Clinical trials
Targeted Therapy clinical trials
Below are recruiting targeted therapy clinical trials, each written for real people, not researchers. We’re tracking 292 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06484790RecruitingPhase 1
Engineered T cell therapy for KRAS-mutated advanced solid tumors
This trial tests a personalized T cell therapy designed to target specific KRAS mutations (G12V or G12D) in people with advanced solid tumors who have no standard treatment options left. The treatment involves collecting your own immune cells, engineering them to recognize and attack cancer cells with these mutations, and then infusing them back into you.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT06475989RecruitingPhase 3
Targeted therapy vs. chemotherapy for thyroid cancer
This trial compares a targeted therapy pill combination (dabrafenib and trametinib) with cabozantinib or chemotherapy for people with a specific type of advanced thyroid cancer (differentiated thyroid cancer) that has a BRAF V600E mutation. It aims to find which treatment works better after previous treatments have stopped working.
Anchorage, AlaskaAges 18 years+ - NCT06228599Recruiting
Targeted therapy for pancreatic cancer with high risk of return
This trial tests if personalized medicines, chosen based on the genetic profile of your tumor, can help prevent pancreatic cancer from coming back after surgery. It is for people who have had their pancreatic tumor removed but have features that suggest a higher chance of recurrence.
Milwaukee, WisconsinAges 18 years+ - NCT06174220RecruitingPhase 2
Tideglusib for genetic arrhythmogenic cardiomyopathy
This trial tests a medication called tideglusib to see if it can reduce extra heartbeats in people with a genetic form of arrhythmogenic cardiomyopathy. It may help stabilize the heart's rhythm and slow disease progression.
Calgary, AlbertaAges 18 years+ - NCT05024929Recruiting
Test targeted drugs to help radioactive iodine reach thyroid cancer
This study looks at whether certain cancer “targeted therapy” medicines can make radioactive iodine (RAI) therapy work better for thyroid cancer that has spread to the lungs. It also involves taking special whole-body scans to measure how much radioactive iodine gets taken up by the cancer.
San Francisco, CaliforniaAges birth+ - NCT05983159RecruitingPhase 2
Targeted therapy for slow-flow or fast-flow vascular malformations
This trial tests two targeted medicines for people with certain types of vascular malformations (abnormal blood vessels). If you have a slow-flow malformation, you may receive alpelisib; if you have a fast-flow malformation, you may receive mirdametinib. Genetic testing is needed to see if your malformation has a specific change that these drugs target.
Parkville, VictoriaAges 2 years+ - NCT04900935Recruiting
Survivorship and palliative care planning for metastatic lung cancer
This study tests a more patient-centered way to plan survivorship care and comfort (palliative) care for people with metastatic lung cancer. It may help you get support that matches your goals, especially alongside your current targeted treatment.
Boston, MassachusettsAges 18 years+ - NCT05678933Enrolling by invitationPhase 3
Test adding a targeted drug to CHOP for untreated PTCL
This Phase 3 study compares two chemo options—CHOP alone versus CHOP plus AC—for people whose peripheral T-cell lymphoma is the “T-follicular helper” type (PTCL-TFH). The goal is to see which treatment works better for people who have not received lymphoma treatment yet.
Tianjin, Tianjin MunicipalityAges 18–70 - NCT05564377RecruitingPhase 2
Find targeted cancer treatments using genetic testing
This study matches people with advanced solid tumors to targeted treatment plans based on genetic testing. It also requires tumor sample testing to help doctors choose the most promising therapy for your specific tumor changes.
Birmingham, AlabamaAges Any age - NCT05522660RecruitingPhase 3
Immunotherapy or targeted therapy with focused brain radiation
This Phase 3 study tests whether immunotherapy or targeted medicine, with or without a one-time focused brain radiation procedure, can control brain metastases from melanoma or non-small cell lung cancer. It mainly enrolls people who have no (or minimal) brain symptoms and are newly diagnosed in the brain (except for certain recent brain surgery).
NaplesAges 18 years+ - NCT05482893RecruitingPhase 1/Phase 2
Study of spevatamig for advanced gastrointestinal cancers
This trial tests a new drug called spevatamig (PT886) alone or with other treatments for advanced stomach, gastric, pancreatic, bile duct, or colorectal cancers. The goal is to see if it helps slow or stop cancer growth.
