Clinical trials
Vagus Nerve Stimulation clinical trials
Below are recruiting vagus nerve stimulation clinical trials, each written for real people, not researchers. We’re tracking 155 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05272488Recruiting
Manual therapy plus vagus nerve stimulation for jaw muscle pain
This trial tests whether combining hands-on jaw treatment with a vagus nerve stimulator can reduce jaw muscle pain and improve jaw movement. It may help people whose jaw pain has been present recently and who have not had recent physiotherapy.
Alcalá de Henares, MadridAges 18 years+ - NCT04557618Recruiting
Ear nerve stimulation after a brain bleed
This trial studies whether stimulating a nerve near the ear (auricular VNS) can help after a spontaneous subarachnoid hemorrhage, a type of bleeding around the brain. If you qualify, you may receive the ear stimulation as an added treatment while doctors monitor your recovery.
St Louis, MissouriAges 18 years+ - NCT05090267Recruiting
Gut-brain treatments for alcohol use and memory changes
This study tests whether gut-brain–targeted treatments (including probiotics and stimulation of a nerve) can improve thinking and inflammation-related health in people who use alcohol. You may be able to join if you have memory/thinking problems and meet specific medical limits, including HIV immune system levels.
Coral Gables, FloridaAges 35–70 - NCT04534556Enrolling by invitation
Wireless nerve stimulation to improve stroke recovery
This study tests a wireless nerve stimulation device placed near the vagus nerve to help people recover after a stroke. It focuses on people with specific remaining arm/hand movement and recovery levels at least 12 months after stroke.
Dallas, TexasAges 22–79 - NCT04100486Enrolling by invitation
Testing a noninvasive device to measure your body signals
This study uses a noninvasive bioelectronic device to record your body’s automatic (involuntary) signals. The goal is to see how well the device can analyze these signals and how your body responds in a controlled setting.
Manhasset, New YorkAges 18–60 - NCT03887715Recruiting
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Birmingham, AlabamaAges 18 years+ - NCT07254390Recruiting
Vagus nerve stimulation for arm recovery after stroke
This trial tests whether gentle electrical stimulation of the vagus nerve in the ear can improve arm and hand recovery when combined with physical therapy. It is for people who had a stroke within the last 6 months and have some arm weakness but can still move their arm a little.
Montescano, PaviaAges 18 years+ - NCT05321355Recruiting
Sleep disorder patient registry for narcolepsy and other conditions
This is a research registry that collects information from people with narcolepsy and other neurological sleep disorders. It may help doctors better understand sleep problems and improve future care.
Mainz, Rhineland-PalatinateAges 18–120 - NCT05469607Recruiting
Tested a device to treat Crohn’s after bowel surgery
This study looks at using a new neurotechnology-based approach (a technology that talks to the nervous system) for people with Crohn’s disease after they’ve had bowel surgery. It’s meant for patients whose new surgical connection (an anastomosis) looks normal on scope and is reachable by colonoscopy.
Melbourne, VictoriaAges 18–80 - NCT07866183Recruiting
New approaches to fat loss for class 1 obesity
This study tests new methods to help people with mild obesity (class 1) lose fat. It aims to find more effective and safe ways to support weight loss.
MoscowAges 25–50 - NCT07813962Recruiting
Reducing PTSD risk after trauma surgery
This study tests whether a sedative medication (dexmedetomidine) plus a gentle electrical stimulation on the ear can lower the chance of developing post-traumatic stress disorder (PTSD) after emergency surgery for a serious injury. If you qualify, you will receive this treatment during your operation and be checked for PTSD symptoms for one month afterward.
Nantong, JiangsuAges 18–80 - NCT07791290Recruiting
Testing a nerve-stimulating ear device
This study is testing a device that stimulates a nerve in the ear (called the vagus nerve) using a gentle electrical pulse. It might help with certain conditions by affecting the brain and body, but the specific condition it aims to treat is not listed here.
New Hyde Park, New YorkAges 18 years+ - NCT07772401Recruiting
Ear stimulation for social anxiety disorder
This study tests whether a gentle electrical pulse through the ear can help reduce symptoms of social anxiety. It's a non-invasive treatment that may offer a new way to manage anxiety without medication.
