Clinical trials
Safety and Effectiveness clinical trials
Below are recruiting safety and effectiveness clinical trials, each written for real people, not researchers. We’re tracking 396 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06335082Enrolling by invitation
Study of Farapulse ablation for atrial fibrillation
This registry is collecting information to see how well the Farapulse PFA system works and how safe it is for treating atrial fibrillation (AF), a common heart rhythm problem. If you are scheduled to have an ablation for AF with this system, this study will follow your progress.
Birmingham, AlabamaAges 18 years+ - NCT03198702RecruitingPhase 3
Early botulinum shots to prevent shoulder shape problems
This trial tests whether early injections of botulinum toxin into a baby’s arm muscles can prevent the shoulder from changing shape in infants with obstetrical brachial plexus palsy (OBPP). It also checks that the injections are safe and effective over time.
BrestAges 10 months–11 months - NCT03427996Recruiting
Study of rotational stent treatment in everyday care
This trial looks at how safe and effective rotational atherectomy (a procedure used to treat blocked heart arteries) is when used in routine clinical practice. It mainly gathers follow-up information from adults who already had this procedure.
Bucheon-siAges 19 years+ - NCT03667196Recruiting
Test opening blocked heart arteries using two different procedures
This trial studies whether two ways of threading a device to open a long-term blocked coronary artery are both safe and effective. You may qualify if you have a chronic total blockage and heart-related symptoms, and you can follow the study follow-up plan.
AnyangAges 19 years+ - NCT03887715Recruiting
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Birmingham, AlabamaAges 18 years+ - NCT03918408RecruitingPhase 1
Platinum eye drops and light to slow keratoconus
This Phase 1 study tests whether a specific corneal cross-linking system (called PXL-Platinum 330) is safe and effective for people with progressive keratoconus, a condition that makes the cornea thin and bulge. The goal is to slow vision changes and see how well the treatment works in the short term.
Eugene, OregonAges 12–45 - NCT06885034RecruitingPhase 1/Phase 2
Testing a new drug for advanced colorectal or pancreatic cancer
This study tests a new drug called GSK5764227, alone or with other treatments, for people with advanced colorectal or pancreatic cancer that has not responded to prior therapy. The goal is to see if it is safe and effective.
Los Alamitos, CaliforniaAges 18 years+ - NCT04094090RecruitingPhase 2
Corneal strengthening treatment for thinning eye shape
This Phase 2 study tests how safe and well a corneal cross-linking device (called PXL-Platinum 330) works for people with corneal ectasia (a thinning/steepening of the cornea). If you qualify, the goal is to help stop or slow further worsening of your cornea shape and improve eye stability.
San Francisco, CaliforniaAges 10 years+ - NCT04142437Recruiting
Tracking how larotrectinib works for NTRK fusion cancers in routine care
This study follows people with cancers that have an NTRK gene fusion to learn how safe and effective larotrectinib is during everyday treatment. It may help confirm whether this medicine works well in real-world patients and side effects stay manageable.
Mesa, ArizonaAges Any age - NCT04443530Recruiting
Testing Ultimaster stents in everyday patient care
This trial looks at how safe and effective two specific stents are when doctors use them as part of routine care. You may be a candidate if you’re an adult receiving one of these Ultimaster stents and can follow the study check-in schedule.
ChuncheonAges 19 years+ - NCT04671771Recruiting
Testing a new graft for hemodialysis access in kidney failure
This study tests whether an “AV graft” implant works safely and well for people with end-stage kidney disease who need hemodialysis. It may help your dialysis access last and work better, compared with current expectations for AV grafts.
Phoenix, ArizonaAges 18–90 - NCT04733404Recruiting
Dragonfly device study for functional mitral valve leakage
This trial tests a catheter-based procedure (putting a small device through blood vessels) to repair a leaking mitral valve caused by heart muscle problems. It aims to reduce symptoms and improve heart function and safety in people who are still having heart failure symptoms despite standard treatment.
Hangzhou, ZhejiangAges 18 years+ - NCT04742478Recruiting
Study of atherectomy and ultrasound for heavily calcified heart arteries
This study looks at how safe and effective a treatment is for heart artery blockages that are heavily hardened by calcium. It enrolls people who need a procedure to open the artery (with or without a stent) and whose blockage matches specific imaging or access problems.
