Clinical trials
Severe Aortic Valve Stenosis clinical trials
Below are recruiting severe aortic valve stenosis clinical trials, each written for real people, not researchers. We’re tracking 166 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07794436Recruiting
Measuring valve and lung changes after minimally invasive heart valve replacement
This study looks at how replacing a narrowed heart valve affects fluid in the lungs. It may help doctors better understand recovery after this procedure.
Istanbul, IstanbulAges 18 years+ - NCT07752732Recruiting
Heart scans for amyloidosis in people with severe aortic valve stenosis
This study looks at how often cardiac amyloidosis occurs in people with severe aortic valve stenosis. It uses different heart scans to find out more. If you have both conditions, this research may help doctors understand your situation better.
TübingenAges 18 years+ - NCT06595992Recruiting
Observing moderate aortic valve disease over time
This study follows people with moderate aortic valve disease to learn how their condition changes. It does not test a new treatment but will help doctors better understand the disease.
Hangzhou, ZhejiangAges 18 years+ - NCT06007222RecruitingPhase 4
No blood thinners after TAVI: a trial for heart valve patients
This trial is for people who have had a TAVI procedure to replace a narrowed heart valve, and it tests whether it is safe to skip blood thinners afterward. The goal is to find the best way to protect your health without unnecessary medication.
Shinjuku, TokyoAges 20 years+ - NCT06025149Recruiting
Study of a New Biological Heart Valve 'UniLine'
This study tests a new biological heart valve called 'UniLine' for people who need to replace their mitral valve (the valve between the left heart chambers) or aortic valve (the main valve sending blood to the body) for the first time. If you qualify, you would have planned surgery (not an emergency) and need to be free of certain other serious health conditions.
Kemerovo, Kemerovo OblastAges 18–80 - NCT07715279RecruitingPhase 2
Vericiguat for slowing aortic valve calcium buildup
This trial tests if the drug vericiguat can slow down the buildup of calcium in the aortic valve, which causes it to narrow and stiffen. If you have mild-to-moderate aortic valve stenosis and meet the other criteria, this study may help protect your valve from getting worse.
Chengdu, SichuanAges 35–80 - NCT07709858Recruiting
Outcomes after TAVR for severe aortic valve disease
This is a registry study that tracks how people do after a TAVR procedure for a severely narrowed aortic heart valve. It helps doctors learn more about long-term outcomes and improve care for future patients.
SeoulAges 18 years+ - NCT05439863Recruiting
Valve procedure trial for severe aortic valve problems
This trial studies people with severe aortic valve disease who will receive a catheter-based valve replacement (TAVR). It aims to check how well this approach works for fixing a narrowed or leaky aortic valve, and to monitor outcomes afterward.
Nanjing, JiangsuAges 18 years+ - NCT07620925Recruiting
Aortic Valve Calcium Score Study Using Heart Ultrasound
This study develops and tests a new way to diagnose severe aortic stenosis (narrowing of the aortic valve) by measuring calcium buildup on the valve using heart ultrasound. If you're already getting both an ultrasound and a CT scan of your heart, this study compares how well the ultrasound method can identify severe stenosis.
BolognaAges 18 years+ - NCT04882488Recruiting
Testing heart scan measurements in severe aortic valve narrowing
This trial compares two pressure-based measurements of blood flow in the coronary arteries with a PET heart scan in people with severe aortic valve stenosis. It may help doctors choose the most accurate way to assess blood flow and guide care during valve treatment.
Bad Oeynhausen, North Rhine-WestphaliaAges 65 years+ - NCT06706635Recruiting
Better info for aortic stenosis patients before TAVI
This trial tests whether giving extra information before heart valve replacement (TAVI) helps patients feel more informed and improves their reported outcomes. If you have severe aortic stenosis and are planning to get a TAVI, this study may be for you.
Bad OeynhausenAges 18 years+ - NCT07604402Recruiting
Aortic Valve Replacement Without On-Site Surgery
This study tests a catheter-based procedure to replace a narrowed aortic valve without traditional open-heart surgery. It's designed for patients who are at higher risk for surgery due to age, health conditions, or anatomy.
