruitingPhase 2
Sirolimus plus low-dose chemotherapy for high-risk childhood tumors
This Phase 2 study tests whether sirolimus combined with low-dose (“metronomic”) chemotherapy can help children and young adults with certain high-risk solid tumors stay in remission or reduce recurrence risk. It is designed for people whose cancer has responded well to initial treatment, with only minimal or no visible disease on scans.
Atlanta, GeorgiaAges 1–30 - NCT05852223RecruitingPhase 2
Pembrolizumab for high-risk thyroid cancer that cannot be fully removed
This study tests pembrolizumab (an immune therapy) in people with high-risk thyroid cancer that is hard to treat with surgery alone. It looks at whether this drug can reduce persistent or recurrent cancer after your planned treatment.
Pavia, LombardyAges 18 years+ - NCT06348264RecruitingPhase 2
Rezvilutamide with hormone therapy for high-risk salivary duct cancer
This trial tests a new drug, Rezvilutamide, combined with standard hormone therapy for people with a rare and aggressive type of salivary gland cancer that has a high risk of coming back. The treatment aims to reduce the chance of cancer returning after surgery.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06833827Recruiting
Clot removal vs clot-busting drugs for severe lung clots
This study compares two ways to treat a large blood clot in the lungs that is causing life-threatening symptoms. One method uses a device to remove the clot, the other uses medicine to dissolve it.
Leiden, South HollandAges 18 years+ - NCT06335420Recruiting
Can carrot juice prevent colon polyps from coming back?
This study tests whether drinking carrot juice every day can lower the chance that large colon polyps or early colon cancers will come back. Researchers want to see if the nutrients in carrot juice help protect the lining of the colon.
OdenseAges 18 years+ - NCT06221670RecruitingPhase 2
Toripalimab after surgery for high-risk early lung cancer
This trial tests whether giving a drug called Toripalimab after surgery can help prevent early-stage non-squamous non-small cell lung cancer from coming back. It is for people whose tumors have high-risk features and PD-L1 levels of at least 1%.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT02446431RecruitingEarly Phase 1
Low-dose cancer medicine for children with sarcoma at high risk
This early-phase study tests a continuous, low-dose (“metronomic”) cancer medicine to help delay cancer coming back in children and young adults with certain sarcomas. You must have finished first-line treatment and currently be in remission, starting the study soon after treatment ends.
Long Beach, CaliforniaAges 1–31 - NCT07311577RecruitingPhase 2
Trial of a drug combo for HER2-positive ovarian cancer
This trial tests a combination of disitamab vedotin, platinum chemotherapy, and bevacizumab as first treatment for high-risk ovarian cancer that has a protein called HER2. The goal is to see if this therapy helps control the cancer and keeps it from growing.
Nanjing, JiangsuAges 18–75 - NCT06050252RecruitingPhase 2
Durvalumab plus chemo before surgery for high-risk bile duct cancer
This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy (gemcitabine and cisplatin) before surgery helps people with a high-risk type of bile duct cancer live longer. If you qualify, you would receive the drug combination before your planned surgery.
Irvine, CaliforniaAges 18 years+ - NCT06753916RecruitingPhase 2
Trial of a new treatment for high-risk cornea transplants
This study tests a new approach to help prevent cornea transplant failure in people with high-risk conditions, such as blood vessels growing into the cornea. It aims to see if this treatment can improve transplant success.
Irvine, CaliforniaAges 18 years+ - NCT07508982RecruitingPhase 1/Phase 2
Combination therapy for high-risk acute myeloid leukemia
This trial tests a new drug called APG1252 combined with azacitidine (AZA) for people with high-risk AML or certain related blood cancers. The goal is to see if the combination works better than standard treatments.
Houston, TexasAges 18 years+ - NCT06607757RecruitingPhase 2
Capivasertib plus fulvestrant for high-risk lobular breast cancer
This trial tests adding capivasertib to fulvestrant for women with a certain type of breast cancer (invasive lobular carcinoma) that is hormone-receptor positive and has a high risk of coming back. The treatment is given before surgery to see if it works better than fulvestrant alone.
