Clinical trials
Preoperative clinical trials
Below are recruiting preoperative clinical trials, each written for real people, not researchers. We’re tracking 376 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05719220Recruiting
Group pelvic floor training before HoLEP surgery
This trial tests whether group pelvic floor exercises done before HoLEP surgery can improve recovery and urinary symptoms in men with an enlarged prostate. It may help some people feel better sooner by strengthening the muscles that control urination.
San Francisco, CaliforniaAges 50–90 - NCT05124236Recruiting
Pre-surgery vs post-surgery focused radiation for brain metastases
This trial compares two ways of giving focused radiation for brain metastases: before surgery or after surgery. It aims to see which timing works better to control tumors while keeping you safe.
InnsbruckAges 18 years+ - NCT05036538Recruiting
Reducing pre-surgery stress to help prevent confusion after heart surgery
This study tests whether a stress-reducing relaxation method before heart surgery can lower the risk of postoperative delirium (sudden confusion) and longer-term thinking problems. It may help you keep clearer thinking in the days and weeks after surgery.
Bad Nauheim, HesseAges 18 years+ - NCT03857945Recruiting
Training to prevent falls after foot or ankle surgery
This trial studies whether teaching people to use mobility devices before surgery can lower the chance of falling afterward. It’s for adults having planned (elective) one-sided foot or ankle surgery and who will need limited walking after surgery.
Birmingham, AlabamaAges 18 years+ - NCT07877285Recruiting
Nutrition and monitoring to prevent confusion after gynecologic cancer surgery
This trial tests whether giving special nutrition before and possibly during surgery, along with careful brain monitoring during anesthesia, can reduce confusion (delirium) after surgery in older women with gynecologic cancer.
Elâzığ, ElâzığAges 65–80 - NCT07874542Recruiting
Blood test to help classify kidney masses before surgery
This study looks at whether a simple blood test can help doctors tell if a kidney mass is cancer before surgery. It aims to improve how kidney masses are classified and guide treatment decisions.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT03671252RecruitingPhase 3
Chemotherapy before surgery for rectal cancer vs chemo with radiation
This Phase 3 trial compares two treatment plans given before rectal surgery. It tests whether stronger chemotherapy alone works better than chemotherapy pills plus long-term radiation to improve outcomes for locally advanced rectal cancer.
Guangzhou, GuangdongAges 18–75 - NCT04288999RecruitingPhase 3
Surgery plus chemo versus chemo-radiation then surgery for recurrent rectal cancer
This study compares two treatment plans for locally recurrent rectal cancer: (1) surgery plus chemo, or (2) chemo plus radiation first, then surgery, followed by chemo. It aims to see which approach works better in controlling the cancer and helping patients recover.
ChibaAges 20–80 - NCT04833491Recruiting
Eye measurements before cataract surgery and vision quality after
This study uses very specific eye measurements done before cataract surgery to see how they relate to the clarity of vision after surgery. It may help surgeons choose the best surgical approach and improve visual outcomes.
HangzhouAges 2–90 - NCT05334459Recruiting
Radiation and medicines after surgery for new metastatic breast cancer
This trial looks at giving radiation and anti-cancer medicines after surgery to treat newly diagnosed (de novo) metastatic breast cancer. It may help patients by improving local control of the breast area while also treating cancer throughout the body.
AnkaraAges 18–80 - NCT03466424Recruiting
Short radiation then chemotherapy for locally advanced rectal cancer
This trial tests a short course of radiation given before chemotherapy for people with locally advanced rectal cancer (cancer that has grown into nearby tissue and/or nearby lymph nodes but can still be removed). It may help shrink the tumor and make treatment more effective while assessing how well this approach works.
Fuzhou, FujianAges 18–70 - NCT05136326RecruitingPhase 2
Pre-surgery chemo-radiation for rectal cancer without MGMT
This trial studies whether adding two chemotherapy medicines (capecitabine and temozolomide) to standard pre-surgery chemo-radiation can work better for people with locally advanced rectal cancer that has a specific tumor marker pattern (MGMT “silenced”) and is mismatch-repair proficient (MSS). It aims to shrink the tumor before surgery and improve cancer control.
