Clinical trials
Sarcoma clinical trials
Below are recruiting sarcoma clinical trials, each written for real people, not researchers. We’re tracking 401 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06094101RecruitingPhase 1/Phase 2
Personalized vaccine for fusion-positive sarcoma patients
This trial tests a personalized vaccine made from your tumor's unique gene fusion. It's for people with certain sarcomas that have spread and are now in remission or stable after standard treatment. The vaccine aims to help your immune system keep the cancer from coming back.
EssenAges 2–40 - NCT02811523RecruitingPhase 1
Testing a lung procedure to treat sarcoma lung metastases
This early-phase study tests a special way to deliver medicine directly to the lungs (called IVLP) for sarcoma that has spread to both lungs. It aims to control lung metastases while reducing side effects, and it uses a plan that often includes surgery or focused radiation around the procedure.
TorontoAges birth–64 years - NCT05663502Recruiting
Donate blood and tissue samples for HIV-related cancer research
This study collects blood and tissue samples to help researchers learn more about cancers related to HIV/AIDS. You may be able to join if you’re 18+ and have HIV and a cancer diagnosis, or (if HIV-negative) a certain cancer that is closely linked to AIDS-related cancers.
La Jolla, CaliforniaAges 18 years+ - NCT05224934Recruiting
Radiation before surgery for retroperitoneal soft-tissue sarcoma
This trial tests giving a shorter, lower-dose radiation treatment before surgery for a retroperitoneal (deep belly/back space) soft-tissue sarcoma. The goal is to shrink or control the tumor and make surgery more effective and safe.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05051059Recruiting
Life quality check after leg sarcoma surgery
This study checks how people with leg sarcoma are functioning and how satisfied they are with their quality of life after treatment. It mainly looks at patients at least one year after limb-sparing surgery, to understand long-term effects and support.
Leuven, Vlaams-BrabantAges 18–95 - NCT05033288Recruiting
Compare radiation types and surgery for pelvic bone sarcomas
This study compares three treatment approaches—carbon ion radiation, proton radiation, and surgery—for sarcomas in the pelvis that involve bone. It looks to see which option best controls the tumor while helping protect nearby tissues.
Scottsdale, ArizonaAges 15 years+ - NCT04897321RecruitingPhase 1
CAR T therapy for children with B7-H3 solid tumors
This early-phase study tests a lab-made immune therapy (CAR T cells) made from your own cells to treat children’s solid tumors that have a specific marker called B7-H3. It is designed for kids whose cancer has come back or did not respond to standard treatment, aiming to shrink tumors and keep the therapy safe.
Memphis, TennesseeAges Up to 21 years - NCT03244020Enrolling by invitationPhase 4
Aspirin or low-dose blood thinner after bone or leg surgery
This trial compares aspirin versus a low-dose injectable blood thinner (LMWH) to prevent blood clots after certain orthopedic cancer surgeries. It may help lower the risk of dangerous clotting while balancing bleeding and side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT03838718Recruiting
Registry study for adults after retroperitoneal sarcoma surgery
This study follows adults who have had surgery for a retroperitoneal sarcoma. It collects clinical and imaging information after treatment to better understand outcomes and guide future care.
Los Angeles, CaliforniaAges 18 years+ - NCT04330456Recruiting
Radiation plus surgery for first soft tissue sarcoma
This trial studies a treatment plan for newly diagnosed soft tissue sarcoma that combines precisely targeted radiation before surgery and conformal radiation after surgery. It may help by improving tumor control while allowing the surgeon to remove the tumor safely.
Saint PetersburgAges 18–75 - NCT05373810Recruiting
Study for people with bone or soft tissue sarcoma
This study is for people who have been diagnosed with bone or soft tissue sarcoma confirmed by a tissue test. It may help researchers understand sarcoma better, but you must be able to understand and consent to take part.
ArnhemAges 18 years+ - NCT05620693Recruiting
Cell therapy study for NY-ESO-1–positive soft tissue cancer
This trial tests an engineered immune cell treatment (NY-ESO-1 TCR-T) for people with advanced soft tissue sarcoma that has returned or spread after standard treatment. It aims to treat cancer cells that show a specific marker (NY-ESO-1) in the tumor.
