Treatment
High Dose Chemotherapy clinical trials
We’re tracking 149 recruiting studies that include High Dose Chemotherapy, each written for real people, not researchers, below.
Recruiting studies
- NCT05083247RecruitingPhase 2
Pre-surgery chemotherapy plus targeted radiation for borderline pancreatic cancer
This trial studies whether giving chemotherapy before surgery, and possibly adding a focused high-dose radiation treatment, can improve outcomes for people with borderline resectable pancreatic cancer. It aims to shrink or control the cancer and help more patients get to surgery safely.
AntwerpAges 18 years+ - NCT07177079RecruitingPhase 1
High-dose vitamin C with standard therapy for newly diagnosed AML
This trial tests adding high-dose vitamin C (ascorbate) to the standard two-drug treatment (azacitidine and venetoclax) for people with newly diagnosed acute myeloid leukemia who are not candidates for intensive chemo. The goal is to see if the vitamin C makes the standard treatment work better and helps control the leukemia.
Iowa City, IowaAges 18–75 - NCT06630611RecruitingPhase 2
A new immune cell therapy for melanoma, lung, and cervical cancer
This trial tests a new way to boost your immune cells after they are collected from your tumor and grown in a lab. Instead of high-dose IL-2, you would get a modified version called ANV419, which may have fewer side effects.
BarcelonaAges 18 years+ - NCT07775209Enrolling by invitationPhase 2
Shorter radiation and chemo for anal cancer
This trial tests a shorter course of radiation therapy given with chemotherapy for people with high-risk anal cancer. The goal is to see if the shorter treatment is just as effective but causes fewer side effects and is more convenient.
Burlington, VermontAges 18 years+ - NCT06652048RecruitingPhase 2
High-dose Furmonertinib for advanced lung cancer after progression
This trial tests a higher dose of the targeted therapy Furmonertinib, either alone or with chemotherapy, for people with advanced non-small cell lung cancer that has progressed after initial treatment with a third-generation EGFR inhibitor like Osimertinib or Almonertinib.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07818629RecruitingPhase 1
Testing a vaccine to prevent stomach flu in healthy adults
This trial tests an investigational vaccine called INT101 to see if it can prevent norovirus, a common cause of stomach flu (vomiting and diarrhea). It is given to healthy adults to check its safety and how well it works before moving to larger studies.
SeoulAges 19–48 - NCT07039968RecruitingPhase 2
Standard vs. high dose radiation for spine cancer spread
This trial compares standard and higher doses of focused radiation (stereotactic radiosurgery) to treat cancer that has spread to the spine. It aims to find if a higher dose works better while keeping side effects manageable.
TaipeiAges 18 years+ - NCT04945642Recruiting
Radiation combination therapy for intermediate to high-risk prostate cancer
This trial studies a combination of two radiation types—high-dose-rate brachytherapy and stereotactic body radiotherapy—to treat certain intermediate- to high-risk prostate cancers. It may help by aiming radiation closely at the prostate while also targeting the cancer from outside the body.
Los Angeles, CaliforniaAges 18 years+ - NCT07296315RecruitingPhase 2
Testing a new treatment for mild-to-moderate ulcerative colitis
This study tests an investigational drug for people with active mild-to-moderate ulcerative colitis. It aims to see if the drug can improve symptoms without needing advanced treatments like biologics.
Miami, FloridaAges 16 years+ - NCT06492759RecruitingPhase 2
High-dose radiation with pembrolizumab and chemo for pd-l1 positive tnbc
This trial tests giving high-dose radiation along with the immunotherapy drug pembrolizumab and chemo to people with a specific subtype of advanced breast cancer (PD-L1 positive triple negative). It may help shrink tumors and keep them from growing.
Atlanta, GeorgiaAges 18 years+ - NCT05728268RecruitingPhase 2
Test dose-dense chemo before surgery for high-growth hormone-positive breast cancer
This Phase 2 study tests a faster, more frequent chemotherapy schedule given before surgery (neoadjuvant therapy) for certain breast cancers that grow quickly. It may help shrink the tumor before the operation and improve treatment response in people who fit the tumor and health criteria.
Shantou, GuangdongAges 18–70 - NCT06824168RecruitingPhase 2
Quizartinib maintenance for FLT3-ITD AML in remission
This trial tests two different doses of an oral targeted pill called quizartinib (a FLT3 inhibitor) to keep AML with a FLT3-ITD mutation in remission after initial chemo. If you are in first complete remission and haven't had a transplant, this might be an option to lower the chance of relapse.