Duarte, CaliforniaAges 18 years+ - NCT05443087Recruiting
Checking blood levels of targeted drugs for digestive cancers
This trial monitors how your prescribed targeted cancer medicine moves through your body by doing extra blood tests. The goal is to understand the drug’s levels and dosing in people with advanced digestive cancers, so treatment can be better managed.
AmiensAges 18 years+ - NCT05142800Recruiting
Screening for Lymphedema in Breast Cancer Targeted Therapy
This study is looking at whether targeted therapy for breast cancer changes the risk of arm swelling (lymphedema). It is a screening trial that uses a machine to measure arm size and check for any swelling early on.
Boston, MassachusettsAges 18–80 - NCT05130138Recruiting
Medication review for drug interactions in chronic myeloid leukemia
This study looks at how your current leukemia medicines and herbal or plant-based products may interact, and how that could affect outcomes in chronic myeloid leukemia. It may help doctors better understand which drug combinations are safest and most effective.
Saint-EtienneAges 18 years+ - NCT04929223RecruitingPhase 1
Targeted drug study for metastatic colon or rectal cancer
This Phase 1 study tests targeted cancer treatments in people with metastatic colorectal cancer, using genetic “biomarker” results to match you to the right treatment group. It focuses first on safety, and also looks for early signs the treatment may work in specific tumor subgroups.
Birmingham, AlabamaAges 18 years+ - NCT04821843RecruitingPhase 3
Study before-surgery treatments for esophageal cancer
This Phase 3 trial compares different “treatments before surgery” for people with esophageal (or esophagus-to-stomach) cancer. It aims to see which approach works better to control the cancer and improve outcomes after surgery.
BeijingAges 18 years+ - NCT04821778RecruitingPhase 3
Testing chemoradiotherapy for esophageal and stomach junction cancer
This Phase 3 study tests a cancer treatment plan that combines chemotherapy and radiation for people with esophageal or esophagus-stomach junction cancer. It aims to see whether this approach works better than standard care for cancers at stages I to IVA.
Anyang, HenanAges 18 years+ - NCT04374305RecruitingPhase 2
Study tests targeted treatments for NF2 tumors
This trial studies targeted medicines in people with neurofibromatosis type 2 (NF2) who have growing tumors on scans. The goal is to slow tumor growth and improve symptoms by testing different drug combinations in separate study groups.
Los Angeles, CaliforniaAges 12 years+ - NCT03321045RecruitingEarly Phase 1
PET scan to predict benefit from HER2-targeted breast cancer therapy
This early-phase study uses a special PET scan with a drug tagged for imaging to predict how well HER2-targeted treatments will work. It may help doctors choose the most effective therapy for HER2-positive breast cancer.
Birmingham, AlabamaAges 18 years+ - NCT03089554RecruitingPhase 2
Genetic tumor testing to guide targeted cancer treatments
This trial studies how doing genetic (DNA) testing on your cancer helps doctors choose targeted treatments, and how those treatments affect outcomes. It is for adults whose cancer has not responded to the first standard treatment or who do not have curative options.
Lexington, KentuckyAges 18 years+ - NCT07627334Recruiting
Personalized drug testing for newly diagnosed brain tumors
This trial tests whether customized drug screening on your tumor cells can help doctors choose the best treatment for you. Your tumor cells will be grown in the lab and tested against different drugs to find what works best, combined with short-course radiation therapy.
Vienna, State of ViennaAges Any age - NCT07000253RecruitingPhase 2
Timing of local treatment for limited metastatic stomach or esophageal cancer
This trial tests whether giving local treatments (like surgery or radiation) to cancer spots later—after starting immunotherapy or targeted therapy—helps people with stomach or esophageal cancer that has spread to a few places. It aims to improve outcomes by timing treatments carefully.
AmsterdamAges 18 years+ - NCT07359105Recruiting
Statin vs. LDL Goal Therapy for Older Adults with Diabetes
This trial compares two approaches to lower cholesterol in people aged 70+ with type 2 diabetes: a moderate statin dose versus adjusting treatment to reach a personalized LDL-C target. It aims to find which strategy better prevents heart problems.
SeoulAges 70 years+ - NCT06753981Recruiting
Triple drug therapy for new PAH patients
This trial tests whether a combination of three medications works well and is safe for people newly diagnosed with pulmonary arterial hypertension (PAH) that is not low-risk. It aims to see if starting with triple therapy early can improve outcomes.
Jinan, ShandongAges 18–80
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Common questions
- Are there clinical trials for targeted therapy?
- Yes. Clin2 currently lists 292 recruiting targeted therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a targeted therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a targeted therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.