Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 507 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04312399Recruiting
Hormone treatment study for Alzheimer risk in postmenopausal women
This study looks at whether hormone treatment can help prevent or slow Alzheimer’s disease in women who have gone through menopause. It may help by testing a hormone-based approach in a carefully selected group.
GhentAges 40–65 - NCT07454980Recruiting
Tricuspid valve replacement for severe leakage (TRINITY trial).
This trial tests a new catheter-based replacement for the tricuspid valve, which controls blood flow from the body into the heart. It aims to help people with severe tricuspid regurgitation (a leaky valve) who still have symptoms despite medication.
Naples, FloridaAges 21 years+ - NCT07456787Recruiting
Cold therapy after knee replacement surgery
This trial tests a cold therapy approach (cryopressotherapy) to improve recovery after total knee replacement. It may help reduce pain and swelling so you can move better sooner.
Milan, ItalyAges 18–80 - NCT07462624Recruiting
Comparing treatments for a failing surgical aortic valve
This trial compares two ways to treat a failing aortic valve that was replaced with a tissue valve during surgery: another surgical replacement or a less invasive catheter-based valve-in-valve procedure. It is for people with low to intermediate surgical risk who are between 18 and 75 years old.
Leipzig, SaxonyAges 18–75 - NCT07453407Recruiting
Tavi valve vs surgery for severe aortic regurgitation
This trial compares a new catheter-based valve (J-Valve) with open-heart surgery for people with severe aortic regurgitation, a condition where the aortic valve doesn't close tightly. It aims to see which treatment is safer and more effective.
Hefei, AnhuiAges 65 years+ - NCT07450911RecruitingPhase 1
Mitral valve replacement with the ReValve system
This study is for people with severe mitral valve leakage (mitral regurgitation) who may need a valve replacement. It tests whether the ReValve system is safe and can help improve symptoms and heart function.
TbilisiAges 18 years+ - NCT07436793RecruitingPhase 2
Progestin therapy before hysterectomy for endometrial cancer
This trial tests whether taking progestin (a hormone medication) before scheduled surgery can improve outcomes for women with a type of uterine cancer called endometrioid adenocarcinoma. You might be able to join if you are planning to have a hysterectomy and are open to hormone therapy before the procedure.
Iowa City, IowaAges 18 years+ - NCT07441824RecruitingPhase 3
Enzyme pills for severe pancreas damage
This trial tests if taking pancreatic enzyme pills can help people who have lost weight after a severe first-time pancreas attack with more than half of the organ damaged. It aims to see if the pills improve nutrition and recovery.
Guwahati, AssamAges 18–60 - NCT07429955Recruiting
Study on muscle and recovery after hip surgery in older adults
This trial looks at how muscle health affects your ability to get back to normal activities after hip replacement surgery for a broken hip or severe arthritis. By using MRI scans and other tests, researchers hope to understand if having less muscle makes recovery harder.
MontpellierAges 75 years+ - NCT06814574Recruiting
Pacemaker after tricuspid valve replacement
This study looks at whether people who need a new tricuspid heart valve also need a pacemaker soon after. Researchers want to learn more about heart rhythm changes after valve replacement.
München, BavariaAges Any age - NCT07425457Recruiting
Cold nerve treatment before knee replacement surgery
This trial tests a cold therapy on nerves before knee replacement to reduce pain. It may help you recover with less discomfort after surgery.
AthensAges 18 years+ - NCT07418593RecruitingPhase 4
Blood test for pancreas function in chronic pancreatitis
This trial tests a new blood test to measure how well your pancreas works. It may help people with chronic pancreatitis understand their condition and quality of life.
Baltimore, MarylandAges 18 years+ - NCT04195984Recruiting
Heart valve replacement through a catheter for leaky mitral valve
This trial studies a new way to replace a damaged mitral heart valve using a catheter (a thin tube), instead of open-heart surgery. It may help people who have severe leaking of the mitral valve but are considered too high-risk for surgery.
Beijing, Beijing MunicipalityAges 65 years+ - NCT07406412Recruiting
Hormones and heart health before and after ovary removal
This study looks at how hormones affect heart health and metabolism in women who are having their ovaries removed (for non-cancer reasons). It will help researchers understand the changes that happen after surgery and how to better manage health during this transition.
HelsinkiAges 35–50 - NCT07404982RecruitingPhase 2
Speeding Recovery from Spinal Anesthesia After Joint Surgery
This trial tests a way to make the leg numbness and weakness from spinal anesthesia wear off faster after joint replacement surgery. Researchers use a small tube (catheter) placed in your spine during the procedure to reverse the muscle block sooner.
Boston, MassachusettsAges Any age - NCT07398911Enrolling by invitation
3D simulated TAVR for aortic valve leak
This trial tests whether a 3D computer simulation can help guide a less invasive procedure (TAVR) to replace a leaky aortic valve. It may be an option for people with severe aortic regurgitation who are at least 65 years old.
Xi’an, ShanxiAges 65 years+ - NCT03286868Recruiting
Tested knee replacement alignment during knee surgery
This study looks at how a specific computer/measurement approach (“Verasense”) helps position the knee during total knee replacement for people with knee arthritis. It may help improve how the new knee fits and aligns as you recover.
Halifax, Nova ScotiaAges 21–80 - NCT07392515Recruiting
Digital rehab for hip fracture recovery in older adults
This trial tests whether a digital rehabilitation program can help older adults recover their thinking and movement skills after hip fracture surgery. It uses sensors and digital tools to guide therapy, making it easier to do from a rehabilitation ward.
Messina, ItalyAges 65–89 - NCT07394582Recruiting
Pre-surgery optimization for hip or knee replacement
This trial tests a program to improve your health before hip or knee replacement surgery. It aims to help you recover better and reduce risks.
Innsbruck, TyrolAges 18–99 - NCT06835816Recruiting
Amino acid supplements during dialysis
This trial tests whether adding amino acid supplements during dialysis helps people with kidney failure. It may be an option if your doctor decides you need these supplements.
StockholmAges 18 years+ - NCT07380854Recruiting
Thyroid Hormone After Heart Bypass for Mild Underactive Thyroid
This study looks at whether giving thyroid hormone replacement to people with mild underactive thyroid (subclinical hypothyroidism) after heart bypass surgery improves their recovery. It is for adults who are scheduled for bypass surgery and have not recently used thyroid or anti-thyroid medications.
Seongnam-siAges 19–90 - NCT06578182RecruitingPhase 3
Can colchicine reduce knee or hip replacement?
This study tests whether a low-dose medicine called colchicine can lower the chance that people with knee or hip arthritis will need a joint replacement. If you have arthritis in your knee or hip and are not already scheduled for surgery, you may be able to join.
NijmegenAges 45–80 - NCT06839807Recruiting
Testing a new device for knee replacement loosening
This study tests a new device (AtMoves Knee System) to help diagnose if a knee replacement is loose. It is for people who have had a knee replacement and have symptoms that might mean the implant is loose, but standard tests have not given a clear answer.
Nijmegen, GelderlandAges 18 years+ - NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 507 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.