Clinical trials
Prostate Cancer Surgery clinical trials
Below are recruiting prostate cancer surgery clinical trials, each written for real people, not researchers. We’re tracking 463 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03802851Recruiting
Laser procedure before radiation for prostate cancer symptoms
This trial looks at whether doing a prostate “laser procedure” (called HoLEP) before starting radiation and hormone therapy can improve severe urinary symptoms and reduce urine retention problems. It is for people with prostate cancer who are planning radiation plus hormone treatment and who have significant bladder/urinary trouble.
Kansas City, KansasAges 18 years+ - NCT03650595Recruiting
MRI-guided laser treatment for prostate cancer
This trial tests a minimally invasive prostate treatment using MRI guidance and a focal laser to destroy only the cancer spot (not the whole prostate). If you have low-to-intermediate risk, MRI-visible prostate cancer in a limited area, it may help control the cancer while potentially reducing treatment side effects.
Toronto, OntarioAges 40–80 - NCT02706561Recruiting
Helping men stick with erectile rehab after prostate surgery
This study tests a program to help men follow sexual (erection) rehabilitation after prostate cancer surgery. It may help improve or maintain erectile functioning by supporting the right rehab steps in the months after surgery.
New York, New YorkAges 21 years+ - NCT02526368RecruitingEarly Phase 1
Scan your prostate with special MRI using pyruvate to find high-grade cancer
This trial tests whether a specialized MRI scan using a pyruvate tracer can better detect high-grade (more aggressive) prostate cancer. It may help doctors find cancer more accurately and guide treatment decisions or targeted follow-up.
San Francisco, CaliforniaAges 18 years+ - NCT01492972RecruitingPhase 3
Lighter radiation, with or without hormone suppression
This Phase 3 trial tests whether giving a smaller amount of radiation (“hypo-fractionated” means fewer, larger sessions) can work as well as standard approaches for intermediate-risk prostate cancer. It also compares adding hormone therapy (“androgen suppression”) to radiation versus using radiation alone.
Scottsdale, ArizonaAges 18 years+ - NCT00949819Recruiting
Active surveillance study for localized prostate cancer
This trial studies a “watchful waiting” approach, where doctors closely monitor certain prostate cancers with regular checkups and repeat biopsies. It may help people avoid or delay treatment side effects while watching for signs the cancer needs treatment.
Los Angeles, CaliforniaAges 30–85 - NCT05884632Recruiting
Personalized daily radiation for prostate cancer after surgery
This trial studies a “daily adaptive” way of planning and delivering radiation after prostate surgery to treat prostate cancer that is coming back locally. It may help target the tumor more precisely while limiting radiation to healthy tissue.
Negrar, VeronaAges 18–80 - NCT07871110RecruitingPhase 2
New pill combined with hormone therapy for advanced prostate cancer
This study tests a new pill (TT00420) taken with standard hormone therapy for prostate cancer that has spread and is no longer responding to initial hormone treatment. The goal is to see if the combination can help slow the cancer's growth and is safe.
Fuzhou, FujianAges 18 years+ - NCT07795723Recruiting
Biopsy method comparison for diagnosing prostate cancer
This study compares two ways of doing prostate biopsies (sampling tissue from the prostate) to see if one is better. It is for men who have a suspicious MRI finding on one side of the prostate and have not had a biopsy before. Participation may help determine which method is more accurate and could influence future care.
Nanjing, JiangsuAges 19 years+ - NCT06362577Recruiting
HIFU vs Robot Surgery for Localized Prostate Cancer
This trial compares two treatments for localized prostate cancer: high-intensity focused ultrasound (HIFU) using a device called Sonablate and robot-assisted surgery. It aims to see which works better and has fewer side effects.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT06325995Recruiting
Short radiation course after prostate surgery for rising PSA
This trial tests a shorter, stronger course of radiation (hypofractionated radiotherapy) given after prostate removal surgery. It may help people whose PSA levels rise again after surgery, aiming to reduce side effects and improve outcomes.
Shanghai, Shanghai MunicipalityAges Any age - NCT07580196Recruiting
Comparing lymph node removal approaches in aggressive prostate cancer
This trial compares two surgical approaches for removing lymph nodes during prostate cancer surgery in men with high-risk disease on one side of the prostate. The goal is to determine whether removing lymph nodes from both sides or just one side provides better outcomes.