Birmingham, AlabamaAges 18 years+ - NCT07243119Enrolling by invitationPhase 4
Heart failure study with adenosine scans to predict recovery
This trial tests whether high-dose adenosine during a heart scan can better predict how well your heart muscle might recover, compared to standard dosing. The information could help doctors personalize treatment for people newly diagnosed with heart failure and a low ejection fraction.
HerningAges 18–100 - NCT06513065RecruitingPhase 3
Lower dose vs standard dose HIPEC for pseudomyxoma peritonei
This trial compares a lower dose of heated chemotherapy (HIPEC) given during surgery to a standard dose for patients with pseudomyxoma peritonei (a condition where jelly-like mucus builds up in the abdomen). The goal is to see if the lower dose works just as well with fewer side effects.
Basingstoke, HampshireAges 16 years+ - NCT06092957RecruitingPhase 3
Reduced radiation after chemo-immunotherapy for high-risk nasopharyngeal cancer
This trial tests whether a lower dose of radiation, with or without additional chemo-immunotherapy, works as well as the standard full-dose chemoradiation for people with advanced nasopharyngeal cancer who had a complete response after initial chemo-immunotherapy.
Guangzhou, GuangdongAges 18–70 - NCT07833436RecruitingPhase 1
Testing a new Lassa fever vaccine
This trial tests a new vaccine against Lassa fever to see if it is safe and how well it triggers an immune response. It may help protect against this serious infection.
ParisAges 18–55 - NCT07510308RecruitingPhase 1
Vaccine trial for advanced colorectal cancer
This trial tests a personalized vaccine made from your own tumor cells for advanced colorectal cancer that is mismatch repair proficient (pMMR). It aims to see if the vaccine can help when standard treatments have stopped working.
Chengdu, SichuanAges 18–75 - NCT07279077RecruitingPhase 2
Low-dose radiation with chemo and immunotherapy for high-risk colon cancer
This trial tests a combination of low-dose radiation, chemotherapy, and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of high-risk colon cancer that has not spread. The goal is to see if this approach can shrink the tumor before surgery and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT03507842Enrolling by invitationPhase 3
Testing two induction chemo options for newly diagnosed AML
This Phase 3 trial compares two chemotherapy approaches given first (induction) for people newly diagnosed with AML. It aims to find which option works better and is safer to help achieve remission.
SeoulAges 15–60 - NCT03500133RecruitingPhase 4
Low-dose chemotherapy and less radiation for childhood Hodgkin lymphoma
This trial studies a treatment plan for children with classical Hodgkin lymphoma that uses lower total doses of chemotherapy and reduced radiation. The goal is to help control the lymphoma while lowering long-term side effects.
Buenos Aires, Buenos Aires F.D.Ages 2–18 - NCT06683521Recruiting
Understanding the immune system in FPIES
This study looks at how the immune system works in people with Food Protein-Induced Enterocolitis Syndrome (FPIES). It aims to learn more about this condition to improve future diagnosis and treatment.
New York, New YorkAges 1–60 - NCT07838298RecruitingPhase 4
Flu vaccine response in older adults who get it yearly
This study checks how well the seasonal flu vaccine works in people 65 and older who have had flu shots regularly. It compares their immune response to that of younger adults to see if repeated vaccination still protects them.
SeoulAges 19 years+ - NCT06771479RecruitingPhase 1
Monkeypox vaccine safety and immune response study
This trial tests a new monkeypox vaccine to see if it is safe and helps the body build protection. It may be an option for adults who were born before 1980 and received a smallpox vaccine, or who meet other health criteria.
Zhengzhou, HenanAges 18 years+ - NCT07688252RecruitingPhase 1
Immunotherapy and chemotherapy for newly diagnosed high-risk neuroblastoma
This trial tests a new drug combination (dinutuximab-beta plus chemotherapy) for children and young adults with newly diagnosed high-risk neuroblastoma. The goal is to see if adding this targeted therapy to standard chemo improves outcomes.
Taipei, TaiwanAges 1–30
Common questions
- Are there clinical trials studying High Dose Chemotherapy?
- Yes. Clin2 currently lists 149 recruiting studies that include High Dose Chemotherapy, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a High Dose Chemotherapy trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is High Dose Chemotherapy an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether High Dose Chemotherapy or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.