Clinical trials
Prostate cancer clinical trials
Cancer of the prostate gland, one of the most common cancers in men. We’re tracking 1,212 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05739565Recruiting
Peer-supported exercise program for men with prostate cancer
This trial tests whether a structured physical activity plan, supported by peers (other participants), can help men with prostate cancer who are currently not very active. It aims to improve motivation and make it easier to exercise safely.
ChambéryAges 18 years+ - NCT05893381RecruitingPhase 2
Targeted PSMA scan plus focused radiation vs radiation alone
This trial tests whether adding a PSMA-targeted radioactive medicine (Lu-PSMA) to focused stereotactic radiation to a few prostate cancer spots works better than radiation alone. It may help people with limited, asymptomatic spread of prostate cancer by improving cancer control while carefully monitoring side effects.
Cesena, FCAges 18 years+ - NCT05790213RecruitingPhase 2
Hormone therapy plus targeted prostate treatment for intermediate cancer
This Phase 2 study tests whether combining hormone treatment (androgen deprivation therapy) with focal ablation (targeted destruction of prostate tissue) controls intermediate-risk prostate cancer. It may help some men avoid or reduce more aggressive treatment, while still aiming for cancer control.
Chicago, IllinoisAges 18 years+ - NCT05616650RecruitingPhase 2
Targeted radiation for one prostate tumor spot
This Phase 2 study tests a focused radiation approach using stereotactic body radiation therapy (SBRT) for people with one prostate tumor visible on imaging. It aims to treat a single tumor area while limiting treatment to the rest of the prostate.
Bethesda, MarylandAges 18–120 - NCT05588128Recruiting
Scan study for prostate cancer after PSA comes back
This study follows people with prostate cancer whose PSA blood test has risen again after standard treatment. It uses an approved PET scan tracer to look for cancer spread, which may help doctors understand how the disease is progressing.
Bethesda, MarylandAges 18 years+ - NCT05515978RecruitingEarly Phase 1
Metformin study for prostate cancer patients with weight or sugar issues
This early-phase study tests whether metformin can help prostate cancer patients who have higher body weight and/or early blood sugar problems. You would be screened for eligibility using your medical record, and the study looks mainly at your current health factors and medicines.
Aurora, ColoradoAges 18 years+ - NCT05489211RecruitingPhase 2
Testing a cancer drug for advanced solid tumors
This Phase 2 study tests the drug Dato-DXd (alone or with other cancer medicines) in people with advanced solid tumors. It looks for tumor shrinkage and how safely the treatment can be given.
Los Angeles, CaliforniaAges 18–130 - NCT05469269Recruiting
Study to screen for prostate cancer risk in Black men
This project aims to learn about prostate cancer risk and screening needs in Black or African American adults. You may be asked questions and tested as part of determining who might benefit from prostate screening.
Cleveland, OhioAges 40 years+ - NCT05413421RecruitingPhase 1
ORIC-944 for metastatic prostate cancer after hormone therapy
This early-phase trial tests ORIC-944 to see how well it works and what dose is safest for metastatic prostate cancer that has progressed after hormone-targeted pills. It may help people whose cancer has stopped responding to prior prostate cancer hormone treatments.
Colorado Springs, ColoradoAges 18 years+ - NCT05351424Recruiting
Spanish-language cancer care support for breast or prostate radiation
This study tests an educational and communication support program to help Spanish-speaking people stay on track with treatment when they’re getting radiation for non-spread (non-metastatic) breast or prostate cancer. It may help by improving understanding through interpreter-supported visits.
Miami Beach, FloridaAges 18 years+ - NCT05155501Recruiting
Surgery planning approaches for localized prostate cancer
This study compares different approaches used during prostate cancer surgery for men whose cancer is only in the prostate. It may help doctors choose the safest and most effective surgical plan for your situation.
Duarte, CaliforniaAges 40–80 - NCT05184790Recruiting
Using imaging during radiation therapy to improve AI planning
This study tests how well an artificial intelligence system can use special X-ray images taken during certain radiation treatments to improve care. You may qualify if you’re having radiation for specific conditions and your treatment center uses the required imaging steps.
