Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,067 recruiting studies in this area right now.
By phase
- Not applicable3,005
- Phase 21,060
- Phase 1794
- Phase 1/Phase 2441
- Phase 3435
- Phase 4233
- Phase 2/Phase 399
Top conditions
- Multiple Sclerosis330
- Multiple Myeloma328
- Asthma194
- Lymphoma179
- Type 1 Diabetes132
- Rheumatoid Arthritis131
- Atopic Dermatitis122
- Systemic Lupus Erythematosus121
- Acute Lymphoblastic Leukemia118
- HIV Infections105
- Chronic Lymphocytic Leukemia96
- Autoimmune Diseases79
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)68
- Hodgkin Lymphoma64
- Diabetes Mellitus, Type 163
- Leukemia63
- Type 1 Diabetes Mellitus63
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca64
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- Mayo Clinic50
- City of Hope Medical Center49
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California498
- Maryland198
- Alabama178
- Florida151
- Arizona150
- Massachusetts118
- New York114
- Texas112
- Illinois84
- Colorado81
Recruiting studies6,067 total
- NCT04232085RecruitingPhase 2
Stem cell transplant to rebuild immunity in genetic immune disorders
This Phase 2 trial tests a stem cell (bone marrow) transplant approach to restore bone marrow function and immune function in people with certain inherited immune problems. If you have one of these conditions and a suitable donor, the study may offer a path to rebuild blood and immune systems.
Baltimore, MarylandAges 4 months–50 years - NCT05826535RecruitingPhase 1/Phase 2
Test of CAR T-cell therapy for aggressive B-cell lymphoma
This Phase 1/2 study tests a lab-made immune cell treatment (CAR T cells) made from your own blood cells to treat aggressive large B-cell lymphoma that has come back or didn’t respond. If you qualify, the goal is to see whether this treatment is safe and can shrink lymphoma.
Irvine, CaliforniaAges 18 years+ - NCT05828511RecruitingPhase 1/Phase 2
Study drug for newly diagnosed myeloma before standard treatment
This trial tests linvoseltamab (a new targeted immune treatment) to see if it’s safe and how well it works in adults with recently diagnosed multiple myeloma who haven’t started treatment yet. Because it’s a “window of opportunity” study, it’s meant to learn early results before standard therapy is fully underway.
Los Angeles, CaliforniaAges 18 years+ - NCT05833724RecruitingPhase 2
Chidamide for relapsed or resistant peripheral T-cell lymphoma
This trial tests chidamide (a targeted medicine that affects how cells manage gene activity) in people whose peripheral T-cell lymphoma has come back or did not respond to treatment. It may help shrink measurable tumors and control the disease after prior therapies.
Kaohsiung CityAges 20–75 - NCT05835310RecruitingPhase 3
IV anifrolumab for active lupus in children
This study tests whether an intravenous medicine called anifrolumab can safely improve active systemic lupus (SLE) in children. If you qualify, you may receive the study treatment and be closely monitored for safety and lupus symptoms.
Phoenix, ArizonaAges 5–17 - NCT03792659Recruiting
Myasthenia gravis registry for storing your health data
This trial is a registry that collects your clinical information and biological samples to help researchers better understand myasthenia gravis. You may benefit indirectly by helping studies that could improve future care for people with this condition.
New Haven, ConnecticutAges 18 years+ - NCT05842161Recruiting
Smoking cessation program for people with HIV and TB in South Africa
This study is testing a program to help people who are living with HIV and TB to stop smoking. It aims to see if quitting smoking improves their engagement with HIV and TB care.
RondeboschAges 18 years+ - NCT05822609RecruitingPhase 2
Semaglutide for kidney disease in adults with type 1 diabetes
This Phase 2 study tests semaglutide (a diabetes and weight-related medicine) to see if it can slow or improve diabetic kidney disease in people with type 1 diabetes. You may be able to join if you have type 1 diabetes for at least 5 years and ongoing signs of kidney damage measured in urine tests.
Aurora, ColoradoAges 18 years+ - NCT05838599RecruitingEarly Phase 1
Imiquimod cream plus local radiation for skin lymphoma lesions
This early-stage study tests whether a cancer-killing cream (imiquimod) combined with targeted local radiation can shrink and control mycosis fungoides skin lesions. It may help people whose skin lymphoma has not responded to at least one prior standard treatment.
Chicago, IllinoisAges 18–90 - NCT05819008Recruiting
Online brain testing for people with neurological conditions
This trial studies how well a remote, online memory and thinking assessment works for people with neurological disorders or injuries. You may be invited if you can do the computer-based testing and speak Swedish.
UmeåAges 18 years+ - NCT05814510Recruiting
Help deliver an asthma program in schools and homes
This study tests an asthma education and management program for children, involving caregivers at home and staff at participating schools. You may be able to help by taking part in the program and supporting asthma care at home or school.