KitakyushuAges 21 years+ - NCT04848896Recruiting
Safety and outcomes study of a smart knee replacement
This trial studies whether a “smart” knee replacement system (CORI) is safe and works well for people getting a total knee arthroplasty (TKA). If you’re a good candidate for a cemented standard knee replacement, the study follows you for two years to check results after surgery.
EppingAges 18 years+ - NCT04888975Recruiting
Device study for one-arm swelling after lymph surgery
This study tests a medical device (Dayspring Technology) to reduce swelling in the arm caused by breast cancer treatment and lymph surgery. You may be eligible if you have one-sided arm swelling after lymphatic surgery and meet safety checks for the device.
Palo Alto, CaliforniaAges 18 years+ - NCT04893603Recruiting
TAVR valve test for severe, hard-to-pump heart valve
This trial studies whether a new through-the-blood-vessel heart valve (TAVR) is safe and works well for people with severe aortic stenosis who are too risky for traditional surgery. If you qualify, you would be closely followed to check your symptoms and valve function over time.
BeijingAges 70 years+ - NCT04905056RecruitingPhase 2
Ablation treatment for lung ground-glass nodules that don’t go away
This Phase 2 trial studies whether a procedure called “ablation” is safe and effective for certain lung cancers that appear as ground-glass spots on CT scans and do not improve after 3 months. It may help people who cannot fully have surgery for their condition.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT04905745Recruiting
Integrative Korean medicine for new one-sided Bell’s palsy
This trial studies whether an integrative Korean medicine treatment can safely improve symptoms of Bell’s palsy. It’s meant for people whose facial weakness started recently, to see if treatment helps recovery.
Seoul, Gangnam-GuAges 19–69 - NCT07298421RecruitingPhase 3
Testing afimkibart for children with Crohn's disease
This trial tests a medicine called afimkibart for children with moderately to severely active Crohn's disease. It aims to see how well the drug works and how safe it is when used for both starting and ongoing treatment.
Parkville, VictoriaAges 2–17 - NCT05018520RecruitingPhase 3
Two chemotherapy schedules for newly diagnosed low-risk DLBCL
This trial compares two different shortened treatment schedules of R-CHOP to see which one is safer and works better for people with low-risk diffuse large B-cell lymphoma (DLBCL). It aims to reduce risk from treatment while maintaining strong cancer control after an initial response.
Shanghai, Shanghai MunicipalityAges 14–75 - NCT05044273Recruiting
Study of two new stents and their safety in adults
This study checks how safe and effective two types of heart stents (Synergy XD and Synergy Megatron) are after they are placed. You might consider it if you’re an adult getting one of these stents and can follow required clinic visits.
AnyangAges 19 years+ - NCT05318417Recruiting
Cochlear implant study for one-sided deafness
This study checks whether cochlear implantation is safe and effective for people who have very poor hearing in one ear (single-sided deafness) while the other ear hears normally or nearly normally. You may be enrolled if you meet specific hearing test and health/surgery readiness requirements.
Palo Alto, CaliforniaAges 5 years+ - NCT05349955Recruiting
Primary care diabetes guideline program for older adults
This trial tests whether a diabetes treatment plan (based on published guidelines) delivered by primary care doctors in the community is safe and helpful for older adults. It focuses on people with type 2 diabetes who also have kidney problems and/or higher heart and blood-vessel risk.
Suzhou, JaingsuAges 65 years+ - NCT05356741RecruitingPhase 1/Phase 2
Study drug VIR-5818 with and without pembrolizumab
This early trial tests whether VIR-5818 given through a vein is safe and whether it works better when combined with pembrolizumab. It’s for adults with HER2-positive cancers that are locally advanced or spread, and the study checks safety, side effects, and early signs of effect.
Melbourne, VictoriaAges 18 years+
Hear when a new Safety and Effectiveness trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for safety and effectiveness?
- Yes. Clin2 currently lists 396 recruiting safety and effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a safety and effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a safety and effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.