Shenzhen, GuangdongAges 18–70 - NCT05761054Recruiting
Pre-surgery radiation to shrink soft-tissue sarcoma
This trial studies giving radiation before surgery to help control a soft-tissue sarcoma while keeping surgery as less extensive as possible. It may help shrink the tumor and improve what the surgeon can remove.
Florence, FiAges 18 years+ - NCT04621201Recruiting
Testing tumor genetics in young people with bone sarcomas
This study looks at the genetic (DNA) features of tumors in children, teens, and young adults with osteosarcoma, Ewing sarcoma, or synovial sarcoma. It may help researchers better understand these cancers by analyzing a fresh tumor sample and a blood sample.
Torino, TurinAges Up to 24 years - NCT05952310Recruiting
NK cell infusion for children and young adults with sarcoma
This trial tests an infusion of activated NK cells (a type of immune cell) to treat sarcomas that are still detectable or not responding well to standard treatment. If you qualify, you may receive this cell therapy while doctors closely check your organ function and heart strength.
MadridAges Up to 30 years - NCT04758000RecruitingPhase 2
Metformin after bone cancer treatment to prevent relapse
This Phase 2 study tests whether taking metformin after surgery and chemotherapy can reduce the risk of bone cancer coming back in people at high risk of relapse. You may be eligible if you have osteosarcoma or Ewing sarcoma that is not currently spread and you meet specific lab and health criteria.
BolognaAges 14 years+ - NCT05839275RecruitingPhase 1/Phase 2
Radiation plus two medicines for high-risk soft tissue sarcoma
This Phase 1/2 trial tests whether combining radiation with two targeted/immune medicines can shrink or control high-risk soft tissue sarcoma and improve outcomes. It may help patients whose tumors are large, hard to fully remove, or have come back after prior treatment.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06062927Recruiting
Genes and scans predict response to immunotherapy and targeted therapy for advanced sarcoma
This trial is testing whether a combination of two drugs—a targeted therapy (surufatinib) and an immunotherapy (envafolimab)—can help people with advanced soft tissue sarcoma that has spread or cannot be removed by surgery. Researchers will also use a person's genetic information and scans to see if they can predict who will benefit the most.
Beijing, Beijing MunicipalityAges 18–75 - NCT05328258RecruitingPhase 3
Triptorelin to help protect fertility during cancer chemotherapy
This Phase 3 study tests whether a hormone medicine called triptorelin (a GnRH “fertility-protecting” medicine) can better protect ovarian function while you receive chemotherapy. The goal is to help preserve fertility and reduce the risk of early ovarian failure from cancer treatment.
GothenburgAges 14–42 - NCT07864870Recruiting
Sarcoma treatment adherence and survival study
This study looks at how closely patients in the Strasbourg area follow their sarcoma treatment plans and how that affects their survival. Sarcoma is a rare type of cancer that starts in the body's connective tissues, like fat, muscle, or blood vessels.
StrasbourgAges 18 years+ - NCT06236022RecruitingPhase 4
Sirolimus for dilated cardiomyopathy with KSHV infection
This trial tests whether the drug sirolimus (rapamycin) can help people with dilated cardiomyopathy who also have a specific virus (KSHV) in their blood. It aims to see if sirolimus can improve heart function.
Wuhan, HubeiAges 18–70 - NCT06340204RecruitingPhase 1
Weekly liposomal irinotecan for advanced Ewing sarcoma
This trial tests a weekly dose of a chemotherapy drug wrapped in liposomes (tiny fat bubbles) for people with Ewing sarcoma that has come back or not responded to standard treatments. The goal is to see if this new form of the drug can help when other options have stopped working.
Jina, ShandongAges 8–40 - NCT06087341RecruitingPhase 1
CAR T-Cell Therapy for Advanced Sarcoma in Young People
This trial tests a special type of immune cell (called a CAR T-cell) that is trained to attack sarcoma cells. It is for children, teens, and young adults up to age 40 whose sarcoma has not responded to standard therapy. The treatment is given directly into the tumor, and the goal is to see if it is safe and how well it works.
MadridAges Up to 30 years - NCT06436846Recruiting
Genomic risk in retroperitoneal sarcoma
This study is looking at genetic risk factors in people with retroperitoneal liposarcoma who are having surgery to remove the tumor. The goal is to understand how genes affect the disease and possibly guide future treatments.
Philadelphia, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for sarcoma?
- Yes. Clin2 currently lists 401 recruiting sarcoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sarcoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sarcoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.