Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06839807Recruiting
Testing a new device for knee replacement loosening
This study tests a new device (AtMoves Knee System) to help diagnose if a knee replacement is loose. It is for people who have had a knee replacement and have symptoms that might mean the implant is loose, but standard tests have not given a clear answer.
Nijmegen, GelderlandAges 18 years+ - NCT03610789Enrolling by invitation
Follow-up study for a specific hip implant system
This study monitors people who already received a specific hip replacement device (REDAPT) to check how it’s doing over time. It may help confirm long-term safety and performance of these implant parts.
Rancho Mirage, CaliforniaAges 18 years+ - NCT06537609Recruiting
Testing treatments for Gram-negative bloodstream infections
This trial tests different ways to treat infections in the blood caused by Gram-negative bacteria. It looks at whether reducing antibiotics, switching to pills, or managing central lines improves outcomes while keeping you safe.
Kogarah, New South WalesAges birth–130 years - NCT06859944Recruiting
Comparing two types of frozen embryo transfer preparation
This trial compares two ways to prepare the uterus for a frozen embryo transfer: a natural cycle or a new method using hormonal stimulation during the early part of the cycle. It may help improve success rates for people using their own eggs and sperm.
BrusselsAges 18–45 - NCT07464665Recruiting
Comparing two hip socket implants for first-time hip replacement
This trial compares two types of hip socket implants (dual-mobility cups vs. standard cups) during first-time hip replacement through the front of the hip. It aims to see which type may reduce the risk of dislocation after surgery.
BrugesAges 18 years+ - NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT07059793Recruiting
Study of a new mitral valve replacement for heart patients
This trial is testing a replacement valve (called MITRIS) for people whose own mitral valve or a previous artificial valve is not working well. The goal is to see how well the valve works over time after it is implanted.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06800781Recruiting
Chest tube duration to prevent afib after heart surgery
This trial tests if leaving a chest tube in a little longer after heart surgery can lower the chance of developing atrial fibrillation (an irregular heart rhythm). It's for people having certain planned heart surgeries who have not had this rhythm problem before.
LundAges 18 years+ - NCT07319546Recruiting
Faster recovery after first knee replacement
This study tests a faster, more active recovery program for people having their first total knee replacement. It may help you get back to daily activities sooner after surgery.
Dali, YunnanAges 50–80 - NCT07014124Recruiting
Helping smoking fathers quit for their sick child
This study tests whether helping smoking fathers quit can improve their child's health. You and your child will get support through a messaging app, and the child will provide saliva samples.
Hong Kong, PokfulamAges 18 years+ - NCT06280560Recruiting
IVF hormones and womb lining health study
This study looks at how IVF hormone treatments affect the womb lining and whether they cause aging cells to build up. It may help doctors improve IVF success rates.
ValenciaAges 18–45 - NCT07323901Enrolling by invitation
Grape juice for gestational diabetes screening
This study tests if a grape juice drink can be used instead of the standard sugary drink for gestational diabetes screening between weeks 24 and 28 of pregnancy. It might be a more natural and palatable option.
HaifaAges 18 years+ - NCT06997224Recruiting
Breathing exercises after heart valve surgery
This trial tests two breathing exercises (Triflow and deep breathing with cough) to see if they help patients recover lung function after mitral valve replacement surgery. It may help you breathe better after your procedure.
IstanbulAges 18–80 - NCT06972719Recruiting
Hormone therapy after ovary removal for BRCA mutation carriers
This study looks at giving hormone therapy after ovary and fallopian tube removal in women with a BRCA mutation. The goal is to help manage menopause symptoms while you are still premenopausal.
Chapel Hill, North CarolinaAges 19–50 - NCT06932718Recruiting
Smoking cessation program for Hong Kong workers
This study tests a workplace program to help people in Hong Kong quit smoking. It includes support through instant messaging and check-ins over 12 months.
Hong KongAges 18 years+ - NCT06928948Enrolling by invitation
Medium-term results of LPS thigh bone replacement
This study looks at how well the LPS™ system works for replacing the lower part of the thigh bone. It aims to find out the medium-term results for people who had this surgery.
BrestAges Any age - NCT06925880Recruiting
Can creatine help seniors recover strength after knee replacement?
This trial tests if taking creatine supplements can help people aged 65+ rebuild muscle mass and strength more quickly after total knee replacement surgery. Participants will take creatine during their standard outpatient rehab program.
Mataró, BarcelonaAges 65 years+ - NCT07742488Recruiting
Statins and hormone therapy for cholesterol in menopause
This study looks at whether taking statins (cholesterol-lowering medicine) along with hormone replacement therapy (HRT) affects blood clotting in women going through menopause who have high cholesterol. It may help doctors understand how these medicines work together.
Pisa, ItalyAges 45–55 - NCT07625956Enrolling by invitationPhase 4
Nicotine Pouches as a Smoking Substitute Study
This study tests whether nicotine pouches (small pouches you place in your mouth) can help smokers quit or reduce combustible cigarettes. You'll use the pouches as a substitute and attend visits in Charleston, SC to see if this approach works better with new support strategies.
Charleston, South CarolinaAges 21 years+ - NCT05758701RecruitingPhase 4
CT scan study for people getting TAVR
This trial studies your abdomen using a CT scan around the time you receive TAVR (a heart valve procedure). The goal is to understand how the abdomen area looks on CT and what that might mean for care.
Baltimore, MarylandAges 18–88 - NCT06628336Recruiting
Study of HARMONY Evolution hip replacement implants
This study looks at how well HARMONY Evolution implants and tools work for people getting a total hip replacement. It will help doctors understand if the implants are safe and effective over time.
BesançonAges 18–99 - NCT06383962Recruiting
Synergy Disc cervical disc replacement outcomes study
This trial is for people who are getting or have already received a Synergy Disc implant to replace a damaged disc in the neck. It follows patients over time to see how well the disc performs in relieving nerve pain or spinal cord compression.
BirminghamAges 21 years+ - NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+ - NCT06891378Recruiting
Home rehab app for patients after shoulder replacement surgery
This trial tests a digital rehab program you can do at home after reverse total shoulder replacement. The goal is to see if an app-based exercise plan helps you recover safely and effectively.
Seoul, Irwon-ro 81Ages 50 years+
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 509 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.