Clinical trials
Rectal Cancer Surgery clinical trials
Below are recruiting rectal cancer surgery clinical trials, each written for real people, not researchers. We’re tracking 255 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04103372Recruiting
MRI check for early rectal cancer or large polyps
This trial uses a special MRI before treatment to better understand early rectal cancer or suspicious large polyps. It may help doctors choose care that avoids bigger surgery when possible.
Reading, BerkshireAges 16–100 - NCT07669298Recruiting
Monitoring vs chemoradiation for early rectal cancer
This study compares two approaches after early-stage rectal cancer is removed: either careful monitoring or a follow-up treatment with chemotherapy and radiation. The goal is to see which strategy works better to keep the cancer from returning.
LimogesAges 18 years+ - NCT07638410Recruiting
Getting fit before major cancer surgery
This trial tests whether special preparation exercises and wellness support before chemotherapy and major abdominal or pelvic surgery can help you recover better and stay stronger. You'll work with a team including exercise specialists and mental health counselors before your operation.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06693375RecruitingPhase 2
Testing a new imaging agent for rectal cancer lymph nodes
This trial tests a new nanoparticle-based imaging agent to better see lymph nodes near the rectum. It first checks healthy volunteers for safety, then studies people with rectal cancer to see if it can help guide surgery.
UppsalaAges 18–99 - NCT07616297Recruiting
Higher Radiation Dose to Avoid Surgery in Rectal Cancer
This study tests whether giving a higher dose of radiation to rectal cancer tumors can help patients avoid surgery altogether. The goal is to shrink the tumor enough that surgery is no longer needed, preserving normal bowel function.
Rotterdam, South HollandAges 18 years+ - NCT07595874RecruitingPhase 2
New Immunotherapy Drugs Before Surgery for Advanced Colorectal Cancer
This trial tests two immunotherapy drugs (botensilimab and balstilimab) given before surgery to treat advanced colorectal cancer that can be removed. The goal is to help the immune system fight cancer cells and improve outcomes after surgery.
Goodyear, ArizonaAges 18 years+ - NCT07528209RecruitingPhase 3
Chemotherapy with or without immunotherapy for advanced rectal cancer
This study tests whether adding an immunotherapy drug (pucotenlimab) to standard chemotherapy (CAPOX) before surgery helps treat locally advanced rectal cancer better. The goal is to shrink tumors and improve survival while preserving bowel function when possible.
Guangzhou, GuangdongAges 18–75 - NCT07512232Recruiting
Rectal Lavage During Surgery to Lower Cancer Recurrence Risk
This trial tests whether rinsing the rectum with special fluid during minimally invasive surgery for mid-to-low rectal cancer helps prevent the cancer from coming back locally. The procedure aims to wash away cancer cells that might have leaked into the surgical area.
Guangzhou, GuangdongAges 18–75 - NCT06765616RecruitingPhase 2
Immunotherapy with chemo and radiation for rectal cancer before surgery
This trial tests a combination of a PD-L1 inhibitor (adebrelimab), short-course radiation, and chemotherapy given before surgery for locally advanced rectal cancer. The goal is to see if this approach can shrink the tumor and improve outcomes.
Jinan, ShandongAges 18–85 - NCT07463261Recruiting
Rectal cancer surgery: with or without a temporary stoma
This trial compares two ways of doing rectal cancer surgery: one with a temporary stoma (a bag on the belly) and one without. It aims to see if a stoma helps prevent complications after the bowel is reconnected.
MoscowAges 18–70 - NCT07458529RecruitingPhase 2
Chemoradiation plus immunotherapy with or without probiotics for rectal cancer
This trial tests adding an immunotherapy drug (tislelizumab) and a probiotic to standard chemoradiation for locally advanced rectal cancer that has not spread. The goal is to see if the probiotic helps the treatment work better.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06793137RecruitingPhase 2
Antibiotics before surgery for advanced rectal cancer
This trial tests if taking antibiotics before standard treatment can improve outcomes for people with advanced rectal cancer that requires surgery.
São Paulo, São PauloAges 18 years+ - NCT07407465RecruitingPhase 2
Study of a new drug combo for advanced HER2-positive colorectal cancer
This trial tests a combination of three drugs (trastuzumab deruxtecan, capecitabine, and bevacizumab) as the first treatment for people with HER2-positive colorectal cancer that has spread or cannot be removed by surgery. The goal is to see if this combination can shrink tumors and help patients live longer.
