Treatment
High Dose Chemotherapy clinical trials
We’re tracking 149 recruiting studies that include High Dose Chemotherapy, each written for real people, not researchers, below.
Recruiting studies
- NCT07628049RecruitingPhase 1/Phase 2
RSV and hMPV combination vaccine study for adults
This study tests a new vaccine that may protect against two common viruses that cause breathing problems, RSV and hMPV. It is for healthy younger adults (18-49) and older adults (60-80) to see if the vaccine is safe and works well.
Lenexa, KansasAges 18–80 - NCT06724237RecruitingPhase 3
High-dose chemo and stem cell transplant for T-cell lymphoma patients in remission
This trial tests whether high-dose chemotherapy followed by a stem cell transplant using your own cells can help people with certain types of peripheral T-cell lymphoma live longer. You would qualify if you have already finished your first round of chemotherapy and are in complete remission.
Birmingham, AlabamaAges 18–75 - NCT06686030RecruitingPhase 2
AK112 with chemo or olaparib for platinum-sensitive ovarian cancer
This trial tests a new drug called AK112 combined with chemotherapy or another drug (olaparib) for people with ovarian cancer that came back more than 6 months after platinum treatment. The goal is to see if these combinations work better than current options.
WuhanAges 18 years+ - NCT02416388RecruitingPhase 2/Phase 3
Trial for AML treatments and preventing graft-versus-host disease
This trial tests different chemotherapy induction, consolidation (follow-up treatment), and strategies to prevent complications after an allogeneic stem cell transplant. It aims to improve overall survival and reduce serious transplant side effects like graft-versus-host disease (GVHD).
AmiensAges 18–61 - NCT06275958RecruitingPhase 3
Lower starting chemo dose for older adults with metastatic colorectal cancer
This study tests whether starting with a lower dose of chemotherapy works as well as the standard dose for people aged 70 and older with metastatic colorectal cancer. The goal is to find a treatment that is effective but gentler, with fewer side effects.
's-HertogenboschAges 70 years+ - NCT06418789RecruitingPhase 2
High-dose chemo for relapsed germ cell tumors
This trial tests a second-line high-dose chemotherapy for germ cell tumors that have come back after initial treatment. It may be an option for patients whose cancer progressed after 3–4 cycles of standard platinum-based chemo.
Saint Petersburg, Russian FederationAges 18 years+ - NCT06932523RecruitingPhase 1/Phase 2
Shingles vaccine study for healthy adults
This trial tests a new shingles vaccine for healthy adults 40 and older. It aims to see if the vaccine is safe and helps protect against shingles.
Wuhan, HubeiAges 40 years+ - NCT07276880RecruitingPhase 2
Chemo, immunotherapy, and radiation for lymph node-positive triple-negative breast cancer
This trial tests a combination of chemotherapy, the immunotherapy drug pembrolizumab, and low or high-dose radiation before surgery for people with triple-negative breast cancer that has spread to the lymph nodes. The goal is to see if this approach can improve treatment outcomes.
Chapel Hill, North CarolinaAges 18 years+ - NCT03649048Recruiting
Weekly low-dose or high-dose cisplatin with radiation for head and neck cancer
This trial compares two cisplatin dosing schedules (weekly low-dose vs higher dose less often) given alongside radiation for certain head and neck cancers. It’s testing which schedule works well while keeping side effects manageable during planned, curative-intent radiation.
Hamilton, OntarioAges 18 years+ - NCT07280858RecruitingPhase 1/Phase 2
Testing a new sarbecovirus vaccine in healthy adults
This study tests a new vaccine called GBP511, designed to protect against several types of sarbecoviruses (including COVID-19). It is for healthy adults who have already received a primary COVID-19 vaccine series plus at least one booster, at least 24 weeks before joining.
Sydney, Kent StreetAges 18 years+ - NCT06830421RecruitingPhase 3
High-dose chemo with stem cell transplant vs. standard therapy for older adults with CNS lymphoma
This study compares a high-dose chemotherapy followed by your own stem cell transplant to standard chemo-immunotherapy for older adults with newly diagnosed primary CNS lymphoma. The goal is to see which approach works better and is safer for people over 70.
Freiburg im Breisgau, Baden-WurttembergAges 65 years+ - NCT04691284Recruiting
Test how the gut microbiome changes during major cancer treatment
This study looks at your gut “microbiome” (the bacteria in your intestines) while you receive high-dose chemotherapy and a stem cell transplant, or CAR-T cell therapy. Researchers hope to understand how these treatments affect the microbiome, which may relate to how well patients do.