Hangzhou, ZhejiangAges 18–70 - NCT06682689Recruiting
Nerve stimulation study for new mothers' mental health
This study tests whether a gentle nerve stimulation device (tVNS) worn on the ear can help new mothers feel better emotionally after childbirth. It is for women whose babies had normal organ scans and who do not have certain medical conditions or current mood disorders.
Tübingen, Baden-WurttembergAges 18 years+ - NCT07643337Recruiting
Vagus Nerve Stimulation With Rehab to Improve Walking After Stroke
This study tests whether vagus nerve stimulation (a small device that stimulates a nerve in your neck) combined with rehabilitation therapy can help improve walking and leg function in stroke survivors. You would be one of the first to try this combination approach for stroke recovery.
Buffalo, New YorkAges 22–80 - NCT07596030Recruiting
Self-applied ear stimulation for nerve pain after chemo
This trial tests a small device you wear on your ear to see if it can reduce nerve pain caused by chemotherapy (CIPN). You use it yourself at home, and it may help with the tingling, numbness, or burning in your hands and feet.
Coral Gables, FloridaAges 18–80 - NCT06720571Recruiting
Nerve stimulation for emotion and thinking in Prader-Willi syndrome
This trial tests whether a gentle, non-invasive nerve stimulation (like a small device on the neck) can help people with Prader-Willi syndrome regulate emotions and improve planning and focus. It may be a new option if you have trouble with emotional control or daily organization.
BordeauxAges 18 years+ - NCT07557706RecruitingPhase 1
Vagus Nerve Stimulation to Improve Heart Function in Parkinson's Disease
This study tests a non-invasive ear-based stimulation technique (taVNS) to help regulate heart function in people with Parkinson's disease. The goal is to see if this gentle stimulation can improve blood pressure and heart rate control.
Birmingham, AlabamaAges 18–80 - NCT07425652Recruiting
Physiotherapy methods for fibromyalgia pain
This study tests different physiotherapy techniques to help women with fibromyalgia manage pain and improve daily function. It compares several hands-on therapies to find the most effective approach.
AnkaraAges 18–65 - NCT07369908Recruiting
Ear stimulation for anxiety and emotion control
This study tests whether a gentle, non-invasive electrical stimulation on the ear (called taVNS) can help lower anxiety and improve how you manage your emotions. It’s for healthy people who want to explore a potential new way to support emotional well-being.
Chengdu, SichuanAges 18–30 - NCT07368751Recruiting
Vagus nerve stimulation for frozen shoulder treatment
This trial tests if stimulating the vagus nerve can help treat frozen shoulder. It might be an option if you have had shoulder pain and stiffness for at least 3 months and have not received prior treatment for this shoulder problem.
IstanbulAges 40–65 - NCT07344402Recruiting
Optimizing ear stimulation for chronic constipation
This study tests whether mild electrical stimulation on the ear (called taVNS) can help people with difficult-to-treat constipation. It aims to find the best stimulation schedule to improve bowel movements.
Xi'anAges Any age - NCT07288411Recruiting
Vagus nerve stimulation for temporomandibular joint disorders
This study tests if a gentle device that stimulates a nerve in your neck (the vagus nerve) can reduce jaw pain and improve how your jaw moves. It could offer a new, non-drug option for people with TMJ disorders.
Los Angeles, CaliforniaAges 18–50 - NCT07271147Recruiting
Nerve stimulation plus sedative for post-op nausea
This study tests whether combining a very mild nerve stimulation (taVNS) with a sedative (dexmedetomidine) can reduce nausea and vomiting after laparoscopic surgery. It may be a good option if you are scheduled for keyhole surgery and want to feel better afterward.
Nantong, JiangsuAges 18–65
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Common questions
- Are there clinical trials for vagus nerve stimulation?
- Yes. Clin2 currently lists 155 recruiting vagus nerve stimulation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a vagus nerve stimulation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a vagus nerve stimulation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.