Clinical trials
Revision Total Knee Arthroplasty clinical trials
Below are recruiting revision total knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 83 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06124482Recruiting
Study of a new knee replacement implant
This trial tests a new knee replacement implant called the FHK®-CK. It is for people who need a new knee due to arthritis or to replace a failed knee implant.
BeaumontAges 18 years+ - NCT06896240Recruiting
A smoothie supplement before and after knee revision surgery
This study tests whether drinking a special smoothie each day for 2 weeks before and after your knee revision surgery helps reduce inflammation and improve recovery. It is for people who have health conditions that cause inflammation, like diabetes or heart disease, and who are getting a knee replacement.
New York, New YorkAges 40–80 - NCT06880497Recruiting
Comparing knee sounds after two types of knee replacement
This study compares how much noise the knee makes (and how it feels to the patient) after two different kinds of total knee replacement surgery. It aims to help patients know what to expect after surgery.
AuxerreAges 18 years+ - NCT06740214RecruitingPhase 3
Different doses of liposomal bupivacaine for knee replacement pain
This trial tests different doses of a long-acting painkiller (liposomal bupivacaine) injected into a nerve block in the thigh to see which dose works best for pain after knee replacement surgery. It may help you have better pain control and recover faster.
Hong Kong, Hong KongAges 18–80 - NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT06618820Enrolling by invitationPhase 3
Extended tranexamic acid after knee replacement
This trial tests whether taking tranexamic acid (a medicine that helps blood clot) for several days after knee replacement surgery reduces bleeding and improves recovery. It may help patients who have a standard knee replacement and are not on blood thinners.
Germantown, TennesseeAges 18 years+ - NCT06617871Recruiting
Comparing two ways to align a new knee replacement
This study compares two different techniques (mechanical alignment vs. kinematic alignment) used during knee replacement surgery with a special knee system. It aims to see which technique leads to better results for patients.
Chicago, IllinoisAges 21–79 - NCT06264076Recruiting
Ligament balancing in knee replacement
This trial tests a new method of balancing the ligaments during total knee replacement. If you are generally healthy and need a first-time knee replacement due to arthritis, you may be eligible.
Bærums verk, AkershusAges 40 years+ - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80 - NCT06203756Enrolling by invitation
Robotic-Assisted Knee Replacement Outcomes Study
This study tests a robotic-assisted system for knee replacement surgery. It aims to see how well patients do with the robotic help.
Flagstaff, ArizonaAges Any age - NCT06120023Recruiting
Long-term follow-up of the Madison knee replacement system
This study follows patients in France who receive a Madison total knee replacement. It watches how well the knee works and how the patient feels over time, to make sure the implant is safe and effective.
Lyon, RhôneAges 18 years+ - NCT05800457Recruiting
Test synovectomy to reduce pain after knee replacement
This study looks at whether a procedure called synovectomy (removing inflamed joint lining) can reduce pain after a first knee replacement on one side. It focuses on people with clear signs of inflammation on ultrasound and checks follow-up outcomes after surgery.
London, OntarioAges 41–80 - NCT05736549RecruitingPhase 2
Tested stronger pain-blocking shot for knee replacement surgery
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
New Haven, ConnecticutAges 18 years+ - NCT05279092RecruitingPhase 2
Testing two pain-control injections for knee replacement surgery
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
New Haven, ConnecticutAges 18 years+ - NCT05097976RecruitingPhase 4
Medrol tablets to reduce pain after knee replacement
This trial tests whether a short course of Medrol (methylprednisolone) can improve recovery after outpatient total knee replacement done for osteoarthritis. You would be randomly assigned to receive Medrol or a comparison treatment.
Oak Brook, IllinoisAges 18 years+ - NCT04848896Recruiting
Safety and outcomes study of a smart knee replacement
This trial studies whether a “smart” knee replacement system (CORI) is safe and works well for people getting a total knee arthroplasty (TKA). If you’re a good candidate for a cemented standard knee replacement, the study follows you for two years to check results after surgery.
EppingAges 18 years+ - NCT06787417RecruitingPhase 4
Knee alignment study for total knee replacement
This study compares two different surgical techniques for total knee replacement to see which one leads to better knee movement and function. If you need a knee replacement due to arthritis, this trial may help find the best approach for your surgery.
Hamilton, OntarioAges 18 years+ - NCT07360392Recruiting
Nerve block comparison for knee replacement pain
This study compares two numbing techniques (nerve blocks) for pain relief after knee replacement surgery. The goal is to find which one works better and helps you recover with less pain.
AmasyaAges 18–80 - NCT06298721Recruiting
Personalized care to improve knee replacement satisfaction
This study tests a personalized approach to knee replacement surgery designed for people who are at higher risk of being dissatisfied after the procedure. The goal is to see if tailoring care based on patient-reported outcomes can improve satisfaction.
Cleveland, OhioAges 18–80 - NCT06074744Recruiting
Nerve blocks for knee replacement pain relief
This study compares two types of nerve blocks (subsartorial and femoral) to see which provides better pain control after knee replacement surgery. Both are injections that numb the nerves around your knee to help with recovery.
LucerneAges 18 years+ - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT05391828Recruiting
Testing a new knee robot and app support for knee arthritis
This study looks at whether a robot-assisted knee replacement plus remote tracking with an Apple Watch and a smartphone app helps people do better after surgery. You may be eligible if you’re an adult getting a planned (not replacement) knee surgery for arthritis and can use the required devices.
New York, New YorkAges 18 years+ - NCT06293352Recruiting
Comparing two antibiotic spacers for knee infection
This trial compares two types of antibiotic spacers for people with a long-term knee replacement infection. It tests whether a spacer made entirely of antibiotic cement or one with a metal core works better to treat the infection before a new knee replacement.
Chicago, IllinoisAges 18 years+ - NCT07288970Recruiting
Comparing two numbing injections for knee replacement pain
This study compares two types of numbing injections (nerve blocks) to see which provides better pain relief after total knee replacement surgery. If you are 65 or older and having your first knee replacement, you may be able to join.
PoznanAges 65–100
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Common questions
- Are there clinical trials for revision total knee arthroplasty?
- Yes. Clin2 currently lists 83 recruiting revision total knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a revision total knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a revision total knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.