AugsburgAges 18 years+ - NCT06984406Recruiting
Beet product for kidney protection during heart procedure
This trial tests a beet-derived food product (a natural source of nitrate) to see if it can help prevent kidney damage caused by the contrast dye used during a heart procedure called PCI. It is designed for people who already have a higher risk of this kidney problem.
MoscowAges 18 years+ - NCT06561087RecruitingPhase 2
Nivolumab injection for high-risk mouth lesions
This trial tests whether injecting nivolumab directly into high-risk pre-cancerous mouth spots can prevent them from becoming cancer. You randomly receive either the drug or a placebo, and the study monitors how the spots change over time.
Houston, TexasAges 18 years+ - NCT06888102RecruitingEarly Phase 1
Epigenetic therapy before prostate surgery
This trial tests a short course of 'epigenetic therapy' (drugs that change how genes work) given before prostate removal surgery. The goal is to see if it can improve treatment effects and help shrink or control the tumor.
Los Angeles, CaliforniaAges 18 years+ - NCT05775471RecruitingPhase 2
Check PD-1 plus enfortumab after kidney-urine-duct surgery
This Phase 2 study tests giving pembrolizumab (an immune therapy) and enfortumab vedotin (an antibody-drug medicine) before and after surgery to remove high-risk upper urinary tract cancer. The goal is to lower the chance the cancer comes back.
Los Angeles, CaliforniaAges 18 years+ - NCT05796739Recruiting
Stress testing once or only when needed for high calcium risk
This study compares two approaches to stress testing in people who feel fine but have high coronary artery calcium on a scan. It may help determine whether testing routinely is better than doing it only if symptoms or concerns arise.
SeoulAges 19 years+ - NCT07230639RecruitingPhase 2
Shorter radiation with chemo and immunotherapy for high-risk colon cancer
This trial tests a shorter course of radiation combined with chemotherapy and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of high-risk colon cancer that has not spread. The goal is to see if this approach can shrink the tumor before surgery and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT07053436RecruitingPhase 2
New treatment for high-risk myeloma before transplant
This study tests a new treatment combination for people with high-risk multiple myeloma who are newly diagnosed and healthy enough for a stem cell transplant. The goal is to see if the treatment can improve outcomes compared to standard therapy.
Atlanta, GeorgiaAges 18 years+ - NCT06219018RecruitingPhase 1/Phase 2
Testing honey for moderate cervical cell changes
This study tests whether honey applied directly to the cervix can help reverse moderate cervical cell changes (CIN II). It may offer a natural alternative to more invasive procedures.
Heerlen, LimburgAges 18–40 - NCT03868722RecruitingPhase 2/Phase 3
Acalabrutinib plus venetoclax for high-risk CLL with infection risk
This study tests whether acalabrutinib plus venetoclax can control newly diagnosed chronic lymphocytic leukemia (CLL) in people who are at higher risk of infections or who likely need treatment soon. It aims to see if this combination can improve disease control while keeping patients safe.
CopenhagenAges 18 years+ - NCT05874674Recruiting
Testing nafamostat to reduce bleeding risk during dialysis
This pilot study tests whether nafamostat is safe for people on hemodialysis who have a high risk of bleeding. It may help clinicians find safer ways to manage blood clotting medicines during dialysis.
Wŏnju, KangwondoAges 18–99 - NCT07376603Recruiting
Radiation therapy alone for early-stage nasopharyngeal cancer
This trial tests whether intense radiation therapy (IMRT) alone is effective for people with stage IB nasopharyngeal carcinoma (a type of head and neck cancer) that has not spread to lower lymph nodes or formed large, matted nodes. If you qualify, you would receive targeted radiation without chemotherapy.
Fuzhou, FujianAges 18–70
Hear when a new Pregnancy, High Risk trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for pregnancy, high risk?
- Yes. Clin2 currently lists 361 recruiting pregnancy, high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pregnancy, high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pregnancy, high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.