LyonAges 18 years+ - NCT07406087Recruiting
Navigation support for young adults after cancer
This study tests a navigation program to help cancer survivors ages 21-45 get the follow-up care they need. It may be a good fit if you were diagnosed with certain cancers as a teen or young adult.
Pasadena, CaliforniaAges 21–45 - NCT07405476RecruitingPhase 2
Zanidatamab before surgery for HER2 positive colon or rectal cancer
This trial tests if the drug zanidatamab, given before surgery, can help treat colon or rectal cancer that has a specific marker called HER2. The goal is to see if this approach can shrink tumors and improve outcomes for people whose cancer has not spread to other parts of the body.
Atlanta, GeorgiaAges 18 years+ - NCT07376980Enrolling by invitation
Modified single-stapled anastomosis for rectal cancer surgery
This trial is testing a modified surgical technique (single-stapled anastomosis) for removing part of the rectum in people with rectal cancer. The goal is to see if this approach can improve recovery or outcomes while using minimally invasive methods like laparoscopic or robotic surgery.
Suwon, Gyeonggi-doAges 19 years+ - NCT07369531Recruiting
Stoma-free survival after new anal-sparing surgery for low rectal cancer
This study compares a two-stage surgical technique (Turnbull-Cutait pull-through) to standard surgery for people with low rectal cancer. The goal is to see which approach helps more patients avoid a permanent stoma (bag) after surgery.
Changchun, JilinAges 18–75 - NCT07359989Recruiting
Leucine plus chemoradiation before surgery for rectal cancer
This trial tests whether adding leucine (a simple amino acid) to standard chemoradiation before surgery can help shrink rectal cancer and improve outcomes. It is for people with locally advanced rectal cancer that hasn't yet spread to other organs.
Hangzhou, ZhejiangAges 18–80 - NCT07346586Recruiting
Tamsulosin to remove catheter earlier after rectal cancer surgery
This study tests whether the drug tamsulosin (used for prostate issues) can help patients pass urine more easily after rectal cancer surgery, allowing the urinary catheter to be removed sooner. It aims to reduce discomfort and shorten recovery time.
Harbin, HeilongjiangAges Any age - NCT07346534Enrolling by invitation
Comparing reinforced vs. standard bowel connection in rectal cancer surgery
This study compares two ways of reconnecting the bowel after removing rectal cancer using keyhole surgery. It aims to see if a reinforced connection (with extra support) helps prevent leaks better than the standard method.
ShanghaiAges 18–85 - NCT05646511RecruitingPhase 3
New chemotherapy timing tests for locally advanced rectal cancer
This Phase 3 trial compares two chemotherapy combinations given with surgery for locally advanced rectal cancer. It aims to find out which approach works better and is safer for shrinking and controlling the cancer before or around the time of treatment.
ChibaAges 18 years+ - NCT07239466RecruitingPhase 2
Ketone supplement with radiation and chemo for rectal cancer
This study tests a combination of a special diet supplement (beta-hydroxybutyrate), short radiation therapy, immunotherapy, and chemotherapy before surgery for locally advanced rectal cancer. The goal is to see if this approach helps shrink the tumor and improve treatment outcomes.
Wuhan, HubeiAges 18–75 - NCT07227636RecruitingPhase 2
Immunotherapy for ctDNA-positive colorectal cancer after surgery
This trial tests two immunotherapy drugs, botensilimab and balstilimab, for people with colorectal cancer who have had surgery and chemotherapy but still have detectable cancer DNA in their blood. The goal is to see if these drugs can help clear the remaining cancer cells.
Basking Ridge, New JerseyAges 18 years+ - NCT06718543RecruitingPhase 2
Short-course radiation with AK112 for rectal cancer before surgery
This trial tests whether combining short-course radiation with an immune therapy drug (AK112) plus chemotherapy before surgery is better than radiation alone for locally advanced rectal cancer. It aims to shrink tumors and improve outcomes without needing stronger treatments later.
Chongqing, Chongqing MunicipalityAges 18–80
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Common questions
- Are there clinical trials for rectal cancer surgery?
- Yes. Clin2 currently lists 255 recruiting rectal cancer surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rectal cancer surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rectal cancer surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.