AndriaAges Any age - NCT06168123Recruiting
Future care for aortic stenosis
This research study is a registry that collects information about people with aortic stenosis, a condition where a heart valve becomes narrow. The goal is to learn more about how this condition is managed and to improve future care.
NieuwegeinAges 18–110 - NCT07596394Recruiting
Registry of Catheter-Based Aortic Valve Replacements
This registry collects information about patients who receive a new valve inserted through a catheter (a thin tube) rather than open surgery. It tracks how well the procedure works and any side effects to help doctors understand the long-term safety and effectiveness of this less invasive approach.
Pavia, PaviaAges 18 years+ - NCT06722066Recruiting
TAVR and heart valve calcium study
This study looks at how calcium buildup in the aortic valve affects long-term results after a TAVR procedure (a minimally invasive heart valve replacement). It may help doctors understand which patients do better over time.
SeoulAges 19 years+ - NCT07566624Recruiting
Registry study of Hydra heart valve replacement procedure
This study tracks patients who receive a Hydra artificial heart valve to replace a severely narrowed aortic valve. Researchers will follow your progress to understand how well the device works and its safety in real-world use.
Fuencarral-El PardoAges 18 years+ - NCT06743568Recruiting
Comparing new valves for tight aortic valve in enlarged aorta
This trial tests two types of replacement heart valves (self-expanding and balloon-expanding) in people who have severe aortic stenosis (tight heart valve) and an enlarged aorta (the main blood vessel from the heart). The goal is to see which valve type works better for these patients.
Beijing, Beijing MunicipalityAges 65 years+ - NCT06477042Recruiting
Act on quality of life in patients with aortic stenosis
This trial studies how a TAVI procedure affects the quality of life of people with aortic stenosis, especially those with multiple health conditions. It may help doctors understand how this treatment improves daily living for patients like you.
Clermont-FerrandAges 18 years+ - NCT07469371Recruiting
CT-FFR guided heart treatment for severe aortic stenosis
This trial tests whether using a special CT scan (CT-FFR) to guide treatment improves outcomes for people with severe aortic stenosis (a narrowed heart valve). It may help doctors decide between valve replacement surgery or a less invasive procedure.
Kunming, YunnanAges 18 years+ - NCT07455292Recruiting
Heart valve study using advanced MRI
This study uses a special type of MRI, called 4D flow MRI, to better understand how severe aortic stenosis (a narrowed heart valve) affects heart function. It may help doctors learn more about different types of this condition and improve future treatment.
San Donato MilaneseAges 18 years+ - NCT07462624Recruiting
Comparing treatments for a failing surgical aortic valve
This trial compares two ways to treat a failing aortic valve that was replaced with a tissue valve during surgery: another surgical replacement or a less invasive catheter-based valve-in-valve procedure. It is for people with low to intermediate surgical risk who are between 18 and 75 years old.
Leipzig, SaxonyAges 18–75 - NCT07456280Recruiting
Early discharge after TAVI using heart monitoring
This study tests if patients who have mild heart electrical changes after TAVI can be sent home early with a portable heart monitor instead of staying in the hospital. It aims to see if this approach is safe and effective.
BarcelonaAges 18 years+ - NCT07453407Recruiting
Tavi valve vs surgery for severe aortic regurgitation
This trial compares a new catheter-based valve (J-Valve) with open-heart surgery for people with severe aortic regurgitation, a condition where the aortic valve doesn't close tightly. It aims to see which treatment is safer and more effective.
Hefei, AnhuiAges 65 years+ - NCT05739253Recruiting
Study how the aorta changes after a valve procedure
This trial looks at how the ascending aorta (the main artery near the heart) changes over time after transcatheter aortic valve replacement. It may help doctors predict who is at risk of aorta enlargement after this less-invasive valve procedure.
Beijing, Beijing MunicipalityAges Any age
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Common questions
- Are there clinical trials for severe aortic valve stenosis?
- Yes. Clin2 currently lists 166 recruiting severe aortic valve stenosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe aortic valve stenosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe aortic valve stenosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.