Safety and Effectiveness clinical trials

Testing afimkibart for children with Crohn's disease

This trial tests a medicine called afimkibart for children with moderately to severely active Crohn's disease. It aims to see how well the drug works and how safe it is when used for both starting and ongoing treatment.

New cuff to measure blood flow during heart procedures

This trial tests a new upper-arm cuff that may measure your heart's blood flow without needing an extra tube in your heart. If you already need a special heart catheter and a wrist arterial line, this study will see if the cuff works just as well.

Adding valbenazine to botox for neck muscle spasms

This study tests if adding a daily pill (valbenazine) to regular botox injections can better reduce neck muscle spasms. It helps people whose botox works but may not be enough.

Study of a treatment for frown lines between the eyebrows

This study tests a new medicine (IPN10200) to see how well it works and how safe it is for reducing moderate to severe frown lines between the eyebrows in adults. If you are unhappy with the appearance of these lines, this trial may help.

Freezing device for skin tags: test of a new pen

This trial tests a new cryogenic pen that freezes off skin tags to see if it works better than an existing device. It may be an option if you have small, soft, skin-colored skin tags in certain body areas.

Preventing nausea and vomiting after GI cancer surgery

This study tests whether the medication NEPA (Netupitant and Palonosetron) can prevent nausea and vomiting in people who have had surgery for liver, gallbladder, or pancreatic cancer. It may help those who want to avoid post-surgery sickness.

Study of a new treatment for moderate to severe frown lines between eyebrows

This trial tests a new medication's effectiveness and safety over time in adults with moderate to severe frown lines between the eyebrows. It aims to see if the treatment can reduce these lines and improve satisfaction with appearance.

DSP dental implant safety study for tooth loss

This trial tests several types of DSP dental implants to see if they are safe and work well for people with missing teeth. It is for patients who have had tooth loss for at least three months and are in good overall health.

ILUVIEN eye implant for kids with recurrent eye inflammation

This trial tests an eye implant (ILUVIEN) in children and teens ages 6 to 17 who have a type of eye inflammation called uveitis that keeps coming back. The implant releases medicine slowly over time to control inflammation and may help reduce the need for other treatments.

Real-world study of Sotyktu for psoriasis in Korea

This study looks at how safe and effective a pill called Sotyktu is for people with moderate-to-severe plaque psoriasis in real-life medical settings in Korea. If you are 19 or older and are about to start Sotyktu for your psoriasis as your doctor prescribes, this study may be an option for you.

Mesotherapy for chronic low back pain study

This trial tests whether injecting a natural substance (collagen) into the lower back can safely reduce chronic pain. It may help people with pain that hasn't spread to the legs.

New device for treating acute pulmonary embolism

This trial tests a new system to remove blood clots from the lungs in people with acute pulmonary embolism (a sudden blockage in a lung artery). It may help those who are stable enough for a catheter-based procedure but still have significant strain on the heart.

A new glucose and ketone monitor for type 1 diabetes

This trial tests a new device that measures blood sugar and ketones continuously. It may help people with type 1 diabetes who use an insulin pump keep better track of their levels.

Study of Lorlatinib for untreated ALK-positive lung cancer

This study looks at how well and how safely the drug lorlatinib works in people with a certain type of advanced lung cancer (ALK-positive NSCLC) who have not had treatment for their advanced cancer yet. The goal is to see how effective it is in the real world.

Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study

Check a new alternative to ileostomy after bowel surgery

This trial tests whether a device called COLO-BT can be a safer, effective alternative to an ileostomy (a temporary or longer-term opening from the intestine to the skin). It’s for certain adults having a bowel connection low in the pelvis, where leak risk matters.

Gene therapy for severe hemophilia B

This trial tests a new gene therapy (REGV131-LNP1265) that aims to let your body produce its own factor IX, reducing or stopping the need for regular infusions. It is for children and adults with severe hemophilia B who are already using factor IX replacement therapy.

New pacemaker vs standard cardiac therapy for heart failure

This study tests a newer type of pacemaker that paces the heart's left bundle branch area, compared to the usual cardiac resynchronization therapy. It is for people with heart failure who need a combined pacemaker-defibrillator (CRT-D) and have a specific heart rhythm pattern (left bundle branch block) with reduced pumping strength.

Testing a New Drug for Advanced Colon, Rectal, or Pancreatic Cancer

This study tests an experimental drug, alone or combined with other treatments, for advanced colon, rectal, or pancreatic cancer that hasn't responded to standard options or cannot be removed by surgery. The goal is to see if it is safe and if it helps shrink or slow the cancer.

Observing elafibranor in everyday care for PBC

This study follows people with primary biliary cholangitis (PBC) who are already taking or starting elafibranor, to see how well it works and how safe it is in everyday life. No extra treatments or tests are required beyond what your doctor normally does.

Testing Upadacitinib for Severe Alopecia Areata

This study tests an oral tablet called upadacitinib for people with severe alopecia areata who have lost at least half of their scalp hair. It aims to see if the drug can safely help hair regrow.

Pumitamig for advanced triple-negative breast cancer

This study tests a new drug called pumitamig for people with a type of breast cancer that is triple-negative or has very low hormone receptors and has come back or spread. It aims to see if pumitamig works better than standard treatment and how safe it is for people who cannot get PD(L)-1 immunotherapy with chemo.

Long-term study of odevixibat in Alagille syndrome

This study follows people with Alagille syndrome who are already taking or starting odevixibat (Bylvay). It looks at how well the medicine works and how safe it is over a long period of time.

Comparing combined vs single drug for ulcerative colitis

Researchers want to see if taking two medications together (upadacitinib and vedolizumab) works better than taking just upadacitinib alone for people with moderate to severe ulcerative colitis. This is a real-world study, meaning it looks at patients being treated in normal medical practice.