Clinical trials
Regurgitation clinical trials
Below are recruiting regurgitation clinical trials, each written for real people, not researchers. We’re tracking 201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04688190Recruiting
Registry study for choosing a mitral valve treatment
This study collects and compares real-world results to help doctors choose the best treatment for mitral valve “leakiness.” If you have clinically significant mitral insufficiency and have already had a specific heart procedure screening, your echocardiogram results may be used to understand outcomes over at least a month.
Tucson, ArizonaAges 18 years+ - NCT04775108Recruiting
Testing a new heart procedure for severe leaking mitral valve
This trial studies a new transcatheter (through the heart without open surgery) mitral valve treatment for people with severe mitral valve leaking who are too high-risk for standard surgery. It may help reduce valve leakage and improve symptoms, but it’s an early “first-in-human” device study.
InnsbruckAges 60 years+ - NCT04797572Recruiting
Testing a tool to measure the aortic valve during surgery
This trial evaluates a measuring tool used during aortic valve surgery. It may help surgeons size the valve opening more accurately when treating valve leakage or a dilated (enlarged) ascending aorta.
BrusselsAges 18–80 - NCT04820764Recruiting
Testing a device to treat leaking mitral valve
This study looks at how long a new mitral valve treatment/device can stay working in people with moderate-to-severe or severe mitral valve leak. It may help avoid or delay surgery for people considered higher risk for mitral valve repair.
Thousand Oaks, CaliforniaAges 18 years+ - NCT04864145Recruiting
Valve procedure trial for severe leaking aortic valve
This trial studies a less invasive heart valve procedure that places a new valve through a catheter, to treat severe leakage of the aortic valve. It may help people who have symptoms or heart enlargement and who are at higher risk for open-heart surgery.
Nanjing, JiangsuAges 60–90 - NCT04888247Recruiting
Testing a new mitral valve replacement for high-risk patients
This study checks whether an innovative device can safely replace a damaged mitral valve in people who are higher risk for open-heart surgery. It looks at how well the procedure and follow-up work for improving mitral leakage symptoms.
AuchenflowerAges 18 years+ - NCT04898335Recruiting
Tendyne heart valve registry for real-world patient experiences
This registry collects information from people who received the Tendyne mitral valve in routine care. It helps doctors understand how the valve performs in everyday practice and may guide future care.
LinzAges 18 years+ - NCT04905017Recruiting
Transcatheter valve treatment study for severe tricuspid valve leakage
This study tests a new, catheter-based procedure to treat moderate-to-severe leaking of the tricuspid valve (a heart valve on the right side). It’s for people who are high surgical risk and might benefit from replacing the valve without open-heart surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT04919980Recruiting
Testing a new mitral valve repair device for high-surgery-risk patients
This study looks at a new way to treat a leaky mitral heart valve using the INNOVALVE system. It’s meant for people who have symptoms from mitral regurgitation but are considered high risk for open-heart surgery, to see if the approach can help safely.
Los Angeles, CaliforniaAges 18 years+ - NCT05021614Recruiting
Valveclip repair study for leaking mitral valve in older adults
This trial tests Valveclip, a catheter-based way to repair a mitral valve that is leaking badly. It may help people who are high-risk for open surgery by aiming to reduce the leak with a less invasive approach.
SichuanAges 60 years+ - NCT05040074Recruiting
Transcatheter repair for leaking mitral valve in high-risk patients
This trial studies a minimally invasive device meant to fix a badly leaking mitral valve (mitral regurgitation) without open-heart surgery. It may be an option if you’re considered too high-risk for standard surgery and your heart anatomy fits the device.
Shenyang, LiaoningAges 18 years+ - NCT05061004Recruiting
Testing a new mitral valve treatment delivered through a catheter
This trial tests a new mitral valve device that may improve blood flow in people with significant mitral valve leakage or narrowing, using a catheter instead of open-heart surgery. It’s meant for patients who doctors think this catheter approach is a better fit than surgery.
