Clinical trials
Prostate Cancer Surgery clinical trials
Below are recruiting prostate cancer surgery clinical trials, each written for real people, not researchers. We’re tracking 446 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06408298RecruitingEarly Phase 1
Hydroxychloroquine before prostate cancer surgery
This trial tests whether a drug called hydroxychloroquine (HCQ) can help before prostate cancer surgery. It is for people with localized prostate cancer who are planning to have their prostate removed.
Lebanon, New HampshireAges 18 years+ - NCT04035642Recruiting
Single high-dose MRI-guided radiation for intermediate prostate cancer
This trial tests whether a single, image-guided radiation treatment can treat intermediate-risk prostate cancer while better protecting the urethra (the urine tube). It may help patients get effective cancer control with potentially fewer urinary side effects, depending on the results.
LisbonAges 18 years+ - NCT05513638Recruiting
AI imaging tool to help diagnose prostate cancer
This study tests an AI computer tool that analyzes prostate scans to help tell if someone may have prostate cancer. It may help improve how doctors interpret imaging results and decide on next steps.
NanjingAges 60–90 - NCT05983783RecruitingPhase 3
Testing two drug combinations for advanced prostate cancer
This trial compares two combinations of drugs for men with metastatic hormone-sensitive prostate cancer that has a high tumor burden. One group gets rezvilutamide plus hormone therapy and chemotherapy, while the other gets rezvilutamide plus hormone therapy alone. The goal is to see which is more effective and safe.
Nanjing, JiangsuAges 40–80 - NCT06172478RecruitingPhase 2
HER3-DXd for advanced solid tumors after prior treatment
This trial tests a new targeted drug called HER3-DXd for people with several types of advanced solid tumors that have stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver chemotherapy directly to cancer cells that have a protein called HER3 on their surface.
Duarte, CaliforniaAges 18 years+ - NCT06487507Recruiting
Mediterranean diets for men before prostate surgery
This study tests whether a medically designed Mediterranean diet can help men before prostate cancer surgery. You would eat special foods and be monitored closely to see how the diet affects your health and recovery.
Miami, FloridaAges 18–80 - NCT06705686RecruitingPhase 1
New drug for advanced prostate cancer
This trial tests an experimental drug called (R)-9b for men with a specific type of advanced prostate cancer that has stopped responding to hormone therapy. The goal is to see if this drug can help control the cancer.
Madison, WisconsinAges 18 years+ - NCT07219147RecruitingPhase 1
Combination treatment for advanced prostate cancer
This trial tests a combination of two treatments for advanced prostate cancer that has stopped responding to hormone therapy. One treatment is a targeted radiation therapy (177Lu-PSMA-617) and the other is an immunotherapy (sipuleucel-T) that helps your immune system fight the cancer.
Duarte, CaliforniaAges 18 years+ - NCT07553754Recruiting
Blood test to predict prostate cancer spread to bones
This study examines special particles in your blood called exosomes to see if they can predict whether prostate cancer might spread to your bones. Researchers will collect a blood sample before any cancer treatment to look for RNA signatures that might indicate bone metastasis risk.
Lanzhou, GansuAges 18 years+ - NCT07200830RecruitingPhase 3
Testing different schedules of a targeted radiation drug for advanced prostate cancer
This trial tests two different dosing schedules of a drug called Lutetium-177 PSMA RLT, which delivers radiation directly to prostate cancer cells. It is for men with advanced prostate cancer that has stopped responding to hormone therapy and has spread, who have not yet had chemotherapy for this stage of the disease.
Anchorage, AlaskaAges 18 years+ - NCT05918263Recruiting
Exercise to slow prostate cancer in men on active surveillance
This trial tests whether moderate exercise can help keep low-risk prostate cancer from growing in men who are monitoring their cancer instead of treating it right away. It may be especially helpful for men with certain risk factors like obesity or being Black or African American.
Boston, MassachusettsAges 18 years+ - NCT06759701RecruitingEarly Phase 1
Weight loss drug before prostate cancer surgery pilot study
This study tests if taking tirzepatide (a weight loss medicine) before prostate removal surgery is safe and helpful for overweight men with intermediate-risk prostate cancer. It aims to see if losing weight can improve surgery outcomes.
