Clinical trials
Vagus Nerve Stimulation clinical trials
Below are recruiting vagus nerve stimulation clinical trials, each written for real people, not researchers. We’re tracking 156 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06954844Enrolling by invitation
Study of ear stimulation for weight-related health in young adults
This study tests whether a gentle electrical stimulation of the ear (tVNS) can affect how the body handles weight. It aims to understand the brain and body changes related to obesity. Participants will receive the stimulation and undergo brain scans.
BonnAges 18–40 - NCT06759818Enrolling by invitation
Vagus nerve stimulation for heart protection after lung surgery in older adults
This trial tests if a gentle ear stimulation device can protect the heart after lung surgery in patients aged 60 and older. It is for those having a planned lung procedure (lobectomy, segmentectomy, or wedge resection) through small chest incisions.
Jiaxing, ZhejiangAges 60 years+ - NCT06642454Enrolling by invitation
Breathing-guided nerve stimulation for Parkinson's disease
This study tests a type of nerve stimulation (vagus nerve) for Parkinson's disease. It compares a method that uses your breathing cycle to deliver stimulation versus standard stimulation. The goal is to see which works better for movement and non-movement symptoms.
Hefei, AnhuiAges 40–80 - NCT06389175Enrolling by invitation
Non-invasive ear stimulation for depression
This study uses a gentle, non-invasive device that stimulates the vagus nerve in your ear to see if it can improve how your stomach and brain communicate, which may help with depression symptoms.
BonnAges 18–55 - NCT04534556Enrolling by invitation
Wireless nerve stimulation to improve stroke recovery
This study tests a wireless nerve stimulation device placed near the vagus nerve to help people recover after a stroke. It focuses on people with specific remaining arm/hand movement and recovery levels at least 12 months after stroke.
Dallas, TexasAges 22–79 - NCT04100486Enrolling by invitation
Testing a noninvasive device to measure your body signals
This study uses a noninvasive bioelectronic device to record your body’s automatic (involuntary) signals. The goal is to see how well the device can analyze these signals and how your body responds in a controlled setting.
Manhasset, New YorkAges 18–60 - NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Birmingham, AlabamaAges 18 years+ - NCT07254390Recruiting
Vagus nerve stimulation for arm recovery after stroke
This trial tests whether gentle electrical stimulation of the vagus nerve in the ear can improve arm and hand recovery when combined with physical therapy. It is for people who had a stroke within the last 6 months and have some arm weakness but can still move their arm a little.
Montescano, PaviaAges 18 years+ - NCT07271147Recruiting
Nerve stimulation plus sedative for post-op nausea
This study tests whether combining a very mild nerve stimulation (taVNS) with a sedative (dexmedetomidine) can reduce nausea and vomiting after laparoscopic surgery. It may be a good option if you are scheduled for keyhole surgery and want to feel better afterward.
Nantong, JiangsuAges 18–65 - NCT07344402Recruiting
Optimizing ear stimulation for chronic constipation
This study tests whether mild electrical stimulation on the ear (called taVNS) can help people with difficult-to-treat constipation. It aims to find the best stimulation schedule to improve bowel movements.
Xi'anAges Any age - NCT06512194RecruitingPhase 2
Psilocybin for depression study
This trial tests whether psilocybin can help people with major depression who are currently having a depressive episode. It aims to understand how the treatment works and if it is safe and effective.
Edwards, ColoradoAges 18–70 - NCT07017257Recruiting
Ear stimulation for ongoing concussion symptoms
This study tests whether a mild electrical stimulation on the ear (like a gentle pulse) can help people who still have symptoms like headache, dizziness, or trouble concentrating for weeks to a year after a concussion. The goal is to see if it helps the brain recover faster.
Liège, LiègeAges 18–65 - NCT07191119Recruiting
Nerve stimulation for insomnia in childhood leukemia survivors
This study tests a small, wearable device that gently stimulates a nerve in your ear (called the vagus nerve) to help with insomnia. It's designed for adult survivors of childhood leukemia who still have trouble sleeping.