Baltimore, MarylandAges Any age - NCT05827549RecruitingPhase 2
Blinatumomab for relapsed ALL, matched by risk group
This Phase 2 study tests how well blinatumomab works for children and adults whose acute lymphoblastic leukemia (ALL) has come back. It also looks at whether results differ based on the patient’s relapse “risk group.”
DaeguAges 1–22 - NCT05833074Enrolling by invitation
Testing HIV risk again each year for male couples
This study looks at whether repeating HIV testing once a year for male couples at higher risk helps results stay on track over time. It includes couples who previously took part in an earlier study and are willing to keep participating.
Ann Arbor, MichiganAges 17–65 - NCT05819138RecruitingPhase 3
Semaglutide for heart outcomes in adults with type 1 diabetes
This trial studies whether semaglutide can improve heart and blood-vessel outcomes in people with type 1 diabetes who use an insulin pump or automated insulin delivery. It may help reduce cardiovascular risks, but you must meet several health and medication-safety requirements.
Aurora, ColoradoAges 18–49 - NCT05814432RecruitingPhase 3
High-dose antifungal for widespread Histoplasmosis in HIV
This Phase 3 trial tests whether a high-dose form of amphotericin B made in tiny fat particles (liposomal amphotericin B) is safer and more effective for treating widespread Histoplasmosis in adults with HIV. It may help people who have a serious, whole-body infection caused by Histoplasma.
Goiânia, GoiásAges 18 years+ - NCT05819528Recruiting
Study of primary cardiac lymphoma treated with anti-CD20 therapy
This trial looks at people with lymphoma that involves mainly the heart (and possibly the lining around the heart) and was treated first with chemotherapy plus an anti-CD20 antibody. The goal is to understand outcomes from this specific treatment approach in patients diagnosed over a defined time period.
Bergamo, BergamoAges 18 years+ - NCT05836896RecruitingPhase 1
Safety check of BCMA CAR T-cells made from your own immune cells
This early-phase trial tests whether a personalized BCMA-targeting CAR T-cell treatment is safe and what dose is tolerable in people whose lymphoma or myeloma has come back or did not respond to prior treatment. If you qualify, the team will monitor you closely for side effects to find the safest maximum tolerated dose.
DresdenAges 18 years+ - NCT05839210Recruiting
Diet and exercise coaching for lymphoma survivors
This study tests whether a Mediterranean-style diet and home exercise plan can improve health and recovery in people who have been treated for non-Hodgkin or Hodgkin lymphoma with chemotherapy. You may also be placed on a waitlist/control group to compare outcomes.
Miami, FloridaAges 18 years+ - NCT05841758RecruitingPhase 4
Hydroxychloroquine to reduce steroid use in sarcoidosis
This trial studies whether hydroxychloroquine can control extrapulmonary sarcoidosis (sarcoidosis outside the lungs) using less steroid treatment. It may help people who need systemic therapy for problems such as eyes, skin, bones, joints, nerves, ENT areas, or high calcium levels from sarcoidosis.
AvignonAges 18 years+ - NCT05825157Recruiting
Tested combined treatment for arm swelling after cancer
This study looks at a combination treatment to improve swelling in one arm caused by lymphedema. You may be a good candidate if your arm swelling has not fully improved with standard compression therapy and you are able to have surgery.
Palo Alto, CaliforniaAges 18–75 - NCT05820841RecruitingPhase 3
Acalabrutinib plus R-miniCHOP for untreated lymphoma in older adults
This study tests whether adding acalabrutinib to a reduced-strength chemotherapy plan (R-miniCHOP) works better and is safer for older adults with newly diagnosed diffuse large B-cell lymphoma. It may help you get a more effective treatment while using a dosing approach meant for people who may not tolerate full-strength therapy.
Homburg, SaarlandAges 61 years+ - NCT05816850Recruiting
Advanced follicular lymphoma study using your lab samples
This study looks at advanced follicular lymphoma by analyzing samples of blood and tissue (and sometimes bone marrow) you may have already provided. It may help doctors understand your lymphoma better and improve future treatments.
AlessandriaAges 18 years+ - NCT05312255Recruiting
Non-drug help to improve quality of life in myeloma
This study tests non-chemotherapy supports meant to improve quality of life and immune health for people with multiple myeloma (or related conditions). Depending on the group, it may involve activities, nutrition, and/or a medication like a beta blocker.
Buffalo, New YorkAges 18 years+ - NCT00898235Recruiting
Collecting samples and health data for amyloidosis
This study collects blood and other samples, along with health information, from people who have—or might have—amyloidosis. It aims to improve understanding of the disease and support future treatments.
Boston, MassachusettsAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,067 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,241 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.