Clinical trials
Severe Asthma clinical trials
Below are recruiting severe asthma clinical trials, each written for real people, not researchers. We’re tracking 69 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07786870Recruiting
Understanding airway proteins in asthma
This study examines a protein called TSLP that may play a role in asthma inflammation. By looking at different versions of TSLP in your airway samples, researchers hope to learn more about asthma and potentially guide future treatments.
Warsaw, WarsawAges 18 years+ - NCT07582211Recruiting
BPAP breathing support for severe asthma attacks in children
This study tests whether a special breathing mask (BPAP) can help children ages 5–17 who come to the emergency room with severe asthma attacks. The mask gently pushes air into the lungs to help them breathe more easily.
New York, New YorkAges 5–17 - NCT06811740Enrolling by invitation
Treating severe asthma by focusing on key health issues
This trial looks at people with severe asthma that is hard to control. It aims to find and treat specific health problems that make asthma worse, by doing a detailed check-up and using treatments that are right for you.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06044051Recruiting
Severe infant asthma and the lung microbiome study
This study looks at the bacteria (microbiome) in the airways of infants under 2 years old with severe asthma. It aims to understand how these bacteria might affect the disease.
RouenAges Up to 2 years - NCT07214753Recruiting
Benralizumab for severe eosinophilic asthma in Italy
This study follows people with severe eosinophilic asthma who are starting benralizumab. It looks at how well the treatment works in real life, outside of a controlled research setting.
Salerno, BattipagliaAges 18 years+ - NCT07869043RecruitingPhase 3
Study of tilrekimig for people with severe asthma
This study tests an investigational medicine called tilrekimig for people with severe asthma that is not well controlled. The goal is to see if it can reduce asthma attacks and improve breathing.
Pittsburgh, PennsylvaniaAges 12–80 - NCT04565483RecruitingPhase 4
Test a blood-test signature to predict benralizumab benefit
This trial studies whether a specific “signature” from asthma tests can predict who will respond to benralizumab (a severe asthma biologic). If you qualify, the researchers will compare your test results to how well benralizumab controls your asthma and prevents flare-ups.
Aix-en-ProvenceAges 18–75 - NCT07772921RecruitingPhase 3
New study medicine for severe asthma
This study tests an investigational medicine called tilrekimig for people with severe asthma that isn't well controlled. It aims to reduce asthma attacks and improve breathing.
Bakersfield, CaliforniaAges 12–80 - NCT04763447RecruitingPhase 4
Short omalizumab treatment for severe allergic asthma
This trial tests whether stopping omalizumab for a short time (or using it differently) can be safe for adults with severe allergic asthma who are doing well. It may help some people avoid long-term injections, but only if asthma remains well controlled.
Paris, Île-de-France RegionAges 18 years+ - NCT02241265Recruiting
Testing how lung breathing tests respond to bronchial treatment
This trial looks at how lung function test results change after bronchial thermoplasty in adults with severe asthma. It may help doctors understand who benefits from this procedure based on breathing test measures.
Oklahoma City, OklahomaAges 18–99 - NCT07219173RecruitingPhase 2
Study of brenipatide for uncontrolled moderate to severe asthma
This study tests an investigational drug called brenipatide for people with moderate to severe asthma that isn't well controlled by current medicines. The purpose is to see if it can reduce asthma attacks better than a placebo (inactive treatment).
Tempe, ArizonaAges 18–75 - NCT06837922RecruitingPhase 3
Study of MG-K10 for moderate to severe asthma
This trial tests a new drug called MG-K10 for people with moderate to severe asthma that is not well controlled with current treatments. It aims to see if the drug can reduce asthma attacks and improve breathing. You may be able to join if you have had asthma for at least a year, use high-dose inhalers plus another controller medicine, and have had a recent flare-up.
Guangzhou, GuangdongAges 12–75 - NCT07189806Recruiting
Asthma study tracking symptoms over 5 years
This study follows adults with mild, moderate, or severe asthma to better understand the condition. You'll attend regular check-ups at the clinic to monitor your lung function and symptoms over five years.
LondonAges 18 years+ - NCT07011524RecruitingPhase 2
Study of CM512 injection for moderate-to-severe asthma
This trial tests a new injection, CM512, for people with moderate-to-severe asthma that is not well controlled with current inhalers. It aims to see if the treatment can reduce asthma attacks and improve symptom control.
Guangzhou, GuangdongAges 18–75 - NCT06977581RecruitingPhase 2
Study of PF-07275315 for moderate-to-severe asthma
This study tests an investigational medicine called PF-07275315 for people with moderate-to-severe asthma that is not well controlled with current treatments. The goal is to see if it can reduce asthma attacks and improve breathing.
Mobile, AlabamaAges 18–75 - NCT06323213RecruitingPhase 3
Testing a new asthma medicine for severe asthma
This study tests an experimental drug called 610 for people with severe asthma that is not well-controlled with standard medicines. The goal is to see if adding 610 can improve asthma control and reduce flare-ups.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06023589RecruitingPhase 3
Testing tezepelumab for kids with severe asthma
This study tests if tezepelumab can help reduce severe asthma attacks in children ages 5 to 11. It compares the drug to a placebo (a dummy treatment) to see if it is safe and effective.
Montgomery, AlabamaAges 5–11 - NCT04743791RecruitingPhase 4
Dupilumab study for clearing mucus in moderate to severe asthma
This study tests whether dupilumab improves how well mucus is cleared from the airways in adults with moderate to severe asthma. It may help find better ways to reduce mucus-related breathing problems in people with a specific asthma type.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07403487RecruitingPhase 2
Study of RC1416 injection for moderate-to-severe asthma
This study tests a new injected medicine, RC1416, for people with moderate-to-severe asthma that is not well controlled with their current inhalers. It aims to see if the treatment can reduce asthma attacks and improve breathing.
Anqing, AnhuiAges 18–75 - NCT07343661Enrolling by invitationPhase 4
Mepolizumab study for asthma or EGPA
This trial tests how well mepolizumab works for people with asthma or a related condition called EGPA, and looks for markers in the blood that may predict organ damage or treatment response.
Cagliari, CagliariAges 18 years+ - NCT07241117RecruitingPhase 4
Community health center asthma support study
This study tests a new way to help manage asthma in community health centers. If you have moderate to severe asthma, you may be able to join and get extra support to improve your asthma control.
St Louis, MissouriAges 12 years+ - NCT00576069Recruiting
Study airflow limits in moderate asthma
This trial looks at why airflow is limited in people with moderate-to-severe persistent asthma who are already on stable treatment. It may help researchers better understand what drives breathing trouble and how to target it.
Lakewood, CaliforniaAges 10–95 - NCT07098403RecruitingPhase 3
Study of SHR-1905 for severe uncontrolled asthma
This trial tests an experimental drug called SHR-1905 for people with severe asthma that is not well controlled by their current treatments. The study aims to see if the drug can reduce asthma attacks and improve breathing.
Guangzhou, GuangdongAges 18 years+ - NCT07709754Recruiting
Lung stimulation for hard-to-control asthma
This trial tests a device that stimulates the lung to help people whose asthma is not controlled by standard treatments. It may offer a new option for those who still have symptoms despite using inhalers or biologic medicines.
Denver, ColoradoAges 18–75
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Common questions
- Are there clinical trials for severe asthma?
- Yes. Clin2 currently lists 69 recruiting severe asthma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe asthma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe asthma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.