Memphis, TennesseeAges 20–50 - NCT03992378Recruiting
Nerve stimulation to calm inflammation in sepsis
This trial tests a form of nerve stimulation to help control the body’s overactive inflammation and “autonomic” nervous system imbalance during sepsis. It may help stabilize blood pressure and reduce complications, depending on the cause of your symptoms.
Oklahoma City, OklahomaAges 18 years+ - NCT05103566Recruiting
Noninvasive vagus nerve stimulation for ruptured brain aneurysm bleed
This trial studies whether a noninvasive device that stimulates the vagus nerve can be safely given soon after a ruptured aneurysm bleed to improve outcomes. It may help calm the brain’s stress response after this type of stroke-like emergency.
Boston, MassachusettsAges 18–85 - NCT05321355Recruiting
Sleep disorder patient registry for narcolepsy and other conditions
This is a research registry that collects information from people with narcolepsy and other neurological sleep disorders. It may help doctors better understand sleep problems and improve future care.
Mainz, Rhineland-PalatinateAges 18–120 - NCT05469607Recruiting
Tested a device to treat Crohn’s after bowel surgery
This study looks at using a new neurotechnology-based approach (a technology that talks to the nervous system) for people with Crohn’s disease after they’ve had bowel surgery. It’s meant for patients whose new surgical connection (an anastomosis) looks normal on scope and is reachable by colonoscopy.
Melbourne, VictoriaAges 18–80 - NCT05554172Recruiting
Non-invasive vagus nerve stimulation during refeeding for low weight
This study tests whether a painless device that stimulates the vagus nerve can help teens who are underweight and working on refeeding (a structured nutrition plan). It aims to see if this treatment improves outcomes while you’re gaining weight.
New York, New YorkAges 14–22 - NCT05583942Recruiting
Nerve stimulation trial for children with steroid-resistant kidney syndrome
This pilot study tests a device that stimulates nerves in the ear to help children with steroid-resistant nephrotic syndrome. It may improve urine protein and kidney-related outcomes for kids whose standard steroid treatment does not work.
New Hyde Park, New YorkAges 3–17 - NCT05588063Recruiting
Device-based nerve stimulation for relapse-preventing kidney disease in kids
This trial tests whether a small non-surgical device can help keep children with steroid-sensitive nephrotic syndrome in remission. If it works, it could lower the chance of relapse (kidney flare-ups) and help maintain kidney health.
New Hyde Park, New YorkAges 3–17 - NCT06170645Recruiting
Vagus nerve stimulation for fatigue in fibromyalgia or long COVID
This trial tests whether a gentle electrical stimulation device on the ear (vagus nerve) can help reduce fatigue when combined with exercise. It is for people with fibromyalgia or long COVID who still feel exhausted after a rehab program.
Saint-EtienneAges 18 years+ - NCT06226493Recruiting
Vagus Nerve Stimulation for Stroke Recovery
This early-stage study tests if putting a mild electrical pulse on the vagus nerve (a nerve in the neck) can help the brain heal after a first-time stroke. It looks for changes in brain activity and certain DNA markers to understand how the treatment works.
Pomona, CaliforniaAges 18–80 - NCT06277063Recruiting
Nerve-stimulation device for headache in children and young adults
This trial tests if a gentle nerve-stimulating device worn on the neck (called nVNS) can prevent and treat common headaches like migraine, cluster, and tension-type headaches in children and young adults. If you often get headaches and want a drug-free option, this might help.
Guangzhou, GuangdongAges 7–20 - NCT06308484Recruiting
Mindfulness and brain stimulation for alcohol recovery
This trial tests if combining a non-invasive brain stimulation technique (like a mild electrical current) with mindfulness training can help people with alcohol dependence stay sober. If you recently stopped drinking and meet the health requirements, you may be able to join.
Berlin, State of BerlinAges 18–70
Hear when a new Vagus Nerve Stimulation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for vagus nerve stimulation?
- Yes. Clin2 currently lists 156 recruiting vagus nerve stimulation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a vagus nerve stimulation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a vagus nerve stimulation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.