MilanAges 18 years+ - NCT05761054Recruiting
Pre-surgery radiation to shrink soft-tissue sarcoma
This trial studies giving radiation before surgery to help control a soft-tissue sarcoma while keeping surgery as less extensive as possible. It may help shrink the tumor and improve what the surgeon can remove.
Florence, FiAges 18 years+ - NCT05808933Recruiting
MRI test before surgery for early cervical cancer spread risk
This trial studies whether a special MRI scan can better predict whether early cervical cancer has spread into tiny lymph and blood vessels (lymphovascular space invasion) before surgery. If it works, it may help doctors plan the best treatment after surgery.
RomaAges 18 years+ - NCT05083247RecruitingPhase 2
Pre-surgery chemotherapy plus targeted radiation for borderline pancreatic cancer
This trial studies whether giving chemotherapy before surgery, and possibly adding a focused high-dose radiation treatment, can improve outcomes for people with borderline resectable pancreatic cancer. It aims to shrink or control the cancer and help more patients get to surgery safely.
AntwerpAges 18 years+ - NCT07863661Recruiting
Virtual reality storytelling vs. storybook reading for dental anxiety in children
This study compares using virtual reality (VR) storytelling with traditional storybook reading to help reduce anxiety in children during dental visits. If your child is anxious about the dentist, this may help them feel more relaxed.
Jeddah, Mecca RegionAges 6–10 - NCT05912075RecruitingPhase 1
New pre-surgery radiation plus ASTX660 for rectal cancer
This early-phase trial tests adding ASTX660 (a new drug) to pre-surgery radiation for locally advanced rectal cancer. It aims to improve control of the tumor before surgery, making it more likely that the surgeon can remove it with clear margins.
Lyon, RhöneAges 18 years+ - NCT07868874Enrolling by invitation
Two versus four weeks of stent before ureteroscopy
This study compares leaving a ureteral stent in place for two weeks versus four weeks before a second procedure to remove kidney stones. The goal is to see which waiting time makes the second procedure easier and safer.
Islamabad, FedralAges 18–65 - NCT06044311RecruitingPhase 2
Vactosertib with chemo and radiation for esophageal cancer
This trial tests whether adding a new drug called vactosertib to standard chemotherapy and radiation before surgery can help treat esophageal adenocarcinoma. It aims to see if the combination is safe and effective for patients with stage II or III disease.
Cleveland, OhioAges 18 years+ - NCT04597294RecruitingPhase 3
Preventive pre-op HIPEC for advanced stomach cancer
This Phase 3 trial studies whether adding a heated chemotherapy procedure during surgery (HIPEC) before the main cancer treatment can lower the chance that stomach cancer returns in the belly. It is for people with advanced stomach cancer who are at higher risk of cancer coming back in the peritoneum (the lining of the abdomen).
Krakow, Lesser Poland VoivodshipAges 18–75 - NCT06304350RecruitingPhase 2
Pembrolizumab plus chemo before surgery for esophageal cancer
This trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (given before surgery) can help shrink stage II/III esophageal cancer. The goal is to make surgery more likely to remove all cancer and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06145074RecruitingPhase 2
Testing propranolol before surgery for pancreatic cancer
This trial tests if taking propranolol (a blood pressure medication) before surgery helps treat pancreatic cancer that can be removed. It aims to see if the drug is safe and works well.
CopenhagenAges 18 years+ - NCT05447273Recruiting
MRI to plan less invasive surgery for penile cancer
This trial studies how functional MRI scans (a special MRI that shows how tissues work) can help doctors plan surgery for newly diagnosed penile squamous cell cancer. It may help more people get organ-sparing surgery, which aims to remove the cancer while preserving as much function as possible.
OsloAges Any age - NCT06398028RecruitingPhase 4
ICG dye before minimally invasive liver surgery
This study tests whether giving a special dye (ICG) before minimally invasive liver surgery helps surgeons see tumors more clearly compared to using ultrasound alone. It’s for people who are already scheduled for keyhole liver surgery.
BarcelonaAges 18 years+
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Common questions
- Are there clinical trials for preoperative?
- Yes. Clin2 currently lists 376 recruiting preoperative studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a preoperative trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a preoperative trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.