Phoenix, ArizonaAges 18 years+ - NCT05114850Recruiting
Follow-up study for people treated with TricValve
This study looks back at patients who were successfully treated with TricValve bicaval valve devices and then follows up with their outcomes. You might join if you (or your legal guardian) agree to be included.
Sankt Pölten, Lower AustriaAges 18 years+ - NCT05179616Recruiting
Study of TriClip treatment for severe leaky tricuspid valve
This study follows adults with a severely leaky tricuspid heart valve who still have symptoms despite medication. It looks at outcomes after a procedure called TriClip, which helps reduce valve leakage.
PforzheimAges 18 years+ - NCT05194423Recruiting
LuX-Valve procedure for severe leaking tricuspid valve
This trial tests a minimally invasive procedure (LuX-Valve placed through a neck vein) to treat severe leaking of the tricuspid valve. It may help people who are too high-risk for open-heart tricuspid surgery.
Beijing, Beijing MunicipalityAges 50 years+ - NCT05298124Recruiting
Repairing a leaking mitral valve in severe heart shock
This trial tests a catheter-based procedure to repair a leaking mitral valve in people who are in severe heart shock and need medication support. The goal is to reduce the valve leak and see if it helps patients stabilize and recover.
Rochester, MinnesotaAges 18 years+ - NCT05459233Recruiting
Testing ultrasound-guided valve settings after valve-in-valve TAVR
This trial compares two ways to check and fine-tune how well a new valve is working after a “valve-in-valve” TAVR procedure. It looks to see whether measurements from ultrasound of the heart (Doppler echocardiography) match results from a catheter test, which could help guide safer, more accurate valve care.
San Francisco, CaliforniaAges 18 years+ - NCT05976165Recruiting
Breath testing study for small bowel bacterial overgrowth
This study checks whether breath tests can help identify small intestinal bacterial overgrowth in people with reflux-like symptoms (heartburn or regurgitation). If you qualify, you may be asked to avoid certain medicines and treatments for a short time so the test results are accurate.
Jacksonville, FloridaAges 18 years+ - NCT06010563Recruiting
Study of a new heart valve for severe pulmonary valve leakage
This study tests a new less-invasive heart valve (VenusP-Valve) for people whose own pulmonary valve is leaking severely. If you qualify, you could get the new valve without open-heart surgery.
Irvine, CaliforniaAges 12 years+ - NCT06033274Recruiting
Global registry for tricuspid valve replacement
This study is a registry that collects data on patients who receive a new type of heart valve replacement for the tricuspid valve through a less invasive catheter procedure. Joining helps doctors learn more about how well this treatment works in real-world patients.
Phoenix, ArizonaAges 18 years+ - NCT06038838Recruiting
Tioga TMVR system feasibility study for mitral regurgitation
This trial tests a new device called the Tioga TMVR system to treat moderate to severe mitral regurgitation (leaky heart valve). It is for people who cannot have standard surgery or other less invasive treatments.
São PauloAges 18 years+ - NCT06162780Recruiting
Clip repair for severe mitral valve leak
This trial tests a clip-based procedure (TEER) to fix a severe leak in the mitral valve for people who have symptoms or heart changes but are at low to medium risk for surgery. The goal is to see if this less invasive option works well and is safe.
Guangzhou, GuangdongAges 18 years+ - NCT06255457Recruiting
Heart rhythm study for patients getting mitral valve surgery
This study looks at heart rhythm problems in people having mitral valve surgery to fix a leaky valve. It may help doctors better understand who is at risk for dangerous rhythms.
Stockholm, Stockholm CountyAges 18 years+ - NCT07624383Recruiting
New topical treatment for nonerosive acid reflux disease
This study tests a new topical treatment for people with chronic heartburn and acid regurgitation who don't have erosions (damage) in their esophagus. The treatment is applied directly to the affected area and may help relieve symptoms without taking daily pills.
Warsaw, Masovian VoivodeshipAges 18 years+
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Common questions
- Are there clinical trials for regurgitation?
- Yes. Clin2 currently lists 201 recruiting regurgitation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a regurgitation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a regurgitation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.