Houston, TexasAges 18 years+ - NCT07450599RecruitingPhase 2
Darolutamide plus hormone therapy before prostate cancer surgery
This trial tests a medicine called darolutamide taken with hormone therapy (ADT) before surgery to remove the prostate. It is for men with a high-risk prostate cancer that has not spread to other parts of the body.
Hefei, AnhuiAges 18 years+ - NCT04857502RecruitingEarly Phase 1
Tracking prostate cancer spread before lymph node surgery
This early study uses a special imaging tracer to show where prostate cancer has spread in the pelvic lymph nodes. It may help doctors better understand how well certain scans guide surgical removal of affected lymph nodes.
Los Angeles, CaliforniaAges Any age - NCT06830850RecruitingPhase 1
Testing a new drug for metastatic prostate cancer
This trial tests a new drug, HRS-5041, for men whose prostate cancer has spread and stopped responding to hormone therapy. The goal is to see if the drug is safe and can help control the cancer.
Sydney, New South WalesAges 18 years+ - NCT06585007RecruitingPhase 3
Radiation for limited cancer growth in castration-resistant prostate cancer
This trial tests whether giving focused radiation to limited areas of cancer growth (up to 3 spots) can help control the disease in men with castration-resistant prostate cancer. You may be eligible if your cancer is growing slowly and you are already on hormone therapy.
LeuvenAges 18 years+ - NCT07357259Recruiting
Delayed pelvic scan with PSMA PET/CT for high-risk prostate cancer
This trial uses a special PET/CT scan with a radioactive tracer (PSMA) to get detailed images of the pelvis in men with high-risk prostate cancer. The goal is to improve cancer staging and detect recurrence more accurately.
Bologna, ItalyAges 30 years+ - NCT06888102RecruitingEarly Phase 1
Epigenetic therapy before prostate surgery
This trial tests a short course of 'epigenetic therapy' (drugs that change how genes work) given before prostate removal surgery. The goal is to see if it can improve treatment effects and help shrink or control the tumor.
Los Angeles, CaliforniaAges 18 years+ - NCT06227156RecruitingPhase 2
Targeted drug for HER2-positive castration-resistant prostate cancer
This trial tests a new drug called Disitamab Vedotin for men with advanced prostate cancer that is no longer responding to hormone therapy. The drug targets a protein called HER2 on cancer cells to try to shrink or slow the cancer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07711314RecruitingPhase 2
Rezvilutamide after prostate removal for high-risk cancer
This trial tests if a daily pill called Rezvilutamide can prevent prostate cancer from returning in men who had their prostate removed and are at high risk of recurrence. It is for men who cannot or choose not to have radiation therapy.
Nanjing, JiangsuAges 18–75 - NCT06274047RecruitingPhase 3
Hormone Therapy Timing for Prostate Cancer After Surgery
This trial compares two ways of giving hormone therapy (apalutamide) along with radiation after prostate removal surgery. It aims to see which approach helps maintain quality of life while controlling cancer.
Gilbert, ArizonaAges 18 years+ - NCT06259279Recruiting
High impact training for prostate cancer with bone spread
This trial tests whether high impact exercise can help men with prostate cancer that has spread to their bones. You may qualify if you have bone metastases and are on hormone therapy.
Herlev, HerlevAges 18 years+ - NCT06582628RecruitingPhase 2
Talazoparib and enzalutamide after abiraterone in prostate cancer
This trial tests two drugs—talazoparib and enzalutamide—given together to men whose metastatic prostate cancer has worsened after treatment with abiraterone (Zytiga). The goal is to see if this combination can help control the cancer.
Badalona, BarcelonaAges 18 years+ - NCT06804785Recruiting
AI-assisted MRI reading for prostate cancer diagnosis
This trial is testing a new 'smart' system that combines artificial intelligence (AI) with doctor oversight to better read prostate MRI scans and guide decisions for men who have not yet had a biopsy. It may help avoid unnecessary biopsies while catching cancer early.
Bethesda, MarylandAges 18–89
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Common questions
- Are there clinical trials for prostate cancer surgery?
- Yes. Clin2 currently lists 446 recruiting prostate cancer surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prostate cancer surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prostate cancer surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.