Clinical trials
Temporomandibular Disorder clinical trials
Below are recruiting temporomandibular disorder clinical trials, each written for real people, not researchers. We’re tracking 75 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07514208Enrolling by invitation
Headache Sensitivity and Pain Testing Study
This study examines how sensitive the skin and tissues around the head are in people with migraines or tension headaches. Researchers will perform gentle touch and pressure tests to understand pain patterns, which may help improve headache treatment in the future.
Barcelona, BarcelonaAges 18 years+ - NCT03991728Recruiting
TMJ implant registry for adults with a new jaw joint replacement
This registry is for adults getting an artificial (alloplastic) full replacement of the jaw joint (TMJ). It collects real-world information about your implant and care to help improve future outcomes.
São PauloAges 18 years+ - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT05710952Recruiting
Orthodontic braces study and how they affect jaw joints
This study looks at whether multi-attachment orthodontic treatment (either on the front or back of teeth) changes the temporomandibular joint, which is the jaw joint. The researchers will assess your jaw joint using a tool called Modjaw.
MontpellierAges 18 years+ - NCT06760884Recruiting
Pregnancy and jaw function study
This study looks at jaw joint function, oral habits, and pain in pregnant and non-pregnant women. It aims to understand how pregnancy might affect these issues.
TrabzonAges 18–45 - NCT07090772Enrolling by invitation
Comparing jaw position methods for splint therapy in TMJ disc displacement
This trial tests different ways to determine the best jaw position for a mouth splint used to treat a specific type of temporomandibular joint (TMJ) problem where the disc is out of place and doesn't go back. The goal is to see which method works better for reducing pain and improving jaw function.
Fuzhou, FujianAges 13–50 - NCT05676827Enrolling by invitation
Study pain and stress in people with long-term jaw muscle pain
This trial looks at how long-lasting jaw (masticatory) muscle pain relates to the nervous system and emotional stress. It may help researchers understand why symptoms persist and guide future treatments.
WroclawAges 18–80 - NCT07203456Recruiting
Teaching dental students about jaw pain
This trial tests different ways to teach dental students about temporomandibular disorders (jaw pain conditions). It aims to find the best teaching method so future dentists can better help patients with jaw pain.
Downers Grove, IllinoisAges 18 years+ - NCT05916235Recruiting
Laser light treatment for jaw pain from TMJ disorder
This trial tests whether a specific type of light therapy (called photobiomodulation/laser) can reduce pain from temporomandibular disorder (TMJ) affecting the jaw muscles. If you have jaw muscle pain for at least 3 months, the study will compare your symptoms while you follow the treatment and diary requirements.
Gainesville, FloridaAges 18–99 - NCT07351812Recruiting
Two treatments for jaw muscle pain
This study compares two different treatments for people who have pain in their jaw muscles (not the joint itself). It aims to find which treatment works better for muscle-related temporomandibular disorders (TMD).
AlexandriaAges 18–45 - NCT05720065RecruitingPhase 2
Testing botulinum toxin A for jaw muscle pain
This trial studies whether botulinum toxin A (a type of muscle-relaxing medicine) can reduce jaw muscle pain and help explain why it happens. It focuses on people with specific jaw muscle pain patterns and tests outcomes after injection/biopsy.
Huddinge, Stockholm CountyAges 20–45 - NCT07511959Enrolling by invitation
Blood-derived treatment for chronic jaw pain
This trial tests whether a treatment made from your own blood (platelet-rich plasma exosomes) can help relieve long-term jaw joint pain and improve function. If you qualify, you would receive injections directly into your jaw area.
WroclawAges 18 years+ - NCT05232604Recruiting
Exercise vs local pain exercises for jaw and neck pain
This study compares two types of treatment: aerobic exercise versus exercises aimed at the painful jaw/neck area. It may help people with long-term jaw and neck pain by testing which approach improves pain and function.
Osnabrück, Lower SaxonyAges 18–60 - NCT06214923Recruiting
Virtual reality for jaw pain caused by TMD
This study tests whether immersive virtual reality can reduce chronic jaw pain from Temporomandibular Disorder (TMD). It uses EEG to see how VR affects brain activity related to pain.
