Clinical trials
Severe Asthma clinical trials
Below are recruiting severe asthma clinical trials, each written for real people, not researchers. We’re tracking 66 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07214753Recruiting
Benralizumab for severe eosinophilic asthma in Italy
This study follows people with severe eosinophilic asthma who are starting benralizumab. It looks at how well the treatment works in real life, outside of a controlled research setting.
Salerno, BattipagliaAges 18 years+ - NCT06023589RecruitingPhase 3
Testing tezepelumab for kids with severe asthma
This study tests if tezepelumab can help reduce severe asthma attacks in children ages 5 to 11. It compares the drug to a placebo (a dummy treatment) to see if it is safe and effective.
Montgomery, AlabamaAges 5–11 - NCT04743791RecruitingPhase 4
Dupilumab study for clearing mucus in moderate to severe asthma
This study tests whether dupilumab improves how well mucus is cleared from the airways in adults with moderate to severe asthma. It may help find better ways to reduce mucus-related breathing problems in people with a specific asthma type.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04565483RecruitingPhase 4
Test a blood-test signature to predict benralizumab benefit
This trial studies whether a specific “signature” from asthma tests can predict who will respond to benralizumab (a severe asthma biologic). If you qualify, the researchers will compare your test results to how well benralizumab controls your asthma and prevents flare-ups.
Aix-en-ProvenceAges 18–75 - NCT04763447RecruitingPhase 4
Short omalizumab treatment for severe allergic asthma
This trial tests whether stopping omalizumab for a short time (or using it differently) can be safe for adults with severe allergic asthma who are doing well. It may help some people avoid long-term injections, but only if asthma remains well controlled.
Paris, Île-de-France RegionAges 18 years+ - NCT06323213RecruitingPhase 3
Testing a new asthma medicine for severe asthma
This study tests an experimental drug called 610 for people with severe asthma that is not well-controlled with standard medicines. The goal is to see if adding 610 can improve asthma control and reduce flare-ups.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07219173RecruitingPhase 2
Study of brenipatide for uncontrolled moderate to severe asthma
This study tests an investigational drug called brenipatide for people with moderate to severe asthma that isn't well controlled by current medicines. The purpose is to see if it can reduce asthma attacks better than a placebo (inactive treatment).
Tempe, ArizonaAges 18–75 - NCT06837922RecruitingPhase 3
Study of MG-K10 for moderate to severe asthma
This trial tests a new drug called MG-K10 for people with moderate to severe asthma that is not well controlled with current treatments. It aims to see if the drug can reduce asthma attacks and improve breathing. You may be able to join if you have had asthma for at least a year, use high-dose inhalers plus another controller medicine, and have had a recent flare-up.
Guangzhou, GuangdongAges 12–75 - NCT06977581RecruitingPhase 2
study of PF-07275315 for moderate-to-severe asthma
This study tests a new medicine called PF-07275315 for people with moderate-to-severe asthma that is not well controlled with their current inhalers. It is for adults who have had asthma for at least a year, have had recent flare-ups needing steroids, and are not taking other biologic treatments.
Mobile, AlabamaAges 18–70 - NCT07011524RecruitingPhase 2
Study of CM512 injection for moderate-to-severe asthma
This trial tests a new injection, CM512, for people with moderate-to-severe asthma that is not well controlled with current inhalers. It aims to see if the treatment can reduce asthma attacks and improve symptom control.
Guangzhou, GuangdongAges 18–75 - NCT07189806Recruiting
Asthma study tracking symptoms over 5 years
This study follows adults with mild, moderate, or severe asthma to better understand the condition. You'll attend regular check-ups at the clinic to monitor your lung function and symptoms over five years.
LondonAges 18 years+ - NCT02241265Recruiting
Testing how lung breathing tests respond to bronchial treatment
This trial looks at how lung function test results change after bronchial thermoplasty in adults with severe asthma. It may help doctors understand who benefits from this procedure based on breathing test measures.
Oklahoma City, OklahomaAges 18–99 - NCT06147453Enrolling by invitation
Oscillating positive expiratory pressure therapy for mucus in asthma
This trial tests a device that uses vibrations to help clear mucus from your lungs. It may improve airflow and mucus buildup in people with moderate to severe asthma.
Hamilton, OntarioAges 18 years+ - NCT06286007Recruiting
How whooping cough and RSV affect asthma in adults
This study looks at how infections like whooping cough and RSV impact asthma symptoms and control in adults. It aims to understand if these infections make asthma worse, which could help improve future treatment and prevention.
Santiago de Compostela, A CoruñaAges 18–99 - NCT07241117RecruitingPhase 4
CHEST: Helping clinics use SMART for asthma
This study tests a program to help community health clinics use a special asthma treatment approach called SMART. The goal is to see if it improves asthma care and reduces flare-ups.
St Louis, MissouriAges 12 years+ - NCT07343661Enrolling by invitationPhase 4
Mepolizumab study for asthma or EGPA
This trial tests how well mepolizumab works for people with asthma or a related condition called EGPA, and looks for markers in the blood that may predict organ damage or treatment response.
Cagliari, CagliariAges 18 years+ - NCT07098403RecruitingPhase 3
Study of SHR-1905 for severe uncontrolled asthma
This trial tests an experimental drug called SHR-1905 for people with severe asthma that is not well controlled by their current treatments. The study aims to see if the drug can reduce asthma attacks and improve breathing.
Guangzhou, GuangdongAges 18 years+ - NCT00576069Recruiting
Study airflow limits in moderate asthma
This trial looks at why airflow is limited in people with moderate-to-severe persistent asthma who are already on stable treatment. It may help researchers better understand what drives breathing trouble and how to target it.
Lakewood, CaliforniaAges 10–95 - NCT06705764RecruitingPhase 4
Tezepelumab for asthma attacks in the emergency room
This trial tests if a drug called Tezepelumab can help adults with asthma who visit the emergency room. It aims to reduce severe asthma attacks and improve breathing control.
Edmonton, AlbertaAges 18–55 - NCT06360393Recruiting
Checking inhaler use with a smart spacer for severe asthma on biologics
This trial tests if a smart spacer can help people with severe asthma use their inhaler correctly and stick to their medication schedule. It’s for adults already taking biologic drugs for asthma.
Zwolle, OverijsselAges 18 years+ - NCT06829784RecruitingPhase 3
Study of TQC2731 for severe asthma
This trial tests an investigational drug called TQC2731 for people with severe asthma that is not well controlled despite high-dose inhaled steroids. The study aims to see if this treatment can reduce asthma attacks.
Bozhou, AnhuiAges 18–75 - NCT07323654RecruitingPhase 2
Oral KT-621 for moderate to severe eosinophilic asthma
This trial tests an oral medication called KT-621 for people with moderate to severe eosinophilic asthma. It aims to see if the drug can help control asthma better than the standard inhaled treatments alone.
Lancaster, CaliforniaAges 18–75 - NCT05192499Recruiting
Study gut-and-lung bacteria in very young children with asthma
This study looks at whether differences in the body’s bacteria (in the gut and/or airways) can help predict which toddlers with asthma may develop a more severe form. It may help doctors identify children at higher risk earlier so they can be monitored more closely.
Brest, FinistèreAges 1–3 - NCT06126692Recruiting
Asthma study comparing different biologic treatments
This study looks at how well different biologic treatments work for people with severe or mild-to-moderate asthma, and compares them to healthy volunteers. It aims to find which treatments work best for different asthma types.
CopenhagenAges Any age
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Common questions
- Are there clinical trials for severe asthma?
- Yes. Clin2 currently lists 66 recruiting severe asthma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe asthma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe asthma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.