Clinical trials
Weight Loss clinical trials
Below are recruiting weight loss clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07124832Recruiting
Weight loss study for adults with obesity
This study tests a program to help people with obesity lose weight. It looks at how well the program works and if it is safe for participants.
ManisaAges 18–65 - NCT07092618RecruitingPhase 2/Phase 3
Trial for keeping weight off after stopping GLP-1 meds
This study tests if other medicines (naltrexone, metformin, or rapamycin) can help people keep off weight they lost while taking GLP-1 drugs like Wegovy or Ozempic, after they stop taking them. It is for AgelessRx patients aged 40 to 85 who have lost at least 15 pounds on GLP-1s.
Chicago, IllinoisAges 40–85 - NCT07095543Recruiting
Plant-based weight loss through online program
This study tests an online weight loss program based on a plant-based diet. You may be able to join if you live in the U.S., are overweight, can travel to Washington DC for a body scan, and are not using weight loss medications.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07082608Recruiting
Weight loss procedure plus lifestyle changes for sleep apnea
This study tests whether a stomach procedure called endoscopic sleeve gastroplasty (ESG) plus lifestyle changes helps people with sleep apnea lose more weight and improve their breathing compared to lifestyle changes alone. If you have moderate to severe sleep apnea and have struggled to lose weight, this may be an option.
Hyderabad, TelanganaAges 18 years+ - NCT07065643Recruiting
Calorie restriction study for healthy overweight adults
This study looks at how sex hormones affect the benefits of a low-calorie diet in men and women of different ages. If you are a healthy overweight adult, the study may help understand how hormones and age influence weight loss results.
AberdeenAges 18–65 - NCT07059104Recruiting
Breast reconstruction after weight loss surgery study
This study looks at how breast reconstruction with implants works for women who have had major weight loss surgery. It uses national health registries to track outcomes and help doctors and patients make better choices.
GothenburgAges Any age - NCT06988150Recruiting
SIBO and weight loss in pancreatic cancer
This study looks at whether a condition called SIBO (too many bacteria in the small intestine) is linked to weight loss in people with pancreatic cancer. You might join if you have pancreatic cancer and have lost weight recently.
Los Angeles, CaliforniaAges 18 years+ - NCT06989437RecruitingPhase 2/Phase 3
Study of Ponsegromab for Pancreatic Cancer with Weight Loss
This study tests an experimental drug called ponsegromab for people with advanced pancreatic cancer who experience severe weight loss and fatigue. It aims to see if the drug can help improve weight and energy levels while you continue standard chemotherapy.
Birmingham, AlabamaAges 18 years+ - NCT06948825RecruitingPhase 2
Lifestyle program vs. metformin for mothers after gestational diabetes
This study compares a lifestyle program (diet and exercise) with the medication metformin to see which better helps mothers who recently had gestational diabetes improve their health. You may be eligible if you had a single baby, are between 8 weeks and 12 months postpartum, and have a BMI of 25 to 45.
Washington D.C., District of ColumbiaAges 18–45 - NCT06930495Enrolling by invitation
Weight loss and heart failure with normal pumping strength
This study tests whether weight loss treatments can improve muscle and blood vessel function in people with a specific type of heart failure (HFpEF) who also have obesity. It may help if you have heart failure with a normal ejection fraction and a high BMI.
Dallas, TexasAges 18 years+ - NCT06928571Enrolling by invitation
Online tools for weight loss support
This study tests if using online tools can help people lose weight. You will work with your primary care doctor and use a scale and website to track your progress.
Gainesville, FloridaAges 18 years+ - NCT06913712Recruiting
BMI and treatment response in IIH
This study looks at how body weight (BMI) affects how well people with Idiopathic Intracranial Hypertension (IIH) respond to treatment. It may help doctors understand if weight influences symptom relief.
Valencia, ValenciaAges 18 years+ - NCT06862375Recruiting
Mayo Clinic diet for weight loss study
This trial tests if following the Mayo Clinic Diet helps adults with overweight or obesity lose weight. You would use the diet book and app and get support from the study team.
Rochester, MinnesotaAges 18–64 - NCT06852391RecruitingPhase 4
Weight loss program with or without semaglutide for teens with obesity
This trial studies how the body adapts to weight loss in teens with obesity. You will either get a behavioral lifestyle program alone or with a weight loss medication called semaglutide.
Hamilton, OntarioAges 12–17 - NCT06843512Recruiting
How GLP-1 meds change eating habits
This study looks at how starting a GLP-1 medication (like Wegovy or Ozempic) changes your food choices and eating habits. It may help you understand if these medicines work for weight loss.
State College, PennsylvaniaAges 18 years+ - NCT06811324RecruitingPhase 2
Tirzepatide for muscle and vessel health in older adults
This study tests if the drug tirzepatide can improve muscle and blood vessel health in older adults with obesity. You may be eligible if you are 50 or older, have a BMI between 30 and 40, and do not have diabetes.
San Antonio, TexasAges 50 years+ - NCT06759701RecruitingEarly Phase 1
Weight loss drug before prostate cancer surgery pilot study
This study tests if taking tirzepatide (a weight loss medicine) before prostate removal surgery is safe and helpful for overweight men with intermediate-risk prostate cancer. It aims to see if losing weight can improve surgery outcomes.
Houston, TexasAges 18 years+ - NCT06751589RecruitingEarly Phase 1
Weight loss drug study for people with endometrial cancer
This study tests if adding a weight loss medication (tirzepatide or semaglutide) during chemotherapy helps people with early-stage endometrial cancer who are overweight or have diabetes. It aims to see if weight loss can improve treatment outcomes.
Basking Ridge, New JerseyAges 18 years+ - NCT06736028Recruiting
Ketogenic diet for weight loss maintenance in obesity
This study tests whether a ketogenic diet helps people with obesity keep weight off by changing how your body burns energy and controls appetite. You will follow a low-carb, high-fat diet and be monitored for several months.
Birmingham, AlabamaAges 18–65 - NCT06717334Recruiting
Lung cancer screening for people with unexplained weight loss
This study looks at using low-dose CT scans to check for lung cancer in people who have lost some weight without a clear reason. The goal is to see if screening can find lung cancer early in this group.
Basking Ridge, New JerseyAges 50–80 - NCT04320264Recruiting
Study tests muscle fuel patterns in adults with BMI 25–30
This study looks at how your muscles use fuel during exercise by measuring blood lactate. It may help researchers understand “metabolic inflexibility” and why some people rely more on fast, short-lasting energy during activity.
Greenville, North CarolinaAges 18–50 - NCT06706284RecruitingPhase 4
GLP-1 agonist for diabetes after spinal cord injury
This trial tests whether a GLP-1 agonist (a type of diabetes medicine that also helps with weight loss) is safe and effective for people with spinal cord injury and type 2 diabetes who are not on other glucose-lowering drugs.
San Antonio, TexasAges 18–70 - NCT06681246Recruiting
How gut bacteria affect weight regain after weight loss
This study looks at how the natural bacteria in your gut (the microbiome) might be linked to regaining weight after losing it. It tests whether a short course of antibiotics or a placebo (a sugar pill) affects this process. The goal is to find new ways to help people keep weight off long-term.
RehovotAges 18–65 - NCT06658912Recruiting
Weight loss program for breast cancer survivors
This study tests a weight loss program designed specifically for women who have finished breast cancer treatment. It aims to help improve overall health after cancer.
Durham, North CarolinaAges 21–90
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Common questions
- Are there clinical trials for weight loss?
- Yes. Clin2 currently lists 181 recruiting weight loss studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a weight loss trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a weight loss trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.