Bratislava, SlovakiaAges 18 years+ - NCT05441813RecruitingPhase 2
Coconut oil mouth rinse to prevent mouth sores during transplant
This study tests whether a coconut oil mouth rinse can help prevent mouth sores in children and young adults who are about to receive intense chemotherapy for a stem cell transplant. If mouth sores can be prevented, it may make treatment more comfortable and reduce complications.
Charlotte, North CarolinaAges 7–26 - NCT05889585Recruiting
Life after germ cell cancer treatment side effects study
This study looks at long-term health problems and quality of life in people who survived germ cell tumors after strong chemotherapy with a stem cell transplant or other standard treatments. It may help doctors understand which late side effects are most common and how to better support survivors.
VillejuifAges 18 years+ - NCT06814405Recruiting
Early discharge program for high-dose chemo patients
This trial tests whether people with blood cancers who receive high-dose chemotherapy can safely go home earlier with a hospital-at-home program. It aims to find out if this approach is safe and feasible.
Bologna, BolognaAges 18–75 - NCT01558544Recruiting
Freezing ovarian tissue for future fertility after early menopause risk
This study looks at freezing (cryopreserving) ovarian tissue in people who are at risk of early menopause because of cancer treatment or surgery. It may help preserve natural hormone function and possible future fertility for those who cannot or do not want to freeze eggs or embryos.
New York, New YorkAges Up to 45 years - NCT06453486RecruitingPhase 2
High dose radiation for pancreatic cancer after chemo
This trial tests whether giving a strong, focused dose of radiation can help people with locally advanced pancreatic cancer that has shrunk or stayed stable with first-line chemotherapy. It aims to improve outcomes for those who cannot have surgery.
Toronto, OntarioAges 18 years+ - NCT05420779RecruitingPhase 2
TSL-1502 for breast cancer with BRCA gene mutations
This Phase 2 trial tests TSL-1502 capsules, a targeted medicine for breast cancer, in people whose blood test shows a harmful BRCA gene mutation. It aims to see whether it can control the cancer and how safe it is after prior treatment.
BeijingAges 18–75 - NCT07343531Recruiting
Radiation and chemo for cervical cancer
This trial tests a shorter course of radiation combined with chemotherapy and brachytherapy (internal radiation) for cervical cancer that has not spread widely. It aims to make treatment more efficient while still being effective.
Cairo, Cairo GovernorateAges 18 years+ - NCT04583254RecruitingPhase 2
Shorter radiation plan for certain early cervical cancers
This trial tests a feasibility (“can it be done safely?”) approach that delivers radiation in a shorter schedule for some cervical cancer patients. It also uses weekly cisplatin chemotherapy and includes a radiation procedure called brachytherapy to improve treatment effectiveness.
Kelowna, British ColumbiaAges 18 years+ - NCT07035249RecruitingPhase 1/Phase 2
DCSZ11 plus standard therapy for advanced solid tumors
This trial tests a new drug called DCSZ11 combined with usual chemotherapy and immunotherapy for people with advanced or metastatic solid tumors. It aims to see if adding DCSZ11 works better than standard treatments alone.
Chengdu, SichuanAges 18 years+ - NCT07232134RecruitingPhase 3
Treating AML in children with Down syndrome
This trial tests a treatment plan for children with Down syndrome who have been diagnosed with acute myeloid leukemia (AML) or a related bone marrow condition. The goal is to see how well the therapy works and to help guide doctors in choosing the best approach.
MoscowAges 1 day–18 years - NCT05338866Enrolling by invitation
Chemo plus targeted high-dose radiation for low rectal cancer
This trial tests whether combining chemotherapy with high-dose radiation guided by MRI (a special scan) can better treat low rectal cancer. It may help shrink the tumor and improve local control while targeting the tumor more precisely.
Guangzhou, GuangdongAges 18–80 - NCT06476184RecruitingPhase 3
Adjusted chemo dosing for hard-to-treat ovarian cancer
This trial tests a different way of giving chemotherapy to people with advanced ovarian cancer that didn't respond well to initial treatment. The goal is to see if changing the dose and schedule can improve outcomes.
AngersAges 18 years+
What High Dose Chemotherapy is being studied for
Conditions with recruiting High Dose Chemotherapy studies.
Common questions
- Are there clinical trials studying High Dose Chemotherapy?
- Yes. Clin2 currently lists 149 recruiting studies that include High Dose Chemotherapy, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a High Dose Chemotherapy trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is High Dose Chemotherapy an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether High Dose Chemotherapy or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.