Rozzano, MilanoAges 18 years+ - NCT07460843Recruiting
Comparing two types of prostate biopsy for diagnosis
This study compares two methods of taking prostate biopsy samples (TB+PB vs TB+6SB) to see which is better at diagnosing prostate cancer. It is for men who have a suspicious spot on their MRI and meet certain PSA or exam criteria.
Beijing, Beijing MunicipalityAges 18–85 - NCT07249281Recruiting
New MRI scan for better prostate cancer detection
This study tests a new type of MRI scan (called TDDMRI) that looks at tiny details in prostate tissue to better detect cancer. If you are already getting a prostate MRI, this extra scan may help doctors find cancer more accurately.
Beijing, Beijing MunicipalityAges Any age - NCT07198633RecruitingPhase 1/Phase 2
Study of new drugs for advanced prostate cancer
This trial tests two new drugs (QLC5508 and QLH12016) alone or together with other treatments for prostate cancer that has spread to other parts of the body. It may be an option if standard treatments have stopped working or caused side effects.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT05915442RecruitingPhase 2
Adenosine blocker plus immunotherapy for limited prostate spread
This Phase 2 study tests a medicine that affects “adenosine” signaling along with an immune checkpoint inhibitor (immunotherapy) in men with hormone-sensitive prostate cancer that has spread in only a small, limited way. It aims to stop or slow that limited spread by helping the immune system work better.
New York, New YorkAges 18–99 - NCT06960291Recruiting
EXCEL Exercise Program for Cancer Patients in Canada
This study tests a national exercise program called EXCEL for people with cancer. It helps you start or continue safe physical activity to manage side effects and improve your well-being.
Calgary, AlbertaAges 18 years+ - NCT05191680RecruitingPhase 2
Testing apalutamide in early prostate cancer active surveillance
This Phase 2 trial tests whether apalutamide can help people with early prostate cancer who choose active surveillance. It uses MRI and biopsy results to confirm the cancer type and location, then checks if treatment is safe and potentially helpful.
Cambridge, CambridgeshireAges 18 years+ - NCT06864572Enrolling by invitationEarly Phase 1
New imaging tracer for metastatic prostate cancer
This trial tests a new radioactive tracer that may help doctors see and treat prostate cancer that has spread. The tracer attaches to cancer cells so they show up on scans, and may also help guide treatment.
BeijingAges 18–85 - NCT06582017RecruitingPhase 1
Study of QXL138AM for advanced solid tumors and multiple myeloma
This trial tests an investigational drug called QXL138AM for people with advanced solid tumors or multiple myeloma that has not responded to standard treatments. The goal is to see if the drug is safe and effective.
Los Angeles, CaliforniaAges 18 years+ - NCT06582628RecruitingPhase 2
Talazoparib and enzalutamide for advanced prostate cancer after prior treatment
This trial tests a combination of two drugs, talazoparib and enzalutamide, in men with advanced prostate cancer that has progressed after previous treatment with a hormone therapy called an AR inhibitor. It aims to see if this combination can help control the cancer and delay further progression.
BordeauxAges 18 years+ - NCT06470685Enrolling by invitation
Preventive prostate removal for prostate cancer risk
This study tests whether removing the prostate before cancer develops can help people at higher risk, such as those with certain gene changes (like BRCA2), a strong family history, or Black African/Caribbean ancestry. It also includes people who have already had their prostate removed for cancer treatment.
LondonAges 18 years+ - NCT06267729RecruitingPhase 1/Phase 2
A new cell therapy for advanced prostate cancer
This trial tests a new cell therapy (AZD0754) for metastatic prostate cancer that has stopped responding to standard hormone therapy and chemotherapy. It’s looking for people whose cancer has gotten worse despite prior treatments, and who are still in fairly good health.
Duarte, CaliforniaAges 18–130 - NCT06217822RecruitingPhase 1
Testing a new radiation therapy for advanced prostate cancer
This trial tests a new radioactive drug, 225Ac-PSMA-Trillium, that targets prostate cancer cells. It is for people whose advanced prostate cancer has stopped responding to hormone therapy and may have spread.
Duarte, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for prostate cancer surgery?
- Yes. Clin2 currently lists 463 recruiting prostate cancer surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prostate cancer surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prostate cancer surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.