Baltimore, MarylandAges 18–88 - NCT06357702Recruiting
Physical Self-Regulation vs Placebo for Chronic Jaw Pain
This study tests whether a physical self-regulation treatment (like relaxation or biofeedback) can help reduce chronic jaw muscle pain. It compares the treatment to a placebo (inactive) version to see if it works better.
Lexington, KentuckyAges 18 years+ - NCT06617494Recruiting
Study of pain control in chronic jaw pain
This study looks at how well the body's natural pain control system works in people with long-term jaw pain (TMD). It compares people with and without jaw pain to better understand why some have trouble turning off pain signals.
Minneapolis, MinnesotaAges 18–74 - NCT06659991RecruitingEarly Phase 1
Pain and daily tasks in jaw joint disorder
This study tests how pain from a jaw joint disorder (TMD) affects your ability to do daily tasks. You'll track your pain and activities on your smartphone to help researchers understand the link.
Minneapolis, MinnesotaAges 21–65 - NCT06941636RecruitingPhase 3
Botox for jaw muscle pain from TMD
This trial tests whether Botox injections can reduce jaw and face muscle pain in people with temporomandibular disorders (TMD). It is for those who have had moderate to severe pain for at least 3 months and have not received Botox recently.
StockholmAges 18–50 - NCT07022795Recruiting
Controlling oral habits for jaw pain relief
This trial tests behavioral techniques to help reduce harmful oral habits like teeth clenching or jaw tension, which can cause jaw pain and disorders. If you often clench or grind, this study may help you learn new habits to ease discomfort.
Toronto, OntarioAges 18 years+ - NCT07433725Recruiting
Comparing 3D-printed vs. standard splints for teeth grinding and jaw pain
This trial compares a new 3D-printed splint with a standard acrylic splint for treating teeth grinding (bruxism) and jaw joint problems. Participants wear the splint at night for 3 months to see which type works better.
AnkaraAges 18–25 - NCT07445516Recruiting
Bite adjustment for TMD: long-term follow-up
This trial follows up with people who previously had a dental bite adjustment (occlusal equilibration) for TMD (jaw or face muscle/joint pain). It compares their long-term results with a group that received a 'sham' (fake) procedure.
Santiago de Compostela, A CoruñaAges 18–85 - NCT07517172Recruiting
Brain Stimulation Patch for Jaw Pain: Home Treatment Study
This study tests whether a small, stick-on electrical patch placed on your ear can reduce temporomandibular disorder (TMD) jaw pain when used at home. You would apply the patch yourself and complete surveys about your pain to help researchers learn if this non-invasive approach is safe and feasible.
Minneapolis, MinnesotaAges 18–65 - NCT07345351Enrolling by invitation
Pilates vs. lifestyle advice for jaw muscle pain
This study compares two non-drug treatments for jaw muscle pain: clinical Pilates vs. lifestyle counseling. It aims to see which approach better reduces pain and improves jaw function in women.
Antakya, HatayAges 18–45 - NCT06070558Recruiting
Study of normal and abnormal jaw joint motion using real-time MRI
This study uses real-time MRI to take detailed images of your jaw joint (the temporomandibular joint) to better understand its normal and painful variations. It may help if you have jaw pain or clicking, but you don't need to have a problem to join.
NancyAges 18 years+
Hear when a new Temporomandibular Disorder trial opens
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Common questions
- Are there clinical trials for temporomandibular disorder?
- Yes. Clin2 currently lists 75 recruiting temporomandibular disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a temporomandibular disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a temporomandibular disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Temporomandibular Disorders (TMD)
- Temporomandibular Joint Disorders
- Temporomandibular Disorders (TMDs)
- Temporomandibular Joint Dysfunction
- Temporomandibular Joint Dysfunction Syndrome
- Temporomandibular Dysfunction (TMD)
- Temporomandibular Joint Disc Displacement, Without Reduction
- Temporomandibular Joint and Muscle Disorder
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.