Saint Leonards, New South WalesAges 18 years+ - NCT05011383RecruitingPhase 2
High-dose testosterone for prostate cancer with certain gene changes
This trial tests whether high doses of testosterone, a male hormone, can help slow or shrink prostate cancer that has stopped responding to usual hormone treatments, specifically in people whose tumors have changes in the ATM, CDK12, or CHEK2 genes.
Aurora, ColoradoAges 18 years+ - NCT03258320RecruitingPhase 2/Phase 3
Testing chemo plus surgery for certain prostate cancers
This trial compares different chemotherapy drugs given around the time of surgery to see which approach works best for men with certain locally advanced prostate cancer. It may help find a better way to control the cancer after surgery.
Qingdao, ShandongAges 40–75 - NCT03322891Recruiting
Helping African-American men understand prostate cancer care
This study tests an approach to improve health understanding for African-American patients with early-stage prostate cancer. It may help you communicate better with your care team and feel more confident managing your diagnosis and next steps.
Atlanta, GeorgiaAges 25–100 - NCT03237026Recruiting
Urine tests to predict outcomes in prostate cancer treatment
This study looks for urine markers (proteins and metabolites) that may help predict how prostate cancer patients respond to treatment and what their outcomes are. You may be asked to give a urine sample and allow use of your medical and treatment details for analysis (results are not shared with you).
TaipeiAges 30–100 - NCT02706561Recruiting
Helping men stick with erectile rehab after prostate surgery
This study tests a program to help men follow sexual (erection) rehabilitation after prostate cancer surgery. It may help improve or maintain erectile functioning by supporting the right rehab steps in the months after surgery.
New York, New YorkAges 21 years+ - NCT07354919RecruitingPhase 2
Testing axelopran for advanced cancer patients on opioids
This trial tests if axelopran can help people with advanced prostate, breast, pancreatic, or lung cancer who are taking opioid pain medicines. It aims to see if the drug is safe and helps with bowel function.
Saint Louis Park, MinnesotaAges 18 years+ - NCT06931340RecruitingPhase 3
Adding chemo to hormone therapy for advanced prostate cancer
This trial is for men with metastatic prostate cancer that has already spread beyond the pelvis. It tests whether adding a chemotherapy drug (docetaxel) to the usual hormone therapy plus apalutamide can help control the cancer better than hormone therapy alone.
Tucson, ArizonaAges 18 years+ - NCT06650579RecruitingPhase 3
Heart safety study of relugolix vs leuprolide for prostate cancer
This trial compares two hormone therapy combinations for men with prostate cancer that hasn't spread. The goal is to see if a newer oral medication (Relugolix) plus abiraterone works better than the standard injectable therapy (Lupron) plus abiraterone, while also checking heart safety.
Atlanta, GeorgiaAges 18 years+ - NCT06099093RecruitingPhase 4
PSMA PET scan before standard therapy for advanced prostate cancer
This trial will test if a special PET scan (18F-DCFPyL) can help doctors plan your treatment with a radioactive medicine called 177Lu-vipivotide tetraxetan. You are eligible if you already qualify for that standard therapy and have had a prior PSMA PET scan showing at least one active cancer site.
Boston, MassachusettsAges 18 years+ - NCT06039371RecruitingPhase 2
High dose testosterone during chemo for advanced prostate cancer
This trial tests if adding high doses of testosterone to standard chemotherapy (etoposide and carboplatin) can make the chemo work better in men whose prostate cancer has stopped responding to other treatments. It aims to see if this approach can shrink tumors or slow cancer growth.
Seattle, WashingtonAges 18 years+ - NCT05919264RecruitingPhase 1/Phase 2
FOG-001 for advanced solid tumors with certain gene changes
This trial tests a new drug, FOG-001, alone or with other treatments, for people with advanced solid tumors that have specific changes in the WNT pathway genes. It aims to see if the drug can shrink tumors or slow their growth.
Phoenix, ArizonaAges 18 years+ - NCT07221825Recruiting
Radium-223 imaging study for men with prostate cancer
This study uses a special type of scan (quantitative SPECT) to measure how Radium-223 (Xofigo) works in your bones. It helps doctors better understand treatment for prostate cancer that has spread to the bones.
St Louis, MissouriAges 18 years+
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Common questions
- Are there clinical trials for prostate cancer?
- Yes. Clin2 currently lists 1,212 recruiting prostate cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a prostate cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a prostate cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.