Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 506 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06374121Recruiting
Kidney preservation with or without machine perfusion
This study compares two ways of preserving kidneys from older or less healthy donors before transplant – one using a machine that pumps fluid through the kidney, and one without. It may help improve how well these kidneys work after transplant.
Bergamo, BGAges 50 years+ - NCT06323980Recruiting
Study of a new stemless shoulder replacement
This trial tests a new shoulder replacement system that does not require a stem (a long piece that goes into the arm bone). It is for patients with severe shoulder arthritis or rotator cuff problems. The study will see how well the device works and how it compares to other treatments.
Irvine, CaliforniaAges 22 years+ - NCT06290869RecruitingPhase 3
Tobacco education and lung scan study
This study tests whether a special health education program, along with a free lung scan, can help long-term smokers quit. You may be able to join if you are a current smoker between 50 and 80 years old and have never had lung cancer.
Washington D.C., District of ColumbiaAges 50–80 - NCT06126614RecruitingPhase 3
Infection prevention in joint replacement surgery
This trial tests a way to prevent infections for people getting a hip or knee replacement. It compares different methods to see which works best and may help lower your risk of infection after surgery.
Hamilton, OntarioAges 18 years+ - NCT05738408Recruiting
Remote smoking help for hospitalized heart patients
This trial tests a phone-based (remote) smoking quit program for people hospitalized for a recent heart-related event. It may help you quit smoking by offering support when you’re in the hospital and afterward.
Burlington, VermontAges 18 years+ - NCT07330011Recruiting
Study on measuring patient assistance after joint surgery
This study tests if training staff improves how they measure the level of help patients need after hip or knee surgery. It may help standardize care for these patients.
BolognaAges 18 years+ - NCT07337772Recruiting
Comparing corticosteroid doses in knee replacement pain relief injection
This study compares different doses of a corticosteroid (an anti-inflammatory medicine) injected into the knee during total knee replacement surgery. The goal is to see which dose provides the best pain relief after surgery. It is for people having their first knee replacement due to osteoarthritis.
Fuzhou, FujianAges 18–100 - NCT06172569Recruiting
Study of a new hip replacement system
This study is testing a new hip replacement system (Spartan, World Cup, and World Liner) in people who need their first hip replacement due to arthritis or similar conditions. It aims to see how well the implant works and how safe it is over time.
Cleveland, OhioAges 18–75 - NCT06533865RecruitingPhase 3
Romosozumab and estrogen for bone loss from missed periods
This study tests whether a bone-building medication (romosozumab) combined with estrogen replacement therapy can improve bone density in young women with hypothalamic amenorrhea (missing periods due to low energy or stress). It aims to find a better treatment for low bone density caused by this condition.
Boston, MassachusettsAges 14–30 - NCT06143306RecruitingPhase 4
Adding a second numbing shot for shoulder replacement pain
This study tests whether adding an extra numbing shot (pectoserratus block) to the standard shoulder block reduces pain after total shoulder replacement. It may help you recover more comfortably and use fewer pain medicines.
Minneapolis, MinnesotaAges 18–85 - NCT05275088Recruiting
Transcatheter valve replacement for badly calcified heart valves
This trial tests Prizvalve, a catheter-based procedure to replace a severely damaged “atrioventricular” valve in people at high risk from open-heart surgery. It may help reduce symptoms caused by valve narrowing or leaking when traditional surgery is not a good option.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05796375RecruitingPhase 2
Urine testing instead of repeat bladder scope checks
This Phase 2 study tests whether urine tests can help monitor “non-muscle-invasive” bladder cancer without doing as many invasive bladder scopes (cystoscopies). If you qualify, you may be able to replace some scope visits with urine sample testing while still keeping close watch for cancer coming back.
West Haven, ConnecticutAges 18 years+ - NCT07733375Recruiting
Smart wristband study for thyroid hormone therapy after surgery
This trial tests whether a smart wristband can help monitor thyroid hormone replacement after total thyroidectomy. It may make follow-up easier and more convenient for patients.
Istanbul, KadıköyAges 18 years+ - NCT07450911RecruitingPhase 1
Mitral valve replacement with the ReValve system
This study is for people with severe mitral valve leakage (mitral regurgitation) who may need a valve replacement. It tests whether the ReValve system is safe and can help improve symptoms and heart function.
TbilisiAges 18 years+ - NCT07454980Recruiting
A new valve replacement for leaky tricuspid heart valve
This trial tests a new device, the LuX-Valve Plus, to replace the tricuspid valve in people with severe leakage. It compares this new approach to an existing valve replacement to see which works better for patients whose symptoms continue despite medication.
The Bronx, New YorkAges 21 years+ - NCT05283356RecruitingPhase 4
Ticagrelor or aspirin after heart valve replacement
This trial compares two blood thinners (ticagrelor and aspirin) to see which one works better at preventing blood clots after a less-invasive heart valve replacement (TAVI). It is for people with severe aortic stenosis who also have diabetes, heart disease, or artery disease.
Vigo, PontevedraAges 18 years+ - NCT05508360Recruiting
Testing an artificial spacer implant for one-level low back pain
This study tests whether inserting a small artificial implant into a single painful disc can reduce long-term low back pain and disability. It’s for people who tried non-surgical treatments for at least 6 months but still have significant symptoms from degenerative disc disease.
Medellín, AntioquiaAges 22 years+ - NCT07089901RecruitingPhase 4
Smartphone app to help you quit smoking
This study uses a smartphone app and a breath carbon monoxide monitor to help people understand their smoking patterns and quit. It tests a digital approach to quitting, and you'll get support with nicotine replacement therapy if eligible.
Durham, North CarolinaAges 21 years+ - NCT06183684Recruiting
Study of a new tricuspid valve replacement for severe leakage
This study tests a new, less invasive way to replace the tricuspid valve (the valve between the right upper and lower heart chambers) in people with severe leakage. The valve is delivered through a vein in the neck or leg, avoiding open-heart surgery.
Tucson, ArizonaAges 18–90 - NCT06506942Recruiting
TRICURE device study for leaky heart valve
This study tests a new device to help people with severe tricuspid regurgitation (leaky heart valve) who are at higher risk from surgery. It aims to see if the device can reduce the leak and improve symptoms.
Atlanta, GeorgiaAges 18 years+ - NCT07718464Recruiting
AKI risk test for children in the ICU
This study tests a new way to find children in the pediatric ICU who are at risk for serious kidney injury early, so doctors can start treatment sooner. Your child's kidney stress markers will be checked from a blood or urine sample.
Cincinnati, OhioAges Any age - NCT07720882Recruiting
Brain implant study to restore hand function after spinal cord injury
This trial tests a fully implanted wireless brain-computer interface (BCI) to help people with paralysis from a neck-level spinal cord injury regain hand and arm movement. The BCI reads brain signals and sends them to your arm, bypassing the damaged spinal cord.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06991517Recruiting
TAVR sizing study for bicuspid aortic valve patients
This study tests a special sizing method (ABC algorithm) to help doctors select the right valve for people with a bicuspid aortic valve. It aims to improve outcomes for those getting a Sapien 3 valve through a catheter (TAVR).
St Leonards, New South WalesAges Any age - NCT07704710Enrolling by invitation
Changing Pulse Oximeter Probe Placement to Prevent Skin Injury in the ICU
This study looks at whether changing the position of the pulse oximeter clip on the finger every so often can help prevent skin injuries (like pressure sores) in ICU patients. It is for adults in intensive care who are deeply unconscious and will be there for several days.
AnkaraAges 18 years+
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 506 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.